Abstract：
:Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man died as a result of renal and respiratory failure after admission to a hospital in Jeddah, Saudi Arabia. The aetiological agent was eventually identified as a coronavirus and designated Middle East respiratory syndrome coronavirus (MERS-CoV). MERS-CoV has now been reported in more than 27 countries across the Middle East, Europe, North Africa and Asia. As of July 2017, 2040 MERS-CoV laboratory confirmed cases, resulting in 712 deaths, were reported globally, with a majority of these cases from the Arabian Peninsula. This review summarises the current understanding of MERS-CoV, with special reference to the (i) genome structure; (ii) clinical features; (iii) diagnosis of infection; and (iv) treatment and vaccine development.
journal_name
Virusesjournal_title
Virusesauthors
Chafekar A,Fielding BCdoi
10.3390/v10020093subject
Has Abstractpub_date
2018-02-24 00:00:00issue
2issn
1999-4915pii
v10020093journal_volume
10pub_type
杂志文章,评审相关文献
Viruses-Basel文献大全abstract：:Hepatitis C Virus (HCV) remains an important public health threat with approximately 170 million carriers worldwide who are at risk of developing hepatitis C-associated end-stage liver diseases. Despite improvement of HCV treatment using the novel direct-acting antivirals (DAAs) targeting viral replication, there is a...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10120669
更新日期：2018-11-27 00:00:00
abstract：:Porcine epidemic diarrhea (PED) is a highly contagious disease in newborn piglets. In our previous study, a genetically engineered Lactobacillus casei oral vaccine (pPG-COE-DCpep/L393) expressing a dendritic cell (DC)-targeting peptide fused with porcine epidemic diarrhea virus (PEDV) COE antigen was developed. This v...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10030106
更新日期：2018-03-01 00:00:00
abstract：:Peptide-displayed phage libraries are billion-clone collections of diverse chimeric bacteriophage particles, decorated by genetically fused peptides built from a random combination of natural amino acids. Studying the molecular evolution of peptide-displayed libraries in mammalian model systems, using in vivo phage di...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11110988
更新日期：2019-10-26 00:00:00
abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is a complex retrovirus that infects CD4+ T cells and causes adult T-cell leukemia/lymphoma (ATLL) in 3%-5% of infected individuals after a long latent period. HTLV-1 Tax is a trans-activating protein that regulates viral gene expression and also modulates cellular signaling...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v6103925
更新日期：2014-10-23 00:00:00
abstract：:Lettuce is often implicated in human norovirus (HuNoV) foodborne outbreaks. We identified H-like histo-blood group antigens (HBGAs) on lettuce leaves as specific binding moieties for virus-like particles (VLPs) of HuNoV GII.4/HS194/2009 strain. The objective of this study was to determine whether HuNoV-lettuce binding...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11090833
更新日期：2019-09-08 00:00:00
abstract：:HIV continues to spread among vulnerable heterosexual (HET), Men-having-Sex with Men (MSM) and intravenous drug user (IDU) populations, influenced by a complex array of biological, behavioral and societal factors. Phylogenetics analyses of large sequence datasets from national drug resistance testing programs reveal t...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v10010010
更新日期：2017-12-28 00:00:00
abstract：:Salmonid alphavirus (SAV) is the cause of pancreas disease and sleeping disease in farmed salmonid fish in Europe. The spread of these diseases has been difficult to control with biosecurity and current vaccination strategies, and increased understanding of the viral pathogenesis could be beneficial for the developmen...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12101071
更新日期：2020-09-24 00:00:00
abstract：:Exosomes are membrane-enclosed vesicles actively released into the extracellular space, whose content reflect the physiological/pathological state of the cells they originate from. These vesicles participate in cell-to-cell communication and transfer of biologically active proteins, lipids, and RNAs. Their role in vir...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v7062770
更新日期：2015-06-19 00:00:00
abstract：:Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated "CiHHV-6A/B". These affect approximately 1.0% of human populations, giving potential for virus gene expression in every cell. We previously showed that CiHHV-6A w...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8010019
更新日期：2016-01-15 00:00:00
abstract：:Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain⁻Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZI...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11020092
更新日期：2019-01-22 00:00:00
abstract：:Extensive surveillance in bat populations in response to recent emerging diseases has revealed that this group of mammals acts as a reservoir for a large range of viruses. However, the oldest known association between a zoonotic virus and a bat is that between rabies virus and the vampire bat. Vampire bats are only fo...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v6051911
更新日期：2014-04-29 00:00:00
abstract：:Highly pathogenic avian influenza (HPAI) and Newcastle disease are economically important avian diseases worldwide. Effective vaccination is critical to control these diseases in poultry. Live attenuated Newcastle disease virus (NDV) vectored vaccines have been developed for bivalent vaccination against HPAI viruses a...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v11030300
更新日期：2019-03-26 00:00:00
abstract：:Dendritic cells (DCs) are involved in human and simian immunodeficiency virus (HIV and SIV) pathogenesis but also play a critical role in orchestrating innate and adaptive vaccine-specific immune responses. Effective HIV/SIV vaccines require strong antigen-specific CD4 T cell responses, cytotoxic activity of CD8 T cel...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12010024
更新日期：2019-12-24 00:00:00
abstract：:Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbr...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12050533
更新日期：2020-05-12 00:00:00
abstract：:Chikungunya virus (CHIKV) has caused extensive outbreaks in several countries within the Americas, Asia, Oceanic/Pacific Islands, and Europe. In humans, CHIKV infections cause a debilitating disease with acute febrile illness and long-term polyarthralgia. Acute and chronic symptoms impose a major economic burden to he...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11040322
更新日期：2019-04-03 00:00:00
abstract：:At the end of 2019, a new disease appeared and spread all over the world, the COVID-19, produced by the coronavirus SARS-CoV-2. As a consequence of this worldwide health crisis, the scientific community began to redirect their knowledge and resources to fight against it. Here we summarize the recent research on viruse...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12101172
更新日期：2020-10-16 00:00:00
abstract：:Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection. High-throughput next-generation sequencing has been used in characterizing the virome of different bat species. The cave nectar bat, Eonycteris spelaea, has a broad...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11030250
更新日期：2019-03-12 00:00:00
abstract：:Laboratories throughout the world that perform work with Risk Group 4 Pathogens generally adopt one of two approaches within BSL-4 environments: either the use of positive pressure air-fed suits or using Class III microbiological safety cabinets and isolators for animal work. Within the UK at present, all laboratories...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v4081202
更新日期：2012-08-01 00:00:00
abstract：:Environmental genomics can describe all forms of organisms--cellular and viral--present in a community. The analysis of such eco-systems biology data relies heavily on reference databases, e.g., taxonomy or gene function databases. Reference databases of symbiosis sensu lato, although essential for the analysis of org...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8030066
更新日期：2016-03-01 00:00:00
abstract：:P4 is a mobile genetic element (MGE) that can exist as a plasmid or integrated into its Escherichia coli host genome, but becomes packaged into phage particles by a helper bacteriophage, such as P2. P4 is the original example of what we have termed "molecular piracy", the process by which one MGE usurps the life cycle...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12090953
更新日期：2020-08-27 00:00:00
abstract：:: African swine fever is a devastating hemorrhagic infectious disease, which affects domestic and wild swines (Susscrofa) of all breeds and ages, with a high lethality of up to 90-100% in naïve animals. The causative agent, African swine fever virus (ASFV), is a large and complex double-stranded DNA arbovirus which is...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11100882
更新日期：2019-09-20 00:00:00
abstract：:A highly virulent porcine epidemic diarrhea virus (PEDV) appeared in China and spread rapidly to neighbor countries, which have led to great economic losses to the pig industry. In the present study, we isolated a PEDV using Vero cells and serially propagated 100 passages. PEDV SDSX16 was characterized in vitro and in...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12040391
更新日期：2020-04-01 00:00:00
abstract：:The human gut contains an expanse of largely unstudied bacteriophages. Among the most common are crAss-like phages, which were predicted to infect Bacteriodetes hosts. CrAssphage, the first crAss-like phage to be discovered, contains a protein encoding a Bacteroides-associated carbohydrate-binding often N-terminal (BA...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11121085
更新日期：2019-11-21 00:00:00
abstract：:In rabies diagnosis, it is essential to count on a rapid test to give a quick response. The combined sensitivity and robustness of the TaqMan RT-PCR assays (qRT-PCR) have made these methods a valuable alternative for rabies virus (RABV) detection. We conducted a study to compare the applicability of two widely used qR...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v13010023
更新日期：2020-12-25 00:00:00
abstract：:Viral encephalitis causes acute inflammation of the brain parenchyma and is a significant cause of human morbidity and mortality. Although Herpes Simplex encephalitis is the most frequent known cause of fatal sporadic encephalitis in humans, an increasingly wide range of viruses and other microbial pathogens are impli...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9060138
更新日期：2017-06-06 00:00:00
abstract：:Preclinical infection model systems are extremely valuable tools to aid in our understanding of Human Papillomavirus (HPV) biology, disease progression, prevention, and treatments. In this context, rodent papillomaviruses and their respective infection models are useful tools but remain underutilized resources in the ...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9120362
更新日期：2017-11-27 00:00:00
abstract：:It has been demonstrated that MEK1, one of the two MEK isoforms in Raf-MEK-ERK1/2 pathway, is essential for successful EV71 propagation. However, the distinct function of ERK1 and ERK2 isoforms, the downstream kinases of MEKs, remains unclear in EV71 replication. In this study, specific ERK siRNAs and selective inhibi...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v7031344
更新日期：2015-03-20 00:00:00
abstract：:The extension of virology beyond its traditional medical, veterinary, or agricultural applications, now called environmental virology, has shown that viruses are both the most numerous and diverse biological entities on Earth. In particular, virus isolations from unicellular eukaryotic hosts (heterotrophic and photosy...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12101130
更新日期：2020-10-06 00:00:00
abstract：:Herpes simplex virus 1 (HSV-1) can infect a wide range of cell types, including cells of the adaptive and innate immunity but, normally, it completes a fully-permissive replication cycle only in epithelial or neural cells. Complex mechanisms controlling this delicate balance in immune cells and consequent restriction ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11050428
更新日期：2019-05-10 00:00:00
abstract：:Two sister orders of the brown macroalgae (class Phaeophyceae), the morphologically complex Laminariales (commonly referred to as kelp) and the morphologically simple Ectocarpales are natural hosts for the dsDNA phaeoviruses (family Phycodnaviridae) that persist as proviruses in the genomes of their hosts. We have pre...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10080410
更新日期：2018-08-05 00:00:00
