Suppression of Type I Interferon Signaling by Flavivirus NS5.

abstract：:For the past two decades, norovirus pandemic variants have emerged every 3⁻5 years, and dominate until they are replaced by alternate strains. However, this scenario changed in 2016 with the co-circulation of six prevalent viruses, three of which possessed the pandemic GII.4 Sydney 2012 capsid. An increased number of ...

journal_title：Viruses

authors： Lun JH,Hewitt J,Yan GJH,Enosi Tuipulotu D,Rawlinson WD,White PA

更新日期：2018-10-09 00:00:00

abstract：:As more cases of COVID-19 are studied and treated worldwide, it had become apparent that the lethal and most severe cases of pneumonia are due to an out-of-control inflammatory response to the SARS-CoV-2 virus. I explored the putative causes of this specific feature through a detailed genomic comparison with the close...

journal_title：Viruses

authors： Claverie JM

更新日期：2020-06-15 00:00:00

abstract：:Circoviruses infect a variety of animal species and have small (~1.8-2.2 kb) circular single-stranded DNA genomes. Recently a penguin circovirus (PenCV) was identified associated with an Adélie Penguin (Pygoscelis adeliae) with feather disorder and in the cloacal swabs of three asymptomatic Adélie Penguins at Cape Cro...

journal_title：Viruses

authors： Levy H,Fiddaman SR,Djurhuus A,Black CE,Kraberger S,Smith AL,Hart T,Varsani A

更新日期：2020-08-06 00:00:00

abstract：:While PCR amplicons extend to a few thousand bases, the length of sequences from direct Sanger sequencing is limited to 500-800 nucleotides. Therefore, several fragments may be required to cover an amplicon, a gene or an entire genome. These fragments are typically sequenced in an overlapping fashion and assembled by ...

journal_title：Viruses

authors： Bell TG,Kramvis A

更新日期：2013-03-12 00:00:00

abstract：:Lettuce is often implicated in human norovirus (HuNoV) foodborne outbreaks. We identified H-like histo-blood group antigens (HBGAs) on lettuce leaves as specific binding moieties for virus-like particles (VLPs) of HuNoV GII.4/HS194/2009 strain. The objective of this study was to determine whether HuNoV-lettuce binding...

journal_title：Viruses

authors： Esseili MA,Gao X,Boley P,Hou Y,Saif LJ,Brewer-Jensen P,Lindesmith LC,Baric RS,Atmar RL,Wang Q

更新日期：2019-09-08 00:00:00

abstract：:Diagnostic electron microscopy for infectious diseases has the advantage that "everything" in the specimen can be observed, without a priori knowledge of the likely identity of the microorganisms present in the sample. The classical specimen preparation method used employs a droplet of sample, which allows particles t...

journal_title：Viruses

authors： Beniac DR,Siemens CG,Wright CJ,Booth TF

更新日期：2014-09-19 00:00:00

abstract：:The Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012, and circulated worldwide with high mortality. The continual outbreaks of MERS-CoV highlight the importance of developing antiviral therapeutics. Here, we rationally designed a novel fusion inhibitor named MERS-five-helix bundle (ME...

journal_title：Viruses

authors： Sun Y,Zhang H,Shi J,Zhang Z,Gong R

更新日期：2017-09-14 00:00:00

abstract：:Respiratory viral infections are strongly associated with asthma exacerbations. Rhinovirus is most frequently-detected pathogen; followed by respiratory syncytial virus; metapneumovirus; parainfluenza virus; enterovirus and coronavirus. In addition; viral infection; in combination with genetics; allergen exposure; mic...

journal_title：Viruses

authors： Han M,Rajput C,Ishikawa T,Jarman CR,Lee J,Hershenson MB

更新日期：2018-12-01 00:00:00

abstract：:H1N1 swine influenza viruses (SIV) are prevalent in pigs globally, and occasionally emerge in humans, which raises concern about their pandemic threats. To stimulate hemagglutination (HA) of A/Swine/Guangdong/LM/2004 (H1N1) (SW/GD/04) antibody response, eukaryotic expression plasmid pCI-neo-HA was constructed and used...

journal_title：Viruses

authors： Liu Y,Li H,Xue Y,Zhao S,Li C,Qu L,Zhang Y,Liu M

更新日期：2017-08-08 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection is a major cause of liver disease and hepatocellular carcinoma (HCC)-the second leading, and rising, cause of death due to cancer world-wide [...]. ...

journal_title：Viruses

authors： Baumert TF,Hoshida Y

更新日期：2019-05-15 00:00:00

abstract：:Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can lead to integration of the viral genome in human chromosomes. When integration occurs in germinal cells, the integrated HHV-6A/B genome can be transmitted to 50% of descendants. Such individuals, carrying one copy of the HHV-6A/B ge...

journal_title：Viruses

authors： Collin V,Flamand L

更新日期：2017-06-26 00:00:00

abstract：:Knowledge of the antibody-mediated immune response to SARS-CoV-2 is crucial to understand virus immunogenicity, establish seroprevalence, and determine whether subjects or recovered patients are at risk for infection/reinfection and would therefore benefit from vaccination. Here, we describe a novel and simple cell-EL...

journal_title：Viruses

authors： Zarletti G,Tiberi M,De Molfetta V,Bossù M,Toppi E,Bossù P,Scapigliati G

更新日期：2020-11-08 00:00:00

abstract：:Until vaccines and effective therapeutics become available, the practical solution to transit safely out of the current coronavirus disease 19 (CoVID-19) lockdown may include the implementation of an effective testing, tracing and tracking system. However, this requires a reliable and clinically validated diagnostic p...

journal_title：Viruses

authors： Rohaim MA,Clayton E,Sahin I,Vilela J,Khalifa ME,Al-Natour MQ,Bayoumi M,Poirier AC,Branavan M,Tharmakulasingam M,Chaudhry NS,Sodi R,Brown A,Burkhart P,Hacking W,Botham J,Boyce J,Wilkinson H,Williams C,Whittingham-Dow

更新日期：2020-09-01 00:00:00

abstract：:Type II transmembrane serine proteases (TTSPs) facilitate the spread and replication of viruses such as influenza and human coronaviruses, although it remains unclear whether TTSPs play a role in the progression of animal coronavirus infections, such as that by porcine epidemic diarrhea virus (PEDV). In this study, TT...

journal_title：Viruses

authors： Shi W,Fan W,Bai J,Tang Y,Wang L,Jiang Y,Tang L,Liu M,Cui W,Xu Y,Li Y

更新日期：2017-05-18 00:00:00

abstract：:Vaccination is the most effective means to prevent influenza virus infection, although current approaches are associated with suboptimal efficacy. Here, we generated virus-like particles (VLPs) composed of the hemagglutinin (HA), neuraminidase (NA) and matrix protein (M1) of A/Changchun/01/2009 (H1N1) with or without ...

journal_title：Viruses

authors： Ji X,Ren Z,Xu N,Meng L,Yu Z,Feng N,Sang X,Li S,Li Y,Wang T,Zhao Y,Wang H,Zheng X,Jin H,Li N,Yang S,Cao J,Liu W,Gao Y,Xia X

更新日期：2016-04-21 00:00:00

abstract：:Arthropod-borne flaviviruses are human pathogens of global medical importance, against which no effective small molecule-based antiviral therapy has currently been reported. Arbidol (umifenovir) is a broad-spectrum antiviral compound approved in Russia and China for prophylaxis and treatment of influenza. This compoun...

journal_title：Viruses

authors： Haviernik J,Štefánik M,Fojtíková M,Kali S,Tordo N,Rudolf I,Hubálek Z,Eyer L,Ruzek D

更新日期：2018-04-10 00:00:00

abstract：:The initial step of viral infection is the binding of a virus onto the host cell surface. This first viral-host interaction would determine subsequent infection steps and the fate of the entire infection process. A basic understating of the underlining mechanism of initial virus-host binding is a prerequisite for esta...

journal_title：Viruses

authors： Chatterjee S,Rothenberg E

更新日期：2012-11-15 00:00:00

abstract：:Human coronaviruses (HCoVs) cause mild to severe respiratory diseases. Six types of HCoVs have been discovered, the most recent one termed the Middle East respiratory syndrome coronavirus (MERS-CoV). The aim of this study is to monitor the circulation of HCoV types in the population during 2015⁻2016 in Israel. HCoVs w...

journal_title：Viruses

authors： Friedman N,Alter H,Hindiyeh M,Mendelson E,Shemer Avni Y,Mandelboim M

更新日期：2018-09-21 00:00:00

abstract：:Viral encephalitis causes acute inflammation of the brain parenchyma and is a significant cause of human morbidity and mortality. Although Herpes Simplex encephalitis is the most frequent known cause of fatal sporadic encephalitis in humans, an increasingly wide range of viruses and other microbial pathogens are impli...

journal_title：Viruses

authors： Kennedy PGE,Quan PL,Lipkin WI

更新日期：2017-06-06 00:00:00

abstract：:Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research l...

journal_title：Viruses

authors： Wahl-Jensen V,Bollinger L,Safronetz D,de Kok-Mercado F,Scott DP,Ebihara H

更新日期：2012-12-14 00:00:00

abstract：:Herpesviruses use a vesicle-mediated transfer of intranuclearly assembled nucleocapsids through the nuclear envelope (NE) for final maturation in the cytoplasm. The molecular basis for this novel vesicular nucleo-cytoplasmic transport is beginning to be elucidated in detail. The heterodimeric viral nuclear egress comp...

journal_title：Viruses

authors： Mettenleiter TC

更新日期：2016-09-27 00:00:00

abstract：:Ebola virus is the causative agent of Ebola virus disease in humans. The lethality of Ebola virus infection is about 50%, supporting the urgent need to develop anti-Ebola drugs. Glycoprotein (GP) is the only surface protein of the Ebola virus, which is functionally critical for the virus to attach and enter the host c...

journal_title：Viruses

authors： Cui Q,Cheng H,Xiong R,Zhang G,Du R,Anantpadma M,Davey RA,Rong L

更新日期：2018-11-30 00:00:00

abstract：:The human OAS1 (hOAS1) gene produces multiple possible isoforms due to alternative splicing events and sequence variation among individuals, some of which affect splicing. The unique C-terminal sequences of the hOAS1 isoforms could differentially affect synthetase activity, protein stability, protein partner interacti...

journal_title：Viruses

authors： Di H,Elbahesh H,Brinton MA

更新日期：2020-01-29 00:00:00

abstract：:Commentary on Hare, S.; Gupta, S.S.; Valkov, E.; Engelman, A.; Cherepanov, P. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature2010, 464, 232-236. ...

journal_title：Viruses

authors： Grandgenett D,Korolev S

更新日期：2010-05-01 00:00:00

abstract：:Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma samples obtained from 50...

journal_title：Viruses

authors： Matsuzawa Y,Iwatsuki-Horimoto K,Nishimoto Y,Abe Y,Fukuyama S,Hamabata T,Okuda M,Go Y,Watanabe T,Imai M,Arai Y,Fouchier RAM,Yamayoshi S,Kawaoka Y

更新日期：2019-10-23 00:00:00

abstract：:African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected soft tick bites. As already described, European soft ticks (Orni...

journal_title：Viruses

authors： Pereira De Oliveira R,Hutet E,Duhayon M,Guionnet JM,Paboeuf F,Vial L,Le Potier MF

更新日期：2020-03-11 00:00:00

abstract：:The International Virus Bioinformatics Meeting 2020 was originally planned to take place in Bern, Switzerland, in March 2020. However, the COVID-19 pandemic put a spoke in the wheel of almost all conferences to be held in 2020. After moving the conference to 8-9 October 2020, we got hit by the second wave and finally ...

journal_title：Viruses

authors： Hufsky F,Beerenwinkel N,Meyer IM,Roux S,Cook GM,Kinsella CM,Lamkiewicz K,Marquet M,Nieuwenhuijse DF,Olendraite I,Paraskevopoulou S,Young F,Dijkman R,Ibrahim B,Kelly J,Le Mercier P,Marz M,Ramette A,Thiel V

更新日期：2020-12-06 00:00:00

abstract：:During the epizootic of highly pathogenic avian influenza (HPAI) H5N8 virus in Europe in 2016-2017, HPAI viruses of subtype H5N5 were also isolated. However, the detection of H5N5 viruses was limited compared to H5N8. In this study, we show that the genetic constellation of a newly isolated H5N5 virus is different fro...

journal_title：Viruses

authors： Bergervoet SA,Ho CKY,Heutink R,Bossers A,Beerens N

更新日期：2019-05-31 00:00:00

abstract：:MicroRNAs (miRNAs) are non-coding but functional RNA molecules of 21-25 nucleotides in length. MiRNAs play significant regulatory roles in diverse plant biological processes. In order to decipher the relationship between nbe-miR1919c-5p and the accumulations of tobacco curly shoot virus (TbCSV) and its betasatellite (...

journal_title：Viruses

authors： Du J,Wu R,Liu Z,Sun M,Ghanem H,Li M,Wu G,Qing L

更新日期：2020-04-01 00:00:00

abstract：:Research on human enteroviruses has resulted in the identification of more than 100 enterovirus types, which use more than 10 protein receptors and/or attachment factors required in cell binding and initiation of the replication cycle. Many of these "viral" receptors are overexpressed in cancer cells. Receptor binding...

journal_title：Viruses

authors： Ylä-Pelto J,Tripathi L,Susi P

更新日期：2016-02-23 00:00:00