Bombyx mori Nuclear Polyhedrosis Virus (BmNPV) Induces Host Cell Autophagy to Benefit Infection.

abstract：:The use of integrase inhibitors (INI) is increasing in antiretroviral therapies (ART) and INI are not all equal regarding genetic barrier to resistance. The aim of this manuscript was to review main in vivo and in vitro knowledge about two particular integrase resistance-associated mutations: R263K and E157Q. The R263...

journal_title：Viruses

authors： Charpentier C,Descamps D

更新日期：2018-01-18 00:00:00

abstract：:The immune-suppressive effects of omega-3 (n-3) polyunsaturated fatty acids (PUFAs) on T cells have been observed via multiple in vitro and in vivo models. However, the precise mechanism that causes these effects is still undefined. In this study, we investigated whether n-3 PUFAs regulated T cell receptor (TCR) and p...

journal_title：Viruses

authors： Lim Y,Kim S,Kim S,Kim DI,Kang KW,Hong SH,Lee SM,Koh HR,Seo YJ

更新日期：2020-06-12 00:00:00

abstract：:Influenza A virus is a successful parasite and requires host factors to complete its life cycle. Prop5 is an antisense oligonucleotide, targeting programmed cell death protein 5 (PDCD5). In this study, we tested the antiviral activity of prop5 against mouse-adapted A/FM/1/47 strain of influenza A virus in a mouse mode...

journal_title：Viruses

authors： Li K,Zhou Z,Wang YO,Liu J,Zhao HB,Yang J,Wang SQ

更新日期：2014-02-06 00:00:00

abstract：:Metagenomics studies have accelerated the discovery of novel or divergent viruses of the honey bee. However, most of these studies predominantly focused on RNA viruses, and many suffer from the relatively low abundance of viral nucleic acids in the samples (i.e., compared to that of the host). Here, we explored the vi...

journal_title：Viruses

authors： Gebremedhn H,Deboutte W,Schoonvaere K,Demaeght P,De Smet L,Amssalu B,Matthijnssens J,de Graaf DC

更新日期：2020-10-27 00:00:00

abstract：:Internal ribosome entry is a key mechanism for viral protein synthesis in a subset of RNA viruses. Cricket paralysis virus (CrPV), a member of Dicistroviridae, has a positive-sense single strand RNA genome that contains two internal ribosome entry sites (IRES), a 5'untranslated region (5'UTR) and intergenic region (IG...

journal_title：Viruses

authors： Khong A,Bonderoff JM,Spriggs RV,Tammpere E,Kerr CH,Jackson TJ,Willis AE,Jan E

更新日期：2016-01-19 00:00:00

abstract：:Chronic hepatitis C virus (HCV) infection is a major cause of liver disease and hepatocellular carcinoma (HCC)-the second leading, and rising, cause of death due to cancer world-wide [...]. ...

journal_title：Viruses

authors： Baumert TF,Hoshida Y

更新日期：2019-05-15 00:00:00

abstract：:We are currently facing a pandemic of COVID-19, caused by a spillover from an animal-originating coronavirus to humans occurring in the Wuhan region of China in December 2019. From China, the virus has spread to 188 countries and regions worldwide, reaching the Sahel region on March 2, 2020. Since whole genome sequenc...

journal_title：Viruses

authors： Kouriba B,Dürr A,Rehn A,Sangaré AK,Traoré BY,Bestehorn-Willmann MS,Ouedraogo J,Heitzer A,Sogodogo E,Maiga A,Walter MC,Zimmermann F,Wölfel R,Antwerpen MH

更新日期：2020-11-02 00:00:00

abstract：:Porcine Reproductive and Respiratory Syndrome (PRRS) is a contagious viral (PRRSV) disease in pigs characterized by poor reproductive health, increased mortality, and reductions in growth rates. PRRSV is known to implement immuno-antagonistic mechanisms to evade detection and mute host responses to infection. To bette...

journal_title：Viruses

authors： Hicks JA,Yoo D,Liu HC

更新日期：2020-11-12 00:00:00

abstract：:Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection. However, to-date no direct anti-HDV drugs are available in clinical practice. Here, we identified conserved and variable regions in...

journal_title：Viruses

authors： Colagrossi L,Salpini R,Scutari R,Carioti L,Battisti A,Piermatteo L,Bertoli A,Fabeni L,Minichini C,Trimoulet P,Fleury H,Nebuloso E,De Cristofaro M,Cappiello G,Spanò A,Malagnino V,Mari T,Barlattani A,Iapadre N,Lichtne

更新日期：2018-07-09 00:00:00

abstract：:Eukaryotic translation is a complex process composed of three main steps: initiation, elongation, and termination. During infections by RNA- and DNA-viruses, the eukaryotic translation machinery is used to assure optimal viral protein synthesis. Human immunodeficiency virus type I (HIV-1) uses several non-canonical pa...

journal_title：Viruses

authors： Guerrero S,Batisse J,Libre C,Bernacchi S,Marquet R,Paillart JC

更新日期：2015-01-19 00:00:00

abstract：:Cotton leaf curl disease (CLCuD) is one of the most economically important diseases and is a constraint to cotton production in major producers, Pakistan and India. CLCuD is caused by monopartite plant viruses belonging to the family Geminiviridae (genus Begomovirus), in association with an essential, disease-specific...

journal_title：Viruses

authors： Zubair M,Zaidi SS,Shakir S,Amin I,Mansoor S

更新日期：2017-09-29 00:00:00

abstract：:SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying immunity. Because SARS-CoV-2 is a biosafety-level-3 virus, one way to simplify such assays is ...

journal_title：Viruses

authors： Crawford KHD,Eguia R,Dingens AS,Loes AN,Malone KD,Wolf CR,Chu HY,Tortorici MA,Veesler D,Murphy M,Pettie D,King NP,Balazs AB,Bloom JD

更新日期：2020-05-06 00:00:00

abstract：:Current measles vaccines suffer from poor effectiveness in young infants due primarily to the inhibitory effect of residual maternal immunity on vaccine responses. The development of a measles vaccine that resists such passive immunity would strongly contribute to the stalled effort toward measles eradication. In this...

journal_title：Viruses

authors： Julik E,Reyes-Del Valle J

更新日期：2017-09-21 00:00:00

abstract：:The first discovered human retrovirus, Human T-Lymphotropic Virus type 1 (HTLV-1), is responsible for an aggressive form of T cell leukemia/lymphoma. Mouse models recapitulating the leukemogenesis process have been helpful for understanding the mechanisms underlying the pathogenesis of this retroviral-induced disease....

journal_title：Viruses

authors： Pérès E,Bagdassarian E,This S,Villaudy J,Rigal D,Gazzolo L,Duc Dodon M

更新日期：2015-12-07 00:00:00

abstract：:Angola variant (MARV/Ang) has replaced Mt. Elgon variant Musoke isolate (MARV/MtE-Mus) as the consensus standard variant for Marburg virus research and is regarded as causing a more aggressive phenotype of disease in animal models; however, there is a dearth of published evidence supporting the higher virulence of MAR...

journal_title：Viruses

authors： Blair PW,Keshtkar-Jahromi M,Psoter KJ,Reisler RB,Warren TK,Johnston SC,Goff AJ,Downey LG,Bavari S,Cardile AP

更新日期：2018-11-21 00:00:00

abstract：:Present in many cell types, non-degradative secretory autophagy is a newly discovered pathway in which autophagosomes fuse with the plasma membrane instead of lysosomes. Surprisingly, some viruses exploit secretory autophagy to exit cells non-lytically, shedding into the extracellular environment as particle populatio...

journal_title：Viruses

authors： Mutsafi Y,Altan-Bonnet N

更新日期：2018-03-20 00:00:00

abstract：:Hematopoietic stem cell transplantation from anti-cytomegalovirus immunoglobulin G (anti-CMV-IgG) positive donors facilitated immunological recovery post-transplant, which may indicate that chronic CMV infection has an effect on the immune system. This can be seen in the recipients after reconstitution with donor lymp...

journal_title：Viruses

authors： Jaskula E,Dlubek D,Tarnowska A,Lange J,Mordak-Domagala M,Suchnicki K,Sedzimirska M,Borowik A,Mizia S,Lange A

更新日期：2015-03-23 00:00:00

abstract：:Innate immune interferons (IFNs), including type I and III IFNs, constitute critical antiviral mechanisms. Recent studies reveal that IFN dysregulation is key to determine COVID-19 pathogenesis. Effective IFN stimulation or prophylactic administration of IFNs at the early stage prior to severe COVID-19 may elicit an a...

journal_title：Viruses

authors： Lopez L,Sang PC,Tian Y,Sang Y

更新日期：2020-12-13 00:00:00

abstract：:Foamy viruses (FVs) are globally prevalent retroviruses that establish apparently apathogenic lifelong infections. Feline FV (FFV) has been isolated from domestic cats with concurrent diseases, including urinary syndromes. We experimentally infected five cats with FFV to study viral kinetics and tropism, peripheral bl...

journal_title：Viruses

authors： Ledesma-Feliciano C,Troyer RM,Zheng X,Miller C,Cianciolo R,Bordicchia M,Dannemiller N,Gagne R,Beatty J,Quimby J,Löchelt M,VandeWoude S

更新日期：2019-07-19 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) can infect a wide range of cell types, including cells of the adaptive and innate immunity but, normally, it completes a fully-permissive replication cycle only in epithelial or neural cells. Complex mechanisms controlling this delicate balance in immune cells and consequent restriction ...

journal_title：Viruses

authors： Marino-Merlo F,Papaianni E,Frezza C,Pedatella S,De Nisco M,Macchi B,Grelli S,Mastino A

更新日期：2019-05-10 00:00:00

abstract：:Zika virus recently re-emerged and caused global outbreaks mainly in Central Africa, Southeast Asia, the Pacific Islands and in Central and South America. Even though there is a declining trend, the virus continues to spread throughout different geographical regions of the world. Since its re-emergence in 2015, massiv...

journal_title：Viruses

authors： Alves MP,Vielle NJ,Thiel V,Pfaender S

更新日期：2018-10-30 00:00:00

abstract：UNLABELLED:Cytomegalovirus (CMV) is a prevalent pathogen in the immunocompromised host and invasive pneumonia is a feared complication of the virus in this population. In this pediatric case series we characterized CMV lung infection in 15 non-HIV infected children (median age 3 years; IQR 0.2-4.9 years), using current...

journal_title：Viruses

authors： Restrepo-Gualteros SM,Jaramillo-Barberi LE,Gonzalez-Santos M,Rodriguez-Martinez CE,Perez GF,Gutierrez MJ,Nino G

更新日期：2014-05-07 00:00:00

abstract：:Heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar) was first diagnosed in Norway in 1999. The disease is caused by Piscine orthoreovirus-1 (PRV-1). The virus is prevalent in farmed Atlantic salmon, but not always associated with disease. Phylogeny and sequence analyses of 31 PRV-1 ge...

journal_title：Viruses

authors： Dhamotharan K,Tengs T,Wessel Ø,Braaen S,Nyman IB,Hansen EF,Christiansen DH,Dahle MK,Rimstad E,Markussen T

更新日期：2019-05-22 00:00:00

abstract：:The successful control of HBV infection requires an efficient expansion of distinct elements of the adaptive immune system (B cells, helper and cytotoxic T cells) that, due to the hepatotropic nature of HBV, need to operate in the liver parenchyma. In this respect, we will discuss broad features of HBV immunity in pat...

journal_title：Viruses

authors： Bertoletti A,Tan AT,Gehring AJ

更新日期：2009-09-01 00:00:00

abstract：:The hepatitis C virus (HCV), a hepatotropic plus-strand RNA virus of the family Flaviviridae, encodes a set of 10 viral proteins. These viral factors act in concert with host proteins to mediate virus entry, and to coordinate RNA replication and virus production. Recent evidence has highlighted the complexity of HCV a...

journal_title：Viruses

authors： Steinmann E,Pietschmann T

更新日期：2010-09-01 00:00:00

abstract：:The phenotype of HTLV-1-transformed CD4(+) T lymphocytes largely depends on defined viral effector molecules such as the viral oncoprotein Tax. In this review, we exemplify the expression pattern of characteristic lineage markers, costimulatory receptors and ligands of the tumor necrosis factor superfamily, cytokine r...

journal_title：Viruses

authors： Kress AK,Grassmann R,Fleckenstein B

更新日期：2011-08-01 00:00:00

abstract：:Although most hepatitis E virus (HEV) infections are asymptomatic, some can be severe, causing fulminant hepatitis and extra-hepatic manifestations, including neurological and kidney injuries. Chronic HEV infections may also occur in immunocompromised patients. This review describes how our understanding of the pathog...

journal_title：Viruses

authors： Lhomme S,Marion O,Abravanel F,Chapuy-Regaud S,Kamar N,Izopet J

更新日期：2016-08-05 00:00:00

abstract：:In rabies diagnosis, it is essential to count on a rapid test to give a quick response. The combined sensitivity and robustness of the TaqMan RT-PCR assays (qRT-PCR) have made these methods a valuable alternative for rabies virus (RABV) detection. We conducted a study to compare the applicability of two widely used qR...

journal_title：Viruses

authors： Caraballo DA,Lombardo MA,Becker P,Sabio MS,Lema C,Martínez LM,Beltrán FJ,Li Y,Cisterna DM

更新日期：2020-12-25 00:00:00

abstract：:Noroviruses are the most common etiological agent of acute gastroenteritis worldwide. Despite their high infectivity, a subpopulation of individuals is resistant to infection and disease. This susceptibility is norovirus genotype-dependent and is largely mediated by the presence or absence of human histo-blood group a...

journal_title：Viruses

authors： Nordgren J,Svensson L

更新日期：2019-03-06 00:00:00

abstract：:RNA viruses are extraordinary evolution machines that efficiently ensure their replication by taking advantage of the association with viral and cellular components to form ribonucleic complexes (vRNPs) [...]. ...

journal_title：Viruses

authors： Bernacchi S

更新日期：2020-11-26 00:00:00