MERS-CoV: Understanding the Latest Human Coronavirus Threat.

Abstract:

:Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man died as a result of renal and respiratory failure after admission to a hospital in Jeddah, Saudi Arabia. The aetiological agent was eventually identified as a coronavirus and designated Middle East respiratory syndrome coronavirus (MERS-CoV). MERS-CoV has now been reported in more than 27 countries across the Middle East, Europe, North Africa and Asia. As of July 2017, 2040 MERS-CoV laboratory confirmed cases, resulting in 712 deaths, were reported globally, with a majority of these cases from the Arabian Peninsula. This review summarises the current understanding of MERS-CoV, with special reference to the (i) genome structure; (ii) clinical features; (iii) diagnosis of infection; and (iv) treatment and vaccine development.

journal_name

Viruses

journal_title

Viruses

authors

Chafekar A,Fielding BC

doi

10.3390/v10020093

subject

Has Abstract

pub_date

2018-02-24 00:00:00

issue

2

issn

1999-4915

pii

v10020093

journal_volume

10

pub_type

杂志文章,评审
  • Advanced Therapeutics, Vaccinations, and Precision Medicine in the Treatment and Management of Chronic Hepatitis B Viral Infections; Where Are We and Where Are We Going?

    abstract::The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide analogue (NUC) drugs, and the widespread use of immune stimulators such as interferon-alpha (IFNα) or PEGylated interferon-alpha (PEG-IFNα), sub...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v12090998

    authors: Duraisamy GS,Bhosale D,Lipenská I,Huvarova I,Růžek D,Windisch MP,Miller AD

    更新日期:2020-09-07 00:00:00

  • New Markers in Monitoring the Reactivation of Hepatitis B Virus Infection in Immunocompromised Hosts.

    abstract::Hepatitis B virus (HBV) persistence is at the basis of HBV reactivation as a consequence of chemotherapy and immunosuppressive treatments. The identification of early viral replication indicators and markers of effective HBV immunological control would be useful in monitoring patients who are at risk of potential vira...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v11090783

    authors: Svicher V,Salpini R,Malagnino V,Piermatteo L,Alkhatib M,Cerva C,Sarmati L

    更新日期:2019-08-25 00:00:00

  • A Decade in Review: A Systematic Review of Universal Influenza Vaccines in Clinical Trials during the 2010 Decade.

    abstract::On average, there are 3-5 million severe cases of influenza virus infections globally each year. Seasonal influenza vaccines provide limited protection against divergent influenza strains. Therefore, the development of a universal influenza vaccine is a top priority for the NIH. Here, we report a comprehensive summary...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v12101186

    authors: Corder BN,Bullard BL,Poland GA,Weaver EA

    更新日期:2020-10-20 00:00:00

  • Substantial Antigenic Drift in the Hemagglutinin Protein of Swine Influenza A Viruses.

    abstract::The degree of antigenic drift in swine influenza A viruses (swIAV) has historically been regarded as minimal compared to that of human influenza A virus strains. However, as surveillance activities on swIAV have increased, more isolates have been characterized, revealing a high level of genetic and antigenic differenc...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v12020248

    authors: Ryt-Hansen P,Pedersen AG,Larsen I,Kristensen CS,Krog JS,Wacheck S,Larsen LE

    更新日期:2020-02-23 00:00:00

  • Therapeutic Use of Native and Recombinant Enteroviruses.

    abstract::Research on human enteroviruses has resulted in the identification of more than 100 enterovirus types, which use more than 10 protein receptors and/or attachment factors required in cell binding and initiation of the replication cycle. Many of these "viral" receptors are overexpressed in cancer cells. Receptor binding...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v8030057

    authors: Ylä-Pelto J,Tripathi L,Susi P

    更新日期:2016-02-23 00:00:00

  • Construction and Immunogenicity of Novel Chimeric Virus-Like Particles Bearing Antigens of Infectious Bronchitis Virus and Newcastle Disease Virus.

    abstract::Infectious bronchitis virus (IBV) and Newcastle disease virus (NDV) are two poultry pathogens seriously affecting the poultry industry. Here, IBV S1 and the ectodomain of NDV F proteins were separately linked with the trans-membrane and carboxy-terminal domain of IBV S protein (STMCT), composing rS and rF; thus, a nov...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v11030254

    authors: Wu X,Zhai X,Lai Y,Zuo L,Zhang Y,Mei X,Xiang R,Kang Z,Zhou L,Wang H

    更新日期:2019-03-13 00:00:00

  • Transcriptome Analysis and In Situ Hybridization for FcaGHV1 in Feline Lymphoma.

    abstract::Lymphoma is one of the most common malignancies in domestic cats. The lymphomagenic potential of Felis catus gammaherpesvirus 1 (FcaGHV1), a common infection in domestic cats, is unknown. In other species, including humans, cellular transformation by gammaherpesviruses is typically mediated by viral genes expressed du...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v10090464

    authors: Aghazadeh M,Shi M,Pesavento PA,Durham AC,Polley T,Donahoe SL,Troyer RM,Barrs VR,Holmes EC,Beatty JA

    更新日期:2018-08-30 00:00:00

  • Induction of Brain Tumors by the Archetype Strain of Human Neurotropic JCPyV in a Transgenic Mouse Model.

    abstract::JC Virus (JCPyV), a member of the Polyomaviridiæ family, is a human neurotropic virus with world-wide distribution. JCPyV is the established opportunistic infectious agent of progressive multifocal leukoencephalopathy, a fatal demyelinating disease, which results from the cytolytic infection of oligodendrocytes. Mutat...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v13020162

    authors: Del Valle L,Khalili K

    更新日期:2021-01-22 00:00:00

  • Vampire bat rabies: ecology, epidemiology and control.

    abstract::Extensive surveillance in bat populations in response to recent emerging diseases has revealed that this group of mammals acts as a reservoir for a large range of viruses. However, the oldest known association between a zoonotic virus and a bat is that between rabies virus and the vampire bat. Vampire bats are only fo...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v6051911

    authors: Johnson N,Aréchiga-Ceballos N,Aguilar-Setien A

    更新日期:2014-04-29 00:00:00

  • Super-resolution microscopy: a virus' eye view of the cell.

    abstract::It is difficult to observe the molecular choreography between viruses and host cell components, as they exist on a spatial scale beyond the reach of conventional microscopy. However, novel super-resolution microscopy techniques have cast aside technical limitations to reveal a nanoscale view of virus replication and c...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v6031365

    authors: Grove J

    更新日期:2014-03-19 00:00:00

  • Rotavirus Genomic RNA Complex Forms via Specific RNA-RNA Interactions: Disruption of RNA Complex Inhibits Virus Infectivity.

    abstract::Rotavirus (RV), a member of the Reoviridae family, causes infection in children and infants, with high morbidity and mortality. To be viable, the virus particle must package a set of eleven RNA segments. In order to understand the packaging mechanism, here, we co-synthesized sets of RNA segments in vitro in different ...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v9070167

    authors: Fajardo T,Sung PY,Celma CC,Roy P

    更新日期:2017-06-29 00:00:00

  • Noncanonical expression of a murine cytomegalovirus early protein CD8 T-cell epitope as an immediate early epitope based on transcription from an upstream gene.

    abstract::Viral CD8 T-cell epitopes, represented by viral peptides bound to major histocompatibility complex class-I (MHC-I) glycoproteins, are often identified by "reverse immunology", a strategy not requiring biochemical and structural knowledge of the actual viral protein from which they are derived by antigen processing. In...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v6020808

    authors: Fink A,Büttner JK,Thomas D,Holtappels R,Reddehase MJ,Lemmermann NA

    更新日期:2014-02-14 00:00:00

  • Replication cycle and molecular biology of the West Nile virus.

    abstract::West Nile virus (WNV) is a member of the genus Flavivirus in the family Flaviviridae. Flaviviruses replicate in the cytoplasm of infected cells and modify the host cell environment. Although much has been learned about virion structure and virion-endosomal membrane fusion, the cell receptor(s) used have not been defin...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v6010013

    authors: Brinton MA

    更新日期:2013-12-27 00:00:00

  • Application of CRISPR/Cas9 Gene Editing System on MDV-1 Genome for the Study of Gene Function.

    abstract::Marek's disease virus (MDV) is a member of alphaherpesviruses associated with Marek's disease, a highly contagious neoplastic disease in chickens. Complete sequencing of the viral genome and recombineering techniques using infectious bacterial artificial chromosome (BAC) clones of Marek's disease virus genome have ide...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v10060279

    authors: Zhang Y,Tang N,Sadigh Y,Baigent S,Shen Z,Nair V,Yao Y

    更新日期:2018-05-24 00:00:00

  • Interactions of Human Dermal Dendritic Cells and Langerhans Cells Treated with Hyalomma Tick Saliva with Crimean-Congo Hemorrhagic Fever Virus.

    abstract::Crimean-Congo hemorrhagic fever virus is one the most important and wide spread tick-borne viruses. Very little is known about the transmission from the tick and the early aspects of pathogenesis. Here, we generate human cutaneous antigen presenting cells-dermal dendritic cells and Langerhans cells-from umbilical cord...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v10070381

    authors: Rodriguez SE,McAuley AJ,Gargili A,Bente DA

    更新日期:2018-07-20 00:00:00

  • Phylogenomic Analysis of Global Isolates of Canid Alphaherpesvirus 1.

    abstract::Canid alphaherpesvirus 1 (CHV-1) is a widespread pathogen of dogs with multiple associated clinical signs. There has been limited prior investigation into the genomics and phylogeny of this virus using whole viral genome analysis. Fifteen CHV-1 isolates were collected from animals with ocular disease based in the USA....

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v12121421

    authors: Lewin AC,Coghill LM,Mironovich M,Liu CC,Carter RT,Ledbetter EC

    更新日期:2020-12-10 00:00:00

  • Serological Survey of Lyssaviruses in Polish Bats in the Frame of Passive Rabies Surveillance Using an Enzyme-Linked Immunosorbent Assay.

    abstract::Background: Bats are known to host a number of nonpathogenic viruses, as well as highly pathogenic viruses causing fatal diseases like rabies. Serological surveys as part of active and passive bat rabies surveillance mainly use seroneutralization assays, demonstrating the presence of lyssavirus-specific antibodies in ...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v12030271

    authors: Orłowska A,Smreczak M,Freuling CM,Müller T,Trębas P,Rola J

    更新日期:2020-02-28 00:00:00

  • Portable Rabies Virus Sequencing in Canine Rabies Endemic Countries Using the Oxford Nanopore MinION.

    abstract::As countries with endemic canine rabies progress towards elimination by 2030, it will become necessary to employ techniques to help plan, monitor, and confirm canine rabies elimination. Sequencing can provide critical information to inform control and vaccination strategies by identifying genetically distinct virus va...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v12111255

    authors: Gigante CM,Yale G,Condori RE,Costa NC,Long NV,Minh PQ,Chuong VD,Tho ND,Thanh NT,Thin NX,Hanh NTH,Wambura G,Ade F,Mito O,Chuchu V,Muturi M,Mwatondo A,Hampson K,Thumbi SM,Thomae BG,de Paz VH,Meneses S,Munyua P,

    更新日期:2020-11-04 00:00:00

  • In Vitro Inhibition of Zika Virus Replication with Poly(Sodium 4-Styrenesulfonate).

    abstract::Zika virus (ZIKV) is an emerging mosquito-borne pathogen associated with microcephaly and other congenital abnormalities in newborns as well as neurologic complications in adults. The explosive transmission of the virus in the last ten years put it in the limelight and improved our understanding of its biology and pat...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v12090926

    authors: Botwina P,Obłoza M,Szczepański A,Szczubiałka K,Nowakowska M,Pyrć K

    更新日期:2020-08-23 00:00:00

  • Requirements within the Ebola Viral Glycoprotein for Tetherin Antagonism.

    abstract::Tetherin is an interferon-induced, intrinsic cellular response factor that blocks release of numerous viruses, including Ebola virus, from infected cells. As with many viruses targeted by host factors, Ebola virus employs a tetherin antagonist, the viral glycoprotein (EboGP), to counteract restriction and promote viru...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v7102888

    authors: Vande Burgt NH,Kaletsky RL,Bates P

    更新日期:2015-10-26 00:00:00

  • Herpesviruses placating the unwilling host: manipulation of the MHC class II antigen presentation pathway.

    abstract::Lifelong persistent infection by herpesviruses depends on the balance between host immune responses and viral immune evasion. CD4 T cells responding to antigens presented on major histocompatibility complex class II (MHC-II) molecules are known to play an important role in controlling herpesvirus infections. Here we r...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v4081335

    authors: Zuo J,Rowe M

    更新日期:2012-08-01 00:00:00

  • Ethanol Extract of Caesalpinia decapetala Inhibits Influenza Virus Infection In Vitro and In Vivo.

    abstract::Influenza virus infections can lead to viral pneumonia and acute respiratory distress syndrome in severe cases, causing significant morbidity and mortality and posing a great threat to human health. Because of the diversity of influenza virus strains and drug resistance to the current direct antiviral agents, there ha...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v12050557

    authors: Zhang L,Chen J,Ke C,Zhang H,Zhang S,Tang W,Liu C,Liu G,Chen S,Hu A,Sun W,Xiao Y,Liu M,Chen X

    更新日期:2020-05-18 00:00:00

  • Comparative Analysis of Different Serological and Molecular Tests for the Detection of Small Ruminant Lentiviruses (SRLVs) in Belgian Sheep and Goats.

    abstract::Countries rely on good diagnostic tests and appropriate testing schemes to fight against economically important small ruminant lentivirus (SRLV) infections. We undertook an extensive comparative analysis of seven commercially available serological tests and one in-house real-time PCR (qPCR) detecting genotype A and B ...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v10120696

    authors: Michiels R,Van Mael E,Quinet C,Adjadj NR,Cay AB,De Regge N

    更新日期:2018-12-08 00:00:00

  • Influence of Irradiance and Temperature on the Virus MpoV-45T Infecting the Arctic Picophytoplankter Micromonas polaris.

    abstract::Arctic marine ecosystems are currently undergoing rapid changes in temperature and light availability. Picophytoplankton, such as Micromonas polaris, are predicted to benefit from such changes. However, little is known about how these environmental changes affect the viruses that exert a strong mortality pressure on t...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v10120676

    authors: Piedade GJ,Wesdorp EM,Montenegro-Borbolla E,Maat DS,Brussaard CPD

    更新日期:2018-11-29 00:00:00

  • Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection.

    abstract::Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbr...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v12050533

    authors: Kanda T,Sasaki R,Masuzaki R,Matsumoto N,Ogawa M,Moriyama M

    更新日期:2020-05-12 00:00:00

  • RNase L Is Involved in Liposaccharide-Induced Lung Inflammation.

    abstract::RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in t...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v12010073

    authors: Wei R,Chen G,Algehainy N,Zeng C,Liu C,Liu H,Liu W,Stacey D,Zhou A

    更新日期:2020-01-07 00:00:00

  • A Survey of Mycoviral Infection in Fusarium spp. Isolated from Maize and Sorghum in Argentina Identifies the First Mycovirus from Fusarium verticillioides.

    abstract::Mycoviruses appear to be widespread in Fusarium species worldwide. The aim of this work was to identify mycoviral infections in Fusarium spp., isolated from maize and sorghum grown in Argentina, and to estimate their potential effects on the pathogenicity and toxigenesis of the host fungus towards maize. Mycoviruses w...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v12101161

    authors: Jacquat AG,Theumer MG,Cañizares MC,Debat HJ,Iglesias J,García Pedrajas MD,Dambolena JS

    更新日期:2020-10-14 00:00:00

  • Factors That Improve RT-QuIC Detection of Prion Seeding Activity.

    abstract::Rapid and sensitive detection of prions is important in managing prion diseases. The real-time quaking-induced conversion (RT-QuIC) assay for prion seeding activity has been applied to many prion diseases and provides for specific antemortem diagnostic testing. We evaluated RT-QuIC's long-term consistency and varied m...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v8050140

    authors: Orrú CD,Hughson AG,Groveman BR,Campbell KJ,Anson KJ,Manca M,Kraus A,Caughey B

    更新日期:2016-05-23 00:00:00

  • Organization, Function, and Therapeutic Targeting of the Morbillivirus RNA-Dependent RNA Polymerase Complex.

    abstract::The morbillivirus genus comprises major human and animal pathogens, including the highly contagious measles virus. Morbilliviruses feature single stranded negative sense RNA genomes that are wrapped by a plasma membrane-derived lipid envelope. Genomes are encapsidated by the viral nucleocapsid protein forming ribonucl...

    journal_title:Viruses

    pub_type: 杂志文章,评审

    doi:10.3390/v8090251

    authors: Sourimant J,Plemper RK

    更新日期:2016-09-10 00:00:00

  • Characterization of a Novel Thermobifida fusca Bacteriophage P318.

    abstract::Thermobifida fusca is of biotechnological interest due to its ability to produce an array of plant cell wall hydrolytic enzymes. Nonetheless, only one T. fusca bacteriophage with genome information has been reported to date. This study was aimed at discovering more relevant bacteriophages to expand the existing knowle...

    journal_title:Viruses

    pub_type: 杂志文章

    doi:10.3390/v11111042

    authors: Cheepudom J,Lin TL,Lee CC,Meng M

    更新日期:2019-11-08 00:00:00