Construction and Immunogenicity of Novel Chimeric Virus-Like Particles Bearing Antigens of Infectious Bronchitis Virus and Newcastle Disease Virus.

abstract：:Post translational modification of proteins is a critical requirement that regulates function. Among the diverse kinds of protein post translational modifications, phosphorylation plays essential roles in protein folding, protein:protein interactions, signal transduction, intracellular localization, transcription regu...

journal_title：Viruses

authors： Keck F,Ataey P,Amaya M,Bailey C,Narayanan A

更新日期：2015-10-12 00:00:00

abstract：:Lymphoma is one of the most common malignancies in domestic cats. The lymphomagenic potential of Felis catus gammaherpesvirus 1 (FcaGHV1), a common infection in domestic cats, is unknown. In other species, including humans, cellular transformation by gammaherpesviruses is typically mediated by viral genes expressed du...

journal_title：Viruses

authors： Aghazadeh M,Shi M,Pesavento PA,Durham AC,Polley T,Donahoe SL,Troyer RM,Barrs VR,Holmes EC,Beatty JA

更新日期：2018-08-30 00:00:00

abstract：:Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells. We analysed the biological features of canine tetherin and found it to be an unstable hydrophilic type I transmembrane protein with one transmem...

journal_title：Viruses

authors： Zheng Y,Hao X,Zheng Q,Lin X,Zhang X,Zeng W,Ding S,Zhou P,Li S

更新日期：2018-10-16 00:00:00

abstract：:Endemic to West Africa and South America, mammalian arenaviruses can cross the species barrier from their natural rodent hosts to humans, resulting in illnesses ranging from mild flu-like syndromes to severe and fatal haemorrhagic zoonoses. The increased frequency of outbreaks and associated high fatality rates of the...

journal_title：Viruses

authors： Stott RJ,Strecker T,Foster TL

更新日期：2020-07-21 00:00:00

abstract：:Alfuy (ALFV) is an attenuated flavivirus related to the Murray Valley encephalitis virus (MVEV). We previously identified markers of attenuation in the envelope (E) protein of the prototype strain (ALFV3929), including the hinge region (E273-277) and lack of glycosylation at E154-156. To further determine the mechanis...

journal_title：Viruses

authors： Westlake D,Bielefeldt-Ohmann H,Prow NAA,Hall RAA

更新日期：2021-01-20 00:00:00

abstract：:Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress toward...

journal_title：Viruses

authors： Schindewolf C,Menachery VD

更新日期：2019-01-17 00:00:00

abstract：:Parrot bornaviruses (PaBVs) are the causative agents of proventricular dilatation disease (PDD), a chronic and often fatal neurologic disorder in Psittaciformes. The disease is widely distributed in private parrot collections and threatens breeding populations of endangered species. Thus, immunoprophylaxis strategies ...

journal_title：Viruses

authors： Rall I,Amann R,Malberg S,Herden C,Rubbenstroth D

更新日期：2019-12-06 00:00:00

abstract：:Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populatio...

journal_title：Viruses

authors： Mutsafi Y,Altan-Bonnet N

更新日期：2018-03-20 00:00:00

abstract：:The smaller tea tortrix, Adoxophyes honmai (Lepidoptera: Tortricidae), is an economically important pest of tea in Japan. Previous work showed that a fast-killing nucleopolyhedrovirus (NPV) isolated from A. orana (AdorNPV) and a slow-killing NPV isolated from A. honmai (AdhoNPV) are both infectious to A. honmai larvae...

journal_title：Viruses

authors： Takahashi M,Nakai M,Saito Y,Sato Y,Ishijima C,Kunimi Y

更新日期：2015-03-18 00:00:00

abstract：:Rotavirus (RV), a member of the Reoviridae family, causes infection in children and infants, with high morbidity and mortality. To be viable, the virus particle must package a set of eleven RNA segments. In order to understand the packaging mechanism, here, we co-synthesized sets of RNA segments in vitro in different ...

journal_title：Viruses

authors： Fajardo T,Sung PY,Celma CC,Roy P

更新日期：2017-06-29 00:00:00

abstract：:West Nile virus (WNV) is an important emerging neurotropic virus, responsible for increasingly severe encephalitis outbreaks in humans and horses worldwide. However, the mechanism by which the virus gains entry to the brain (neuroinvasion) remains poorly understood. Hypotheses of hematogenous and transneural entry hav...

journal_title：Viruses

authors： Suen WW,Prow NA,Hall RA,Bielefeldt-Ohmann H

更新日期：2014-07-18 00:00:00

abstract：:Infection with Hepatitis C Virus (HCV) causes chronic disease in approximately 80% of cases, resulting in chronic inflammation and cirrhosis. Current treatments are not completely effective, and a vaccine has yet to be developed. Spontaneous resolution of infection is associated with effective host adaptive immunity t...

journal_title：Viruses

authors： Tarr AW,Urbanowicz RA,Ball JK

更新日期：2012-01-01 00:00:00

abstract：:Cyclophilins are peptidyl-prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for c...

journal_title：Viruses

authors： Frausto SD,Lee E,Tang H

更新日期：2013-07-11 00:00:00

abstract：:Temperate bacteriophages possess a molecular switch, which regulates the lytic and lysogenic growth. The genomes of the temperate telomere phages N15, PY54 and ɸKO2 harbor a primary immunity region (immB) comprising genes for the prophage repressor, the lytic repressor and a putative antiterminator. The roles of these...

journal_title：Viruses

authors： Hammerl JA,Roschanski N,Lurz R,Johne R,Lanka E,Hertwig S

更新日期：2015-06-02 00:00:00

abstract：:HIV-1 causes a chronic infection in humans that is characterized by high plasma viremia, progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in opportunistic disease and AIDS. Viral persistence is mediated in part by the ability of the Nef protein to down-regulate HLA molecules on the infecte...

journal_title：Viruses

authors： Mwimanzi P,Markle TJ,Ueno T,Brockman MA

更新日期：2012-09-01 00:00:00

abstract：:Ebola virus (EBOV) is a highly lethal pathogen that has caused several outbreaks of severe hemorrhagic fever in humans since its emergence in 1976. The EBOV glycoprotein (GP1,2) is the sole viral envelope protein and a major component of immunogenicity; it is encoded by the GP gene along with two truncated versions: s...

journal_title：Viruses

authors： Zhu W,Banadyga L,Emeterio K,Wong G,Qiu X

更新日期：2019-10-31 00:00:00

abstract：:We are currently facing a pandemic of COVID-19, caused by a spillover from an animal-originating coronavirus to humans occurring in the Wuhan region of China in December 2019. From China, the virus has spread to 188 countries and regions worldwide, reaching the Sahel region on March 2, 2020. Since whole genome sequenc...

journal_title：Viruses

authors： Kouriba B,Dürr A,Rehn A,Sangaré AK,Traoré BY,Bestehorn-Willmann MS,Ouedraogo J,Heitzer A,Sogodogo E,Maiga A,Walter MC,Zimmermann F,Wölfel R,Antwerpen MH

更新日期：2020-11-02 00:00:00

abstract：:Delivering rapid protection against infectious agents to non-immune populations is a formidable public health challenge. Although passive immunotherapy is a fast and effective method of protection, large-scale production and administration of monoclonal antibodies (mAbs) is expensive and unpractical. Viral vector-medi...

journal_title：Viruses

authors： Michelini Z,Minkoff JM,Yang J,Negri D,Cara A,Hanson BJ,Salvatore M

更新日期：2020-12-17 00:00:00

abstract：:Bats are an important source of viral zoonoses, including paramyxoviruses. The paramyxoviral Pararubulavirus genus contains viruses mostly derived from bats that are common, diverse, distributed throughout the Old World, and known to be zoonotic. Here, we describe a new member of the genus Achimota pararubulavirus 3 (...

journal_title：Viruses

authors： Baker KS,Tachedjian M,Barr J,Marsh GA,Todd S,Crameri G,Crameri S,Smith I,Holmes CEG,Suu-Ire R,Fernandez-Loras A,Cunningham AA,Wood JLN,Wang LF

更新日期：2020-10-30 00:00:00

abstract：:About 70% of all Ewing sarcoma (EWS) patients are diagnosed under the age of 20 years. Over the last decades little progress has been made towards finding effective treatment approaches for primarily metastasized or refractory Ewing sarcoma in young patients. Here, in the context of the search for novel therapeutic op...

journal_title：Viruses

authors： Lacroix J,Kis Z,Josupeit R,Schlund F,Stroh-Dege A,Frank-Stöhr M,Leuchs B,Schlehofer JR,Rommelaere J,Dinsart C

更新日期：2018-06-03 00:00:00

abstract：:It is difficult to observe the molecular choreography between viruses and host cell components, as they exist on a spatial scale beyond the reach of conventional microscopy. However, novel super-resolution microscopy techniques have cast aside technical limitations to reveal a nanoscale view of virus replication and c...

journal_title：Viruses

authors： Grove J

更新日期：2014-03-19 00:00:00

abstract：:One hundred Prunus trees, including almond (P. dulcis), apricot (P. armeniaca), nectarine (P. persica var. nucipersica), peach (P. persica), plum (P. domestica), purple leaf plum (P. cerasifera) and sweet cherry (P. avium), were selected from growing regions Australia-wide and tested for the presence of 34 viruses and...

journal_title：Viruses

authors： Kinoti WM,Nancarrow N,Dann A,Rodoni BC,Constable FE

更新日期：2020-02-23 00:00:00

abstract：:Herpesviruses use a vesicle-mediated transfer of intranuclearly assembled nucleocapsids through the nuclear envelope (NE) for final maturation in the cytoplasm. The molecular basis for this novel vesicular nucleo-cytoplasmic transport is beginning to be elucidated in detail. The heterodimeric viral nuclear egress comp...

journal_title：Viruses

authors： Mettenleiter TC

更新日期：2016-09-27 00:00:00

abstract：:The phenotype of HTLV-1-transformed CD4(+) T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory receptors and ligands of the tumor necrosis factor superfamily, cytokine r...

journal_title：Viruses

authors： Kress AK,Grassmann R,Fleckenstein B

更新日期：2011-08-01 00:00:00

abstract：:Astroviral infection is considered to be one of the causes of mammalian diarrheal diseases. It has been shown that astrovirus infections cause varying degrees of diarrhea in turkeys and mice. However, the pathogenesis of porcine astrovirus is unknown. In this study, the virulence of a cytopathic porcine astrovirus (PA...

journal_title：Viruses

authors： Fang Q,Wang C,Liu H,Wu Q,Liang S,Cen M,Dong Q,Wei Y,Chen Y,Ouyang K,Wei Z,Huang W

更新日期：2019-12-13 00:00:00

abstract：:Influenza A virus (IAV) has caused seasonal influenza epidemics and influenza pandemics, which resulted in serious threat to public health and socioeconomic impacts. Until now, only 5 drugs belong to two categories are used for prophylaxis and treatment of IAV infection. Hemagglutinin (HA), the envelope glycoprotein o...

journal_title：Viruses

authors： Yang J,Li M,Shen X,Liu S

更新日期：2013-01-22 00:00:00

abstract：:Shigella ssp. and enterotoxigenic Escherichiacoli are the most common etiological agents of diarrheal diseases in malnourished children under five years of age in developing countries. The ever-growing issue of antibiotic resistance and the potential negative impact of antibiotic use on infant commensal microbiota are...

journal_title：Viruses

authors： Kaczorowska J,Casey E,Neve H,Franz CMAP,Noben JP,Lugli GA,Ventura M,Sinderen DV,Mahony J

更新日期：2019-09-26 00:00:00

abstract：:Marek's disease virus (MDV) is a member of alphaherpesviruses associated with Marek's disease, a highly contagious neoplastic disease in chickens. Complete sequencing of the viral genome and recombineering techniques using infectious bacterial artificial chromosome (BAC) clones of Marek's disease virus genome have ide...

journal_title：Viruses

authors： Zhang Y,Tang N,Sadigh Y,Baigent S,Shen Z,Nair V,Yao Y

更新日期：2018-05-24 00:00:00

abstract：:Since deer were introduced into Australia in the mid-1800s, their wild populations have increased in size and distribution, posing a potential risk to the livestock industry, through their role in pathogen transmission cycles. In comparison to livestock, there are limited data on viral infections in all wildlife, incl...

journal_title：Viruses

authors： Huaman JL,Pacioni C,Forsyth DM,Pople A,Hampton JO,Carvalho TG,Helbig KJ

更新日期：2020-07-13 00:00:00

abstract：:Although there have been many epidemiological reports of the inter-country transmission of measles, systematic analysis of the global transmission dynamics of the measles virus (MV) is limited. In this study, we applied phylogeographic analysis to characterize the global transmission dynamics of the MV using large-sca...

journal_title：Viruses

authors： Furuse Y,Oshitani H

更新日期：2017-04-16 00:00:00