Abstract：
:Autophagy and apoptosis are two important evolutionarily conserved host defense mechanisms against viral invasion and pathogenesis. However, the association between the two pathways during the viral infection of T lymphocytes remains to be elucidated. Simian type D retrovirus (SRV) is an etiological agent of fatal simian acquired immunodeficiency syndrome (SAIDS), which can display disease features that are similar to acquired immunodeficiency syndrome in humans. In this study, we demonstrate that infection with SRV-8, a newly isolated subtype of SRV, triggered both autophagic and apoptotic pathways in Jurkat T lymphocytes. Following infection with SRV-8, the autophagic proteins LC3 and p62/SQSTM1 interacted with procaspase-8, which might be responsible for the activation of the caspase-8/-3 cascade and apoptosis in SRV-8-infected Jurkat cells. Our findings indicate that autophagic responses to SRV infection of T lymphocytes promote the apoptosis of T lymphocytes, which, in turn, might be a potential pathogenetic mechanism for the loss of T lymphocytes during SRV infection.
journal_name
Virusesjournal_title
Virusesauthors
Zhu J,Yang L,Zhang Q,Meng J,Lu ZL,Rong Rdoi
10.3390/v12040381subject
Has Abstractpub_date
2020-03-31 00:00:00issue
4issn
1999-4915pii
v12040381journal_volume
12pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract：:There is an epidemic of obesity starting about 1980 in both developed and undeveloped countries definitely associated with multiple etiologies. About 670 million people worldwide are obese. The incidence of obesity has increased in all age groups, including children. Obesity causes numerous diseases and the interactio...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v7072787
更新日期：2015-07-08 00:00:00
abstract：:We are currently facing a pandemic of COVID-19, caused by a spillover from an animal-originating coronavirus to humans occurring in the Wuhan region of China in December 2019. From China, the virus has spread to 188 countries and regions worldwide, reaching the Sahel region on March 2, 2020. Since whole genome sequenc...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12111251
更新日期：2020-11-02 00:00:00
abstract：:The extension of virology beyond its traditional medical, veterinary, or agricultural applications, now called environmental virology, has shown that viruses are both the most numerous and diverse biological entities on Earth. In particular, virus isolations from unicellular eukaryotic hosts (heterotrophic and photosy...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12101130
更新日期：2020-10-06 00:00:00
abstract：:One hundred Prunus trees, including almond (P. dulcis), apricot (P. armeniaca), nectarine (P. persica var. nucipersica), peach (P. persica), plum (P. domestica), purple leaf plum (P. cerasifera) and sweet cherry (P. avium), were selected from growing regions Australia-wide and tested for the presence of 34 viruses and...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12020246
更新日期：2020-02-23 00:00:00
abstract：:Lymphoma is one of the most common malignancies in domestic cats. The lymphomagenic potential of Felis catus gammaherpesvirus 1 (FcaGHV1), a common infection in domestic cats, is unknown. In other species, including humans, cellular transformation by gammaherpesviruses is typically mediated by viral genes expressed du...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10090464
更新日期：2018-08-30 00:00:00
abstract：:Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain⁻Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZI...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11020092
更新日期：2019-01-22 00:00:00
abstract：:Timely implementation of antiviral treatment and other public health based responses are dependent on accurate and rapid diagnosis of the novel pandemic influenza A(H1N1) strain. In this study we developed a duplex real-time PCR (RT-PCR) (dFLU-TM) assay for the simultaneous detection of a broad range of influenza A su...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v1031204
更新日期：2009-12-01 00:00:00
abstract：:Several notable human diseases are caused by enveloped RNA viruses: influenza, AIDS, hepatitis C, dengue hemorrhagic fever, microcephaly, and Guillain-Barré Syndrome. Being enveloped, the life cycle of this group of viruses is critically dependent on host lipid biosynthesis. Viral binding and entry involve interaction...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v11100912
更新日期：2019-10-01 00:00:00
abstract：:Hantaviruses are an established cause of haemorrhagic fever with renal syndrome (HFRS) in Europe. Following a confirmed case of HFRS in the UK, in an individual residing on a farm in North Yorkshire and the Humber, a tidal estuary on the east coast of Northern England, and the subsequent isolation of a Seoul hantaviru...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v6020524
更新日期：2014-02-05 00:00:00
abstract：:Extracellular vesicles (EVs) play an important role in intercellular communication. They are naturally released from cells into the extracellular environment. Based on their biogenesis, release pathways, size, content, and function, EVs are classified into exosomes, microvesicles (MVs), and apoptotic bodies (ApoBDs). ...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12060584
更新日期：2020-05-27 00:00:00
abstract：:Porcine circovirus 2 (PCV2) is the etiological agent that causes porcine circovirus diseases and porcine circovirus-associated diseases (PCVD/PCVAD), which are present in every major swine-producing country in the world. PCV2 infections may downregulate the host immune system and enhance the infection and replication ...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v11020185
更新日期：2019-02-21 00:00:00
abstract：:RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in t...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12010073
更新日期：2020-01-07 00:00:00
abstract：:The HIV/AIDS epidemic remains a global health problem, especially in Sub-Saharan Africa. An effective HIV-1 vaccine is therefore badly required to mitigate this ever-expanding problem. Since HIV-1 infects its host through the mucosal surface, a vaccine for the virus needs to trigger mucosal as well as systemic immune ...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v5092062
更新日期：2013-08-28 00:00:00
abstract：:The hepatitis B virus (HBV) represents a worldwide public health problem; the virus is present in one third of the global population. However, this rate may in fact be higher due to occult hepatitis B virus infection (OBI). This condition is characterized by the presence of the viral genome in the liver of individuals...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v6041590
更新日期：2014-04-08 00:00:00
abstract：:West Nile (WNV) and Dengue (DENV) viruses are major arboviral human pathogens belonging to the genus Flavivirus. At the current time, there are no approved prophylactics (e.g., vaccines) or specific therapeutics available to prevent or treat human infections by these pathogens. Due to their minimal genome, these virus...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v6020683
更新日期：2014-02-10 00:00:00
abstract：:The human cytomegalovirus (HCMV) terminase complex is part of DNA-packaging machinery that delivers a unit-length genome into a procapsid. Sequence comparison of herpesvirus homologs allowed us to identify a potential LATLNDIERFL and zinc finger pattern in N-terminal part of pUL56. Recombinant viruses were generated w...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11121093
更新日期：2019-11-26 00:00:00
abstract：:Oropouche fever is an emerging zoonotic disease caused by Oropouche virus (OROV), an arthropod transmitted Orthobunyavirus circulating in South and Central America. During the last 60 years, more than 30 epidemics and over half a million clinical cases attributed to OROV infection have been reported in Brazil, Peru, P...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v10040175
更新日期：2018-04-04 00:00:00
abstract：:The capsid domain (CA) of the lentiviral Gag polyproteins has two distinct roles during virion morphogenesis. As a domain of Gag, it mediates the Gag-Gag interactions that drive immature particle assembly, whereas as a mature protein, it self-assembles into the conical core of the mature virion. Lentiviral CA proteins...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11090816
更新日期：2019-09-04 00:00:00
abstract：:We studied whether cytosine phosphate-guanine (CpG) recoding in a viral genome may provide oncolytic candidates with reduced infection kinetics in nonmalignant brain cells, but with high virulence in glioblastoma stem cells (GSCs). As a model, we used well-characterized CpG-recoded Zika virus vaccine candidates that p...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12050579
更新日期：2020-05-25 00:00:00
abstract：:With the inclusion of new members, understanding about evolutionary mechanisms and processes by which members of the proposed order, Megavirales, have evolved has become a key area of interest. The central role of gene acquisition has been shown in previous studies. However, the major drawback in gene acquisition stud...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v9040072
更新日期：2017-04-07 00:00:00
abstract：:Autophagy is a potent cell autonomous defense mechanism that engages the lysosomal pathway to fight intracellular pathogens. Several autophagy receptors can recognize invading pathogens in order to target them towards autophagy for their degradation after the fusion of pathogen-containing autophagosomes with lysosomes...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v9050123
更新日期：2017-05-22 00:00:00
abstract：:Rotavirus (RV), a member of the Reoviridae family, causes infection in children and infants, with high morbidity and mortality. To be viable, the virus particle must package a set of eleven RNA segments. In order to understand the packaging mechanism, here, we co-synthesized sets of RNA segments in vitro in different ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v9070167
更新日期：2017-06-29 00:00:00
abstract：:Temperate bacteriophages possess a molecular switch, which regulates the lytic and lysogenic growth. The genomes of the temperate telomere phages N15, PY54 and ɸKO2 harbor a primary immunity region (immB) comprising genes for the prophage repressor, the lytic repressor and a putative antiterminator. The roles of these...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v7062746
更新日期：2015-06-02 00:00:00
abstract：:The ability of a cell to combat an intracellular pathogen requires a mechanism to recognize the threat and elicit a transcriptional response against it. In the context of virus infection, the cell must take measures to inhibit viral replication, meanwhile, convey warning signals to neighboring cells of the imminent th...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v2010055
更新日期：2010-01-01 00:00:00
abstract：:Bovine lactoferrin (bLf) is an iron-binding glycoprotein folded in two symmetric globular lobes (N- and C-lobes) with potent antimicrobial and immunomodulatory activities. Recently, we have shown that bLf, and in particular its C-lobe, interacts with influenza A virus hemagglutinin and prevents infection by different ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11010051
更新日期：2019-01-11 00:00:00
abstract：:Rotavirus causes severe gastroenteritis in children. Although vaccines are implemented, rotavirus-related diarrhea still claims ~200,000 lives annually worldwide, mainly in low-income settings, pointing to a need for improved vaccine tactics. To meet such a public health need, a P24-VP8* nanoparticle displaying the gl...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v13010072
更新日期：2021-01-06 00:00:00
abstract：:Microvirin (MVN) is one of the human immunodeficiency virus (HIV-1) entry inhibitor lectins, which consists of two structural domains sharing 35% sequence identity and contrary to many other antiviral lectins, it exists as a monomer. In this study, we engineered an MVN variant, LUMS1, consisting of two domains with 10...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12020199
更新日期：2020-02-11 00:00:00
abstract：:The DNA damage response (DDR) is a complex signalling network activated when DNA is altered by intrinsic or extrinsic agents. DDR plays important roles in genome stability and cell cycle regulation, as well as in tumour transformation. Viruses have evolved successful life cycle strategies in order to ensure a chronic ...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9120390
更新日期：2017-12-19 00:00:00
abstract：:Viral lysis is a main mortality factor for bacteria in deep-sea sediments, leading to changing microbial community structures and the release of cellular components to the environment. Nature and fate of these compounds and the role of viruses for microbial diversity is largely unknown. We investigated the effect of v...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12090922
更新日期：2020-08-22 00:00:00
abstract：:Infectious bursal disease (IBD) is an immunosuppressive, highly contagious, and lethal disease of young chickens caused by IBD virus (IBDV). It results in huge economic loss to the poultry industry worldwide. Infection caused by very virulent IBDV (vvIBDV) strains results in high mortality in young chicken flocks. How...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12020249
更新日期：2020-02-23 00:00:00
