Abstract:
:Since the human immunodeficiency virus (HIV) was discovered as the etiological agent of acquired immunodeficiency syndrome (AIDS), it has encouraged much research into antiviral compounds. The reverse transcriptase (RT) of HIV has been a main target for antiviral drugs. However, all drugs developed so far inhibit the polymerase function of the enzyme, while none of the approved antiviral agents inhibit specifically the necessary ribonuclease H (RNase H) function of RT. This review provides a background on structure-function relationships of HIV-1 RNase H, as well as an outline of current attempts to develop novel, potent chemotherapeutics against a difficult drug target.
journal_name
Virusesjournal_title
Virusesauthors
Beilhartz GL,Götte Mdoi
10.3390/v2040900subject
Has Abstractpub_date
2010-04-01 00:00:00pages
900-26issue
4issn
1999-4915pii
viruses-02-00900journal_volume
2pub_type
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