Sphingolipids as Potential Therapeutic Targets against Enveloped Human RNA Viruses.

Abstract:

:Several notable human diseases are caused by enveloped RNA viruses: influenza, AIDS, hepatitis C, dengue hemorrhagic fever, microcephaly, and Guillain-Barré Syndrome. Being enveloped, the life cycle of this group of viruses is critically dependent on host lipid biosynthesis. Viral binding and entry involve interactions between viral envelope glycoproteins and cellular receptors localized to lipid-rich regions of the plasma membrane. Subsequent infection by these viruses leads to reorganization of cellular membranes and lipid metabolism to support the production of new viral particles. Recent work has focused on defining the involvement of specific lipid classes in the entry, genome replication assembly, and viral particle formation of these viruses in hopes of identifying potential therapeutic targets for the treatment or prevention of disease. In this review, we will highlight the role of host sphingolipids in the lifecycle of several medically important enveloped RNA viruses.

journal_name

Viruses

journal_title

Viruses

authors

Yager EJ,Konan KV

doi

10.3390/v11100912

subject

Has Abstract

pub_date

2019-10-01 00:00:00

issue

10

issn

1999-4915

pii

v11100912

journal_volume

11

pub_type

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