Abstract：
:Bombyx mori bidensovirus (BmBDV) is a single-stranded DNA (ssDNA) virus from the genus Bidensovirus of the Bidnaviridae family, which, thus far, solely infects insects. It has a unique genome that contains bipartite DNA molecules (VD1 and VD2). In this study, we explored the detailed transcription mapping of the complete BmBDV genome (VD1 and VD2) by rapid amplification of cDNA ends (RACE), reverse transcription quantitative real-time PCR (RT-qPCR), and luciferase assays. For the first time, we report the transcription map of VD2. Our mapping of the transcriptional start sites reveals that the NS genes in VD1 have separate transcripts that are derived from overlapping promoters, P5 and P5.5. Thus, our study provides a strategy for alternative promoter usage in the expression of BmBDV genes.
journal_name
Virusesjournal_title
Virusesauthors
Li R,Chang P,Lü P,Hu Z,Chen K,Yao Q,Yu Qdoi
10.3390/v11040325subject
Has Abstractpub_date
2019-04-03 00:00:00issue
4issn
1999-4915pii
v11040325journal_volume
11pub_type
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