Abstract:
:Many geometric forms are found in nature, some of them adhering to mathematical laws or amazing aesthetic rules. One of the best-known examples in microbiology is the icosahedral shape of certain viruses with 20 triangular facets and 12 edges. What is less known, however, is that a complementary object displaying 12 faces and 20 edges called a 'dodecahedron' can be produced in huge amounts during certain adenovirus replication cycles. The decahedron was first described more than 50 years ago in the human adenovirus (HAdV3) viral cycle. Later on, the expression of this recombinant scaffold, combined with improvements in cryo-electron microscopy, made it possible to decipher the structural determinants underlying their architecture. Recently, this particle, which mimics viral entry, was used to fish the long elusive adenovirus receptor, desmoglein-2, which serves as a cellular docking for some adenovirus serotypes. This breakthrough enabled the understanding of the physiological role played by the dodecahedral particles, showing that icosahedral and dodecahedral particles live more than a simple platonic story. All these points are developed in this review, and the potential use of the dodecahedron in therapeutic development is discussed.
journal_name
Virusesjournal_title
Virusesauthors
Besson S,Vragniau C,Vassal-Stermann E,Dagher MC,Fender Pdoi
10.3390/v12070718subject
Has Abstractpub_date
2020-07-02 00:00:00issue
7issn
1999-4915pii
v12070718journal_volume
12pub_type
杂志文章,评审相关文献
Viruses-Basel文献大全abstract::Two sister orders of the brown macroalgae (class Phaeophyceae), the morphologically complex Laminariales (commonly referred to as kelp) and the morphologically simple Ectocarpales are natural hosts for the dsDNA phaeoviruses (family Phycodnaviridae) that persist as proviruses in the genomes of their hosts. We have pre...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10080410
更新日期:2018-08-05 00:00:00
abstract::Porcine Reproductive and Respiratory Syndrome (PRRS) is a contagious viral (PRRSV) disease in pigs characterized by poor reproductive health, increased mortality, and reductions in growth rates. PRRSV is known to implement immuno-antagonistic mechanisms to evade detection and mute host responses to infection. To bette...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12111299
更新日期:2020-11-12 00:00:00
abstract::Timely implementation of antiviral treatment and other public health based responses are dependent on accurate and rapid diagnosis of the novel pandemic influenza A(H1N1) strain. In this study we developed a duplex real-time PCR (RT-PCR) (dFLU-TM) assay for the simultaneous detection of a broad range of influenza A su...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v1031204
更新日期:2009-12-01 00:00:00
abstract::Arboviruses continue to be a significant global health concern. The unbiased metagenomic analyses of mosquito-borne and mosquito-specific viruses are useful to understand viral diversity and for the surveillance of pathogens of medical and veterinary importance. Metagenomic analysis was conducted on 6368 mosquitoes (7...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11030222
更新日期:2019-03-05 00:00:00
abstract::Mycoviruses infect a large number of diverse fungal species, but considering their prevalence, relatively few high-quality genome sequences have been determined. Many mycoviruses have linear double-stranded RNA genomes, which makes it technically challenging to ascertain their nucleotide sequence using conventional se...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11010070
更新日期:2019-01-16 00:00:00
abstract::Emerging viruses have caused concerns about pollinator population declines, as multi-host RNA viruses may pose a health threat to pollinators and associated arthropods. In order to understand the ecology and impact these viruses have, we studied their host range and determined to what extent host and spatial variation...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12030358
更新日期:2020-03-24 00:00:00
abstract::Currently, Brazil lives a triple arboviruses epidemic (DENV, ZIKV and CHIKV) making the differential diagnosis difficult for health professionals. Here, we aimed to investigate chikungunya cases and the possible occurrence of co-infections during the epidemic in Amapá (AP) that started in 2014 when the first autochtho...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10110623
更新日期:2018-11-12 00:00:00
abstract::Aplastic anemia is a rare blood disease characterized by the destruction of the hematopoietic stem cells (HSC) in the bone marrow that, in the majority of cases, is caused by an autoimmune reaction. Patients with aplastic anemia are treated with immunosuppressive drugs and some of them, especially younger individuals ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040416
更新日期:2020-04-08 00:00:00
abstract::Tailoring public health responses to growing HIV transmission clusters depends on accurately mapping the risk network through which it spreads and identifying acute infections that represent the leading edge of cluster growth. HIV transmission links, especially those involving persons with acute HIV infection (AHI), c...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12020145
更新日期:2020-01-27 00:00:00
abstract::Evidence that Hepatitis D virus (HDV) genotype is involved in HDV infection pathogenesis is increasing. Indeed, HDV genotypes have been shown to be linked to different outcomes in terms of liver fibrosis and treatment response. Herein, we show that the promising HDVdb genotyping tool available online can lead to wrong...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12101066
更新日期:2020-09-23 00:00:00
abstract::Lentiviruses are infectious agents of a number of animal species, including sheep, goats, horses, monkeys, cows, and cats, in addition to humans. As in the human case, the host immune response fails to control the establishment of chronic persistent infection that finally leads to a specific disease development. Despi...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10080435
更新日期:2018-08-17 00:00:00
abstract::Porcine circovirus 3 (PCV3) has been identified as a putative swine pathogen with a subset of infections resulting in stillborn and mummified fetuses, encephalitis and myocarditis in perinatal, and periarteritis in growing pigs. Three PCV3 isolates were isolated from weak-born piglets or elevated stillborn and mummifi...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12020219
更新日期:2020-02-16 00:00:00
abstract::Retroviruses are well known pathogens of mammals, birds and fish. Their potential to induce cancer in chickens was already described almost 100 years ago and murine retroviruses have been a subject of study for 50 years. The first human retroviruses, HTLV and HIV, were discovered more than 30 years ago, surprising res...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v3081312
更新日期:2011-08-01 00:00:00
abstract::The Gammacoronavirus infectious bronchitis virus (IBV) causes a highly contagious and economically important respiratory disease in poultry. In the laboratory, most IBV strains are restricted to replication in ex vivo organ cultures or in ovo and do not replicate in cell culture, making the study of their basic virolo...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12101102
更新日期:2020-09-29 00:00:00
abstract::Our loyal friend and colleague, Jan van der Noordaa, passed away unexpectedly at the age of 80 on the evening of 17 June 2015. [...]. ...
journal_title:Viruses
pub_type: 传,历史文章,杂志文章
doi:10.3390/v7092859
更新日期:2015-09-15 00:00:00
abstract::Potato virus Y (PVY) is the most economically important virus infecting cultivated potato (Solanum tuberosum L.). Accurate diagnosis is crucial to regulate the trade of tubers and for the sanitary selection of plant material for propagation. However, high genetic diversity of PVY represents a challenge for the detecti...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040478
更新日期:2020-04-23 00:00:00
abstract::In rabies diagnosis, it is essential to count on a rapid test to give a quick response. The combined sensitivity and robustness of the TaqMan RT-PCR assays (qRT-PCR) have made these methods a valuable alternative for rabies virus (RABV) detection. We conducted a study to compare the applicability of two widely used qR...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010023
更新日期:2020-12-25 00:00:00
abstract:BACKGROUND:Retroviruses rely on host factors for cell entry, replication, transcription, and other major steps during their life cycle. Human Immunodeficiency Virus-1 (HIV-1) is well known for utilizing a plethora of strategies to evade the host immune response, including the establishment of latent infection within a ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7020543
更新日期:2015-02-05 00:00:00
abstract::Respiratory viral infections are strongly associated with asthma exacerbations. Rhinovirus is most frequently-detected pathogen; followed by respiratory syncytial virus; metapneumovirus; parainfluenza virus; enterovirus and coronavirus. In addition; viral infection; in combination with genetics; allergen exposure; mic...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10120682
更新日期:2018-12-01 00:00:00
abstract::Staphylococcus aureus is a common and often virulent pathogen in humans. This bacterium is widespread, being present on the skin and in the nose of healthy people. Staphylococcus aureus can cause infections with severe outcomes ranging from pustules to sepsis and death. The introduction of antibiotics led to a general...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v6072551
更新日期:2014-07-01 00:00:00
abstract::Autophagy and apoptosis are two important evolutionarily conserved host defense mechanisms against viral invasion and pathogenesis. However, the association between the two pathways during the viral infection of T lymphocytes remains to be elucidated. Simian type D retrovirus (SRV) is an etiological agent of fatal sim...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040381
更新日期:2020-03-31 00:00:00
abstract::Rapid and sensitive detection of prions is important in managing prion diseases. The real-time quaking-induced conversion (RT-QuIC) assay for prion seeding activity has been applied to many prion diseases and provides for specific antemortem diagnostic testing. We evaluated RT-QuIC's long-term consistency and varied m...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8050140
更新日期:2016-05-23 00:00:00
abstract::Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1-4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and M...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v13010057
更新日期:2021-01-04 00:00:00
abstract::Usutu virus (USUV) is a neurotropic flavivirus closely related to West Nile virus (WNV). Its enzootic cycle mainly involves mosquitoes and birds. Human infection can occur with occasional, but sometimes severe, neurological complications. Since its emergence and spread in Europe over the last two decades, USUV has bee...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12020164
更新日期:2020-01-31 00:00:00
abstract::The emergence of phage-resistant mutants is a key aspect of lytic phages-bacteria interaction and the main driver for the co-evolution between both organisms. Here, we analyze the impact of PA5oct jumbo phage treatment on planktonic/cell line associated and sessile P. aeruginosa population. Besides its broad-spectrum ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11121089
更新日期:2019-11-23 00:00:00
abstract::The neutrophil extracellular trap (ET) is a eukaryotic host defense machinery that operates by capturing and concentrating pathogens in a filamentous network manufactured by neutrophils and made of DNA, histones, and many other components. Respiratory virus-induced ETs are involved in tissue damage and impairment of t...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12070723
更新日期:2020-07-04 00:00:00
abstract::Depletion and functional impairment of circulating plasmacytoid dendritic cells (pDCs) are characteristic attributes of HIV-1-infection. The mechanism of dysfunction of pDCs is unclear. Here, we studied the development of phenotype of pDCs in a cohort of HIV-1-infected individuals monitored before the initiation and d...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10040154
更新日期:2018-03-28 00:00:00
abstract::Viruses were recognized as the causative agents of fish diseases, such as infectious pancreatic necrosis and Oregon sockeye disease, in the early 1960s [1], and have since been shown to be responsible for diseases in all marine life from bacteria to protists, mollusks, crustaceans, fish and mammals [2].[...]. ...
journal_title:Viruses
pub_type: 社论
doi:10.3390/v9100302
更新日期:2017-10-18 00:00:00
abstract::Cervical cancer is the fourth most frequently occurring cancer in women around the world and can affect them during their reproductive years. Since the development of the Papanicolaou (Pap) test, screening has been essential in identifying cervical cancer at a treatable stage. With the identification of the human papi...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10120729
更新日期:2018-12-19 00:00:00
abstract::Porcine endogenous retroviruses (PERVs) are integrated in the genome of pigs and are transmitted like cellular genes from parents to the offspring. Whereas PERV-A and PERV-B are present in all pigs, PERV-C was found to be in many, but not all pigs. When PERV-C is present, recombination with PERV-A may happen and the P...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040419
更新日期:2020-04-08 00:00:00