Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease.

abstract：:Rabies is a highly fatal zoonotic disease which is primarily caused by rabies virus (RABV) although other members of the genus Lyssavirus can cause rabies as well. As yet, 14 serologically and genetically diverse lyssaviruses have been identified, mostly in bats. To assess the quality of rabies vaccines and immunoglob...

journal_title：Viruses

authors： Moeschler S,Locher S,Conzelmann KK,Krämer B,Zimmer G

更新日期：2016-09-16 00:00:00

abstract：:Interferon-inducible transmembrane proteins (IFITM1/2/3) have been reported to suppress the entry of a wide range of viruses. However, their antiviral functional residues and specific mechanisms are still unclear. Here, we firstly resolved the topology of IFITM1 on the plasma membrane where N-terminus points into the ...

journal_title：Viruses

authors： Sun F,Xia Z,Han Y,Gao M,Wang L,Wu Y,Sabatier JM,Miao L,Cao Z

更新日期：2020-03-08 00:00:00

abstract：:The impact of topical applications of deltamethrin and ivermectin to cattle on Culicoides spp. landing and blood-feeding was studied in this work using sticky traps mounted on Friesian heifers' backs. There was no effect of the insecticides on total numbers of Culicoides trapped or the proportion engorged. Deltamethri...

journal_title：Viruses

authors： Murchie AK,Thompson GM,Clawson S,Brown A,Gordon AW,Jess S

更新日期：2019-08-08 00:00:00

abstract：:The non-structural protein NSs of the Phenuiviridae family members appears to have a role in the host immunity escape. The stability of Toscana virus (TOSV) NSs protein was tested by a cycloheximide (CHX) chase approach on cells transfected with NSs deleted versions fused to a reporter gene. The presence of intrinsica...

journal_title：Viruses

authors： Gori Savellini G,Bini L,Gagliardi A,Anichini G,Gandolfo C,Prathyumnan S,Cusi MG

更新日期：2020-10-12 00:00:00

abstract：:The neutrophil extracellular trap (ET) is a eukaryotic host defense machinery that operates by capturing and concentrating pathogens in a filamentous network manufactured by neutrophils and made of DNA, histones, and many other components. Respiratory virus-induced ETs are involved in tissue damage and impairment of t...

journal_title：Viruses

authors： Real-Hohn A,Zhu R,Ganjian H,Ibrahim N,Hinterdorfer P,Kowalski H,Blaas D

更新日期：2020-07-04 00:00:00

abstract：:Lymphoma is one of the most common malignancies in domestic cats. The lymphomagenic potential of Felis catus gammaherpesvirus 1 (FcaGHV1), a common infection in domestic cats, is unknown. In other species, including humans, cellular transformation by gammaherpesviruses is typically mediated by viral genes expressed du...

journal_title：Viruses

authors： Aghazadeh M,Shi M,Pesavento PA,Durham AC,Polley T,Donahoe SL,Troyer RM,Barrs VR,Holmes EC,Beatty JA

更新日期：2018-08-30 00:00:00

abstract：:Bovine rotavirus A (RVA), a major causative pathogen of diarrhea in dairy and Japanese beef calves, has led to severe economic losses in numerous countries. A dual genotyping system based on genomic segments encoding VP7 (G genotype) and VP4 (P genotype), comprising the outer layer of the virion, has been used to unde...

journal_title：Viruses

authors： Odagiri K,Yoshizawa N,Sakihara H,Umeda K,Rahman S,Nguyen SV,Suzuki T

更新日期：2020-12-03 00:00:00

abstract：:Foot-and-mouth disease virus (FMDV) causes a highly contagious disease with catastrophic economic impact for affected countries. BHK21 suspension cells are preferred for the industrial production of FMDV vaccine antigen, but not all virus strains can be successfully propagated in these cells. Serotype Asia-1 is often ...

journal_title：Viruses

authors： Dill V,Hoffmann B,Zimmer A,Beer M,Eschbaumer M

更新日期：2017-08-18 00:00:00

abstract：:At present, the clinical detection method of human papillomavirus (HPV) is mainly based on the PCR method. However, this method can only be used to detect HPV DNA and HPV types, and cannot be used to accurately predict cervical cancer. HPV16 E7 is an oncoprotein selectively expressed in cervical cancers. In this study...

journal_title：Viruses

authors： Hu R,Dong Z,Zhang K,Pan G,Li C,Cui H

更新日期：2020-03-19 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), employs host-cell angiotensin-converting enzyme 2 (ACE2) for cell entry. Genetic analyses of ACE2 have identified several single-nucleotide polymorphisms (SNPs) specific to different human populati...

journal_title：Viruses

authors： Hashizume M,Gonzalez G,Ono C,Takashima A,Iwasaki M

更新日期：2021-01-06 00:00:00

abstract：:HIV-1 is a global health crisis that has infected more than 37 million people. Latent reservoirs throughout the body are a major hurdle when it comes to eradicating the virus. In our previous study, we found that exosomes, a type of extracellular vesicle (EV), from uninfected cells activate the transcription of HIV-1 ...

journal_title：Viruses

authors： Barclay RA,Mensah GA,Cowen M,DeMarino C,Kim Y,Pinto DO,Erickson J,Kashanchi F

更新日期：2020-06-19 00:00:00

abstract：:Significantly higher numbers of human infections with H5N1 virus have occurred in Indonesia and Egypt, compared with other affected areas, and it is speculated that there are specific viral factors for human infection with avian H5N1 viruses in these locations. We previously showed PB2-K526R is present in 80% of Indon...

journal_title：Viruses

authors： Wang P,Song W,Mok BW,Zheng M,Lau SY,Liu S,Chen P,Huang X,Liu H,Cremin CJ,Chen H

更新日期：2019-03-22 00:00:00

abstract：:Sandfly-borne phleboviruses pathogenic to humans, such as Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV), are endemic in the Mediterranean region. In France, several autochthonous cases of TOSV infection have been described, causing either meningitis or encephalitis. The aim of the present study was to i...

journal_title：Viruses

authors： Masse S,Ayhan N,Capai L,Bosseur F,de Lamballerie X,Charrel R,Falchi A

更新日期：2019-09-04 00:00:00

abstract：:Mutations are incorporated into the genomes of RNA viruses at an optimal frequency and altering this precise frequency has been proposed as a strategy to create live-attenuated vaccines. However, determining the effect of specific mutations that alter fidelity has been difficult because of the rapid selection of the v...

journal_title：Viruses

authors： Patterson EI,Khanipov K,Swetnam DM,Walsdorf S,Kautz TF,Thangamani S,Fofanov Y,Forrester NL

更新日期：2020-05-15 00:00:00

abstract：:Human coronaviruses (HCoVs) cause mild to severe respiratory diseases. Six types of HCoVs have been discovered, the most recent one termed the Middle East respiratory syndrome coronavirus (MERS-CoV). The aim of this study is to monitor the circulation of HCoV types in the population during 2015⁻2016 in Israel. HCoVs w...

journal_title：Viruses

authors： Friedman N,Alter H,Hindiyeh M,Mendelson E,Shemer Avni Y,Mandelboim M

更新日期：2018-09-21 00:00:00

abstract：:CD4 and CD8 T lymphocytes are adaptive immune cells that play a key role in the immune response to pathogens. They have been extensively studied in a variety of model systems and the mechanisms by which they function are well described. However, the responses by these cell types vary widely from pathogen to pathogen. ...

journal_title：Viruses

authors： Netland J,Bevan MJ

更新日期：2013-10-22 00:00:00

abstract：:West Nile virus (WNV) is prevalent in Africa, Europe, the Middle East, West Asia, and North America, and causes epidemic encephalitis. To date, no effective therapy for WNV infection has been developed; therefore, there is urgent need to find an efficient method to prevent WNV disease. In this study, we prepared and e...

journal_title：Viruses

authors： Cui J,Zhao Y,Wang H,Qiu B,Cao Z,Li Q,Zhang Y,Yan F,Jin H,Wang T,Sun W,Feng N,Gao Y,Sun J,Wang Y,Perlman S,Zhao J,Yang S,Xia X

更新日期：2016-12-18 00:00:00

abstract：:The bacteriophage lambda replication initiation protein P exhibits a toxic effect on its Escherichia coli (E. coli) host, likely due to the formation of a dead-end P-DnaB complex, sequestering the replicative DnaB helicase from further activity. Intracellular expression of P triggers SOS-independent cellular filamenta...

journal_title：Viruses

authors： Hayes S,Wang W,Rajamanickam K,Chu A,Banerjee A,Hayes C

更新日期：2016-06-22 00:00:00

abstract：:Protoparvoviruses are simple single-stranded DNA viruses that infect many animal species. The protoparvovirus minute virus of mice (MVM) infects murine and transformed human cells provoking a sustained DNA damage response (DDR). This DDR is dependent on signaling by the ATM kinase and leads to a prolonged pre-mitotic ...

journal_title：Viruses

authors： Majumder K,Etingov I,Pintel DJ

更新日期：2017-10-31 00:00:00

abstract：:The world's first natural avian-origin H6N1 influenza A virus infection case in dogs was confirmed in Taiwan in 2014. The H6N1 virus in chickens has been endemic in Taiwan since 1972. Whether the dog H6N1 virus has interspecies transmission potential is the key issue we aim to understand. Following one virus passage i...

journal_title：Viruses

authors： Tsai SK,Shih CH,Chang HW,Teng KH,Hsu WE,Lin HJ,Lin HY,Huang CH,Chen HW,Wang LC

更新日期：2020-06-30 00:00:00

abstract：:The Iridoviridae family are large viruses (∼120-200 nm) that contain a linear double-stranded DNA genome. The genomic size of Iridoviridae family members range from 105,903 bases encoding 97 open reading frames (ORFs) for frog virus 3 to 212,482 bases encoding 211 ORFs for Chilo iridescent virus. The family Iridovirid...

journal_title：Viruses

authors： Eaton HE,Ring BA,Brunetti CR

更新日期：2010-07-01 00:00:00

abstract：:Over the last decade, arthropods have been shown to harbour a rich diversity of viruses. Through viral metagenomics a large diversity of single-stranded (ss) DNA viruses have been identified. Here we examine the ssDNA virome of the hematophagous New Zealand blackfly using viral metagenomics. Our investigation reveals ...

journal_title：Viruses

authors： Kraberger S,Schmidlin K,Fontenele RS,Walters M,Varsani A

更新日期：2019-06-08 00:00:00

abstract：:Over the past 15 years we have been investigating an alternative approach to treating HIV-1/AIDS, based on the creation of a disease-resistant immune system through transplantation of autologous, gene-modified (HIV-1-resistant) hematopoietic stem and progenitor cells (GM-HSPC). We propose that the expression of select...

journal_title：Viruses

authors： DiGiusto DL,Stan R,Krishnan A,Li H,Rossi JJ,Zaia JA

更新日期：2013-11-22 00:00:00

abstract：:Mechanistic models are critical for our understanding of both within-host dynamics (i.e., pathogen replication and immune system processes) and among-host dynamics (i.e., transmission). Within-host models, however, are not often fit to experimental data, which can serve as a robust method of hypothesis testing and hyp...

journal_title：Viruses

authors： Mihaljevic JR,Greer AL,Brunner JL

更新日期：2019-04-27 00:00:00

abstract：:Background: Bats are known to host a number of nonpathogenic viruses, as well as highly pathogenic viruses causing fatal diseases like rabies. Serological surveys as part of active and passive bat rabies surveillance mainly use seroneutralization assays, demonstrating the presence of lyssavirus-specific antibodies in ...

journal_title：Viruses

authors： Orłowska A,Smreczak M,Freuling CM,Müller T,Trębas P,Rola J

更新日期：2020-02-28 00:00:00

abstract：:RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in t...

journal_title：Viruses

authors： Wei R,Chen G,Algehainy N,Zeng C,Liu C,Liu H,Liu W,Stacey D,Zhou A

更新日期：2020-01-07 00:00:00

abstract：:Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-...

journal_title：Viruses

authors： Usadi B,Bruhn R,Lin J,Lee TH,Blackburn E,Murphy EL

更新日期：2016-08-11 00:00:00

abstract：:In this review, we describe the distribution and genetic diversity of sapoviruses detected among humans, animals and the environment in African countries. Databases were searched for studies conducted in African countries and published between Jan 2005 and Mar 2019. Only studies where RT- PCR was used for initial dete...

journal_title：Viruses

authors： Makhaola K,Moyo S,Kebaabetswe LP

更新日期：2020-04-27 00:00:00

abstract：:Bats are an important source of viral zoonoses, including paramyxoviruses. The paramyxoviral Pararubulavirus genus contains viruses mostly derived from bats that are common, diverse, distributed throughout the Old World, and known to be zoonotic. Here, we describe a new member of the genus Achimota pararubulavirus 3 (...

journal_title：Viruses

authors： Baker KS,Tachedjian M,Barr J,Marsh GA,Todd S,Crameri G,Crameri S,Smith I,Holmes CEG,Suu-Ire R,Fernandez-Loras A,Cunningham AA,Wood JLN,Wang LF

更新日期：2020-10-30 00:00:00

abstract：:Human immunodeficiency virus (HIV) is a causative agent of acquired immune deficiency syndrome (AIDS). Highly active antiretroviral therapy (HAART) can slow down the replication of HIV-1, leading to an improvement in the survival of HIV-1-infected patients. However, drug toxicities and poor drug administration has led...

journal_title：Viruses

authors： Chupradit K,Moonmuang S,Nangola S,Kitidee K,Yasamut U,Mougel M,Tayapiwatana C

更新日期：2017-09-29 00:00:00