Abstract:
:: Rabies virus (RABV) is the only lyssavirus known to be present within the Caribbean. The island of Trinidad, is richly diverse in chiropteran fauna and endemic for bat-transmitted rabies with low RABV isolation rates observed in this population. We aimed to determine the seroprevalence of rabies virus neutralizing antibodies (RVNA) in light of spatio-temporal and bat demographic factors to infer the extent of natural exposure to RABV in the Trinidadian bat population. RVNA titers were determined by the RABV micro-neutralization test on 383 bat samples representing 21 species, comprising 30.9% of local bat diversity, from 31 locations across the island over 5 years. RVNA was positively detected in 33 samples (8.6%) representing 6 bat species (mainly frugivorous) with titers ranging from 0.1 to 19 IU/mL (mean 1.66 IU/mL). The analyses based on a multivariable binomial generalised linear mixed-effects model showed that bat age and year of capture were significant predictors of seropositivity. Thus, juvenile bats were more likely to be seropositive when compared to adults (estimate 1.13; p = 0.04) which may suggest early exposure to the RABV with possible implications for viral amplification in this population. Temporal variation in rabies seropositivity, 2012-2014 versus 2015-2017 (estimate 1.07; p = 0.03) may have been related to the prevailing rabies epizootic situation. Regarding other factors investigated, RVNA was found in bats from both rural and non-rural areas, as well as in both hematophagous and non-hematophagous bat species. The most common seropositive species, Artibeusjamaicensisplanirostris is ubiquitous throughout the island which may potentially facilitate human exposure. The findings of this study should be factored into public health assessments on the potential for rabies transmission by non-hematophagous bats in Trinidad.
journal_name
Virusesjournal_title
Virusesauthors
Seetahal JFR,Greenberg L,Satheshkumar PS,Sanchez-Vazquez MJ,Legall G,Singh S,Ramkissoon V,Schountz T,Munster V,Oura CAL,Carrington CVFdoi
10.3390/v12020178subject
Has Abstractpub_date
2020-02-05 00:00:00issue
2issn
1999-4915pii
v12020178journal_volume
12pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract::The bacteriophage lambda replication initiation protein P exhibits a toxic effect on its Escherichia coli (E. coli) host, likely due to the formation of a dead-end P-DnaB complex, sequestering the replicative DnaB helicase from further activity. Intracellular expression of P triggers SOS-independent cellular filamenta...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8060172
更新日期:2016-06-22 00:00:00
abstract::In recent decades, chikungunya virus (CHIKV) has become geographically widespread. In 2004, the CHIKV East/Central/South African (ECSA) genotype moved from Africa to Indian ocean islands and India followed by a large epidemic in Southeast Asia. In 2013, the CHIKV Asian genotype drove an outbreak in the Americas. Since...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111319
更新日期:2020-11-17 00:00:00
abstract::The Middle East respiratory syndrome coronavirus (MERS-CoV) was first isolated in 2012, and circulated worldwide with high mortality. The continual outbreaks of MERS-CoV highlight the importance of developing antiviral therapeutics. Here, we rationally designed a novel fusion inhibitor named MERS-five-helix bundle (ME...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v9090255
更新日期:2017-09-14 00:00:00
abstract::Human T-cell leukemia virus type 1 (HTLV-1) is a complex retrovirus that infects CD4+ T cells and causes adult T-cell leukemia/lymphoma (ATLL) in 3%-5% of infected individuals after a long latent period. HTLV-1 Tax is a trans-activating protein that regulates viral gene expression and also modulates cellular signaling...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6103925
更新日期:2014-10-23 00:00:00
abstract::Abstract: Since 2007, highly pathogenic clade 2.3.2 H5N1 avian influenza A (A(H5N1)) viruses have evolved to clade 2.3.2.1a, b, and c; currently only 2.3.2.1c A(H5N1) viruses circulate in wild birds and poultry. During antigenic evolution, clade 2.3.2.1a and c A(H5N1) viruses acquired both S144N and V223I mutations ar...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11100923
更新日期:2019-10-09 00:00:00
abstract::Puumala virus (PUUV) is the agent of nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) in Europe. NE incidence presents a high spatial variation throughout France, while the geographical distribution of the wild reservoir of PUUV, the bank vole, is rather continuous. A missing pi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7102884
更新日期:2015-10-22 00:00:00
abstract::About 70% of all Ewing sarcoma (EWS) patients are diagnosed under the age of 20 years. Over the last decades little progress has been made towards finding effective treatment approaches for primarily metastasized or refractory Ewing sarcoma in young patients. Here, in the context of the search for novel therapeutic op...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10060302
更新日期:2018-06-03 00:00:00
abstract::The Gammacoronavirus infectious bronchitis virus (IBV) causes a highly contagious and economically important respiratory disease in poultry. In the laboratory, most IBV strains are restricted to replication in ex vivo organ cultures or in ovo and do not replicate in cell culture, making the study of their basic virolo...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12101102
更新日期:2020-09-29 00:00:00
abstract::Rabies is a viral infection that targets the nervous system, specifically neurons. The clinical manifestations of the disease are dramatic and their outcome fatal; paradoxically, conventional histopathological descriptions reveal only subtle changes in the affected nervous tissue. Some researchers have considered that...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10030112
更新日期:2018-03-06 00:00:00
abstract::Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are poorly understood autoimmune liver diseases. Immunosuppression is used to treat AIH and ursodeoxycholic acid is used to slow the progression of PBC. Nevertheless, a proportion of patients with both disorders progress to liver failure. Following liver t...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5020423
更新日期:2013-01-24 00:00:00
abstract::The Iridoviridae family are large viruses (∼120-200 nm) that contain a linear double-stranded DNA genome. The genomic size of Iridoviridae family members range from 105,903 bases encoding 97 open reading frames (ORFs) for frog virus 3 to 212,482 bases encoding 211 ORFs for Chilo iridescent virus. The family Iridovirid...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2071458
更新日期:2010-07-01 00:00:00
abstract::Over the last decade, arthropods have been shown to harbour a rich diversity of viruses. Through viral metagenomics a large diversity of single-stranded (ss) DNA viruses have been identified. Here we examine the ssDNA virome of the hematophagous New Zealand blackfly using viral metagenomics. Our investigation reveals ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11060532
更新日期:2019-06-08 00:00:00
abstract::Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of MAR...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10110658
更新日期:2018-11-21 00:00:00
abstract::We mapped the hemagglutinin-esterase (HE) antigenic epitopes of the influenza C virus on the three-dimensional (3D) structure of the HE glycoprotein using 246 escape mutants that were selected by a panel of nine anti-HE monoclonal antibodies (MAbs), including seven of the C/Ann Arbor/1/50 virus and two of the C/Yamaga...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10080417
更新日期:2018-08-09 00:00:00
abstract::Baboons are susceptible to natural Ebola virus (EBOV) infection and share 96% genetic homology with humans. Despite these characteristics, baboons have rarely been utilized as experimental models of human EBOV infection to evaluate the efficacy of prophylactics and therapeutics in the United States. This review will s...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4102400
更新日期:2012-10-23 00:00:00
abstract::The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection. The antigenic volume imposed by persistent and latent viruses exposes the immune ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9100289
更新日期:2017-10-05 00:00:00
abstract::Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbr...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12050533
更新日期:2020-05-12 00:00:00
abstract::Eukaryotic translation is a complex process composed of three main steps: initiation, elongation, and termination. During infections by RNA- and DNA-viruses, the eukaryotic translation machinery is used to assure optimal viral protein synthesis. Human immunodeficiency virus type I (HIV-1) uses several non-canonical pa...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v7010199
更新日期:2015-01-19 00:00:00
abstract::Since the human immunodeficiency virus (HIV) was discovered as the etiological agent of acquired immunodeficiency syndrome (AIDS), it has encouraged much research into antiviral compounds. The reverse transcriptase (RT) of HIV has been a main target for antiviral drugs. However, all drugs developed so far inhibit the ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v2040900
更新日期:2010-04-01 00:00:00
abstract::Rapid and sensitive detection of prions is important in managing prion diseases. The real-time quaking-induced conversion (RT-QuIC) assay for prion seeding activity has been applied to many prion diseases and provides for specific antemortem diagnostic testing. We evaluated RT-QuIC's long-term consistency and varied m...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8050140
更新日期:2016-05-23 00:00:00
abstract::The neutrophil extracellular trap (ET) is a eukaryotic host defense machinery that operates by capturing and concentrating pathogens in a filamentous network manufactured by neutrophils and made of DNA, histones, and many other components. Respiratory virus-induced ETs are involved in tissue damage and impairment of t...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12070723
更新日期:2020-07-04 00:00:00
abstract::It has been recently reported, using in vitro studies, that the herpes simplex virus 1 (HSV-1) encoded envelope glycoprotein B (gB1) interacts with cell surface toll-like receptor 2 (TLR2) and induces the secretion of interleukin-8 (IL8), a representative marker of inflammatory cytokine activation. The purpose of this...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090819
更新日期:2019-09-04 00:00:00
abstract::Endemic to West Africa and South America, mammalian arenaviruses can cross the species barrier from their natural rodent hosts to humans, resulting in illnesses ranging from mild flu-like syndromes to severe and fatal haemorrhagic zoonoses. The increased frequency of outbreaks and associated high fatality rates of the...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12070784
更新日期:2020-07-21 00:00:00
abstract::Circoviruses infect a variety of animal species and have small (~1.8-2.2 kb) circular single-stranded DNA genomes. Recently a penguin circovirus (PenCV) was identified associated with an Adélie Penguin (Pygoscelis adeliae) with feather disorder and in the cloacal swabs of three asymptomatic Adélie Penguins at Cape Cro...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12080858
更新日期:2020-08-06 00:00:00
abstract::The role of hepatitis C virus (HCV) infection in the induction of type II mixed cryoglobulinemia (MCII) and the possible establishment of related lymphoproliferative disorders, such as B-cell non-Hodgkin lymphoma (B-NHL), is well ascertained. However, the molecular pathways involved and the factors predisposing to th...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4112924
更新日期:2012-11-08 00:00:00
abstract::The emergence of phage-resistant mutants is a key aspect of lytic phages-bacteria interaction and the main driver for the co-evolution between both organisms. Here, we analyze the impact of PA5oct jumbo phage treatment on planktonic/cell line associated and sessile P. aeruginosa population. Besides its broad-spectrum ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11121089
更新日期:2019-11-23 00:00:00
abstract::Autophagy is an essential vacuolar process of the cell, leading to lysosomal degradation and recycling of proteins and organelles, which is extremely important in maintaining homeostasis. Multiple roles have been now associated with autophagy, in particular a pro-survival role in nutrient starvation or in stressful en...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9120372
更新日期:2017-12-04 00:00:00
abstract::Emergence of human immunodeficiency virus type 1 (HIV-1) drug resistance arises from mutation fixation in the viral genome during antiretroviral therapy. Primary mutations directly confer antiviral drug resistance, while secondary mutations arise that do not confer drug resistance. The A62V amino acid substitution in ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10070376
更新日期:2018-07-19 00:00:00
abstract::Varroa destructor is an ectoparasitic mite of Asian or Eastern honeybees Apis cerana(A. cerana) which has become a serious threat to European subspecies of Western honeybees Apis mellifera (A. mellifera) within the last century. V.destructor and its vectored honeybee viruses became serious threats for colony survival....
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11020094
更新日期:2019-01-24 00:00:00
abstract::Tospovirus is a tripartite negative stranded RNA virus and is considered as one of the most devastating plant viruses. Successful virus infection in plant requires many host factors. To date, very few host factors have been identified as important in Tospovirus infection in plants. We reported earlier that NSm protein...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10110647
更新日期:2018-11-17 00:00:00