Diversity and Evolution of Viral Pathogen Community in Cave Nectar Bats (Eonycteris spelaea).

abstract：:Over the last decade, arthropods have been shown to harbour a rich diversity of viruses. Through viral metagenomics a large diversity of single-stranded (ss) DNA viruses have been identified. Here we examine the ssDNA virome of the hematophagous New Zealand blackfly using viral metagenomics. Our investigation reveals ...

journal_title：Viruses

authors： Kraberger S,Schmidlin K,Fontenele RS,Walters M,Varsani A

更新日期：2019-06-08 00:00:00

abstract：:We show that focused ion beam/scanning electron microscopy (FIB/SEM) tomography is an excellent method to analyze the three-dimensional structure of a fibroblast nucleus infected with human cytomegalovirus (HCMV). We found that the previously described infoldings of the inner nuclear membrane, which are unique among i...

journal_title：Viruses

authors： Villinger C,Neusser G,Kranz C,Walther P,Mertens T

更新日期：2015-11-04 00:00:00

abstract：:The feline immunodeficiency virus (FIV) vaccine called Fel-O-Vax® FIV is the first commercial FIV vaccine released worldwide for the use in domestic cats against global FIV subtypes (A⁻E). This vaccine consists of inactivated dual-subtype (A plus D) FIV-infected cells, whereas its prototype vaccine consists of inactiv...

journal_title：Viruses

authors： Sahay B,Yamamoto JK

更新日期：2018-05-22 00:00:00

abstract：:Autophagy and apoptosis are two important evolutionarily conserved host defense mechanisms against viral invasion and pathogenesis. However, the association between the two pathways during the viral infection of T lymphocytes remains to be elucidated. Simian type D retrovirus (SRV) is an etiological agent of fatal sim...

journal_title：Viruses

authors： Zhu J,Yang L,Zhang Q,Meng J,Lu ZL,Rong R

更新日期：2020-03-31 00:00:00

abstract：:Staphylococcus aureus is a common and often virulent pathogen in humans. This bacterium is widespread, being present on the skin and in the nose of healthy people. Staphylococcus aureus can cause infections with severe outcomes ranging from pustules to sepsis and death. The introduction of antibiotics led to a general...

journal_title：Viruses

authors： Kaźmierczak Z,Górski A,Dąbrowska K

更新日期：2014-07-01 00:00:00

abstract：:Rapid and sensitive detection of prions is important in managing prion diseases. The real-time quaking-induced conversion (RT-QuIC) assay for prion seeding activity has been applied to many prion diseases and provides for specific antemortem diagnostic testing. We evaluated RT-QuIC's long-term consistency and varied m...

journal_title：Viruses

authors： Orrú CD,Hughson AG,Groveman BR,Campbell KJ,Anson KJ,Manca M,Kraus A,Caughey B

更新日期：2016-05-23 00:00:00

abstract：:Glycoprotein B (gB) plays an important role in alphaherpesvirus cellular entry and acts in concert with gD and the gH/gL complex. To evaluate whether functional differences exist between gB1 and gB4, the corresponding genes were exchanged between the two viruses. The gB4-containing-EHV-1 (EHV-1_gB4) recombinant virus ...

journal_title：Viruses

authors： Spiesschaert B,Osterrieder N,Azab W

更新日期：2015-02-03 00:00:00

abstract：:A number of characteristics including lack of virulence and the ability to grow to high titers, have made bovine adenovirus-3 (BAdV-3) a vector of choice for further development as a vaccine-delivery vehicle for cattle. Despite the importance of blood leukocytes, including dendritic cells (DC), in the induction of pro...

journal_title：Viruses

authors： Khosa S,Araya MB,Griebel P,Arsic N,Tikoo SK

更新日期：2020-12-12 00:00:00

abstract：:Human enteroviruses (HEV), especially coxsackievirus serotype B (CVB) and echovirus (E), have been associated with diseases of both the exocrine and endocrine pancreas, but so far evidence on HEV infection in human pancreas has been reported only in islets and ductal cells. This study aimed to investigate the capabili...

journal_title：Viruses

authors： Sarmiento L,Frisk G,Anagandula M,Hodik M,Barchetta I,Netanyah E,Cabrera-Rode E,Cilio CM

更新日期：2017-01-30 00:00:00

abstract：:Peste des petits ruminants virus (PPRV) causes a contagious disease of high morbidity and mortality in global sheep and goat populations. To better control this disease and inform eradication strategies, an improved understanding of how PPRV transmission risk varies by age is needed. Our study used a piece-wise cataly...

journal_title：Viruses

authors： Herzog CM,de Glanville WA,Willett BJ,Cattadori IM,Kapur V,Hudson PJ,Buza J,Swai ES,Cleaveland S,Bjørnstad ON

更新日期：2020-02-07 00:00:00

abstract：:Avian infectious bronchitis has caused huge economic losses in the poultry industry. Previous studies have reported that infectious bronchitis virus (IBV) infection can produce cytopathic effects (CPE) and apoptosis in some mammalian cells and primary cells. However, there is little research on IBV-induced immune cell...

journal_title：Viruses

authors： Han X,Tian Y,Guan R,Gao W,Yang X,Zhou L,Wang H

更新日期：2017-07-26 00:00:00

abstract：:Background: Bats are known to host a number of nonpathogenic viruses, as well as highly pathogenic viruses causing fatal diseases like rabies. Serological surveys as part of active and passive bat rabies surveillance mainly use seroneutralization assays, demonstrating the presence of lyssavirus-specific antibodies in ...

journal_title：Viruses

authors： Orłowska A,Smreczak M,Freuling CM,Müller T,Trębas P,Rola J

更新日期：2020-02-28 00:00:00

abstract：:Ebola virus is the causative agent of Ebola virus disease in humans. The lethality of Ebola virus infection is about 50%, supporting the urgent need to develop anti-Ebola drugs. Glycoprotein (GP) is the only surface protein of the Ebola virus, which is functionally critical for the virus to attach and enter the host c...

journal_title：Viruses

authors： Cui Q,Cheng H,Xiong R,Zhang G,Du R,Anantpadma M,Davey RA,Rong L

更新日期：2018-11-30 00:00:00

abstract：:In rabies diagnosis, it is essential to count on a rapid test to give a quick response. The combined sensitivity and robustness of the TaqMan RT-PCR assays (qRT-PCR) have made these methods a valuable alternative for rabies virus (RABV) detection. We conducted a study to compare the applicability of two widely used qR...

journal_title：Viruses

authors： Caraballo DA,Lombardo MA,Becker P,Sabio MS,Lema C,Martínez LM,Beltrán FJ,Li Y,Cisterna DM

更新日期：2020-12-25 00:00:00

abstract：:The Bunyaviridae is the largest family of RNA viruses, with over 350 members worldwide. Several of these viruses cause severe diseases in livestock and humans. With an increasing number and frequency of outbreaks, bunyaviruses represent a growing threat to public health and agricultural productivity globally. Yet, the...

journal_title：Viruses

authors： Albornoz A,Hoffmann AB,Lozach PY,Tischler ND

更新日期：2016-05-24 00:00:00

abstract：:The outbreak of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China has been brought to global attention and declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS)...

journal_title：Viruses

authors： Jin Y,Yang H,Ji W,Wu W,Chen S,Zhang W,Duan G

更新日期：2020-03-27 00:00:00

abstract：:Sea star wasting disease (SSWD) is a condition that has affected asteroids for over 120 years, yet mechanistic understanding of this wasting etiology remains elusive. We investigated temporal virome variation in two Pisaster ochraceus specimens that wasted in the absence of external stimuli and two specimens that did ...

journal_title：Viruses

authors： Hewson I,Aquino CA,DeRito CM

更新日期：2020-11-20 00:00:00

abstract：:Old world hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) upon zoonotic transmission to humans. In Europe, the Puumala virus (PUUV) is the main causative agent of HFRS. Tula virus (TULV) is also widely distributed in Europe, but there is little knowledge about the pathogenicity of TULV for humans, as r...

journal_title：Viruses

authors： Bourquain D,Bodenstein C,Schürer S,Schaade L

更新日期：2019-09-14 00:00:00

abstract：:West Nile virus (WNV) is an important emerging neurotropic virus, responsible for increasingly severe encephalitis outbreaks in humans and horses worldwide. However, the mechanism by which the virus gains entry to the brain (neuroinvasion) remains poorly understood. Hypotheses of hematogenous and transneural entry hav...

journal_title：Viruses

authors： Suen WW,Prow NA,Hall RA,Bielefeldt-Ohmann H

更新日期：2014-07-18 00:00:00

abstract：:Global climate change-induced warming of the Artic seas is predicted to shift the phytoplankton community towards dominance of smaller-sized species due to global warming. Yet, little is known about their viral mortality agents despite the ecological importance of viruses regulating phytoplankton host dynamics and div...

journal_title：Viruses

authors： Maat DS,Biggs T,Evans C,van Bleijswijk JDL,van der Wel NN,Dutilh BE,Brussaard CPD

更新日期：2017-06-02 00:00:00

abstract：:Abstract: Since 2007, highly pathogenic clade 2.3.2 H5N1 avian influenza A (A(H5N1)) viruses have evolved to clade 2.3.2.1a, b, and c; currently only 2.3.2.1c A(H5N1) viruses circulate in wild birds and poultry. During antigenic evolution, clade 2.3.2.1a and c A(H5N1) viruses acquired both S144N and V223I mutations ar...

journal_title：Viruses

authors： An SH,Lee CY,Hong SM,Song CS,Kim JH,Kwon HJ

更新日期：2019-10-09 00:00:00

abstract：:The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature of HBV, need to operate in the liver parenchyma. In this respect, we will discuss broad features of HBV immunity in pat...

journal_title：Viruses

authors： Bertoletti A,Tan AT,Gehring AJ

更新日期：2009-09-01 00:00:00

abstract：:During flavivirus infection, some viral proteins move to the nucleus and cellular components are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of the nuclear-cytoplasmic transport, the nuclear pore complex (NPC), was evaluated during infection with dengue virus (DENV) and Zika ...

journal_title：Viruses

authors： De Jesús-González LA,Cervantes-Salazar M,Reyes-Ruiz JM,Osuna-Ramos JF,Farfán-Morales CN,Palacios-Rápalo SN,Pérez-Olais JH,Cordero-Rivera CD,Hurtado-Monzón AM,Ruíz-Jiménez F,Gutiérrez-Escolano AL,Del Ángel RM

更新日期：2020-05-26 00:00:00

abstract：:African swine fever (ASF) has become the major threat for the global swine industry. Furthermore, the epidemiological situation of African swine fever virus (ASFV) in some endemic regions of Sub-Saharan Africa is worse than ever, with multiple virus strains and genotypes currently circulating in a given area. Despite ...

journal_title：Viruses

authors： Lopez E,van Heerden J,Bosch-Camós L,Accensi F,Navas MJ,López-Monteagudo P,Argilaguet J,Gallardo C,Pina-Pedrero S,Salas ML,Salt J,Rodriguez F

更新日期：2020-12-21 00:00:00

abstract：:Commentary on Hare, S.; Gupta, S.S.; Valkov, E.; Engelman, A.; Cherepanov, P. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature2010, 464, 232-236. ...

journal_title：Viruses

authors： Grandgenett D,Korolev S

更新日期：2010-05-01 00:00:00

abstract：:The Gammacoronavirus infectious bronchitis virus (IBV) causes a highly contagious and economically important respiratory disease in poultry. In the laboratory, most IBV strains are restricted to replication in ex vivo organ cultures or in ovo and do not replicate in cell culture, making the study of their basic virolo...

journal_title：Viruses

authors： Stevenson-Leggett P,Keep S,Bickerton E

更新日期：2020-09-29 00:00:00

abstract：:Environmental and agricultural pollination services by honey bees, Apis mellifera, and honey production are compromised by high levels of annual colony losses globally. The majority are associated with disease caused by deformed wing virus (DWV), a positive-strand RNA virus, exacerbated by the ectoparasitic mite Varro...

journal_title：Viruses

authors： Gusachenko ON,Woodford L,Balbirnie-Cumming K,Campbell EM,Christie CR,Bowman AS,Evans DJ

更新日期：2020-05-12 00:00:00

abstract：:Porcine epidemic diarrhea (PED) is a highly contagious disease in newborn piglets. In our previous study, a genetically engineered Lactobacillus casei oral vaccine (pPG-COE-DCpep/L393) expressing a dendritic cell (DC)-targeting peptide fused with porcine epidemic diarrhea virus (PEDV) COE antigen was developed. This v...

journal_title：Viruses

authors： Hou X,Jiang X,Jiang Y,Tang L,Xu Y,Qiao X,Min L,Wen C,Ma G,Li Y

更新日期：2018-03-01 00:00:00

abstract：:Human coronaviruses (HCoVs) cause mild to severe respiratory diseases. Six types of HCoVs have been discovered, the most recent one termed the Middle East respiratory syndrome coronavirus (MERS-CoV). The aim of this study is to monitor the circulation of HCoV types in the population during 2015⁻2016 in Israel. HCoVs w...

journal_title：Viruses

authors： Friedman N,Alter H,Hindiyeh M,Mendelson E,Shemer Avni Y,Mandelboim M

更新日期：2018-09-21 00:00:00

abstract：:Small Ruminant Lentiviruses (SRLVs) are widespread in many countries and cause economically relevant, slow, and persistent diseases in sheep and goats. Monitoring the genetic diversity of SRLVs is useful to improve the diagnostic tools used in the eradication programs. In this study, SRLVs detected in Spanish Assaf sh...

journal_title：Viruses

authors： Gayo E,Cuteri V,Polledo L,Rossi G,García Marín JF,Preziuso S

更新日期：2018-06-09 00:00:00