Identification of a Novel Betacoronavirus (Merbecovirus) in Amur Hedgehogs from China.

abstract：:Virus-induced inflammation plays a critical role in determining the clinical outcome of an acute respiratory virus infection. We have shown previously that the administration of immunobiotic Lactobacillus plantarum (Lp) directly to the respiratory tract prevents lethal inflammatory responses to subsequent infection wi...

journal_title：Viruses

authors： Mai E,Percopo CM,Limkar AR,Sek AC,Ma M,Rosenberg HF

更新日期：2020-12-22 00:00:00

abstract：:The human cytomegalovirus (HCMV)-encoded protein kinase, pUL97, is considered a cyclin-dependent kinase (CDK) ortholog, due to shared structural and functional characteristics. The primary mechanism of CDK activation is binding to corresponding cyclins, including cyclin T1, which is the usual regulatory cofactor of CD...

journal_title：Viruses

authors： Graf L,Webel R,Wagner S,Hamilton ST,Rawlinson WD,Sticht H,Marschall M

更新日期：2013-12-18 00:00:00

abstract：:Micro RNAs (miRNAs) are a class of small non-coding single-stranded RNA, which play an important role in modulating host-Influenza A virus (IAV) crosstalk. The interplay between influenza and miRNA interaction is defined by a plethora of complex mechanisms, which are not fully understood yet. Here, we demonstrate that...

journal_title：Viruses

authors： Sharma S,Chatterjee A,Kumar P,Lal S,Kondabagil K

更新日期：2020-04-15 00:00:00

abstract：:Human metapneumovirus (hMPV), a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. Here we show that infection of plasmacytoid dendritic cells (pDCs) with a recombinant virus lacking SH expression (rhMPV-ΔSH) enhanced the secretion of type I interfer...

journal_title：Viruses

authors： Bao X,Kolli D,Esham D,Velayutham TS,Casola A

更新日期：2018-05-23 00:00:00

abstract：:Porcine endogenous retroviruses (PERVs) are integrated in the genome of pigs and are transmitted like cellular genes from parents to the offspring. Whereas PERV-A and PERV-B are present in all pigs, PERV-C was found to be in many, but not all pigs. When PERV-C is present, recombination with PERV-A may happen and the P...

journal_title：Viruses

authors： Krüger L,Stillfried M,Prinz C,Schröder V,Neubert LK,Denner J

更新日期：2020-04-08 00:00:00

abstract：:We previously characterized a carbohydrate binding protein, Gp047, derived from lytic Campylobacter phage NCTC 12673, as a promising diagnostic tool for the identification of Campylobacter jejuni and Campylobacter coli. We also demonstrated that this protein binds specifically to acetamidino-modified pseudaminic acid ...

journal_title：Viruses

authors： Javed MA,Sacher JC,van Alphen LB,Patry RT,Szymanski CM

更新日期：2015-12-16 00:00:00

abstract：:Hepatitis C Virus (HCV) remains an important public health threat with approximately 170 million carriers worldwide who are at risk of developing hepatitis C-associated end-stage liver diseases. Despite improvement of HCV treatment using the novel direct-acting antivirals (DAAs) targeting viral replication, there is a...

journal_title：Viruses

authors： Hung TC,Jassey A,Lin CJ,Liu CH,Lin CC,Yen MH,Lin LT

更新日期：2018-11-27 00:00:00

abstract：:The hypothesis is presented that bacteriophage DNA packaging motors have a cycle comprised of bind/release thermal ratcheting with release-associated DNA pushing via ATP-dependent protein folding. The proposed protein folding occurs in crystallographically observed peptide segments that project into an axial channel o...

journal_title：Viruses

authors： Serwer P

更新日期：2010-09-01 00:00:00

abstract：:Influenza virus infections can lead to viral pneumonia and acute respiratory distress syndrome in severe cases, causing significant morbidity and mortality and posing a great threat to human health. Because of the diversity of influenza virus strains and drug resistance to the current direct antiviral agents, there ha...

journal_title：Viruses

authors： Zhang L,Chen J,Ke C,Zhang H,Zhang S,Tang W,Liu C,Liu G,Chen S,Hu A,Sun W,Xiao Y,Liu M,Chen X

更新日期：2020-05-18 00:00:00

abstract：:Interferon-inducible transmembrane proteins (IFITM1/2/3) have been reported to suppress the entry of a wide range of viruses. However, their antiviral functional residues and specific mechanisms are still unclear. Here, we firstly resolved the topology of IFITM1 on the plasma membrane where N-terminus points into the ...

journal_title：Viruses

authors： Sun F,Xia Z,Han Y,Gao M,Wang L,Wu Y,Sabatier JM,Miao L,Cao Z

更新日期：2020-03-08 00:00:00

abstract：:Factors controlling the community composition of marine heterotrophic prokaryotes include organic-C, mineral nutrients, predation, and viral lysis. Two mesocosm experiments, performed at an Arctic location and bottom-up manipulated with organic-C, had very different results in community composition for both prokaryote...

journal_title：Viruses

authors： Sandaa RA,Pree B,Larsen A,Våge S,Töpper B,Töpper JP,Thyrhaug R,Thingstad TF

更新日期：2017-08-23 00:00:00

abstract：:Koala retrovirus (KoRV) poses a major threat to koala health and conservation, and currently has 10 identified subtypes: an endogenous subtype (KoRV-A) and nine exogenous subtypes (KoRV-B to KoRV-J). However, subtype-related variations in koala immune response to KoRV are uncharacterized. In this study, we investigate...

journal_title：Viruses

authors： Kayesh MEH,Hashem MA,Maetani F,Eiei T,Mochizuki K,Ochiai S,Ito A,Ito N,Sakurai H,Asai T,Tsukiyama-Kohara K

更新日期：2020-12-09 00:00:00

abstract：:Multi-drug resistance is increasing at alarming rates. The efficacy of phage therapy, treating bacterial infections with bacteriophages alone or in combination with traditional antibiotics, has been demonstrated in emergency cases in the United States and in other countries, however remains to be approved for wide-spr...

journal_title：Viruses

authors： Philipson CW,Voegtly LJ,Lueder MR,Long KA,Rice GK,Frey KG,Biswas B,Cer RZ,Hamilton T,Bishop-Lilly KA

更新日期：2018-04-10 00:00:00

abstract：:Most cases of hemorrhagic fever with renal syndrome (HFRS) in Europe are caused by the Puumala hantavirus (PUUV). Typical features of the disease are increased vascular permeability, acute kidney injury (AKI), and thrombocytopenia. YKL-40 is an inflammatory glycoprotein involved in various forms of acute and chronic i...

journal_title：Viruses

authors： Outinen TK,Mantula P,Jaatinen P,Hämäläinen M,Moilanen E,Vaheri A,Huhtala H,Mäkelä S,Mustonen J

更新日期：2019-08-21 00:00:00

abstract：:A Chikungunya virus (CHIKV) outbreak in Italy in 2007 spread to include the islands of the Caribbean and most of the Americas and still circulates in Europe and Africa. Florida being close in distance to the Caribbean islands experienced a CHIKV outbreak in 2014 and continues to have a few travel-related cases each ye...

journal_title：Viruses

authors： Shin D,Kang S,Smartt CT

更新日期：2020-07-29 00:00:00

abstract：:Merkel cell polyomavirus (MCV) is the only known human oncogenic virus in the polyomaviridae family and the etiological agent of most Merkel cell carcinomas (MCC). MCC is an aggressive and highly metastatic skin cancer with a propensity for recurrence and poor prognosis. Large tumor antigen (LT), is an essential oncop...

journal_title：Viruses

authors： Nwogu N,Ortiz LE,Kwun HJ

更新日期：2020-09-18 00:00:00

abstract：:The objective of this study was to evaluate the effects of A3R phage and Staphylococcus aureus lysate obtained after phage infection on neutrophil degranulation. The exocytosis of primary and secondary granules from neutrophils was investigated in vitro in whole blood specimens by flow cytometry based on the expressio...

journal_title：Viruses

authors： Borysowski J,Międzybrodzki R,Wierzbicki P,Kłosowska D,Korczak-Kowalska G,Weber-Dąbrowska B,Górski A

更新日期：2017-02-21 00:00:00

abstract：:Arboviruses continue to be a significant global health concern. The unbiased metagenomic analyses of mosquito-borne and mosquito-specific viruses are useful to understand viral diversity and for the surveillance of pathogens of medical and veterinary importance. Metagenomic analysis was conducted on 6368 mosquitoes (7...

journal_title：Viruses

authors： Sanborn MA,Klein TA,Kim HC,Fung CK,Figueroa KL,Yang Y,Asafo-Adjei EA,Jarman RG,Hang J

更新日期：2019-03-05 00:00:00

abstract：:Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict v...

journal_title：Viruses

authors： Zhang Y,Xu Z,Cao Y

更新日期：2020-03-29 00:00:00

abstract：:Mycoviruses infect a large number of diverse fungal species, but considering their prevalence, relatively few high-quality genome sequences have been determined. Many mycoviruses have linear double-stranded RNA genomes, which makes it technically challenging to ascertain their nucleotide sequence using conventional se...

journal_title：Viruses

authors： Crabtree AM,Kizer EA,Hunter SS,Van Leuven JT,New DD,Fagnan MW,Rowley PA

更新日期：2019-01-16 00:00:00

abstract：:Hantaviruses, members of the order Bunyavirales, family Hantaviridae, have a world-wide distribution and are responsible for greater than 150,000 cases of disease per year. The spectrum of disease associated with hantavirus infection include hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrom...

journal_title：Viruses

authors： Brocato RL,Hooper JW

更新日期：2019-07-04 00:00:00

abstract：:Nervous necrosis virus (NNV) can infect many species of fish and has an 80-100% mortality rate. NNV capsid protein (NNVCP) is the only structural protein of NNV, but there are few studies on the protein-protein interaction between NNVCP and the host cell. To investigate NNV morphogenesis, native NNV capsid protein (NN...

journal_title：Viruses

authors： Huang PY,Hsiao HC,Wang SW,Lo SF,Lu MW,Chen LL

更新日期：2020-09-04 00:00:00

abstract：:Current measles vaccines suffer from poor effectiveness in young infants due primarily to the inhibitory effect of residual maternal immunity on vaccine responses. The development of a measles vaccine that resists such passive immunity would strongly contribute to the stalled effort toward measles eradication. In this...

journal_title：Viruses

authors： Julik E,Reyes-Del Valle J

更新日期：2017-09-21 00:00:00

abstract：:In the last 20 years, molecular ecology approaches have proven to be extremely useful to identify and assess factors associated with viral emerging diseases, particularly in economically and socially important tropical crops such as maize (maize streak disease) and cassava (cassava mosaic disease). Molecular ecology a...

journal_title：Viruses

authors： Péréfarres F,Thierry M,Becker N,Lefeuvre P,Reynaud B,Delatte H,Lett JM

更新日期：2012-12-12 00:00:00

abstract：:Canine parvovirus (CPV-2) is the causative agent of haemorrhagic gastroenteritis in canids. Three antigenic variants-CPV-2a, CPV-2b and CPV-2c-have been described, which are determined by variations at residue 426 of the VP2 capsid protein. In Colombia, the CPV-2a and CPV-2b antigenic variants have previously been rep...

journal_title：Viruses

authors： Giraldo-Ramirez S,Rendon-Marin S,Ruiz-Saenz J

更新日期：2020-04-30 00:00:00

abstract：:At the end of my doctoral studies, in 1988, I published a review article on the major steps of transcription and translation during the mammalian reovirus multiplication cycle, a topic that still fascinates me 30 years later. It is in the nature of scientific research to generate further questioning as new knowledge e...

journal_title：Viruses

authors： Lemay G

更新日期：2018-11-27 00:00:00

abstract：:A field study was undertaken to (i) measure the prevalence of feline leukaemia virus (FeLV) exposure and FeLV infection in a cross-section of healthy Australian pet cats; and (ii) investigate the outcomes following natural FeLV exposure in two Australian rescue facilities. Group 1 (n = 440) consisted of healthy client...

journal_title：Viruses

authors： Westman M,Norris J,Malik R,Hofmann-Lehmann R,Harvey A,McLuckie A,Perkins M,Schofield D,Marcus A,McDonald M,Ward M,Hall E,Sheehy P,Hosie M

更新日期：2019-05-31 00:00:00

abstract：:Fruit trees, such as apricot trees, are constantly exposed to the attack of viruses. As they are propagated in a vegetative way, this risk is present not only in the field, where they remain for decades, but also during their propagation. Metagenomic diagnostic methods, based on next generation sequencing (NGS), offer...

journal_title：Viruses

authors： Baráth D,Jaksa-Czotter N,Molnár J,Varga T,Balássy J,Szabó LK,Kirilla Z,Tusnády GE,Preininger É,Várallyay É

更新日期：2018-06-11 00:00:00

abstract：:Hepatitis C virus (HCV) is the etiological agent accounting for chronic liver disease in approximately 2-3% of the population worldwide. HCV infection often leads to liver fibrosis and cirrhosis, various metabolic alterations including steatosis, insulin and interferon resistance or iron overload, and development of h...

journal_title：Viruses

authors： Ivanov AV,Bartosch B,Smirnova OA,Isaguliants MG,Kochetkov SN

更新日期：2013-01-28 00:00:00

abstract：:Porcine Reproductive and Respiratory Syndrome (PRRS) is a contagious viral (PRRSV) disease in pigs characterized by poor reproductive health, increased mortality, and reductions in growth rates. PRRSV is known to implement immuno-antagonistic mechanisms to evade detection and mute host responses to infection. To bette...

journal_title：Viruses

authors： Hicks JA,Yoo D,Liu HC

更新日期：2020-11-12 00:00:00