Interferon Regulatory Factor 3-Mediated Signaling Limits Middle-East Respiratory Syndrome (MERS) Coronavirus Propagation in Cells from an Insectivorous Bat.

abstract：:Human immunodeficiency virus type 1 (HIV-1) establishes latency in resting memory CD4+ T cells and cells of myeloid lineage. In contrast to the T cells, cells of myeloid lineage are resistant to the HIV-1 induced cytopathic effect. Cells of myeloid lineage including macrophages are present in anatomical sanctuaries ma...

journal_title：Viruses

authors： Abbas W,Tariq M,Iqbal M,Kumar A,Herbein G

更新日期：2015-03-31 00:00:00

abstract：:Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-...

journal_title：Viruses

authors： Usadi B,Bruhn R,Lin J,Lee TH,Blackburn E,Murphy EL

更新日期：2016-08-11 00:00:00

abstract：:The levels of vascular endothelial growth factor-A (VEGF) were estimated in 102 serum samples from 63 hospitalized Greek patients with hemorrhagic fever with renal syndrome (HFRS) caused by Dobrava/Belgrade virus. Significantly higher VEGF levels were seen in the severe when compared with non-severe cases (mean values...

journal_title：Viruses

authors： Tsergouli K,Papa A

更新日期：2013-12-10 00:00:00

abstract：:The environmental factors that lead to the reactivation of human T cell leukemia virus type-1 (HTLV-I) in latently infected T cells in vivo remain unknown. It has been previously shown that heat shock (HS) is a potent inducer of HTLV-I viral protein expression in long-term cultured cell lines. However, the precise HTL...

journal_title：Viruses

authors： Kunihiro M,Fujii H,Miyagi T,Takahashi Y,Tanaka R,Fukushima T,Ansari AA,Tanaka Y

更新日期：2016-07-11 00:00:00

abstract：:Type-I interferons (IFN-I) play an important role in the innate immune response to several retroviruses. They seem to be effective in controlling the in vivo infection, though many of the clinical signs of retroviral infection may be due to their continual presence which over-stimulates the immune system and activates...

journal_title：Viruses

authors： Gómez-Lucía E,Collado VM,Miró G,Doménech A

更新日期：2009-12-01 00:00:00

abstract：:Porcine circovirus type 2 (PCV2) is the etiological agent of porcine circovirus diseases and porcine circovirus-associated diseases (PCVDs/PCVADs). However, the pathogenesis of PCV2 is not fully understood. We previously found that 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) is negatively associated with P...

journal_title：Viruses

authors： Ouyang T,Niu G,Zhang Y,Liu X,Zhang X,Zhang S,Geng Y,Pang D,Ouyang H,Ren L

更新日期：2019-06-11 00:00:00

abstract：:The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions shared among membe...

journal_title：Viruses

authors： Zeidler JD,Fernandes-Siqueira LO,Barbosa GM,Da Poian AT

更新日期：2017-03-13 00:00:00

abstract：:Duck Tembusu virus (DTMUV) is a recently emerging pathogenic flavivirus that has resulted in a huge economic loss in the duck industry. However, no vaccine is currently available to control this pathogen. Consequently, a practical strategy to construct a vaccine against this pathogen should be determined. In this stud...

journal_title：Viruses

authors： Zou Z,Liu Z,Jin M

更新日期：2014-06-20 00:00:00

abstract：:Autophagy is an essential cellular process by which a cell degrades materials within its cytoplasm. Intracellular pathogens like viruses must deal with autophagy, either positively or negatively, for their own survival and replication. For some viruses, autophagy can even play proviral roles, helping their replication...

journal_title：Viruses

authors： Furlong K,Hwang S

更新日期：2019-03-12 00:00:00

abstract：:Non-human primates (NHP) are the only animal model suitable to evaluate the protection efficacy of HIV-1 vaccines. It is important to understand how and when neutralizing antibodies (nAbs) with specificities similar to those of human broadly neutralizing antibodies (bnAbs) develop in NHPs. To address these questions, ...

journal_title：Viruses

authors： Gao N,Gai Y,Meng L,Wang C,Zhang X,Wang W,Qin C,Yu X,Gao F

更新日期：2020-01-31 00:00:00

abstract：:The human cytomegalovirus (HCMV) replicates to high titers in primary human fibroblast cell cultures. A variety of primary human cells and some tumor-derived cell lines do also support permissive HCMV replication, yet at low levels. Cell lines established by transfection of the transforming functions of adenoviruses h...

journal_title：Viruses

authors： Krömmelbein N,Wiebusch L,Schiedner G,Büscher N,Sauer C,Florin L,Sehn E,Wolfrum U,Plachter B

更新日期：2016-02-02 00:00:00

abstract：:The neutrophil extracellular trap (ET) is a eukaryotic host defense machinery that operates by capturing and concentrating pathogens in a filamentous network manufactured by neutrophils and made of DNA, histones, and many other components. Respiratory virus-induced ETs are involved in tissue damage and impairment of t...

journal_title：Viruses

authors： Real-Hohn A,Zhu R,Ganjian H,Ibrahim N,Hinterdorfer P,Kowalski H,Blaas D

更新日期：2020-07-04 00:00:00

abstract：:Canid alphaherpesvirus 1 (CHV-1) is a widespread pathogen of dogs with multiple associated clinical signs. There has been limited prior investigation into the genomics and phylogeny of this virus using whole viral genome analysis. Fifteen CHV-1 isolates were collected from animals with ocular disease based in the USA....

journal_title：Viruses

authors： Lewin AC,Coghill LM,Mironovich M,Liu CC,Carter RT,Ledbetter EC

更新日期：2020-12-10 00:00:00

abstract：:Vaccination is the most effective means to prevent influenza virus infection, although current approaches are associated with suboptimal efficacy. Here, we generated virus-like particles (VLPs) composed of the hemagglutinin (HA), neuraminidase (NA) and matrix protein (M1) of A/Changchun/01/2009 (H1N1) with or without ...

journal_title：Viruses

authors： Ji X,Ren Z,Xu N,Meng L,Yu Z,Feng N,Sang X,Li S,Li Y,Wang T,Zhao Y,Wang H,Zheng X,Jin H,Li N,Yang S,Cao J,Liu W,Gao Y,Xia X

更新日期：2016-04-21 00:00:00

abstract：:Effects of elevated pCO₂ on Emiliania huxleyi genetic diversity and the viruses that infect E. huxleyi (EhVs) have been investigated in large volume enclosures in a Norwegian fjord. Triplicate enclosures were bubbled with air enriched with CO₂ to 760 ppmv whilst the other three enclosures were bubbled with air at ambi...

journal_title：Viruses

authors： Highfield A,Joint I,Gilbert JA,Crawfurd KJ,Schroeder DC

更新日期：2017-03-08 00:00:00

abstract：:An effective vaccine is essential for controlling the spread of the SARS-CoV-2 virus. Here, we describe an influenza virus-based vaccine for SARS-CoV-2. We incorporated a membrane-anchored form of the SARS-CoV-2 spike receptor binding domain (RBD) in place of the neuraminidase (NA) coding sequence in an influenza viru...

journal_title：Viruses

authors： Loes AN,Gentles LE,Greaney AJ,Crawford KHD,Bloom JD

更新日期：2020-09-05 00:00:00

abstract：:Varroa destructor is an ectoparasitic mite of Asian or Eastern honeybees Apis cerana(A. cerana) which has become a serious threat to European subspecies of Western honeybees Apis mellifera (A. mellifera) within the last century. V.destructor and its vectored honeybee viruses became serious threats for colony survival....

journal_title：Viruses

authors： Levin S,Sela N,Erez T,Nestel D,Pettis J,Neumann P,Chejanovsky N

更新日期：2019-01-24 00:00:00

abstract：:Influenza virus is among the most common causes of respiratory illness worldwide and can be complicated by secondary bacterial pneumonia, a frequent cause of mortality. When influenza virus infects the lung, the innate immune response is activated, and interferons and inflammatory mediators are released. This "cytokin...

journal_title：Viruses

authors： Gopal R,Mendy A,Marinelli MA,Richwalls LJ,Seger PJ,Patel S,McHugh KJ,Rich HE,Grousd JA,Forno E,Alcorn JF

更新日期：2019-06-01 00:00:00

abstract：:Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and maintenance of genomic information in both cells and a variety of viral pathogens. While the process of dNTP biosynthesis by cellular enzymes, such as ribonucleotide reductase (RNR) and thymidine kinase (TK), has been extensively inves...

journal_title：Viruses

authors： Coggins SA,Mahboubi B,Schinazi RF,Kim B

更新日期：2020-03-31 00:00:00

abstract：:Viruses protect their genomes by enclosing them into protein capsids that sometimes contain lipid bilayers that either reside above or below the protein layer. Controlled dissociation of virions provides important information on virion composition, interactions, and stoichiometry of virion components, as well as their...

journal_title：Viruses

authors： Eskelin K,Poranen MM

更新日期：2018-10-23 00:00:00

abstract：:RNA secondary structures play diverse roles in positive-sense (+) RNA virus infections, but those located with the replication protein coding sequence can be difficult to investigate. Structures that regulate the translation of replication proteins pose particular challenges, as their potential involvement in post-tra...

journal_title：Viruses

authors： Sun R,Zhang S,Zheng L,Qu F

更新日期：2020-03-22 00:00:00

abstract：:Potato virus Y (PVY) is the most economically important virus infecting cultivated potato (Solanum tuberosum L.). Accurate diagnosis is crucial to regulate the trade of tubers and for the sanitary selection of plant material for propagation. However, high genetic diversity of PVY represents a challenge for the detecti...

journal_title：Viruses

authors： Della Bartola M,Byrne S,Mullins E

更新日期：2020-04-23 00:00:00

abstract：:Half a century of research on membrane-containing phages has had a major impact on virology, providing new insights into virus diversity, evolution and ecological importance. The recent revolutionary technical advances in imaging, sequencing and lipid analysis have significantly boosted the depth and volume of knowled...

journal_title：Viruses

authors： Mäntynen S,Sundberg LR,Oksanen HM,Poranen MM

更新日期：2019-01-18 00:00:00

abstract：:The human gut contains an expanse of largely unstudied bacteriophages. Among the most common are crAss-like phages, which were predicted to infect Bacteriodetes hosts. CrAssphage, the first crAss-like phage to be discovered, contains a protein encoding a Bacteroides-associated carbohydrate-binding often N-terminal (BA...

journal_title：Viruses

authors： Jonge PA,Meijenfeldt FABV,Rooijen LEV,Brouns SJJ,Dutilh BE

更新日期：2019-11-21 00:00:00

abstract：:The RNA3 species of the beet necrotic yellow vein virus (BNYVV), a multipartite positive-stranded RNA phytovirus, contains the 'core' nucleotide sequence required for its systemic movement in Beta macrocarpa. Within this 'core' sequence resides a conserved "coremin" motif of 20 nucleotides that is absolutely essential...

journal_title：Viruses

authors： Flobinus A,Chevigny N,Charley PA,Seissler T,Klein E,Bleykasten-Grosshans C,Ratti C,Bouzoubaa S,Wilusz J,Gilmer D

更新日期：2018-03-19 00:00:00

abstract：:Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in m...

journal_title：Viruses

authors： Warfield KL,Barnard DL,Enterlein SG,Smee DF,Khaliq M,Sampath A,Callahan MV,Ramstedt U,Day CW

更新日期：2016-03-07 00:00:00

abstract：:Enteroviruses, the most common human viral pathogens worldwide, have been associated with serous meningitis, encephalitis, syndrome of acute flaccid paralysis, myocarditis and the onset of diabetes type 1. In the future, the rapid identification of the etiological agent would allow to adjust the therapy promptly and t...

journal_title：Viruses

authors： Krasota A,Loginovskih N,Ivanova O,Lipskaya G

更新日期：2016-01-06 00:00:00

abstract：:Hepatitis delta virus (HDV) is currently only found in humans and is a satellite virus that depends on hepatitis B virus (HBV) envelope proteins for assembly, release, and entry. Using meta-transcriptomics, we identified the genome of a novel HDV-like agent in ducks. Sequence analysis revealed secondary structures tha...

journal_title：Viruses

authors： Wille M,Netter HJ,Littlejohn M,Yuen L,Shi M,Eden JS,Klaassen M,Holmes EC,Hurt AC

更新日期：2018-12-17 00:00:00

abstract：:Human enteroviruses (HEV), especially coxsackievirus serotype B (CVB) and echovirus (E), have been associated with diseases of both the exocrine and endocrine pancreas, but so far evidence on HEV infection in human pancreas has been reported only in islets and ductal cells. This study aimed to investigate the capabili...

journal_title：Viruses

authors： Sarmiento L,Frisk G,Anagandula M,Hodik M,Barchetta I,Netanyah E,Cabrera-Rode E,Cilio CM

更新日期：2017-01-30 00:00:00

abstract：:Astroviruses (AstVs) cause disease in a wide variety of species. Porcine AstVs are highly genetically diverse and conventionally assigned to five genetic lineages (PoAstV1-5). Due to the increasing evidence that porcine astrovirus type 3 (PoAstV3) is a cause of encephalomyelitis in swine and to elucidate important eco...

journal_title：Viruses

authors： Rawal G,Ferreyra FM,Macedo NR,Bradner LK,Harmon KM,Allison G,Linhares DCL,Arruda BL

更新日期：2020-09-07 00:00:00