Recombinant Salmonella enterica serovar Typhimurium as a vaccine vector for HIV-1 Gag.

abstract：:Bats are an important source of viral zoonoses, including paramyxoviruses. The paramyxoviral Pararubulavirus genus contains viruses mostly derived from bats that are common, diverse, distributed throughout the Old World, and known to be zoonotic. Here, we describe a new member of the genus Achimota pararubulavirus 3 (...

journal_title：Viruses

authors： Baker KS,Tachedjian M,Barr J,Marsh GA,Todd S,Crameri G,Crameri S,Smith I,Holmes CEG,Suu-Ire R,Fernandez-Loras A,Cunningham AA,Wood JLN,Wang LF

更新日期：2020-10-30 00:00:00

abstract：:A highly virulent porcine epidemic diarrhea virus (PEDV) appeared in China and spread rapidly to neighbor countries, which have led to great economic losses to the pig industry. In the present study, we isolated a PEDV using Vero cells and serially propagated 100 passages. PEDV SDSX16 was characterized in vitro and in...

journal_title：Viruses

authors： Zhao P,Wang S,Chen Z,Yu J,Tang R,Qiu W,Zhao L,Liu Y,Guo X,He H,Xu G,Li J,Wu J

更新日期：2020-04-01 00:00:00

abstract：:Zika virus (ZIKV) infection can cause severe congenital diseases, such as microcephaly, ocular defects and arthrogryposis in fetuses, and Guillain⁻Barré syndrome in adults. Efficacious therapeutic treatments for infected patients, as well as prophylactic treatments to prevent new infections are needed for combating ZI...

journal_title：Viruses

authors： Siddharthan V,Miao J,Van Wettere AJ,Li R,Wu H,Sullivan E,Jiao J,Hooper JW,Safronetz D,Morrey JD,Julander JG,Wang Z

更新日期：2019-01-22 00:00:00

abstract：:BST-2 or tetherin is a host cell restriction factor that prevents the budding of enveloped viruses at the cell surface, thus impairing the viral spread. Several countermeasures to evade this antiviral factor have been positively selected in retroviruses: the human immunodeficiency virus type 2 (HIV-2) relies on the en...

journal_title：Viruses

authors： Dufrasne FE,Lombard C,Goubau P,Ruelle J

更新日期：2016-10-14 00:00:00

abstract：:Bats provide important ecosystem services as pollinators, seed dispersers, and/or insect controllers, but they have also been found harboring different viruses with zoonotic potential. Virome studies in bats distributed in Asia, Africa, Europe, and North America have increased dramatically over the past decade, wherea...

journal_title：Viruses

authors： Bolatti EM,Zorec TM,Montani ME,Hošnjak L,Chouhy D,Viarengo G,Casal PE,Barquez RM,Poljak M,Giri AA

更新日期：2020-04-09 00:00:00

abstract：:Bacteriophage (phage) therapy is a promising alternative to antibiotics for the treatment of bacterial pathogens, including Clostridiumdifficile. However, as for many species, in C. difficile the physical interactions between phages and bacterial cells have not been studied in detail. The initial interaction, known as...

journal_title：Viruses

authors： Thanki AM,Taylor-Joyce G,Dowah A,Nale JY,Malik D,Clokie MRJ

更新日期：2018-08-06 00:00:00

abstract：:The virion proteins of Kaposi sarcoma-associated herpesvirus (KSHV) were initially characterized in 2005 in two separate studies that combined the detection of 24 viral proteins and a few cellular components via LC-MS/MS or MALDI-TOF. Despite considerable advances in the sensitivity and specificity of mass spectrometr...

journal_title：Viruses

authors： Nabiee R,Syed B,Ramirez Castano J,Lalani R,Totonchy JE

更新日期：2020-12-02 00:00:00

abstract：:HIV-1 Gag polyprotein orchestrates the assembly of viral particles. Its C-terminus consists of the nucleocapsid (NC) domain that interacts with nucleic acids, and p1 and p6, two unstructured regions, p6 containing the motifs to bind ALIX, the cellular ESCRT factor TSG101 and the viral protein Vpr. The processing of Ga...

journal_title：Viruses

authors： Mouhand A,Pasi M,Catala M,Zargarian L,Belfetmi A,Barraud P,Mauffret O,Tisné C

更新日期：2020-09-29 00:00:00

abstract：:Next-generation sequencing (NGS) has opened up the possibility of detecting new viruses in unresolved diseases. Recently, astrovirus brain infections have been identified in neurologically diseased humans and animals by NGS, among them bovine astrovirus (BoAstV) CH13/NeuroS1, which has been found in brain tissues of c...

journal_title：Viruses

authors： Selimovic-Hamza S,Boujon CL,Hilbe M,Oevermann A,Seuberlich T

更新日期：2017-01-18 00:00:00

abstract：:In the original manuscript, the text in figure 1 is illegible. Furthermore, there is an unnecessary carriage return (page 1716, ~line 18) "crystallographic ... methods". ...

journal_title：Viruses

authors： Mwimanzi P,Markle TJ,Ueno T,Brockman MA

更新日期：2012-10-05 00:00:00

abstract：:Photodynamic inactivation (PDI) has been used to inactivate microorganisms through the use of photosensitizers. The inactivation of mammalian viruses and bacteriophages by photosensitization has been applied with success since the first decades of the last century. Due to the fact that mammalian viruses are known to p...

journal_title：Viruses

authors： Costa L,Faustino MA,Neves MG,Cunha A,Almeida A

更新日期：2012-07-01 00:00:00

abstract：:Victoria and Yamagata lineages of influenza B viruses are globally circulating in seasonal epidemics. Madin-Darby canine kidney (MDCK) cells are permissive for viral isolation and vaccine manufacture. Nevertheless, the interplay between influenza B viruses and host microRNAs has not been investigated in this cell line...

journal_title：Viruses

authors： Saengchoowong S,Khongnomnan K,Poomipak W,Praianantathavorn K,Poovorawan Y,Zhang Q,Payungporn S

更新日期：2019-10-25 00:00:00

abstract：:Plant positive strand RNA viruses are intracellular infectious agents that take advantage of cellular lipids and membranes to support replication and protect viral RNA from degradation by host antiviral responses. In this review, we discuss how Tomato bushy stunt virus (TBSV) co-opts lipid transfer proteins and modula...

journal_title：Viruses

authors： Nagy PD,Pogany J,Xu K

更新日期：2016-03-03 00:00:00

abstract：:To assist the global eradication of peste des petits ruminants virus (PPRV), a molecular test for the rapid and reliable detection of PPRV was developed which additionally enables the detection of pathogens relevant for differential diagnostics. For this purpose, the necessary time frame of a magnetic bead-based nucle...

journal_title：Viruses

authors： Halecker S,Mettenleiter TC,Beer M,Hoffmann B

更新日期：2020-10-29 00:00:00

abstract：:Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis. In NSVs, the single strand RNA genome is encapsidated in the line...

journal_title：Viruses

authors： Luo M,Terrell JR,Mcmanus SA

更新日期：2020-07-30 00:00:00

abstract：:Viral codon usage bias may be the product of a number of synergistic or antagonistic factors, including genomic nucleotide composition, translational selection, genomic architecture, and mutational or repair biases. Most studies of viral codon bias evaluate only the relative importance of genomic base composition and ...

journal_title：Viruses

authors： Cardinale DJ,DeRosa K,Duffy S

更新日期：2013-01-15 00:00:00

abstract：:Metagenomics studies have accelerated the discovery of novel or divergent viruses of the honey bee. However, most of these studies predominantly focused on RNA viruses, and many suffer from the relatively low abundance of viral nucleic acids in the samples (i.e., compared to that of the host). Here, we explored the vi...

journal_title：Viruses

authors： Gebremedhn H,Deboutte W,Schoonvaere K,Demaeght P,De Smet L,Amssalu B,Matthijnssens J,de Graaf DC

更新日期：2020-10-27 00:00:00

abstract：:Commentary on Hare, S.; Gupta, S.S.; Valkov, E.; Engelman, A.; Cherepanov, P. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature2010, 464, 232-236. ...

journal_title：Viruses

authors： Grandgenett D,Korolev S

更新日期：2010-05-01 00:00:00

abstract：:It is difficult to observe the molecular choreography between viruses and host cell components, as they exist on a spatial scale beyond the reach of conventional microscopy. However, novel super-resolution microscopy techniques have cast aside technical limitations to reveal a nanoscale view of virus replication and c...

journal_title：Viruses

authors： Grove J

更新日期：2014-03-19 00:00:00

abstract：:Double-stranded DNA viruses package their genomes into pre-assembled protein procapsids. This process is driven by macromolecular motors that transiently assemble at a unique vertex of the procapsid and utilize homomeric ring ATPases to couple genome encapsidation to ATP hydrolysis. Here, we describe the biochemical a...

journal_title：Viruses

authors： Reyes-Aldrete E,Dill EA,Bussetta C,Szymanski MR,Diemer G,Maindola P,White MA,Bujalowski WM,Choi KH,Morais MC

更新日期：2020-12-23 00:00:00

abstract：:Because of its ecological characteristics, the Caxiuanã National Forest (FLONA) is a potential area of arbovirus circulation. The present study aimed to investigate the occurrence of arbovirus transmission cycles at FLONA de Caxiuanã. Five field trips were performed to capture mosquitoes and sylvatic vertebrates. For ...

journal_title：Viruses

authors： Araújo PA,Freitas MO,Chiang JO,Silva FA,Chagas LL,Casseb SM,Silva SP,Nunes-Neto JP,Rosa-Júnior JW,Nascimento BS,Hernández LA,Paz TB,Barros LL,Silva EP,Azevedo RS,Martins LC,Ferreira MS,Vasconcelos PF

更新日期：2019-08-22 00:00:00

abstract：:The Pneumoviridae family includes human metapneumovirus (HMPV) and human orthopneumovirus, which is also known as a respiratory syncytial virus (HRSV). These are large enveloped, negative single-strand RNA viruses. HMPV and HRSV are the human members, which commonly infect children. HMPV, which was discovered in 2001,...

journal_title：Viruses

authors： Diab M,Schmiedel D,Seidel E,Bacharach E,Mandelboim O

更新日期：2020-07-20 00:00:00

abstract：:Timely implementation of antiviral treatment and other public health based responses are dependent on accurate and rapid diagnosis of the novel pandemic influenza A(H1N1) strain. In this study we developed a duplex real-time PCR (RT-PCR) (dFLU-TM) assay for the simultaneous detection of a broad range of influenza A su...

journal_title：Viruses

authors： Rockett RJ,Bialasiewicz S,Whiley DM,Bletchly C,Faux CE,Lambert SB,Nimmo GR,Nissen MD,Sloots TP

更新日期：2009-12-01 00:00:00

abstract：:Merkel cell polyomavirus (MCV) is the only known human oncogenic virus in the polyomaviridae family and the etiological agent of most Merkel cell carcinomas (MCC). MCC is an aggressive and highly metastatic skin cancer with a propensity for recurrence and poor prognosis. Large tumor antigen (LT), is an essential oncop...

journal_title：Viruses

authors： Nwogu N,Ortiz LE,Kwun HJ

更新日期：2020-09-18 00:00:00

abstract：:H1N1 swine influenza viruses (SIV) are prevalent in pigs globally, and occasionally emerge in humans, which raises concern about their pandemic threats. To stimulate hemagglutination (HA) of A/Swine/Guangdong/LM/2004 (H1N1) (SW/GD/04) antibody response, eukaryotic expression plasmid pCI-neo-HA was constructed and used...

journal_title：Viruses

authors： Liu Y,Li H,Xue Y,Zhao S,Li C,Qu L,Zhang Y,Liu M

更新日期：2017-08-08 00:00:00

abstract：:Astroviral infection is considered to be one of the causes of mammalian diarrheal diseases. It has been shown that astrovirus infections cause varying degrees of diarrhea in turkeys and mice. However, the pathogenesis of porcine astrovirus is unknown. In this study, the virulence of a cytopathic porcine astrovirus (PA...

journal_title：Viruses

authors： Fang Q,Wang C,Liu H,Wu Q,Liang S,Cen M,Dong Q,Wei Y,Chen Y,Ouyang K,Wei Z,Huang W

更新日期：2019-12-13 00:00:00

abstract：:In rabies diagnosis, it is essential to count on a rapid test to give a quick response. The combined sensitivity and robustness of the TaqMan RT-PCR assays (qRT-PCR) have made these methods a valuable alternative for rabies virus (RABV) detection. We conducted a study to compare the applicability of two widely used qR...

journal_title：Viruses

authors： Caraballo DA,Lombardo MA,Becker P,Sabio MS,Lema C,Martínez LM,Beltrán FJ,Li Y,Cisterna DM

更新日期：2020-12-25 00:00:00

abstract：:In Europe, cowpox virus (CPXV) infection in South American camelids occurs as a so-called spill-over infection. Although infected animals generally have a mild form of the disease and survive, cases of fatal generalised CPXV infection have also been described. Prevention by prophylactic vaccination is the only way to ...

journal_title：Viruses

authors： Prkno A,Hoffmann D,Kaiser M,Goerigk D,Pfeffer M,Winter K,Vahlenkamp TW,Beer M,Starke A

更新日期：2020-02-20 00:00:00

abstract：:Ebola virus (EBOV) is a highly lethal pathogen that has caused several outbreaks of severe hemorrhagic fever in humans since its emergence in 1976. The EBOV glycoprotein (GP1,2) is the sole viral envelope protein and a major component of immunogenicity; it is encoded by the GP gene along with two truncated versions: s...

journal_title：Viruses

authors： Zhu W,Banadyga L,Emeterio K,Wong G,Qiu X

更新日期：2019-10-31 00:00:00

abstract：BACKGROUND:coronavirus disease 2019 (COVID-19) causes severe illness including cytokine storms, but mortality among countries differs largely. In the present study, we investigated the association between human leukocyte antigen (HLA) class I, which plays a major role in susceptibility to viral infections, and the mort...

journal_title：Viruses

authors： Sakuraba A,Haider H,Sato T

更新日期：2020-11-20 00:00:00