The Roles of Ebola Virus Soluble Glycoprotein in Replication, Pathogenesis, and Countermeasure Development.

abstract：:SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying immunity. Because SARS-CoV-2 is a biosafety-level-3 virus, one way to simplify such assays is ...

journal_title：Viruses

authors： Crawford KHD,Eguia R,Dingens AS,Loes AN,Malone KD,Wolf CR,Chu HY,Tortorici MA,Veesler D,Murphy M,Pettie D,King NP,Balazs AB,Bloom JD

更新日期：2020-05-06 00:00:00

abstract：:Avian infectious bronchitis has caused huge economic losses in the poultry industry. Previous studies have reported that infectious bronchitis virus (IBV) infection can produce cytopathic effects (CPE) and apoptosis in some mammalian cells and primary cells. However, there is little research on IBV-induced immune cell...

journal_title：Viruses

authors： Han X,Tian Y,Guan R,Gao W,Yang X,Zhou L,Wang H

更新日期：2017-07-26 00:00:00

abstract：:Different lines of evidence support an association between Epstein-Barr virus (EBV) and gastric cancer (GC). The main understood risk factor to develop GC is infection by Helicobacter pylori (H. pylori), which triggers a local inflammatory response critical for progression from gastritis to GC. The role of EBV in earl...

journal_title：Viruses

authors： Martínez-López JL,Torres J,Camorlinga-Ponce M,Mantilla A,Leal YA,Fuentes-Pananá EM

更新日期：2014-01-20 00:00:00

abstract：:Nipah virus (NiV) is an emerging zoonotic virus that is transmitted by bats to humans and to pigs, causing severe respiratory disease and often fatal encephalitis. Antibodies directed against the NiV-glycoprotein (G) protein are known to play a major role in clearing NiV infection and in providing vaccine-induced prot...

journal_title：Viruses

authors： Kalodimou G,Veit S,Jany S,Kalinke U,Broder CC,Sutter G,Volz A

更新日期：2019-12-24 00:00:00

abstract：:Arthropod-borne flaviviruses are human pathogens of global medical importance, against which no effective small molecule-based antiviral therapy has currently been reported. Arbidol (umifenovir) is a broad-spectrum antiviral compound approved in Russia and China for prophylaxis and treatment of influenza. This compoun...

journal_title：Viruses

authors： Haviernik J,Štefánik M,Fojtíková M,Kali S,Tordo N,Rudolf I,Hubálek Z,Eyer L,Ruzek D

更新日期：2018-04-10 00:00:00

abstract：:It is increasingly clear that DNA viruses exploit cellular epigenetic processes to control their life cycles during infection. This review will address epigenetic regulation in members of the polyomaviruses, adenoviruses, human papillomaviruses, hepatitis B, and herpes viruses. For each type of virus, what is known ab...

journal_title：Viruses

authors： Balakrishnan L,Milavetz B

更新日期：2017-11-17 00:00:00

abstract：:The objective of this study was to evaluate the effects of A3R phage and Staphylococcus aureus lysate obtained after phage infection on neutrophil degranulation. The exocytosis of primary and secondary granules from neutrophils was investigated in vitro in whole blood specimens by flow cytometry based on the expressio...

journal_title：Viruses

authors： Borysowski J,Międzybrodzki R,Wierzbicki P,Kłosowska D,Korczak-Kowalska G,Weber-Dąbrowska B,Górski A

更新日期：2017-02-21 00:00:00

abstract：:Our loyal friend and colleague, Jan van der Noordaa, passed away unexpectedly at the age of 80 on the evening of 17 June 2015. [...]. ...

journal_title：Viruses

authors： Berkhout B,Bukrinsky M

更新日期：2015-09-15 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is an important cancer-causing human retrovirus that has infected approximately 15 million individuals worldwide. Many aspects of HTLV-1 replication, including virus particle structure and assembly, are poorly understood. Group-specific antigen (Gag) proteins labeled at the ...

journal_title：Viruses

authors： Maldonado JO,Angert I,Cao S,Berk S,Zhang W,Mueller JD,Mansky LM

更新日期：2017-07-19 00:00:00

abstract：:Equine influenza, caused by the H3N8 subtype, is a highly contagious respiratory disease affecting equid populations worldwide and has led to serious epidemics and transboundary pandemics. This study describes the phylogenetic characterization and replication kinetics of recently-isolated H3N8 virus from a nasal swab ...

journal_title：Viruses

authors： Sreenivasan CC,Jandhyala SS,Luo S,Hause BM,Thomas M,Knudsen DEB,Leslie-Steen P,Clement T,Reedy SE,Chambers TM,Christopher-Hennings J,Nelson E,Wang D,Kaushik RS,Li F

更新日期：2018-01-11 00:00:00

abstract：BACKGROUND:Zika virus is a mosquito-borne flavivirus responsible for recent outbreaks of epidemic proportions in Latin America. Sexual transmission of the virus has been reported in 13 countries and may be an important route of infection. Sexual transmission of ZIKV has mostly been male-to-female, and persistence of vi...

journal_title：Viruses

authors： Mlera L,Bloom ME

更新日期：2019-01-09 00:00:00

abstract：:Vaccination is the most effective means to prevent influenza virus infection, although current approaches are associated with suboptimal efficacy. Here, we generated virus-like particles (VLPs) composed of the hemagglutinin (HA), neuraminidase (NA) and matrix protein (M1) of A/Changchun/01/2009 (H1N1) with or without ...

journal_title：Viruses

authors： Ji X,Ren Z,Xu N,Meng L,Yu Z,Feng N,Sang X,Li S,Li Y,Wang T,Zhao Y,Wang H,Zheng X,Jin H,Li N,Yang S,Cao J,Liu W,Gao Y,Xia X

更新日期：2016-04-21 00:00:00

abstract：BACKGROUND:coronavirus disease 2019 (COVID-19) causes severe illness including cytokine storms, but mortality among countries differs largely. In the present study, we investigated the association between human leukocyte antigen (HLA) class I, which plays a major role in susceptibility to viral infections, and the mort...

journal_title：Viruses

authors： Sakuraba A,Haider H,Sato T

更新日期：2020-11-20 00:00:00

abstract：:Viral CD8 T-cell epitopes, represented by viral peptides bound to major histocompatibility complex class-I (MHC-I) glycoproteins, are often identified by "reverse immunology", a strategy not requiring biochemical and structural knowledge of the actual viral protein from which they are derived by antigen processing. In...

journal_title：Viruses

authors： Fink A,Büttner JK,Thomas D,Holtappels R,Reddehase MJ,Lemmermann NA

更新日期：2014-02-14 00:00:00

abstract：:During the epizootic of highly pathogenic avian influenza (HPAI) H5N8 virus in Europe in 2016-2017, HPAI viruses of subtype H5N5 were also isolated. However, the detection of H5N5 viruses was limited compared to H5N8. In this study, we show that the genetic constellation of a newly isolated H5N5 virus is different fro...

journal_title：Viruses

authors： Bergervoet SA,Ho CKY,Heutink R,Bossers A,Beerens N

更新日期：2019-05-31 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the etiological agent for a serious lower respiratory tract disease responsible for close to 200,000 annual deaths worldwide. The first infection is generally most severe, while re-infections usually associate with a milder disease. This observation and the finding that re-infecti...

journal_title：Viruses

authors： Rudraraju R,Jones BG,Sealy R,Surman SL,Hurwitz JL

更新日期：2013-02-05 00:00:00

abstract：:Cytoskeleton defines the shape and structural organization of the cell. Its elements participate in cell motility, intracellular transport and chromosome movement during mitosis. Papillomaviruses (PV) are strictly epitheliotropic and induce self-limiting benign tumors of skin and mucosa, which may progress to malignan...

journal_title：Viruses

authors： Bienkowska-Haba M,Sapp M

更新日期：2011-03-01 00:00:00

abstract：:Salmonid alphavirus (SAV) is the cause of pancreas disease and sleeping disease in farmed salmonid fish in Europe. The spread of these diseases has been difficult to control with biosecurity and current vaccination strategies, and increased understanding of the viral pathogenesis could be beneficial for the developmen...

journal_title：Viruses

authors： Aksnes I,Markussen T,Braaen S,Rimstad E

更新日期：2020-09-24 00:00:00

abstract：:The Vibrio cholerae biotype "El Tor" is responsible for all of the current epidemic and endemic cholera outbreaks worldwide. These outbreaks are clonal, and it is hypothesized that they originate from the coastal areas near the Bay of Bengal, where the lytic bacteriophage ICP1 (International Centre for Diarrhoeal Dise...

journal_title：Viruses

authors： Angermeyer A,Das MM,Singh DV,Seed KD

更新日期：2018-06-01 00:00:00

abstract：:Countries rely on good diagnostic tests and appropriate testing schemes to fight against economically important small ruminant lentivirus (SRLV) infections. We undertook an extensive comparative analysis of seven commercially available serological tests and one in-house real-time PCR (qPCR) detecting genotype A and B ...

journal_title：Viruses

authors： Michiels R,Van Mael E,Quinet C,Adjadj NR,Cay AB,De Regge N

更新日期：2018-12-08 00:00:00

abstract：:Environmental genomics can describe all forms of organisms--cellular and viral--present in a community. The analysis of such eco-systems biology data relies heavily on reference databases, e.g., taxonomy or gene function databases. Reference databases of symbiosis sensu lato, although essential for the analysis of org...

journal_title：Viruses

authors： Mihara T,Nishimura Y,Shimizu Y,Nishiyama H,Yoshikawa G,Uehara H,Hingamp P,Goto S,Ogata H

更新日期：2016-03-01 00:00:00

abstract：:Duck Tembusu virus (DTMUV) is a recently emerging pathogenic flavivirus that has resulted in a huge economic loss in the duck industry. However, no vaccine is currently available to control this pathogen. Consequently, a practical strategy to construct a vaccine against this pathogen should be determined. In this stud...

journal_title：Viruses

authors： Zou Z,Liu Z,Jin M

更新日期：2014-06-20 00:00:00

abstract：:In Europe, cowpox virus (CPXV) infection in South American camelids occurs as a so-called spill-over infection. Although infected animals generally have a mild form of the disease and survive, cases of fatal generalised CPXV infection have also been described. Prevention by prophylactic vaccination is the only way to ...

journal_title：Viruses

authors： Prkno A,Hoffmann D,Kaiser M,Goerigk D,Pfeffer M,Winter K,Vahlenkamp TW,Beer M,Starke A

更新日期：2020-02-20 00:00:00

abstract：:RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in t...

journal_title：Viruses

authors： Wei R,Chen G,Algehainy N,Zeng C,Liu C,Liu H,Liu W,Stacey D,Zhou A

更新日期：2020-01-07 00:00:00

abstract：:Lettuce is often implicated in human norovirus (HuNoV) foodborne outbreaks. We identified H-like histo-blood group antigens (HBGAs) on lettuce leaves as specific binding moieties for virus-like particles (VLPs) of HuNoV GII.4/HS194/2009 strain. The objective of this study was to determine whether HuNoV-lettuce binding...

journal_title：Viruses

authors： Esseili MA,Gao X,Boley P,Hou Y,Saif LJ,Brewer-Jensen P,Lindesmith LC,Baric RS,Atmar RL,Wang Q

更新日期：2019-09-08 00:00:00

abstract：:Staphylococcus aureus is a common and often virulent pathogen in humans. This bacterium is widespread, being present on the skin and in the nose of healthy people. Staphylococcus aureus can cause infections with severe outcomes ranging from pustules to sepsis and death. The introduction of antibiotics led to a general...

journal_title：Viruses

authors： Kaźmierczak Z,Górski A,Dąbrowska K

更新日期：2014-07-01 00:00:00

abstract：:During infection, Citrus tristeza virus (CTV) produces a non-coding subgenomic RNA referred to as low-molecular-weight tristeza 1 (LMT1), which for a long time has been considered as a by-product of the complex CTV replication machinery. In this study, we investigated the role of LMT1 in the virus infection cycle usin...

journal_title：Viruses

authors： Kang SH,Sun YD,Atallah OO,Huguet-Tapia JC,Noble JD,Folimonova SY

更新日期：2019-05-14 00:00:00

abstract：:Samples of two Ageratum conyzoides, one Sonchus oleraceus and one turnip (Brassica rapa var. rapa) exhibiting virus-like symptoms were collected from Pakistan and Nepal. Full-length begomovirus clones were obtained from the four plant samples and betasatellite clones from three of these. The begomovirus sequences were...

journal_title：Viruses

authors： Tahir M,Amin I,Haider MS,Mansoor S,Briddon RW

更新日期：2015-02-10 00:00:00

abstract：:Internal ribosome entry is a key mechanism for viral protein synthesis in a subset of RNA viruses. Cricket paralysis virus (CrPV), a member of Dicistroviridae, has a positive-sense single strand RNA genome that contains two internal ribosome entry sites (IRES), a 5'untranslated region (5'UTR) and intergenic region (IG...

journal_title：Viruses

authors： Khong A,Bonderoff JM,Spriggs RV,Tammpere E,Kerr CH,Jackson TJ,Willis AE,Jan E

更新日期：2016-01-19 00:00:00

abstract：:Several viral factors impact the natural course of hepatitis B virus (HBV) infection, the sensitivity of diagnostic tests, or treatment response to interferon-α and nucleos(t)ide analogues. These factors include the viral genotype and serotype but also mutations affecting the HBV surface antigen, basal core promoter/p...

journal_title：Viruses

authors： Velkov S,Protzer U,Michler T

更新日期：2020-11-23 00:00:00