Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines.

abstract：:Zika virus recently re-emerged and caused global outbreaks mainly in Central Africa, Southeast Asia, the Pacific Islands and in Central and South America. Even though there is a declining trend, the virus continues to spread throughout different geographical regions of the world. Since its re-emergence in 2015, massiv...

journal_title：Viruses

authors： Alves MP,Vielle NJ,Thiel V,Pfaender S

更新日期：2018-10-30 00:00:00

abstract：:Live attenuated influenza vaccines (LAIV) have prevented morbidity and mortality associated with influenza viral infections for many years and represent the best therapeutic option to protect against influenza viral infections in humans. However, the development of LAIV has traditionally relied on empirical methods, s...

journal_title：Viruses

authors： Martínez-Sobrido L,Peersen O,Nogales A

更新日期：2018-10-15 00:00:00

abstract：:Tailoring public health responses to growing HIV transmission clusters depends on accurately mapping the risk network through which it spreads and identifying acute infections that represent the leading edge of cluster growth. HIV transmission links, especially those involving persons with acute HIV infection (AHI), c...

journal_title：Viruses

authors： Campbell EM,Patala A,Shankar A,Li JF,Johnson JA,Westheimer E,Gay CL,Cohen SE,Switzer WM,Peters PJ

更新日期：2020-01-27 00:00:00

abstract：:The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature of HBV, need to operate in the liver parenchyma. In this respect, we will discuss broad features of HBV immunity in pat...

journal_title：Viruses

authors： Bertoletti A,Tan AT,Gehring AJ

更新日期：2009-09-01 00:00:00

abstract：:Phage lytic enzymes are enzymes produced by bacterial viruses, either as part of their virion to facilitate bacterial infection through local peptidoglycan degradation, or as soluble proteins to induce massive cell lysis at the end of the lytic replication cycle [...]. ...

journal_title：Viruses

authors： Briers Y

更新日期：2019-01-29 00:00:00

abstract：:Fruit trees, such as apricot trees, are constantly exposed to the attack of viruses. As they are propagated in a vegetative way, this risk is present not only in the field, where they remain for decades, but also during their propagation. Metagenomic diagnostic methods, based on next generation sequencing (NGS), offer...

journal_title：Viruses

authors： Baráth D,Jaksa-Czotter N,Molnár J,Varga T,Balássy J,Szabó LK,Kirilla Z,Tusnády GE,Preininger É,Várallyay É

更新日期：2018-06-11 00:00:00

abstract：:A Chikungunya virus (CHIKV) outbreak in Italy in 2007 spread to include the islands of the Caribbean and most of the Americas and still circulates in Europe and Africa. Florida being close in distance to the Caribbean islands experienced a CHIKV outbreak in 2014 and continues to have a few travel-related cases each ye...

journal_title：Viruses

authors： Shin D,Kang S,Smartt CT

更新日期：2020-07-29 00:00:00

abstract：:HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the cellular ESCRT factor TSG101 and the viral protein Vpr. The processing of Ga...

journal_title：Viruses

authors： Mouhand A,Pasi M,Catala M,Zargarian L,Belfetmi A,Barraud P,Mauffret O,Tisné C

更新日期：2020-09-29 00:00:00

abstract：:Cyclophilins are peptidyl-prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for c...

journal_title：Viruses

authors： Frausto SD,Lee E,Tang H

更新日期：2013-07-11 00:00:00

abstract：:Extensive surveillance in bat populations in response to recent emerging diseases has revealed that this group of mammals acts as a reservoir for a large range of viruses. However, the oldest known association between a zoonotic virus and a bat is that between rabies virus and the vampire bat. Vampire bats are only fo...

journal_title：Viruses

authors： Johnson N,Aréchiga-Ceballos N,Aguilar-Setien A

更新日期：2014-04-29 00:00:00

abstract：:Low pathogenic avian influenza (LPAI) H7N9 viruses have recently evolved to gain a polybasic cleavage site in the hemagglutinin (HA) protein, resulting in variants with increased lethality in poultry that meet the criteria for highly pathogenic avian influenza (HPAI) viruses. Both LPAI and HPAI variants can cause seve...

journal_title：Viruses

authors： Chan M,Leung A,Hisanaga T,Pickering B,Griffin BD,Vendramelli R,Tailor N,Wong G,Bi Y,Babiuk S,Berhane Y,Kobasa D

更新日期：2020-01-05 00:00:00

abstract：:Several viral infections of swine are responsible for major economic losses and represent a threat to the swine industry worldwide. New tools are needed to prevent and control endemic, emerging, and re-emerging viral diseases. Dendritic cells (DC) play a central role in linking the innate and adaptive arms of the immu...

journal_title：Viruses

authors： Franzoni G,Graham SP,Dei Giudici S,Oggiano A

更新日期：2019-05-16 00:00:00

abstract：:RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in t...

journal_title：Viruses

authors： Wei R,Chen G,Algehainy N,Zeng C,Liu C,Liu H,Liu W,Stacey D,Zhou A

更新日期：2020-01-07 00:00:00

abstract：:Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of MAR...

journal_title：Viruses

authors： Blair PW,Keshtkar-Jahromi M,Psoter KJ,Reisler RB,Warren TK,Johnston SC,Goff AJ,Downey LG,Bavari S,Cardile AP

更新日期：2018-11-21 00:00:00

abstract：:African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected soft tick bites. As already described, European soft ticks (Orni...

journal_title：Viruses

authors： Pereira De Oliveira R,Hutet E,Duhayon M,Guionnet JM,Paboeuf F,Vial L,Le Potier MF

更新日期：2020-03-11 00:00:00

abstract：:Several viral factors impact the natural course of hepatitis B virus (HBV) infection, the sensitivity of diagnostic tests, or treatment response to interferon-α and nucleos(t)ide analogues. These factors include the viral genotype and serotype but also mutations affecting the HBV surface antigen, basal core promoter/p...

journal_title：Viruses

authors： Velkov S,Protzer U,Michler T

更新日期：2020-11-23 00:00:00

abstract：:Staphylococcus aureus is a common and often virulent pathogen in humans. This bacterium is widespread, being present on the skin and in the nose of healthy people. Staphylococcus aureus can cause infections with severe outcomes ranging from pustules to sepsis and death. The introduction of antibiotics led to a general...

journal_title：Viruses

authors： Kaźmierczak Z,Górski A,Dąbrowska K

更新日期：2014-07-01 00:00:00

abstract：:Hepatitis C Virus (HCV) remains an important public health threat with approximately 170 million carriers worldwide who are at risk of developing hepatitis C-associated end-stage liver diseases. Despite improvement of HCV treatment using the novel direct-acting antivirals (DAAs) targeting viral replication, there is a...

journal_title：Viruses

authors： Hung TC,Jassey A,Lin CJ,Liu CH,Lin CC,Yen MH,Lin LT

更新日期：2018-11-27 00:00:00

abstract：:Although most hepatitis E virus (HEV) infections are asymptomatic, some can be severe, causing fulminant hepatitis and extra-hepatic manifestations, including neurological and kidney injuries. Chronic HEV infections may also occur in immunocompromised patients. This review describes how our understanding of the pathog...

journal_title：Viruses

authors： Lhomme S,Marion O,Abravanel F,Chapuy-Regaud S,Kamar N,Izopet J

更新日期：2016-08-05 00:00:00

abstract：:Bluetongue (BT) is an arthropod-borne viral disease of ruminants with serious trade and socio-economic implications. Although the disease has been reported in a number of countries in sub-Saharan Africa, there is currently no information on circulating serotypes and disease distribution in Zambia. Following surveillan...

journal_title：Viruses

authors： Chambaro HM,Sasaki M,Simulundu E,Silwamba I,Sinkala Y,Gonzalez G,Squarre D,Fandamu P,Lubaba CH,Munyeme M,Maseko A,Chimvwele C,Mataa L,Mooya LE,Mukubesa AN,Harima H,Samui KL,Munang'andu HM,Simuunza M,Nalubamba KS,Q

更新日期：2020-08-31 00:00:00

abstract：:Next-generation sequencing (NGS) has opened up the possibility of detecting new viruses in unresolved diseases. Recently, astrovirus brain infections have been identified in neurologically diseased humans and animals by NGS, among them bovine astrovirus (BoAstV) CH13/NeuroS1, which has been found in brain tissues of c...

journal_title：Viruses

authors： Selimovic-Hamza S,Boujon CL,Hilbe M,Oevermann A,Seuberlich T

更新日期：2017-01-18 00:00:00

abstract：:Noroviruses are the most common etiological agent of acute gastroenteritis worldwide. Despite their high infectivity, a subpopulation of individuals is resistant to infection and disease. This susceptibility is norovirus genotype-dependent and is largely mediated by the presence or absence of human histo-blood group a...

journal_title：Viruses

authors： Nordgren J,Svensson L

更新日期：2019-03-06 00:00:00

abstract：:P4 is a mobile genetic element (MGE) that can exist as a plasmid or integrated into its Escherichia coli host genome, but becomes packaged into phage particles by a helper bacteriophage, such as P2. P4 is the original example of what we have termed "molecular piracy", the process by which one MGE usurps the life cycle...

journal_title：Viruses

authors： Kizziah JL,Rodenburg CM,Dokland T

更新日期：2020-08-27 00:00:00

abstract：:The levels of vascular endothelial growth factor-A (VEGF) were estimated in 102 serum samples from 63 hospitalized Greek patients with hemorrhagic fever with renal syndrome (HFRS) caused by Dobrava/Belgrade virus. Significantly higher VEGF levels were seen in the severe when compared with non-severe cases (mean values...

journal_title：Viruses

authors： Tsergouli K,Papa A

更新日期：2013-12-10 00:00:00

abstract：:Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures tha...

journal_title：Viruses

authors： Wille M,Netter HJ,Littlejohn M,Yuen L,Shi M,Eden JS,Klaassen M,Holmes EC,Hurt AC

更新日期：2018-12-17 00:00:00

abstract：:Nef proteins from all primate Lentiviruses, including the simian immunodeficiency virus of chimpanzees (SIVcpz), increase viral progeny infectivity. However, the function of Nef involved with the increase in viral infectivity is still not completely understood. Nonetheless, until now, studies investigating the functio...

journal_title：Viruses

authors： Sabino Cunha M,Lima Sampaio T,Peterlin BM,Jesus da Costa L

更新日期：2016-07-07 00:00:00

abstract：:The smaller tea tortrix, Adoxophyes honmai (Lepidoptera: Tortricidae), is an economically important pest of tea in Japan. Previous work showed that a fast-killing nucleopolyhedrovirus (NPV) isolated from A. orana (AdorNPV) and a slow-killing NPV isolated from A. honmai (AdhoNPV) are both infectious to A. honmai larvae...

journal_title：Viruses

authors： Takahashi M,Nakai M,Saito Y,Sato Y,Ishijima C,Kunimi Y

更新日期：2015-03-18 00:00:00

abstract：:Effects of elevated pCO₂ on Emiliania huxleyi genetic diversity and the viruses that infect E. huxleyi (EhVs) have been investigated in large volume enclosures in a Norwegian fjord. Triplicate enclosures were bubbled with air enriched with CO₂ to 760 ppmv whilst the other three enclosures were bubbled with air at ambi...

journal_title：Viruses

authors： Highfield A,Joint I,Gilbert JA,Crawfurd KJ,Schroeder DC

更新日期：2017-03-08 00:00:00

abstract：:Progression of HIV infection is variable among individuals, and definition disease progression biomarkers is still needed. Here, we aimed to categorize the predictive potential of several variables using feature selection methods and decision trees. A total of seventy-five treatment-naïve subjects were enrolled during...

journal_title：Viruses

authors： Turk G,Ghiglione Y,Hormanstorfer M,Laufer N,Coloccini R,Salido J,Trifone C,Ruiz MJ,Falivene J,Holgado MP,Caruso MP,Figueroa MI,Salomón H,Giavedoni LD,Pando MLÁ,Gherardi MM,Rabinovich RD,Pury PA,Sued O

更新日期：2018-01-13 00:00:00

abstract：:During the past ten years, several new hepatitis E viruses (HEVs) have been identified in various animal species. In parallel, the number of reports of autochthonous hepatitis E in Western countries has increased as well, raising the question of what role these possible animal reservoirs play in human infections. The a...

journal_title：Viruses

authors： Doceul V,Bagdassarian E,Demange A,Pavio N

更新日期：2016-10-03 00:00:00