NS1 Antigenemia and Viraemia Load: Potential Markers of Progression to Dengue Fatal Outcome?

abstract：:Rabies is a viral infection that targets the nervous system, specifically neurons. The clinical manifestations of the disease are dramatic and their outcome fatal; paradoxically, conventional histopathological descriptions reveal only subtle changes in the affected nervous tissue. Some researchers have considered that...

journal_title：Viruses

authors： Monroy-Gómez J,Santamaría G,Torres-Fernández O

更新日期：2018-03-06 00:00:00

abstract：:The immune-suppressive effects of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) on T cells have been observed via multiple in vitro and in vivo models. However, the precise mechanism that causes these effects is still undefined. In this study, we investigated whether n-3 PUFAs regulated T cell receptor (TCR) and p...

journal_title：Viruses

authors： Lim Y,Kim S,Kim S,Kim DI,Kang KW,Hong SH,Lee SM,Koh HR,Seo YJ

更新日期：2020-06-12 00:00:00

abstract：:Dengue, chikungunya and Zika viruses share similar disease features, rendering them difficult to distinguish clinically. Incapacitating arthralgia/arthritis is a specific manifestation associated with chikungunya virus infection. However, the profile of arthralgia/arthritis in Zika virus (ZIKV) cases has not been well...

journal_title：Viruses

authors： Wimalasiri-Yapa BMCR,Yapa HE,Huang X,Hafner LM,Kenna TJ,Frentiu FD

更新日期：2020-10-07 00:00:00

abstract：:One of the major obstacles that must be overcome in the design of effective lentiviral vaccines is the ability of lentiviruses to evolve in order to escape from neutralizing antibodies. The primary target for neutralizing antibodies is the highly variable viral envelope glycoprotein (Env), a glycoprotein that is essen...

journal_title：Viruses

authors： Hosie MJ,Pajek D,Samman A,Willett BJ

更新日期：2011-10-01 00:00:00

abstract：:HIV-1 is a global health crisis that has infected more than 37 million people. Latent reservoirs throughout the body are a major hurdle when it comes to eradicating the virus. In our previous study, we found that exosomes, a type of extracellular vesicle (EV), from uninfected cells activate the transcription of HIV-1 ...

journal_title：Viruses

authors： Barclay RA,Mensah GA,Cowen M,DeMarino C,Kim Y,Pinto DO,Erickson J,Kashanchi F

更新日期：2020-06-19 00:00:00

abstract：:Influenza A viruses (IAV) carrying reporter genes provide a powerful tool to study viral infection and pathogenesis in vivo, however, incorporating a non-essential gene into the IAV genome often results in virus attenuation and genetic instability. Very few studies have systematically compared different reporter IAVs,...

journal_title：Viruses

authors： Zhao X,Wang L,Cui Q,Li P,Wang Y,Zhang Y,Yang Y,Rong L,Du R

更新日期：2018-11-30 00:00:00

abstract：:We recently developed a test based on the Agilent SureSelect target enrichment system capturing genomic fragments from 191 human papillomaviruses (HPV) types for Illumina sequencing. This enriched whole genome sequencing (eWGS) assay provides an approach to identify all HPV types in a sample. Here we present a machine...

journal_title：Viruses

authors： Lomsadze A,Li T,Rajeevan MS,Unger ER,Borodovsky M

更新日期：2020-06-30 00:00:00

abstract：:Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated "CiHHV-6A/B". These affect approximately 1.0% of human populations, giving potential for virus gene expression in every cell. We previously showed that CiHHV-6A w...

journal_title：Viruses

authors： Tweedy J,Spyrou MA,Pearson M,Lassner D,Kuhl U,Gompels UA

更新日期：2016-01-15 00:00:00

abstract：:It has been demonstrated that MEK1, one of the two MEK isoforms in Raf-MEK-ERK1/2 pathway, is essential for successful EV71 propagation. However, the distinct function of ERK1 and ERK2 isoforms, the downstream kinases of MEKs, remains unclear in EV71 replication. In this study, specific ERK siRNAs and selective inhibi...

journal_title：Viruses

authors： Zhu M,Duan H,Gao M,Zhang H,Peng Y

更新日期：2015-03-20 00:00:00

abstract：:Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and maintenance of genomic information in both cells and a variety of viral pathogens. While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been extensively inves...

journal_title：Viruses

authors： Coggins SA,Mahboubi B,Schinazi RF,Kim B

更新日期：2020-03-31 00:00:00

abstract：:Countries rely on good diagnostic tests and appropriate testing schemes to fight against economically important small ruminant lentivirus (SRLV) infections. We undertook an extensive comparative analysis of seven commercially available serological tests and one in-house real-time PCR (qPCR) detecting genotype A and B ...

journal_title：Viruses

authors： Michiels R,Van Mael E,Quinet C,Adjadj NR,Cay AB,De Regge N

更新日期：2018-12-08 00:00:00

abstract：:The Vibrio cholerae biotype "El Tor" is responsible for all of the current epidemic and endemic cholera outbreaks worldwide. These outbreaks are clonal, and it is hypothesized that they originate from the coastal areas near the Bay of Bengal, where the lytic bacteriophage ICP1 (International Centre for Diarrhoeal Dise...

journal_title：Viruses

authors： Angermeyer A,Das MM,Singh DV,Seed KD

更新日期：2018-06-01 00:00:00

abstract：:Influenza A viruses (IAVs) harbor a segmented RNA genome that is organized into eight distinct viral ribonucleoprotein (vRNP) complexes. Although a segmented genome may be a major advantage to adapt to new host environments, it comes at the cost of a highly sophisticated genome packaging mechanism. Newly synthesized v...

journal_title：Viruses

authors： Giese S,Bolte H,Schwemmle M

更新日期：2016-06-17 00:00:00

abstract：:Viral outbreaks of varying frequencies and severities have caused panic and havoc across the globe throughout history. Influenza, small pox, measles, and yellow fever reverberated for centuries, causing huge burden for economies. The twenty-first century witnessed the most pathogenic and contagious virus outbreaks of ...

journal_title：Viruses

authors： Soman Pillai V,Krishna G,Valiya Veettil M

更新日期：2020-04-20 00:00:00

abstract：:We show that focused ion beam/scanning electron microscopy (FIB/SEM) tomography is an excellent method to analyze the three-dimensional structure of a fibroblast nucleus infected with human cytomegalovirus (HCMV). We found that the previously described infoldings of the inner nuclear membrane, which are unique among i...

journal_title：Viruses

authors： Villinger C,Neusser G,Kranz C,Walther P,Mertens T

更新日期：2015-11-04 00:00:00

abstract：:The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system is widely explored for sequence-specific attack on HIV-1 proviral DNA. We recently identified dual-guide RNA (dual-gRNA) combinations that can block HIV-1 replication permanently in infected cell cultures and prevent viral escape. Altho...

journal_title：Viruses

authors： Darcis G,Binda CS,Klaver B,Herrera-Carrillo E,Berkhout B,Das AT

更新日期：2019-03-13 00:00:00

abstract：:The MinION sequencer is increasingly being used for the detection and outbreak surveillance of pathogens due to its rapid throughput. For RNA viruses, MinION's new direct RNA sequencing is the next significant development. Direct RNA sequencing studies are currently limited and comparisons of its diagnostic performanc...

journal_title：Viruses

authors： Leigh DM,Schefer C,Cornejo C

更新日期：2020-07-25 00:00:00

abstract：:Bacteriophage (phage) therapy is a promising alternative to antibiotics for the treatment of bacterial pathogens, including Clostridiumdifficile. However, as for many species, in C. difficile the physical interactions between phages and bacterial cells have not been studied in detail. The initial interaction, known as...

journal_title：Viruses

authors： Thanki AM,Taylor-Joyce G,Dowah A,Nale JY,Malik D,Clokie MRJ

更新日期：2018-08-06 00:00:00

abstract：:Viruses represent important test cases for data federation due to their genome size and the rapid increase in sequence data in publicly available databases. However, some consequences of previously decentralized (unfederated) data are lack of consensus or comparisons between feature annotations. Unifying or displaying...

journal_title：Viruses

authors： Martí-Carreras J,Gener AR,Miller SD,Brito AF,Camacho CE,Connor R,Deboutte W,Glickman C,Kristensen DM,Meyer WK,Modha S,Norris AL,Saha S,Belford AK,Biederstedt E,Brister JR,Buchmann JP,Cooley NP,Edwards RA,Javkar K,

更新日期：2020-12-10 00:00:00

abstract：:Until vaccines and effective therapeutics become available, the practical solution to transit safely out of the current coronavirus disease 19 (CoVID-19) lockdown may include the implementation of an effective testing, tracing and tracking system. However, this requires a reliable and clinically validated diagnostic p...

journal_title：Viruses

authors： Rohaim MA,Clayton E,Sahin I,Vilela J,Khalifa ME,Al-Natour MQ,Bayoumi M,Poirier AC,Branavan M,Tharmakulasingam M,Chaudhry NS,Sodi R,Brown A,Burkhart P,Hacking W,Botham J,Boyce J,Wilkinson H,Williams C,Whittingham-Dow

更新日期：2020-09-01 00:00:00

abstract：:JC Virus (JCPyV), a member of the Polyomaviridiæ family, is a human neurotropic virus with world-wide distribution. JCPyV is the established opportunistic infectious agent of progressive multifocal leukoencephalopathy, a fatal demyelinating disease, which results from the cytolytic infection of oligodendrocytes. Mutat...

journal_title：Viruses

authors： Del Valle L,Khalili K

更新日期：2021-01-22 00:00:00

abstract：:Delivering rapid protection against infectious agents to non-immune populations is a formidable public health challenge. Although passive immunotherapy is a fast and effective method of protection, large-scale production and administration of monoclonal antibodies (mAbs) is expensive and unpractical. Viral vector-medi...

journal_title：Viruses

authors： Michelini Z,Minkoff JM,Yang J,Negri D,Cara A,Hanson BJ,Salvatore M

更新日期：2020-12-17 00:00:00

abstract：:African swine fever is a highly lethal hemorrhagic fever of Suidae, threatening pig production globally. Suidae can be infected by different ways like ingestion of contaminated feed, direct contact with infected animals or fomites, and biting by infected soft tick bites. As already described, European soft ticks (Orni...

journal_title：Viruses

authors： Pereira De Oliveira R,Hutet E,Duhayon M,Guionnet JM,Paboeuf F,Vial L,Le Potier MF

更新日期：2020-03-11 00:00:00

abstract：:Influenza is a serious public health concern worldwide, as it causes significant morbidity and mortality. The emergence of drug-resistant viral strains requires new approaches for the treatment of influenza. In this study, Rubus coreanus seed (RCS) that is left over from the production of wine or juice was found to sh...

journal_title：Viruses

authors： Lee JH,Oh M,Seok JH,Kim S,Lee DB,Bae G,Bae HI,Bae SY,Hong YM,Kwon SO,Lee DH,Song CS,Mun JY,Chung MS,Kim KH

更新日期：2016-06-06 00:00:00

abstract：:MicroRNAs (miRNAs) are non-coding but functional RNA molecules of 21-25 nucleotides in length. MiRNAs play significant regulatory roles in diverse plant biological processes. In order to decipher the relationship between nbe-miR1919c-5p and the accumulations of tobacco curly shoot virus (TbCSV) and its betasatellite (...

journal_title：Viruses

authors： Du J,Wu R,Liu Z,Sun M,Ghanem H,Li M,Wu G,Qing L

更新日期：2020-04-01 00:00:00

abstract：:Laboratories throughout the world that perform work with Risk Group 4 Pathogens generally adopt one of two approaches within BSL-4 environments: either the use of positive pressure air-fed suits or using Class III microbiological safety cabinets and isolators for animal work. Within the UK at present, all laboratories...

journal_title：Viruses

authors： Steward JA,Lever MS

更新日期：2012-08-01 00:00:00

abstract：:: Rabies virus (RABV) is the only lyssavirus known to be present within the Caribbean. The island of Trinidad, is richly diverse in chiropteran fauna and endemic for bat-transmitted rabies with low RABV isolation rates observed in this population. We aimed to determine the seroprevalence of rabies virus neutralizing a...

journal_title：Viruses

authors： Seetahal JFR,Greenberg L,Satheshkumar PS,Sanchez-Vazquez MJ,Legall G,Singh S,Ramkissoon V,Schountz T,Munster V,Oura CAL,Carrington CVF

更新日期：2020-02-05 00:00:00

abstract：:Emergence of human immunodeficiency virus type 1 (HIV-1) drug resistance arises from mutation fixation in the viral genome during antiretroviral therapy. Primary mutations directly confer antiviral drug resistance, while secondary mutations arise that do not confer drug resistance. The A62V amino acid substitution in ...

journal_title：Viruses

authors： Maldonado JO,Mansky LM

更新日期：2018-07-19 00:00:00

abstract：:Monkeypox is a smallpox-like illness that can be accompanied by a range of significant medical complications. To date there are no standard or optimized guidelines for the clinical management of monkeypox (MPX) patients, particularly in low-resource settings. Consequently, patients can experience protracted illness an...

journal_title：Viruses

authors： Reynolds MG,McCollum AM,Nguete B,Shongo Lushima R,Petersen BW

更新日期：2017-12-12 00:00:00

abstract：:Lifelong persistent infection by herpesviruses depends on the balance between host immune responses and viral immune evasion. CD4 T cells responding to antigens presented on major histocompatibility complex class II (MHC-II) molecules are known to play an important role in controlling herpesvirus infections. Here we r...

journal_title：Viruses

authors： Zuo J,Rowe M

更新日期：2012-08-01 00:00:00