Attenuated Influenza Virions Expressing the SARS-CoV-2 Receptor-Binding Domain Induce Neutralizing Antibodies in Mice.

abstract：:Viral codon usage bias may be the product of a number of synergistic or antagonistic factors, including genomic nucleotide composition, translational selection, genomic architecture, and mutational or repair biases. Most studies of viral codon bias evaluate only the relative importance of genomic base composition and ...

journal_title：Viruses

authors： Cardinale DJ,DeRosa K,Duffy S

更新日期：2013-01-15 00:00:00

abstract：:Diagnostic electron microscopy for infectious diseases has the advantage that "everything" in the specimen can be observed, without a priori knowledge of the likely identity of the microorganisms present in the sample. The classical specimen preparation method used employs a droplet of sample, which allows particles t...

journal_title：Viruses

authors： Beniac DR,Siemens CG,Wright CJ,Booth TF

更新日期：2014-09-19 00:00:00

abstract：:Persistent infection by human papillomaviruses (HPVs), small, double-stranded DNA viruses that infect keratinocytes of the squamous epithelia, can lead to the development of cervical and other cancers. The viral oncoprotein E7 contributes to viral persistence in part by regulating host gene expression through binding ...

journal_title：Viruses

authors： Rice S,Kim SM,Rodriguez C,Songock W,Raikhy G,Lopez R,Henderson L,Yusufji A,Bodily J

更新日期：2020-03-13 00:00:00

abstract：:Several viral infections of swine are responsible for major economic losses and represent a threat to the swine industry worldwide. New tools are needed to prevent and control endemic, emerging, and re-emerging viral diseases. Dendritic cells (DC) play a central role in linking the innate and adaptive arms of the immu...

journal_title：Viruses

authors： Franzoni G,Graham SP,Dei Giudici S,Oggiano A

更新日期：2019-05-16 00:00:00

abstract：:The use of the rabies vaccine for post-exposure prophylaxis started as early as 1885, revealing a safe and efficient tool to prevent human rabies cases. Preventive vaccination is the basis for the control of canine-mediated rabies, which has already been eliminated from extensive parts of the world, including Europe. ...

journal_title：Viruses

authors： Echevarría JE,Banyard AC,McElhinney LM,Fooks AR

更新日期：2019-09-24 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the etiological agent for a serious lower respiratory tract disease responsible for close to 200,000 annual deaths worldwide. The first infection is generally most severe, while re-infections usually associate with a milder disease. This observation and the finding that re-infecti...

journal_title：Viruses

authors： Rudraraju R,Jones BG,Sealy R,Surman SL,Hurwitz JL

更新日期：2013-02-05 00:00:00

abstract：:Bacterial infections pose a challenge to human health and burden the health care system, especially with the spread of antibiotic-resistant populations. To provide effective treatment and improved prognosis, effective diagnostic methods are of great importance. Here we present phage-mediated molecular detection (PMMD)...

journal_title：Viruses

authors： Malagon F,Estrella LA,Stockelman MG,Hamilton T,Teneza-Mora N,Biswas B

更新日期：2020-04-11 00:00:00

abstract：:A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved ...

journal_title：Viruses

authors： Feldmann J,Schwartz O

更新日期：2010-08-01 00:00:00

abstract：:Monkeypox is a smallpox-like illness that can be accompanied by a range of significant medical complications. To date there are no standard or optimized guidelines for the clinical management of monkeypox (MPX) patients, particularly in low-resource settings. Consequently, patients can experience protracted illness an...

journal_title：Viruses

authors： Reynolds MG,McCollum AM,Nguete B,Shongo Lushima R,Petersen BW

更新日期：2017-12-12 00:00:00

abstract：:Current measles vaccines suffer from poor effectiveness in young infants due primarily to the inhibitory effect of residual maternal immunity on vaccine responses. The development of a measles vaccine that resists such passive immunity would strongly contribute to the stalled effort toward measles eradication. In this...

journal_title：Viruses

authors： Julik E,Reyes-Del Valle J

更新日期：2017-09-21 00:00:00

abstract：:Currently, Brazil lives a triple arboviruses epidemic (DENV, ZIKV and CHIKV) making the differential diagnosis difficult for health professionals. Here, we aimed to investigate chikungunya cases and the possible occurrence of co-infections during the epidemic in Amapá (AP) that started in 2014 when the first autochtho...

journal_title：Viruses

authors： de Souza TMA,Ribeiro ED,Corrêa VCE,Damasco PV,Santos CC,de Bruycker-Nogueira F,Chouin-Carneiro T,Faria NRDC,Nunes PCG,Heringer M,Lima MDRQ,Badolato-Corrêa J,Cipitelli MDC,Azeredo EL,Nogueira RMR,Dos Santos FB

更新日期：2018-11-12 00:00:00

abstract：:Dendritic cells (DCs) are involved in human and simian immunodeficiency virus (HIV and SIV) pathogenesis but also play a critical role in orchestrating innate and adaptive vaccine-specific immune responses. Effective HIV/SIV vaccines require strong antigen-specific CD4 T cell responses, cytotoxic activity of CD8 T cel...

journal_title：Viruses

authors： Ko EJ,Robert-Guroff M

更新日期：2019-12-24 00:00:00

abstract：:Tetherin (BST2/CD317/HM1.24) has emerged as a key host-cell ·defence molecule that acts by inhibiting the release and spread of diverse enveloped virions from infected cells. We analysed the biological features of canine tetherin and found it to be an unstable hydrophilic type I transmembrane protein with one transmem...

journal_title：Viruses

authors： Zheng Y,Hao X,Zheng Q,Lin X,Zhang X,Zeng W,Ding S,Zhou P,Li S

更新日期：2018-10-16 00:00:00

abstract：:Although polyethylene glycol (PEG) application is the most widely used method in removing nonstructural proteins (NSPs) for foot-and-mouth disease (FMD) vaccine production, some NSPs remaining in the antigen could elicit antibodies against these proteins after repeated vaccinations in livestock. Therefore, the purpose...

journal_title：Viruses

authors： Park SY,Lee JM,Kim AY,Park SH,Kim JS,Kim H,Park JW,Park JH,Ko YJ,Park CK

更新日期：2020-12-07 00:00:00

abstract：:HIV continues to spread among vulnerable heterosexual (HET), Men-having-Sex with Men (MSM) and intravenous drug user (IDU) populations, influenced by a complex array of biological, behavioral and societal factors. Phylogenetics analyses of large sequence datasets from national drug resistance testing programs reveal t...

journal_title：Viruses

authors： Brenner BG,Ibanescu RI,Hardy I,Roger M

更新日期：2017-12-28 00:00:00

abstract：:In July 2018, a novel avian influenza virus (A/Mandarin duck/South Korea/KNU18-12/2018(H11N9)) was isolated from Mandarin ducks in South Korea. Phylogenetic and molecular analyses were conducted to characterize the genetic origins of the H11N9 strain. Phylogenetic analysis indicated that eight gene segments of strain ...

journal_title：Viruses

authors： Tuong HT,Nguyen NM,Sung HW,Park H,Yeo SJ

更新日期：2020-02-12 00:00:00

abstract：:With the inclusion of new members, understanding about evolutionary mechanisms and processes by which members of the proposed order, Megavirales, have evolved has become a key area of interest. The central role of gene acquisition has been shown in previous studies. However, the major drawback in gene acquisition stud...

journal_title：Viruses

authors： Jain S,Panda A,Colson P,Raoult D,Pontarotti P

更新日期：2017-04-07 00:00:00

abstract：:Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic ...

journal_title：Viruses

authors： Majumder K,Etingov I,Pintel DJ

更新日期：2017-10-31 00:00:00

abstract：:HIV-1 causes a chronic infection in humans that is characterized by high plasma viremia, progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in opportunistic disease and AIDS. Viral persistence is mediated in part by the ability of the Nef protein to down-regulate HLA molecules on the infecte...

journal_title：Viruses

authors： Mwimanzi P,Markle TJ,Ueno T,Brockman MA

更新日期：2012-09-01 00:00:00

abstract：:Crimean-Congo hemorrhagic fever virus is one the most important and wide spread tick-borne viruses. Very little is known about the transmission from the tick and the early aspects of pathogenesis. Here, we generate human cutaneous antigen presenting cells-dermal dendritic cells and Langerhans cells-from umbilical cord...

journal_title：Viruses

authors： Rodriguez SE,McAuley AJ,Gargili A,Bente DA

更新日期：2018-07-20 00:00:00

abstract：:Under physiological conditions, the function of astrocytes in providing brain metabolic support is compromised under pathophysiological conditions caused by human immunodeficiency virus (HIV) and opioids. Herein, we examined the role of autophagy, a lysosomal degradation pathway important for cellular homeostasis and ...

journal_title：Viruses

authors： Rodriguez M,Lapierre J,Ojha CR,Estrada-Bueno H,Dever SM,Gewirtz DA,Kashanchi F,El-Hage N

更新日期：2017-07-28 00:00:00

abstract：:Emerging viruses have caused concerns about pollinator population declines, as multi-host RNA viruses may pose a health threat to pollinators and associated arthropods. In order to understand the ecology and impact these viruses have, we studied their host range and determined to what extent host and spatial variation...

journal_title：Viruses

authors： Dobelmann J,Felden A,Lester PJ

更新日期：2020-03-24 00:00:00

abstract：:Until vaccines and effective therapeutics become available, the practical solution to transit safely out of the current coronavirus disease 19 (CoVID-19) lockdown may include the implementation of an effective testing, tracing and tracking system. However, this requires a reliable and clinically validated diagnostic p...

journal_title：Viruses

authors： Rohaim MA,Clayton E,Sahin I,Vilela J,Khalifa ME,Al-Natour MQ,Bayoumi M,Poirier AC,Branavan M,Tharmakulasingam M,Chaudhry NS,Sodi R,Brown A,Burkhart P,Hacking W,Botham J,Boyce J,Wilkinson H,Williams C,Whittingham-Dow

更新日期：2020-09-01 00:00:00

abstract：:Porcine epidemic diarrhea (PED) has re-emerged in recent years and has already caused huge economic losses to the porcine industry all over the world. Therefore, it is urgent for us to find out efficient ways to prevent and control this disease. In this study, the antiviral activity of a cationic amphibian antimicrobi...

journal_title：Viruses

authors： Guo N,Zhang B,Hu H,Ye S,Chen F,Li Z,Chen P,Wang C,He Q

更新日期：2018-09-18 00:00:00

abstract：:Knowledge of the antibody-mediated immune response to SARS-CoV-2 is crucial to understand virus immunogenicity, establish seroprevalence, and determine whether subjects or recovered patients are at risk for infection/reinfection and would therefore benefit from vaccination. Here, we describe a novel and simple cell-EL...

journal_title：Viruses

authors： Zarletti G,Tiberi M,De Molfetta V,Bossù M,Toppi E,Bossù P,Scapigliati G

更新日期：2020-11-08 00:00:00

abstract：:The APOBEC3 family of proteins in mammals consists of cellular cytosine deaminases and well-known restriction factors against retroviruses, including lentiviruses. APOBEC3 genes are highly amplified and diversified in mammals, suggesting that their evolution and diversification have been driven by conflicts with ancie...

journal_title：Viruses

authors： Uriu K,Kosugi Y,Ito J,Sato K

更新日期：2021-01-17 00:00:00

abstract：:Zika virus (ZIKV) infection during pregnancy leads to severe congenital Zika syndrome, which includes microcephaly and other neurological malformations. No therapeutic agents have, so far, been approved for the treatment of ZIKV infection in humans; as such, there is a need for a continuous effort to develop effective...

journal_title：Viruses

authors： Gao Y,Tai W,Wang N,Li X,Jiang S,Debnath AK,Du L,Chen S

更新日期：2019-11-02 00:00:00

abstract：:Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection. However, to-date no direct anti-HDV drugs are available in clinical practice. Here, we identified conserved and variable regions in...

journal_title：Viruses

authors： Colagrossi L,Salpini R,Scutari R,Carioti L,Battisti A,Piermatteo L,Bertoli A,Fabeni L,Minichini C,Trimoulet P,Fleury H,Nebuloso E,De Cristofaro M,Cappiello G,Spanò A,Malagnino V,Mari T,Barlattani A,Iapadre N,Lichtne

更新日期：2018-07-09 00:00:00

abstract：:Streptococcus thermophilus is considered one of the most important species for the dairy industry. Due to their diffusion in dairy environments, bacteriophages can represent a threat to this widely used bacterial species. Despite the presence of a CRISPR-Cas system in the S. thermophilus genome, some lysogenic strains...

journal_title：Viruses

authors： da Silva Duarte V,Giaretta S,Campanaro S,Treu L,Armani A,Tarrah A,Oliveira de Paula S,Giacomini A,Corich V

更新日期：2018-12-22 00:00:00

abstract：:Enteroviruses are small RNA viruses that affect millions of people each year by causing an important burden of disease with a broad spectrum of symptoms. In routine diagnostic laboratories, enteroviruses are identified by PCR-based methods, often combined with partial sequencing for genotyping. In this proof-of-princi...

journal_title：Viruses

authors： Grädel C,Terrazos Miani MA,Baumann C,Barbani MT,Neuenschwander S,Leib SL,Suter-Riniker F,Ramette A

更新日期：2020-07-31 00:00:00