Abstract:
:Crimean-Congo hemorrhagic fever virus is one the most important and wide spread tick-borne viruses. Very little is known about the transmission from the tick and the early aspects of pathogenesis. Here, we generate human cutaneous antigen presenting cells-dermal dendritic cells and Langerhans cells-from umbilical cord progenitor cells. In order to mimic the environment created during tick feeding, tick salivary gland extract was generated from semi-engorged Hyalomma marginatum ticks. Our findings indicate that human dermal dendritic cells and Langerhans cells are susceptible and permissive to Crimean-Congo hemorrhagic fever virus infection, however, to different degrees. Infection leads to cell activation and cytokine/chemokine secretion, although these responses vary between the different cell types. Hyalomma marginatum salivary gland extract had minimal effect on cell responses, with some synergy with viral infection with respect to cytokine secretion. However, salivary gland extract appeared to inhibit antigen presenting cells (APCs) migration. Based on the findings here we hypothesize that human dermal dendritic cells and Langerhans cells serve as early target cells. Rather affecting Crimean-Congo hemorrhagic fever virus replication, tick saliva likely immunomodulates and inhibits migration of these APCs from the feeding site.
journal_name
Virusesjournal_title
Virusesauthors
Rodriguez SE,McAuley AJ,Gargili A,Bente DAdoi
10.3390/v10070381subject
Has Abstractpub_date
2018-07-20 00:00:00issue
7issn
1999-4915pii
v10070381journal_volume
10pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract::Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and maintenance of genomic information in both cells and a variety of viral pathogens. While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been extensively inves...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12040382
更新日期:2020-03-31 00:00:00
abstract::Temperate bacteriophages possess a molecular switch, which regulates the lytic and lysogenic growth. The genomes of the temperate telomere phages N15, PY54 and ɸKO2 harbor a primary immunity region (immB) comprising genes for the prophage repressor, the lytic repressor and a putative antiterminator. The roles of these...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7062746
更新日期:2015-06-02 00:00:00
abstract::Autophagy is an essential cellular process by which a cell degrades materials within its cytoplasm. Intracellular pathogens like viruses must deal with autophagy, either positively or negatively, for their own survival and replication. For some viruses, autophagy can even play proviral roles, helping their replication...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11030244
更新日期:2019-03-12 00:00:00
abstract::Hepatitis B surface antigen (HBsAg) promotes persistent hepatitis B virus (HBV) infection. It primarily corresponds to small (S) envelope protein secreted as subviral particles. We previously found that genotype D clones expressed less S protein than genotype A clones but showed higher extracellular/intracellular rati...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12090967
更新日期:2020-09-01 00:00:00
abstract::Victoria and Yamagata lineages of influenza B viruses are globally circulating in seasonal epidemics. Madin-Darby canine kidney (MDCK) cells are permissive for viral isolation and vaccine manufacture. Nevertheless, the interplay between influenza B viruses and host microRNAs has not been investigated in this cell line...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11110986
更新日期:2019-10-25 00:00:00
abstract::The Megalocytivirus genus includes three genotypes, red sea bream iridovirus (RSIV), infectious spleen and kidney necrosis virus (ISKNV), and turbot reddish body iridovirus (TRBIV), and has caused mass mortalities in various marine and freshwater fish species in East and Southeast Asia. Of the three genotypes, TRBIV-l...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12060681
更新日期:2020-06-24 00:00:00
abstract::Human immunodeficiency virus type 1 (HIV-1) establishes latency in resting memory CD4+ T cells and cells of myeloid lineage. In contrast to the T cells, cells of myeloid lineage are resistant to the HIV-1 induced cytopathic effect. Cells of myeloid lineage including macrophages are present in anatomical sanctuaries ma...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v7041578
更新日期:2015-03-31 00:00:00
abstract::The mosquito antiviral response has mainly been studied in the context of arthropod-borne virus (arbovirus) infection in female mosquitoes. However, in nature, both female and male mosquitoes are frequently infected with insect-specific viruses (ISVs). ISVs are capable of infecting the reproductive organs of both sexe...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040468
更新日期:2020-04-21 00:00:00
abstract::The family Totiviridae currently contains five genera Totivirus, Victorivirus, Leishmavirus, Trichomonasvirus, and Giardiavirus. Members in this family generally have a set of two-open reading frame (ORF) elements in their genome with the 5'-proximal ORF (ORF1) encoding a capsid protein (CP) and the 3'-proximal one (O...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11060577
更新日期:2019-06-25 00:00:00
abstract::The ability of a cell to combat an intracellular pathogen requires a mechanism to recognize the threat and elicit a transcriptional response against it. In the context of virus infection, the cell must take measures to inhibit viral replication, meanwhile, convey warning signals to neighboring cells of the imminent th...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2010055
更新日期:2010-01-01 00:00:00
abstract::Double-stranded DNA viruses package their genomes into pre-assembled protein procapsids. This process is driven by macromolecular motors that transiently assemble at a unique vertex of the procapsid and utilize homomeric ring ATPases to couple genome encapsidation to ATP hydrolysis. Here, we describe the biochemical a...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010015
更新日期:2020-12-23 00:00:00
abstract::Background: Bats are known to host a number of nonpathogenic viruses, as well as highly pathogenic viruses causing fatal diseases like rabies. Serological surveys as part of active and passive bat rabies surveillance mainly use seroneutralization assays, demonstrating the presence of lyssavirus-specific antibodies in ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12030271
更新日期:2020-02-28 00:00:00
abstract::Cytoskeleton defines the shape and structural organization of the cell. Its elements participate in cell motility, intracellular transport and chromosome movement during mitosis. Papillomaviruses (PV) are strictly epitheliotropic and induce self-limiting benign tumors of skin and mucosa, which may progress to malignan...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v3030260
更新日期:2011-03-01 00:00:00
abstract::Since deer were introduced into Australia in the mid-1800s, their wild populations have increased in size and distribution, posing a potential risk to the livestock industry, through their role in pathogen transmission cycles. In comparison to livestock, there are limited data on viral infections in all wildlife, incl...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12070752
更新日期:2020-07-13 00:00:00
abstract::BST-2 or tetherin is a host cell restriction factor that prevents the budding of enveloped viruses at the cell surface, thus impairing the viral spread. Several countermeasures to evade this antiviral factor have been positively selected in retroviruses: the human immunodeficiency virus type 2 (HIV-2) relies on the en...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8100285
更新日期:2016-10-14 00:00:00
abstract::Virus-induced inflammation plays a critical role in determining the clinical outcome of an acute respiratory virus infection. We have shown previously that the administration of immunobiotic Lactobacillus plantarum (Lp) directly to the respiratory tract prevents lethal inflammatory responses to subsequent infection wi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010002
更新日期:2020-12-22 00:00:00
abstract::The success of oral infection by viruses depends on their capacity to overcome the gut epithelial barrier of their host to crossing over apical, mucous extracellular matrices. As orally transmitted viruses, densoviruses, are also challenged by the complexity of the insect gut barriers, more specifically by the chitino...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090870
更新日期:2019-09-17 00:00:00
abstract::Hepatitis B virus (HBV) infection affects ~350 million people and poses a major public health problem worldwide. HBV is a major cause of cirrhosis and hepatocellular carcinoma. Fewer than 5% of HBV-infected adults (but up to 90% of HBV-infected infants and children) develop chronic HBV infection as indicated by contin...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12030285
更新日期:2020-03-05 00:00:00
abstract::Human cytomegalovirus (HCMV), the largest human herpesvirus, infects a majority of the world's population. Like all herpesviruses, following primary productive infection, HCMV establishes a life-long latent infection, from which it can reactivate years later to produce new, infectious virus. Despite the presence of a ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4112448
更新日期:2012-10-25 00:00:00
abstract::The human gut contains an expanse of largely unstudied bacteriophages. Among the most common are crAss-like phages, which were predicted to infect Bacteriodetes hosts. CrAssphage, the first crAss-like phage to be discovered, contains a protein encoding a Bacteroides-associated carbohydrate-binding often N-terminal (BA...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11121085
更新日期:2019-11-21 00:00:00
abstract::H1N1 swine influenza viruses (SIV) are prevalent in pigs globally, and occasionally emerge in humans, which raises concern about their pandemic threats. To stimulate hemagglutination (HA) of A/Swine/Guangdong/LM/2004 (H1N1) (SW/GD/04) antibody response, eukaryotic expression plasmid pCI-neo-HA was constructed and used...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9080209
更新日期:2017-08-08 00:00:00
abstract::Microvirin (MVN) is one of the human immunodeficiency virus (HIV-1) entry inhibitor lectins, which consists of two structural domains sharing 35% sequence identity and contrary to many other antiviral lectins, it exists as a monomer. In this study, we engineered an MVN variant, LUMS1, consisting of two domains with 10...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12020199
更新日期:2020-02-11 00:00:00
abstract::Timely implementation of antiviral treatment and other public health based responses are dependent on accurate and rapid diagnosis of the novel pandemic influenza A(H1N1) strain. In this study we developed a duplex real-time PCR (RT-PCR) (dFLU-TM) assay for the simultaneous detection of a broad range of influenza A su...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v1031204
更新日期:2009-12-01 00:00:00
abstract::The nervous system is the target for acute encephalitic viral infections, as well as a reservoir for persisting viruses. Intrathecal antibody (Ab) synthesis is well documented in humans afflicted by infections associated with neurological complications, as well as the demyelinating disease, multiple sclerosis. This re...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5020732
更新日期:2013-02-15 00:00:00
abstract::The capsid domain (CA) of the lentiviral Gag polyproteins has two distinct roles during virion morphogenesis. As a domain of Gag, it mediates the Gag-Gag interactions that drive immature particle assembly, whereas as a mature protein, it self-assembles into the conical core of the mature virion. Lentiviral CA proteins...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090816
更新日期:2019-09-04 00:00:00
abstract::The hydrophobic pocket in the HIV-1 gp41 N-terminal heptad repeat (NHR) domain plays an important role in viral fusion and entry into the host cell, and serves as an attractive target for development of HIV-1 fusion/entry inhibitors. The peptide anti-HIV drug targeting gp41 NHR, T-20 (generic name: enfuvirtide; brand ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5010127
更新日期:2013-01-11 00:00:00
abstract::Changes over time in HIV-1 subtype diversity within a population reflect changes in factors influencing the development of local epidemics. Here we report on the genetic diversity of 2364 reverse transcriptase sequences from people living with HIV-1 in New South Wales (NSW) notified between 2004 and 2018. These data r...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121402
更新日期:2020-12-06 00:00:00
abstract::Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9110323
更新日期:2017-10-31 00:00:00
abstract::Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new strategy designated as Vectored ImmunoProphylaxis (VIP), which involves p...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6020428
更新日期:2014-01-27 00:00:00
abstract::Diagnostic electron microscopy for infectious diseases has the advantage that "everything" in the specimen can be observed, without a priori knowledge of the likely identity of the microorganisms present in the sample. The classical specimen preparation method used employs a droplet of sample, which allows particles t...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v6093458
更新日期:2014-09-19 00:00:00