Abstract：
:The genomes of polyomaviruses are characterized by their tripartite organization with an early region, a late region and a noncoding control region (NCCR). The early region encodes proteins involved in replication and transcription of the viral genome, while expression of the late region generates the capsid proteins. Transcription regulatory sequences for expression of the early and late genes, as well as the origin of replication are encompassed in the NCCR. Cell tropism of polyomaviruses not only depends on the appropriate receptors on the host cell, but cell-specific expression of the viral genes is also governed by the NCCR. Thus far, 15 polyomaviruses have been isolated from humans, though it remains to be established whether all of them are genuine human polyomaviruses (HPyVs). The sequences of the NCCR of these HPyVs show high genetic variability and have been best studied in the human polyomaviruses BK and JC. Rearranged NCCRs in BKPyV and JCPyV, the first HPyVs to be discovered approximately 30 years ago, have been associated with the pathogenic properties of these viruses in nephropathy and progressive multifocal leukoencephalopathy, respectively. Since 2007, thirteen novel PyVs have been isolated from humans: KIPyV, WUPyV, MCPyV, HPyV6, HPyV7, TSPyV, HPyV9, HPyV10, STLPyV, HPyV12, NJPyV, LIPyV and QPyV. This review describes all NCCR variants of the new HPyVs that have been reported in the literature and discusses the possible consequences of NCCR diversity in terms of promoter strength, putative transcription factor binding sites and possible association with diseases.
journal_name
Virusesjournal_title
Virusesauthors
Moens U,Prezioso C,Pietropaolo Vdoi
10.3390/v12121406subject
Has Abstractpub_date
2020-12-07 00:00:00issue
12issn
1999-4915pii
v12121406journal_volume
12pub_type
杂志文章,评审相关文献
Viruses-Basel文献大全abstract：:Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in m...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8030071
更新日期：2016-03-07 00:00:00
abstract：:The management of chronic hepatitis B virus (CHB) infection is an area of massive unmet clinical need worldwide. In spite of the development of powerful nucleoside/nucleotide analogue (NUC) drugs, and the widespread use of immune stimulators such as interferon-alpha (IFNα) or PEGylated interferon-alpha (PEG-IFNα), sub...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12090998
更新日期：2020-09-07 00:00:00
abstract：:Peste des petits ruminants virus (PPRV) causes a contagious disease of high morbidity and mortality in global sheep and goat populations. To better control this disease and inform eradication strategies, an improved understanding of how PPRV transmission risk varies by age is needed. Our study used a piece-wise cataly...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12020186
更新日期：2020-02-07 00:00:00
abstract：:H1N1 swine influenza viruses (SIV) are prevalent in pigs globally, and occasionally emerge in humans, which raises concern about their pandemic threats. To stimulate hemagglutination (HA) of A/Swine/Guangdong/LM/2004 (H1N1) (SW/GD/04) antibody response, eukaryotic expression plasmid pCI-neo-HA was constructed and used...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v9080209
更新日期：2017-08-08 00:00:00
abstract：:Bombyx mori nuclear polyhedrosis virus (BmNPV) is an important pathogen of silkworms. Despite extensive studies in recent decades, the interaction between BmNPV and host cells is still not clearly understood. Autophagy is an intrinsic innate immune mechanism and it controls infection autonomously in virus-infected cel...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10010014
更新日期：2017-12-30 00:00:00
abstract：:The human respiratory syncytial virus (hRSV) and human Metapneumovirus (hMPV) are two of the leading etiological agents of acute lower respiratory tract infections, which constitute the main cause of mortality in infants. However, there are currently approved vaccines for neither hRSV nor hMPV. Moreover, despite the s...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12060637
更新日期：2020-06-12 00:00:00
abstract：:Seoul virus (SEOV) is a zoonotic orthohantavirus carried by black and brown rats, and can cause hemorrhagic fever with renal syndrome in humans. Human cases of SEOV virus infection have most recently been reported in the USA, United Kingdom, France and the Netherlands and were primarily associated with contact with pe...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11060531
更新日期：2019-06-07 00:00:00
abstract：:The extension of virology beyond its traditional medical, veterinary, or agricultural applications, now called environmental virology, has shown that viruses are both the most numerous and diverse biological entities on Earth. In particular, virus isolations from unicellular eukaryotic hosts (heterotrophic and photosy...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12101130
更新日期：2020-10-06 00:00:00
abstract：:We recently developed a test based on the Agilent SureSelect target enrichment system capturing genomic fragments from 191 human papillomaviruses (HPV) types for Illumina sequencing. This enriched whole genome sequencing (eWGS) assay provides an approach to identify all HPV types in a sample. Here we present a machine...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12070710
更新日期：2020-06-30 00:00:00
abstract：:Campylobacter jejuni is a frequent foodborne pathogen of humans. As C. jejuni infections commonly arise from contaminated poultry, phage treatments have been proposed to reduce the C. jejuni load on farms to prevent human infections. While a prior report documented the transcriptome of C. jejuni phages during the carr...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10060332
更新日期：2018-06-16 00:00:00
abstract：:Direct-acting antiviral drugs (DAAs) are currently replacing antiviral therapy for Hepatitis C infection. Treatment related side effects are even worse and the emergence of resistant viruses must be avoided because of the direct-antiviral action. Altogether it remains a challenge to take treatment decisions in a clini...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v4123281
更新日期：2012-12-01 00:00:00
abstract：:Arboviruses continue to be a significant global health concern. The unbiased metagenomic analyses of mosquito-borne and mosquito-specific viruses are useful to understand viral diversity and for the surveillance of pathogens of medical and veterinary importance. Metagenomic analysis was conducted on 6368 mosquitoes (7...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11030222
更新日期：2019-03-05 00:00:00
abstract：:The hepatitis B virus (HBV) represents a worldwide public health problem; the virus is present in one third of the global population. However, this rate may in fact be higher due to occult hepatitis B virus infection (OBI). This condition is characterized by the presence of the viral genome in the liver of individuals...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v6041590
更新日期：2014-04-08 00:00:00
abstract：:Avian influenza virus (AIV) is a highly diverse and widespread poultry pathogen. Itsevolution and adaptation may be affected by multiple host and ecological factors, which are stillpoorly understood. In the present study, a turkey-origin H9N2 AIV was used as a model toinvestigate the within-host diversity of the virus...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12030319
更新日期：2020-03-16 00:00:00
abstract：:Cucurbit yellow stunting disorder virus (CYSDV), a bipartite whitefly-transmitted virus, constitutes a major threat to commercial cucurbit production worldwide. Here, construction of full-length CYSDV RNA1 and RNA2 cDNA clones allowed the in vitro synthesis of RNA transcripts able to replicate in cucumber protoplasts....
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8060170
更新日期：2016-06-14 00:00:00
abstract：:Bacteriophages represent a valuable source for studying the mechanisms underlying virus-host interactions. A better understanding of the host-specificity of viruses at the molecular level can promote various phage applications, including bacterial diagnostics, antimicrobial therapeutics, and improve methods in molecul...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v7122932
更新日期：2015-11-27 00:00:00
abstract：:Chronic hepatitis C virus (HCV) infection is a major cause of liver disease and hepatocellular carcinoma (HCC)-the second leading, and rising, cause of death due to cancer world-wide [...]. ...
journal_title：Viruses
pub_type： 社论
doi：10.3390/v11050441
更新日期：2019-05-15 00:00:00
abstract：:Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis. In NSVs, the single strand RNA genome is encapsidated in the line...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v12080835
更新日期：2020-07-30 00:00:00
abstract：:Koalas (Phascolarctos cinereus) are native Australian marsupials whose populations are in decline from a range of threats. Infectious diseases caused by the bacterium Chlamydia pecorum and other pathogens are of particular concern. We analysed 26 poly-A selected RNA-sequencing libraries from a data set designed to stu...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11030211
更新日期：2019-03-02 00:00:00
abstract：:The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects almost everyone in the world in many ways. We previously predicted antivirals (atazanavir, remdesivir and lopinavir/ritonavir) and non-antiviral drugs (tiotropium and rapamycin) that may inhi...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12070776
更新日期：2020-07-20 00:00:00
abstract：:Viruses protect their genomes by enclosing them into protein capsids that sometimes contain lipid bilayers that either reside above or below the protein layer. Controlled dissociation of virions provides important information on virion composition, interactions, and stoichiometry of virion components, as well as their...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v10110579
更新日期：2018-10-23 00:00:00
abstract：:Lentiviruses are infectious agents of a number of animal species, including sheep, goats, horses, monkeys, cows, and cats, in addition to humans. As in the human case, the host immune response fails to control the establishment of chronic persistent infection that finally leads to a specific disease development. Despi...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v10080435
更新日期：2018-08-17 00:00:00
abstract：:Cotton leaf curl disease (CLCuD) is one of the most economically important diseases and is a constraint to cotton production in major producers, Pakistan and India. CLCuD is caused by monopartite plant viruses belonging to the family Geminiviridae (genus Begomovirus), in association with an essential, disease-specific...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9100280
更新日期：2017-09-29 00:00:00
abstract：:The orthopoxviruses (OPV) comprise several emerging viruses with great importance to human and veterinary medicine, including vaccinia virus (VACV), which causes outbreaks of bovine vaccinia (BV) in South America. Historically, VACV is the most comprehensively studied virus, however, its origin and natural hosts remai...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v9110340
更新日期：2017-11-15 00:00:00
abstract：:Porcine circovirus 3 (PCV3) has been identified as a putative swine pathogen with a subset of infections resulting in stillborn and mummified fetuses, encephalitis and myocarditis in perinatal, and periarteritis in growing pigs. Three PCV3 isolates were isolated from weak-born piglets or elevated stillborn and mummifi...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12020219
更新日期：2020-02-16 00:00:00
abstract：:With the availability of an increasing number of 3D structures of bacteriophage components, combined with powerful in silico predictive tools, it has become possible to decipher the structural assembly and functionality of phage adhesion devices. In the current study, we examined 113 members of the 936 group of lactoc...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v11070631
更新日期：2019-07-09 00:00:00
abstract：:Viral codon usage bias may be the product of a number of synergistic or antagonistic factors, including genomic nucleotide composition, translational selection, genomic architecture, and mutational or repair biases. Most studies of viral codon bias evaluate only the relative importance of genomic base composition and ...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v5010162
更新日期：2013-01-15 00:00:00
abstract：:Bovine rotavirus A (RVA), a major causative pathogen of diarrhea in dairy and Japanese beef calves, has led to severe economic losses in numerous countries. A dual genotyping system based on genomic segments encoding VP7 (G genotype) and VP4 (P genotype), comprising the outer layer of the virion, has been used to unde...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v12121386
更新日期：2020-12-03 00:00:00
abstract：:The chikungunya virus (CHIKV) is an emerging pathogen with widespread distribution in regions of Africa, India, and Asia that threatens to spread into temperate climates with the introduction of its major vector, Aedes albopictus. CHIKV causes a disease frequently misdiagnosed as dengue fever, with potentially life-th...
journal_title：Viruses
pub_type： 杂志文章
doi：10.3390/v8060163
更新日期：2016-06-10 00:00:00
abstract：:Small ruminant lentiviruses include members that infect sheep (ovine lentivirus [OvLV]; also known as ovine progressive pneumonia virus/maedi-visna virus) and goats (caprine arthritis encephalitis virus [CAEV]). Breed differences in seroprevalence and proviral concentration of OvLV had suggested a strong genetic compo...
journal_title：Viruses
pub_type： 杂志文章,评审
doi：10.3390/v5061466
更新日期：2013-06-14 00:00:00
