Translation-Independent Roles of RNA Secondary Structures within the Replication Protein Coding Region of Turnip Crinkle Virus.

abstract：:Viral outbreaks of varying frequencies and severities have caused panic and havoc across the globe throughout history. Influenza, small pox, measles, and yellow fever reverberated for centuries, causing huge burden for economies. The twenty-first century witnessed the most pathogenic and contagious virus outbreaks of ...

journal_title：Viruses

authors： Soman Pillai V,Krishna G,Valiya Veettil M

更新日期：2020-04-20 00:00:00

abstract：:In Europe, cowpox virus (CPXV) infection in South American camelids occurs as a so-called spill-over infection. Although infected animals generally have a mild form of the disease and survive, cases of fatal generalised CPXV infection have also been described. Prevention by prophylactic vaccination is the only way to ...

journal_title：Viruses

authors： Prkno A,Hoffmann D,Kaiser M,Goerigk D,Pfeffer M,Winter K,Vahlenkamp TW,Beer M,Starke A

更新日期：2020-02-20 00:00:00

abstract：BACKGROUND:Duck plague virus (DPV) can induce apoptosis in duck embryo fibroblasts (DEFs) and in infected ducks, but the molecular mechanism of DPV-induced apoptosis remains unknown. METHODS:We first used qRT-PCR and a Caspase-Glo assay to determine whether the caspase protein family plays an important role in DPV-ind...

journal_title：Viruses

authors： Zhao C,Wang M,Cheng A,Yang Q,Wu Y,Jia R,Zhu D,Chen S,Liu M,Zhao X,Zhang S,Liu Y,Yu Y,Zhang L,Tian B,Rehman MU,Pan L,Chen X

更新日期：2019-02-24 00:00:00

abstract：:Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures tha...

journal_title：Viruses

authors： Wille M,Netter HJ,Littlejohn M,Yuen L,Shi M,Eden JS,Klaassen M,Holmes EC,Hurt AC

更新日期：2018-12-17 00:00:00

abstract：:The human OAS1 (hOAS1) gene produces multiple possible isoforms due to alternative splicing events and sequence variation among individuals, some of which affect splicing. The unique C-terminal sequences of the hOAS1 isoforms could differentially affect synthetase activity, protein stability, protein partner interacti...

journal_title：Viruses

authors： Di H,Elbahesh H,Brinton MA

更新日期：2020-01-29 00:00:00

abstract：:Global climate change-induced warming of the Artic seas is predicted to shift the phytoplankton community towards dominance of smaller-sized species due to global warming. Yet, little is known about their viral mortality agents despite the ecological importance of viruses regulating phytoplankton host dynamics and div...

journal_title：Viruses

authors： Maat DS,Biggs T,Evans C,van Bleijswijk JDL,van der Wel NN,Dutilh BE,Brussaard CPD

更新日期：2017-06-02 00:00:00

abstract：:Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1-4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and M...

journal_title：Viruses

authors： Dieng I,Cunha M,Diagne MM,Sembène PM,Zanotto PMA,Faye O,Faye O,Sall AA

更新日期：2021-01-04 00:00:00

abstract：:Human cytomegalovirus (HCMV), the largest human herpesvirus, infects a majority of the world's population. Like all herpesviruses, following primary productive infection, HCMV establishes a life-long latent infection, from which it can reactivate years later to produce new, infectious virus. Despite the presence of a ...

journal_title：Viruses

authors： McSharry BP,Avdic S,Slobedman B

更新日期：2012-10-25 00:00:00

abstract：:The porcine epidemic diarrhea virus (PEDV) poses a great threat to the global swine industries and the unreliable protection induced by the currently available vaccines remains a major challenge. We previously generated a genogroup 2b (G2b) PEDV Taiwan Pintung 52 (PEDVPT) strain, PEDVPT-P96, and determined its promisi...

journal_title：Viruses

authors： Kao CF,Chiou HY,Chang YC,Hsueh CS,Jeng CR,Tsai PS,Cheng IC,Pang VF,Chang HW

更新日期：2018-10-04 00:00:00

abstract：:Eukaryotic translation is a complex process composed of three main steps: initiation, elongation, and termination. During infections by RNA- and DNA-viruses, the eukaryotic translation machinery is used to assure optimal viral protein synthesis. Human immunodeficiency virus type I (HIV-1) uses several non-canonical pa...

journal_title：Viruses

authors： Guerrero S,Batisse J,Libre C,Bernacchi S,Marquet R,Paillart JC

更新日期：2015-01-19 00:00:00

abstract：:Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict v...

journal_title：Viruses

authors： Zhang Y,Xu Z,Cao Y

更新日期：2020-03-29 00:00:00

abstract：:Rabies is a viral infection that targets the nervous system, specifically neurons. The clinical manifestations of the disease are dramatic and their outcome fatal; paradoxically, conventional histopathological descriptions reveal only subtle changes in the affected nervous tissue. Some researchers have considered that...

journal_title：Viruses

authors： Monroy-Gómez J,Santamaría G,Torres-Fernández O

更新日期：2018-03-06 00:00:00

abstract：:The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide analogue (NUC) drugs, and the widespread use of immune stimulators such as interferon-alpha (IFNα) or PEGylated interferon-alpha (PEG-IFNα), sub...

journal_title：Viruses

authors： Duraisamy GS,Bhosale D,Lipenská I,Huvarova I,Růžek D,Windisch MP,Miller AD

更新日期：2020-09-07 00:00:00

abstract：:Bacterial infections pose a challenge to human health and burden the health care system, especially with the spread of antibiotic-resistant populations. To provide effective treatment and improved prognosis, effective diagnostic methods are of great importance. Here we present phage-mediated molecular detection (PMMD)...

journal_title：Viruses

authors： Malagon F,Estrella LA,Stockelman MG,Hamilton T,Teneza-Mora N,Biswas B

更新日期：2020-04-11 00:00:00

abstract：:Like all other viruses, a successful egress of functional particles from infected cells is a prerequisite for foamy virus (FV) spread within the host. The budding process of FVs involves steps, which are shared by other retroviruses, such as interaction of the capsid protein with components of cellular vacuolar protei...

journal_title：Viruses

authors： Hütter S,Zurnic I,Lindemann D

更新日期：2013-04-10 00:00:00

abstract：:Bats are unique mammals, exhibit distinctive life history traits and have unique immunological approaches to suppression of viral diseases upon infection. High-throughput next-generation sequencing has been used in characterizing the virome of different bat species. The cave nectar bat, Eonycteris spelaea, has a broad...

journal_title：Viruses

authors： Mendenhall IH,Wen DLH,Jayakumar J,Gunalan V,Wang L,Mauer-Stroh S,Su YCF,Smith GJD

更新日期：2019-03-12 00:00:00

abstract：:Porcine epidemic diarrhea (PED) is a highly contagious disease in newborn piglets. In our previous study, a genetically engineered Lactobacillus casei oral vaccine (pPG-COE-DCpep/L393) expressing a dendritic cell (DC)-targeting peptide fused with porcine epidemic diarrhea virus (PEDV) COE antigen was developed. This v...

journal_title：Viruses

authors： Hou X,Jiang X,Jiang Y,Tang L,Xu Y,Qiao X,Min L,Wen C,Ma G,Li Y

更新日期：2018-03-01 00:00:00

abstract：:West Nile virus (WNV) is a member of the genus Flavivirus in the family Flaviviridae. Flaviviruses replicate in the cytoplasm of infected cells and modify the host cell environment. Although much has been learned about virion structure and virion-endosomal membrane fusion, the cell receptor(s) used have not been defin...

journal_title：Viruses

authors： Brinton MA

更新日期：2013-12-27 00:00:00

abstract：:Persistent circulative transmission of plant viruses involves complex interactions between the transmitted virus and its insect vector. Several studies have shown that insect vector proteins are involved in the passage and the transmission of the virus. Interestingly, proteins expressed by bacterial endosymbionts that...

journal_title：Viruses

authors： Kliot A,Ghanim M

更新日期：2013-06-19 00:00:00

abstract：:Chikungunya virus (CHIKV) has caused extensive outbreaks in several countries within the Americas, Asia, Oceanic/Pacific Islands, and Europe. In humans, CHIKV infections cause a debilitating disease with acute febrile illness and long-term polyarthralgia. Acute and chronic symptoms impose a major economic burden to he...

journal_title：Viruses

authors： López-Camacho C,Kim YC,Blight J,Lazaro Moreli M,Montoya-Diaz E,Huiskonen JT,Kümmerer BM,Reyes-Sandoval A

更新日期：2019-04-03 00:00:00

abstract：:Several viral infections of swine are responsible for major economic losses and represent a threat to the swine industry worldwide. New tools are needed to prevent and control endemic, emerging, and re-emerging viral diseases. Dendritic cells (DC) play a central role in linking the innate and adaptive arms of the immu...

journal_title：Viruses

authors： Franzoni G,Graham SP,Dei Giudici S,Oggiano A

更新日期：2019-05-16 00:00:00

abstract：:Between January 2012 and March 2012, the infection rates of porcine epidemic diarrhea virus (PEDV) increased substantially in vaccinated swine herds in many porcine farms in Gansu Province, China. The spike (S) glycoprotein is an important determinant for PEDV biological properties. To determine the distribution profi...

journal_title：Viruses

authors： Tian Y,Yu Z,Cheng K,Liu Y,Huang J,Xin Y,Li Y,Fan S,Wang T,Huang G,Feng N,Yang Z,Yang S,Gao Y,Xia X

更新日期：2013-08-15 00:00:00

abstract：:The hepatitis B virus (HBV) infects hepatocytes, which are the main cell type composing a human liver. However, the liver is enriched with immune cells, particularly innate cells (e.g., myeloid cells, natural killer and natural killer T-cells (NK/NKT), dendritic cells (DCs)), in resting condition. Hence, the study of ...

journal_title：Viruses

authors： Faure-Dupuy S,Lucifora J,Durantel D

更新日期：2017-04-28 00:00:00

abstract：:The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions shared among membe...

journal_title：Viruses

authors： Zeidler JD,Fernandes-Siqueira LO,Barbosa GM,Da Poian AT

更新日期：2017-03-13 00:00:00

abstract：:Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes cancer (Adult T cell Leukemia, ATL) and a spectrum of inflammatory diseases (mainly HTLV-associated myelopathy-tropical spastic paraparesis, HAM/TSP). Since virions are particularly unstable, HTLV-1 transmission primarily occurs by transfer of a c...

journal_title：Viruses

authors： Carpentier A,Barez PY,Hamaidia M,Gazon H,de Brogniez A,Perike S,Gillet N,Willems L

更新日期：2015-07-07 00:00:00

abstract：:The precise role of adaptive immune responses in the clinical outcome of HCV infection is still only partially defined. Recent studies suggest that viral-host cell interactions during the acute phase of infection are essential for viral clearance or progression into chronic HCV infection. This review focuses on differ...

journal_title：Viruses

authors： Zeisel MB,Fafi-Kremer S,Robinet E,Habersetzer F,Baumert TF,Stoll-Keller F

更新日期：2009-09-01 00:00:00

abstract：:Hepatitis B virus (HBV) persistence is at the basis of HBV reactivation as a consequence of chemotherapy and immunosuppressive treatments. The identification of early viral replication indicators and markers of effective HBV immunological control would be useful in monitoring patients who are at risk of potential vira...

journal_title：Viruses

authors： Svicher V,Salpini R,Malagnino V,Piermatteo L,Alkhatib M,Cerva C,Sarmati L

更新日期：2019-08-25 00:00:00

abstract：:At the forefront of vector control efforts are strategies that leverage host-microbe associations to reduce vectorial capacity. The most promising of these efforts employs Wolbachia, a maternally transmitted endosymbiotic bacterium naturally found in 40% of insects. Wolbachia can spread through a population of insects...

journal_title：Viruses

authors： Lindsey ARI,Bhattacharya T,Newton ILG,Hardy RW

更新日期：2018-03-21 00:00:00

abstract：:Different developmental stages of Artemia spp. (metanauplii, juveniles and adults) were bath-challenged with two isolates of the Lymphocystis disease virus (LCDV), namely, LCDV SA25 (belonging to the species Lymphocystis disease virus 3) and ATCC VR-342 (an unclassified member of the genus Lymphocystivirus). Viral qua...

journal_title：Viruses

authors： Valverde EJ,Labella AM,Borrego JJ,Castro D

更新日期：2019-06-01 00:00:00

abstract：:The Megalocytivirus genus includes three genotypes, red sea bream iridovirus (RSIV), infectious spleen and kidney necrosis virus (ISKNV), and turbot reddish body iridovirus (TRBIV), and has caused mass mortalities in various marine and freshwater fish species in East and Southeast Asia. Of the three genotypes, TRBIV-l...

journal_title：Viruses

authors： Tsai JM,Huang SL,Yang CD

更新日期：2020-06-24 00:00:00