Hepatitis E Pathogenesis.

abstract：:Both temperature and humidity may independently or jointly contribute to the risk of human rhinovirus (HRV) infections, either through altered survival and spread of viruses in the environment or due to changes in host susceptibility. This study examined the relationship between short-term variations in temperature an...

journal_title：Viruses

authors： Ikäheimo TM,Jaakkola K,Jokelainen J,Saukkoriipi A,Roivainen M,Juvonen R,Vainio O,Jaakkola JJ

更新日期：2016-09-02 00:00:00

abstract：:The human cytomegalovirus (HCMV) terminase complex is part of DNA-packaging machinery that delivers a unit-length genome into a procapsid. Sequence comparison of herpesvirus homologs allowed us to identify a potential LATLNDIERFL and zinc finger pattern in N-terminal part of pUL56. Recombinant viruses were generated w...

journal_title：Viruses

authors： Ligat G,Couvreux A,Cazal R,Alain S,Hantz S

更新日期：2019-11-26 00:00:00

abstract：:RNA virus invasion induces a cytosolic RIG-I-like receptor (RLR) signaling pathway by promoting assembly of the Mitochondrial antiviral-signaling protein (MAVS) signalosome and triggers the rapid production of type I interferons (IFNs) and proinflammatory cytokines. During this process, the pivotal kinase TANK binding...

journal_title：Viruses

authors： He TS,Xie T,Li J,Yang YX,Li C,Wang W,Cao L,Rao H,Ju C,Xu LG

更新日期：2019-02-15 00:00:00

abstract：:Microvirin (MVN) is one of the human immunodeficiency virus (HIV-1) entry inhibitor lectins, which consists of two structural domains sharing 35% sequence identity and contrary to many other antiviral lectins, it exists as a monomer. In this study, we engineered an MVN variant, LUMS1, consisting of two domains with 10...

journal_title：Viruses

authors： Shahid M,Qadir A,Yang J,Ahmad I,Zahid H,Mirza S,Windisch MP,Shahzad-Ul-Hussan S

更新日期：2020-02-11 00:00:00

abstract：:Over the last decade, arthropods have been shown to harbour a rich diversity of viruses. Through viral metagenomics a large diversity of single-stranded (ss) DNA viruses have been identified. Here we examine the ssDNA virome of the hematophagous New Zealand blackfly using viral metagenomics. Our investigation reveals ...

journal_title：Viruses

authors： Kraberger S,Schmidlin K,Fontenele RS,Walters M,Varsani A

更新日期：2019-06-08 00:00:00

abstract：:Most cases of hemorrhagic fever with renal syndrome (HFRS) in Europe are caused by the Puumala hantavirus (PUUV). Typical features of the disease are increased vascular permeability, acute kidney injury (AKI), and thrombocytopenia. YKL-40 is an inflammatory glycoprotein involved in various forms of acute and chronic i...

journal_title：Viruses

authors： Outinen TK,Mantula P,Jaatinen P,Hämäläinen M,Moilanen E,Vaheri A,Huhtala H,Mäkelä S,Mustonen J

更新日期：2019-08-21 00:00:00

abstract：:Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are poorly understood autoimmune liver diseases. Immunosuppression is used to treat AIH and ursodeoxycholic acid is used to slow the progression of PBC. Nevertheless, a proportion of patients with both disorders progress to liver failure. Following liver t...

journal_title：Viruses

authors： Wasilenko ST,Montano-Loza AJ,Mason AL

更新日期：2013-01-24 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. The 3' untranslated region (UTR) of this β-CoV contains essential cis-acting RNA elements for the viral genome transcription and replication. These elements include an equilibrium between an extended bulged s...

journal_title：Viruses

authors： Zhao J,Qiu J,Aryal S,Hackett JL,Wang J

更新日期：2020-12-21 00:00:00

abstract：:Phage lytic enzymes are enzymes produced by bacterial viruses, either as part of their virion to facilitate bacterial infection through local peptidoglycan degradation, or as soluble proteins to induce massive cell lysis at the end of the lytic replication cycle [...]. ...

journal_title：Viruses

authors： Briers Y

更新日期：2019-01-29 00:00:00

abstract：:Andrias davidianus ranavirus (ADRV) is an emerging viral pathogen that causes severe systemic hemorrhagic disease in Chinese giant salamanders. There is an urgent need for developing an effective vaccine against this fatal disease. In this study, DNA vaccines containing the ADRV 2L gene (pcDNA-2L) and the 58L gene (pc...

journal_title：Viruses

authors： Chen ZY,Li T,Gao XC,Wang CF,Zhang QY

更新日期：2018-01-24 00:00:00

abstract：:Virus infections of insects can easily stay undetected, neither showing typical signs of a disease, nor being lethal. Such a stable and most of the time covert infection with Phthorimaea operculella granulovirus (PhopGV) was detected in a Phthorimaea operculella laboratory colony, which originated from Italy (Phop-IT)...

journal_title：Viruses

authors： Larem A,Ben Tiba S,Fritsch E,Undorf-Spahn K,Wennmann JT,Jehle JA

更新日期：2019-04-09 00:00:00

abstract：:The neutrophil extracellular trap (ET) is a eukaryotic host defense machinery that operates by capturing and concentrating pathogens in a filamentous network manufactured by neutrophils and made of DNA, histones, and many other components. Respiratory virus-induced ETs are involved in tissue damage and impairment of t...

journal_title：Viruses

authors： Real-Hohn A,Zhu R,Ganjian H,Ibrahim N,Hinterdorfer P,Kowalski H,Blaas D

更新日期：2020-07-04 00:00:00

abstract：:An outbreak of winter dysentery, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3-4 days after the appearanc...

journal_title：Viruses

authors： Amoroso MG,Lucifora G,Degli Uberti B,Serra F,De Luca G,Borriello G,De Domenico A,Brandi S,Cuomo MC,Bove F,Riccardi MG,Galiero G,Fusco G

更新日期：2020-11-19 00:00:00

abstract：:A novel virus from moribund European chub (Squalius cephalus) was isolated on epithelioma papulosum cyprini (EPC) cells. Transmission electron microscopic examination revealed abundant non-enveloped, hexagonal virus particles in the cytoplasm of infected EPC cells consistent with an iridovirus. Illumina MiSeq sequence...

journal_title：Viruses

authors： Halaly MA,Subramaniam K,Koda SA,Popov VL,Stone D,Way K,Waltzek TB

更新日期：2019-05-15 00:00:00

abstract：:Several viral factors impact the natural course of hepatitis B virus (HBV) infection, the sensitivity of diagnostic tests, or treatment response to interferon-α and nucleos(t)ide analogues. These factors include the viral genotype and serotype but also mutations affecting the HBV surface antigen, basal core promoter/p...

journal_title：Viruses

authors： Velkov S,Protzer U,Michler T

更新日期：2020-11-23 00:00:00

abstract：:Dengue, chikungunya and Zika viruses share similar disease features, rendering them difficult to distinguish clinically. Incapacitating arthralgia/arthritis is a specific manifestation associated with chikungunya virus infection. However, the profile of arthralgia/arthritis in Zika virus (ZIKV) cases has not been well...

journal_title：Viruses

authors： Wimalasiri-Yapa BMCR,Yapa HE,Huang X,Hafner LM,Kenna TJ,Frentiu FD

更新日期：2020-10-07 00:00:00

abstract：:We previously characterized a carbohydrate binding protein, Gp047, derived from lytic Campylobacter phage NCTC 12673, as a promising diagnostic tool for the identification of Campylobacter jejuni and Campylobacter coli. We also demonstrated that this protein binds specifically to acetamidino-modified pseudaminic acid ...

journal_title：Viruses

authors： Javed MA,Sacher JC,van Alphen LB,Patry RT,Szymanski CM

更新日期：2015-12-16 00:00:00

abstract：:Several human monoclonal antibodies (hmAbs) and antibody fragments, including the best characterized in terms of structure-function b12 and Fab X5, exhibit relatively potent and broad HIV-1 neutralizing activity. However, the elicitation of b12 or b12-like antibodies in vivo by vaccine immunogens based on the HIV-1 en...

journal_title：Viruses

authors： Xiao X,Chen W,Feng Y,Dimitrov DS

更新日期：2009-12-01 00:00:00

abstract：:To further understanding of the structure and morphology of the Orthohantavirus, family Hantaviridae, we have employed cryo-electron microscopy (cryo-EM) for three New World hantaviruses: Andes (ANDV), Sin Nombre (SNV), and Black Creek Canal (BCCV). Building upon our prior cryo-EM and cryo-tomography study of the Old ...

journal_title：Viruses

authors： Parvate A,Williams EP,Taylor MK,Chu YK,Lanman J,Saphire EO,Jonsson CB

更新日期：2019-09-16 00:00:00

abstract：:RNA viruses are extraordinary evolution machines that efficiently ensure their replication by taking advantage of the association with viral and cellular components to form ribonucleic complexes (vRNPs) [...]. ...

journal_title：Viruses

authors： Bernacchi S

更新日期：2020-11-26 00:00:00

abstract：:The ability of the host to trigger apoptosis in infected cells is perhaps the most powerful tool by which viruses can be cleared from the host organism. To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and i...

journal_title：Viruses

authors： Yuan CH,Filippova M,Duerksen-Hughes P

更新日期：2012-12-18 00:00:00

abstract：:We use a Species Distribution Modeling (SDM) approach along with Geographic Information Systems (GIS) techniques to examine the potential distribution of hantavirus pulmonary syndrome (HPS) caused by Andes virus (ANDV) in southern Argentina and, more precisely, define and estimate the area with the highest infection p...

journal_title：Viruses

authors： Andreo V,Neteler M,Rocchini D,Provensal C,Levis S,Porcasi X,Rizzoli A,Lanfri M,Scavuzzo M,Pini N,Enria D,Polop J

更新日期：2014-01-14 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV) is a globally-distributed agent responsible for numerous clinical syndromes that lead to major economic losses. Two species, BVDV-1 and BVDV-2, discriminated on the basis of genetic and antigenic differences, are classified in the genus Pestivirus within the Flaviviridae family and d...

journal_title：Viruses

authors： Yeşilbağ K,Alpay G,Becher P

更新日期：2017-05-26 00:00:00

abstract：:Human respiratory syncytial virus (HRSV) is a major cause of pediatric infection and also causes disease in the elderly and those with underlying respiratory problems. There is no vaccine for HRSV and anti-viral therapeutics are not broadly applicable. To investigate the effect of HRSV biology in children, nasopharyng...

journal_title：Viruses

authors： Aljabr W,Armstrong S,Rickett NY,Pollakis G,Touzelet O,Cloutman-Green E,Matthews DA,Hiscox JA

更新日期：2019-10-10 00:00:00

abstract：:The begomoviruses (BGVs) are plant pathogens that evolved in the Old World during the Cretaceous and arrived to the New World (NW) in the Cenozoic era. A subgroup of NW BGVs, the "Squash leaf curl virus (SLCV) lineage" (S-Lin), includes viruses with unique characteristics. To get clues on the evolutionary origin of th...

journal_title：Viruses

authors： Torres-Herrera SI,Romero-Osorio A,Moreno-Valenzuela O,Pastor-Palacios G,Cardenas-Conejo Y,Ramírez-Prado JH,Riego-Ruiz L,Minero-García Y,Ambriz-Granados S,Argüello-Astorga GR

更新日期：2019-07-13 00:00:00

abstract：:Zika virus (ZIKV) is an emerging mosquito-borne pathogen associated with microcephaly and other congenital abnormalities in newborns as well as neurologic complications in adults. The explosive transmission of the virus in the last ten years put it in the limelight and improved our understanding of its biology and pat...

journal_title：Viruses

authors： Botwina P,Obłoza M,Szczepański A,Szczubiałka K,Nowakowska M,Pyrć K

更新日期：2020-08-23 00:00:00

abstract：:Viral lysis is a main mortality factor for bacteria in deep-sea sediments, leading to changing microbial community structures and the release of cellular components to the environment. Nature and fate of these compounds and the role of viruses for microbial diversity is largely unknown. We investigated the effect of v...

journal_title：Viruses

authors： Heinrichs ME,Tebbe DA,Wemheuer B,Niggemann J,Engelen B

更新日期：2020-08-22 00:00:00

abstract：:In cells, positive strand RNA viruses, such as Retroviridae, must selectively recognize their full-length RNA genome among abundant cellular RNAs to assemble and release particles. How viruses coordinate the intracellular trafficking of both RNA and protein components to the assembly sites of infectious particles at t...

journal_title：Viruses

authors： Ferrer M,Henriet S,Chamontin C,Lainé S,Mougel M

更新日期：2016-08-22 00:00:00

abstract：:Because of its ecological characteristics, the Caxiuanã National Forest (FLONA) is a potential area of arbovirus circulation. The present study aimed to investigate the occurrence of arbovirus transmission cycles at FLONA de Caxiuanã. Five field trips were performed to capture mosquitoes and sylvatic vertebrates. For ...

journal_title：Viruses

authors： Araújo PA,Freitas MO,Chiang JO,Silva FA,Chagas LL,Casseb SM,Silva SP,Nunes-Neto JP,Rosa-Júnior JW,Nascimento BS,Hernández LA,Paz TB,Barros LL,Silva EP,Azevedo RS,Martins LC,Ferreira MS,Vasconcelos PF

更新日期：2019-08-22 00:00:00

abstract：:Retroviruses integrate a reverse transcribed double stranded DNA copy of their viral genome into the chromosomal DNA of cells they infect. Occasionally, exogenous retroviruses infect germ cells and when this happens a profound shift in the virus host dynamic occurs. Retroviruses maintained as hereditable viral genetic...

journal_title：Viruses

authors： Liu M,Eiden MV

更新日期：2011-06-01 00:00:00