Glutamic Acid Residues in HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag.

abstract：:An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a membrane-anchored form of the SARS-CoV-2 spike receptor binding domain (RBD) in place of the neuraminidase (NA) coding sequence in an influenza viru...

journal_title：Viruses

authors： Loes AN,Gentles LE,Greaney AJ,Crawford KHD,Bloom JD

更新日期：2020-09-05 00:00:00

abstract：:Post translational modification of proteins is a critical requirement that regulates function. Among the diverse kinds of protein post translational modifications, phosphorylation plays essential roles in protein folding, protein:protein interactions, signal transduction, intracellular localization, transcription regu...

journal_title：Viruses

authors： Keck F,Ataey P,Amaya M,Bailey C,Narayanan A

更新日期：2015-10-12 00:00:00

abstract：:The M112-113 gene is the first early gene of the murine cytomegalovirus (MCMV), and its expression is activated by the immediate-early 3 (IE3) protein during MCMV infection in permissive cells. At its 5' terminus, a 10-bp motif, upstream of the TATA box of the M112-113 gene, was identified to bind to IE3, and it is ne...

journal_title：Viruses

authors： Cruz-Cosme R,Armstrong N,Tang Q

更新日期：2020-08-28 00:00:00

abstract：:Crimean-Congo hemorrhagic fever virus is one the most important and wide spread tick-borne viruses. Very little is known about the transmission from the tick and the early aspects of pathogenesis. Here, we generate human cutaneous antigen presenting cells-dermal dendritic cells and Langerhans cells-from umbilical cord...

journal_title：Viruses

authors： Rodriguez SE,McAuley AJ,Gargili A,Bente DA

更新日期：2018-07-20 00:00:00

abstract：:Currently, only three phages that infect the medically important bacterium Clostridium difficile have been discussed by the International Committee of Viral Taxonomy (ICTV). They are all myoviruses, and have been assigned to the genus "phicd119likevirus". An additional nine phages have since been described in the lite...

journal_title：Viruses

authors： Hargreaves KR,Clokie MR

更新日期：2015-05-21 00:00:00

abstract：:African swine fever (ASF) has become the major threat for the global swine industry. Furthermore, the epidemiological situation of African swine fever virus (ASFV) in some endemic regions of Sub-Saharan Africa is worse than ever, with multiple virus strains and genotypes currently circulating in a given area. Despite ...

journal_title：Viruses

authors： Lopez E,van Heerden J,Bosch-Camós L,Accensi F,Navas MJ,López-Monteagudo P,Argilaguet J,Gallardo C,Pina-Pedrero S,Salas ML,Salt J,Rodriguez F

更新日期：2020-12-21 00:00:00

abstract：:During the early stages of human papillomavirus (HPV) infections, the innate immune system creates a pro-inflammatory microenvironment by recruiting innate immune cells to eliminate the infected cells, initiating an effective acquired immune response. However, HPV exhibits a wide range of strategies for evading immune...

journal_title：Viruses

authors： Amador-Molina A,Hernández-Valencia JF,Lamoyi E,Contreras-Paredes A,Lizano M

更新日期：2013-10-28 00:00:00

abstract：:Historically, mice and guinea pigs have been the rodent models of choice for therapeutic and prophylactic countermeasure testing against Ebola virus disease (EVD). Recently, hamsters have emerged as a novel animal model for the in vivo study of EVD. In this review, we discuss the history of the hamster as a research l...

journal_title：Viruses

authors： Wahl-Jensen V,Bollinger L,Safronetz D,de Kok-Mercado F,Scott DP,Ebihara H

更新日期：2012-12-14 00:00:00

abstract：:Influenza A virus (IAV) in swine, so-called swine influenza A virus (swIAV), causes respiratory illness in pigs around the globe. In Danish pig herds, a H1N2 subtype named H1N2dk is one of the main circulating swIAV. In this cohort study, the infection dynamic of swIAV was evaluated in a Danish pig herd by sampling an...

journal_title：Viruses

authors： Bhatta TR,Ryt-Hansen P,Nielsen JP,Larsen LE,Larsen I,Chamings A,Goecke NB,Alexandersen S

更新日期：2020-09-10 00:00:00

abstract：:Herpesviridae comprise a large family of enveloped DNA viruses all of whom employ orthologs of the same three glycoproteins, gB, gH and gL. Additionally, herpesviruses often employ accessory proteins to bind receptors and/or bind the heterodimer gH/gL or even to determine cell tropism. Sorting out how these proteins f...

journal_title：Viruses

authors： Eisenberg RJ,Atanasiu D,Cairns TM,Gallagher JR,Krummenacher C,Cohen GH

更新日期：2012-05-01 00:00:00

abstract：:Hepatitis B virus (HBV) persistence is at the basis of HBV reactivation as a consequence of chemotherapy and immunosuppressive treatments. The identification of early viral replication indicators and markers of effective HBV immunological control would be useful in monitoring patients who are at risk of potential vira...

journal_title：Viruses

authors： Svicher V,Salpini R,Malagnino V,Piermatteo L,Alkhatib M,Cerva C,Sarmati L

更新日期：2019-08-25 00:00:00

abstract：:P4 is a mobile genetic element (MGE) that can exist as a plasmid or integrated into its Escherichia coli host genome, but becomes packaged into phage particles by a helper bacteriophage, such as P2. P4 is the original example of what we have termed "molecular piracy", the process by which one MGE usurps the life cycle...

journal_title：Viruses

authors： Kizziah JL,Rodenburg CM,Dokland T

更新日期：2020-08-27 00:00:00

abstract：:The hypothesis is presented that bacteriophage DNA packaging motors have a cycle comprised of bind/release thermal ratcheting with release-associated DNA pushing via ATP-dependent protein folding. The proposed protein folding occurs in crystallographically observed peptide segments that project into an axial channel o...

journal_title：Viruses

authors： Serwer P

更新日期：2010-09-01 00:00:00

abstract：:Using different prion strains, such as the variant Creutzfeldt-Jakob disease agent and the atypical bovine spongiform encephalopathy agents, and using transgenic mice expressing human or bovine prion protein, we assessed the reliability of protein misfolding cyclic amplification (PMCA) to model interspecies and geneti...

journal_title：Viruses

authors： Levavasseur E,Privat N,Martin JC,Simoneau S,Baron T,Flan B,Torres JM,Haïk S

更新日期：2014-10-02 00:00:00

abstract：:Victoria and Yamagata lineages of influenza B viruses are globally circulating in seasonal epidemics. Madin-Darby canine kidney (MDCK) cells are permissive for viral isolation and vaccine manufacture. Nevertheless, the interplay between influenza B viruses and host microRNAs has not been investigated in this cell line...

journal_title：Viruses

authors： Saengchoowong S,Khongnomnan K,Poomipak W,Praianantathavorn K,Poovorawan Y,Zhang Q,Payungporn S

更新日期：2019-10-25 00:00:00

abstract：:Lifelong persistent infection by herpesviruses depends on the balance between host immune responses and viral immune evasion. CD4 T cells responding to antigens presented on major histocompatibility complex class II (MHC-II) molecules are known to play an important role in controlling herpesvirus infections. Here we r...

journal_title：Viruses

authors： Zuo J,Rowe M

更新日期：2012-08-01 00:00:00

abstract：:Begomoviruses are one of the major groups of plant viruses with an important economic impact on crop production in tropical and subtropical regions. The global spread of its polyphagous vector, the whitefly Bemisia tabaci, has contributed to the emergence and diversification of species within this genus. In this study...

journal_title：Viruses

authors： Romay G,Geraud-Pouey F,Chirinos DT,Mahillon M,Gillis A,Mahillon J,Bragard C

更新日期：2019-04-04 00:00:00

abstract：:Extracellular vesicles (EVs) play an important role in intercellular communication. They are naturally released from cells into the extracellular environment. Based on their biogenesis, release pathways, size, content, and function, EVs are classified into exosomes, microvesicles (MVs), and apoptotic bodies (ApoBDs). ...

journal_title：Viruses

authors： Alqatawni A,Sharma AL,Attilus B,Tyagi M,Daniel R

更新日期：2020-05-27 00:00:00

abstract：:Developments of genome amplification techniques have rapidly expanded the family of human polyomaviruses (PyV). Following infection early in life, PyV persist in their hosts and are generally of no clinical consequence. High-level replication of PyV can occur in patients under immunosuppressive or immunomodulatory the...

journal_title：Viruses

authors： Barth H,Solis M,Kack-Kack W,Soulier E,Velay A,Fafi-Kremer S

更新日期：2016-10-22 00:00:00

abstract：:Canine parvovirus (CPV-2) is the causative agent of haemorrhagic gastroenteritis in canids. Three antigenic variants-CPV-2a, CPV-2b and CPV-2c-have been described, which are determined by variations at residue 426 of the VP2 capsid protein. In Colombia, the CPV-2a and CPV-2b antigenic variants have previously been rep...

journal_title：Viruses

authors： Giraldo-Ramirez S,Rendon-Marin S,Ruiz-Saenz J

更新日期：2020-04-30 00:00:00

abstract：:Salmonid alphavirus (SAV) is the cause of pancreas disease and sleeping disease in farmed salmonid fish in Europe. The spread of these diseases has been difficult to control with biosecurity and current vaccination strategies, and increased understanding of the viral pathogenesis could be beneficial for the developmen...

journal_title：Viruses

authors： Aksnes I,Markussen T,Braaen S,Rimstad E

更新日期：2020-09-24 00:00:00

abstract：:Thermobifida fusca is of biotechnological interest due to its ability to produce an array of plant cell wall hydrolytic enzymes. Nonetheless, only one T. fusca bacteriophage with genome information has been reported to date. This study was aimed at discovering more relevant bacteriophages to expand the existing knowle...

journal_title：Viruses

authors： Cheepudom J,Lin TL,Lee CC,Meng M

更新日期：2019-11-08 00:00:00

abstract：:An outbreak of winter dysentery, complicated by severe respiratory syndrome, occurred in January 2020 in a high production dairy cow herd located in a hilly area of the Calabria region. Of the 52 animals belonging to the farm, 5 (9.6%) died with severe respiratory distress, death occurring 3-4 days after the appearanc...

journal_title：Viruses

authors： Amoroso MG,Lucifora G,Degli Uberti B,Serra F,De Luca G,Borriello G,De Domenico A,Brandi S,Cuomo MC,Bove F,Riccardi MG,Galiero G,Fusco G

更新日期：2020-11-19 00:00:00

abstract：:The world's first natural avian-origin H6N1 influenza A virus infection case in dogs was confirmed in Taiwan in 2014. The H6N1 virus in chickens has been endemic in Taiwan since 1972. Whether the dog H6N1 virus has interspecies transmission potential is the key issue we aim to understand. Following one virus passage i...

journal_title：Viruses

authors： Tsai SK,Shih CH,Chang HW,Teng KH,Hsu WE,Lin HJ,Lin HY,Huang CH,Chen HW,Wang LC

更新日期：2020-06-30 00:00:00

abstract：:Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. To counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists, and use a multi-layered molecular defense strategy to establish their infections. Among the most potent antagonists is non-stru...

journal_title：Viruses

authors： Thurmond S,Wang B,Song J,Hai R

更新日期：2018-12-14 00:00:00

abstract：:The success of oral infection by viruses depends on their capacity to overcome the gut epithelial barrier of their host to crossing over apical, mucous extracellular matrices. As orally transmitted viruses, densoviruses, are also challenged by the complexity of the insect gut barriers, more specifically by the chitino...

journal_title：Viruses

authors： Pigeyre L,Schatz M,Ravallec M,Gasmi L,Nègre N,Clouet C,Seveno M,El Koulali K,Decourcelle M,Guerardel Y,Cot D,Dupressoir T,Gosselin-Grenet AS,Ogliastro M

更新日期：2019-09-17 00:00:00

abstract：:Viral encephalitis causes acute inflammation of the brain parenchyma and is a significant cause of human morbidity and mortality. Although Herpes Simplex encephalitis is the most frequent known cause of fatal sporadic encephalitis in humans, an increasingly wide range of viruses and other microbial pathogens are impli...

journal_title：Viruses

authors： Kennedy PGE,Quan PL,Lipkin WI

更新日期：2017-06-06 00:00:00

abstract：:Enteroviruses are small RNA viruses that affect millions of people each year by causing an important burden of disease with a broad spectrum of symptoms. In routine diagnostic laboratories, enteroviruses are identified by PCR-based methods, often combined with partial sequencing for genotyping. In this proof-of-princi...

journal_title：Viruses

authors： Grädel C,Terrazos Miani MA,Baumann C,Barbani MT,Neuenschwander S,Leib SL,Suter-Riniker F,Ramette A

更新日期：2020-07-31 00:00:00

abstract：:Poxviruses are important pathogens of man and numerous domestic and wild animal species. Cross species (including zoonotic) poxvirus infections can have drastic consequences for the recipient host. Bats are a diverse order of mammals known to carry lethal viral zoonoses such as Rabies, Hendra, Nipah, and SARS. Consequ...

journal_title：Viruses

authors： Baker KS,Murcia PR

更新日期：2014-04-03 00:00:00

abstract：:Influenza A viruses (IAV) carrying reporter genes provide a powerful tool to study viral infection and pathogenesis in vivo, however, incorporating a non-essential gene into the IAV genome often results in virus attenuation and genetic instability. Very few studies have systematically compared different reporter IAVs,...

journal_title：Viruses

authors： Zhao X,Wang L,Cui Q,Li P,Wang Y,Zhang Y,Yang Y,Rong L,Du R

更新日期：2018-11-30 00:00:00