Abstract:
:The complete sequence and genome organization of a novel Endornavirus from the hypovirulent strain GD-2 of Rhizoctonia solani AG-1 IA, the causal agent of rice sheath blight, were identified using a deep sequencing approach and it was tentatively named as Rhizoctonia solani endornavirus 1 (RsEV1). It was composed of only one segment that was 19,936 bp in length and was found to be the longest endornavirus genome that has been reported so far. The RsEV1 genome contained two open reading frames (ORFs): ORF1 and ORF2. ORF1 contained a glycosyltransferase 1 domain and a conserved RNA-dependent RNA polymerase domain, whereas ORF2 encoded a conserved hypothetical protein. Phylogenetic analysis revealed that RsEV1 was phylogenetically a new endogenous RNA virus. A horizontal transmission experiment indicated that RsEV1 could be transmitted from the host fungal strain GD-2 to a virulent strain GD-118P and resulted in hypovirulence in the derivative isogenic strain GD-118P-V1. Metabolomic analysis showed that 32 metabolites were differentially expressed between GD-118P and its isogenic hypovirulent strain GD-118P-V1. The differential metabolites were mainly classified as organic acids, amino acids, carbohydrates, and the intermediate products of energy metabolism. Pathway annotation revealed that these 32 metabolites were mainly involved in pentose and glucuronate interconversions and glyoxylate, dicarboxylate, starch, and sucrose metabolism, and so on. Taken together, our results showed that RsEV1 is a novel Endornavirus, and the infection of virulent strain GD-118P by RsEV1 caused metabolic disorders and resulted in hypovirulence. The results of this study lay a foundation for the biocontrol of rice sheath blight caused by R. solani AG1-IA.
journal_name
Virusesjournal_title
Virusesauthors
Zheng L,Shu C,Zhang M,Yang M,Zhou Edoi
10.3390/v11020178subject
Has Abstractpub_date
2019-02-20 00:00:00issue
2issn
1999-4915pii
v11020178journal_volume
11pub_type
杂志文章相关文献
Viruses-Basel文献大全abstract::Short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that analysis of telomere length (TL) in human T-cell lymphotropic virus (HTLV) infection and HTLV-associated neuropathy might provide clues to the etiology of HTLV-associated disease and viral dynamics. A subset of 45 human T-...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8080221
更新日期:2016-08-11 00:00:00
abstract::The orthopoxviruses (OPV) comprise several emerging viruses with great importance to human and veterinary medicine, including vaccinia virus (VACV), which causes outbreaks of bovine vaccinia (BV) in South America. Historically, VACV is the most comprehensively studied virus, however, its origin and natural hosts remai...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9110340
更新日期:2017-11-15 00:00:00
abstract::Around 257 million people are living with hepatitis B virus (HBV) chronic infection and 71 million with hepatitis C virus (HCV) chronic infection. Both HBV and HCV infections can lead to liver complications such as cirrhosis and hepatocellular carcinoma (HCC). To take care of these chronically infected patients, one s...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12121440
更新日期:2020-12-14 00:00:00
abstract::Usutu virus (USUV) is a neurotropic flavivirus closely related to West Nile virus (WNV). Its enzootic cycle mainly involves mosquitoes and birds. Human infection can occur with occasional, but sometimes severe, neurological complications. Since its emergence and spread in Europe over the last two decades, USUV has bee...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12020164
更新日期:2020-01-31 00:00:00
abstract::Highly pathogenic avian influenza (HPAI) and Newcastle disease are economically important avian diseases worldwide. Effective vaccination is critical to control these diseases in poultry. Live attenuated Newcastle disease virus (NDV) vectored vaccines have been developed for bivalent vaccination against HPAI viruses a...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v11030300
更新日期:2019-03-26 00:00:00
abstract::The virion proteins of Kaposi sarcoma-associated herpesvirus (KSHV) were initially characterized in 2005 in two separate studies that combined the detection of 24 viral proteins and a few cellular components via LC-MS/MS or MALDI-TOF. Despite considerable advances in the sensitivity and specificity of mass spectrometr...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12121382
更新日期:2020-12-02 00:00:00
abstract::Infection with Hepatitis C Virus (HCV) causes chronic disease in approximately 80% of cases, resulting in chronic inflammation and cirrhosis. Current treatments are not completely effective, and a vaccine has yet to be developed. Spontaneous resolution of infection is associated with effective host adaptive immunity t...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4010001
更新日期:2012-01-01 00:00:00
abstract::Negative strand RNA viruses (NSVs) include many important human pathogens, such as influenza virus, Ebola virus, and rabies virus. One of the unique characteristics that NSVs share is the assembly of the nucleocapsid and its role in viral RNA synthesis. In NSVs, the single strand RNA genome is encapsidated in the line...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v12080835
更新日期:2020-07-30 00:00:00
abstract::Herpesviridae comprise a large family of enveloped DNA viruses all of whom employ orthologs of the same three glycoproteins, gB, gH and gL. Additionally, herpesviruses often employ accessory proteins to bind receptors and/or bind the heterodimer gH/gL or even to determine cell tropism. Sorting out how these proteins f...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4050800
更新日期:2012-05-01 00:00:00
abstract::Interferon (IFN) regulatory factor 3 (IRF3) is the key transcription factor for the induction of IFN and antiviral genes. The absence of antiviral genes in IRF3 deficiency leads to susceptibility to a wide range of viral infections. Previously, we uncovered a function for nontranscriptional IRF3 (nt-IRF3), RLR (RIG-I-...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040442
更新日期:2020-04-14 00:00:00
abstract::Small ruminant lentiviruses include members that infect sheep (ovine lentivirus [OvLV]; also known as ovine progressive pneumonia virus/maedi-visna virus) and goats (caprine arthritis encephalitis virus [CAEV]). Breed differences in seroprevalence and proviral concentration of OvLV had suggested a strong genetic compo...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v5061466
更新日期:2013-06-14 00:00:00
abstract::Potato virus Y (PVY) is the most economically important virus infecting cultivated potato (Solanum tuberosum L.). Accurate diagnosis is crucial to regulate the trade of tubers and for the sanitary selection of plant material for propagation. However, high genetic diversity of PVY represents a challenge for the detecti...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12040478
更新日期:2020-04-23 00:00:00
abstract::African swine fever (ASF) is a lethal hemorrhagic disease of swine caused by a double-stranded DNA virus, ASF virus (ASFV). There is no vaccine to prevent the disease and current control measures are limited to culling and restricting animal movement. Swine infected with attenuated strains are protected against challe...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8100291
更新日期:2016-10-22 00:00:00
abstract::Viruses protect their genomes by enclosing them into protein capsids that sometimes contain lipid bilayers that either reside above or below the protein layer. Controlled dissociation of virions provides important information on virion composition, interactions, and stoichiometry of virion components, as well as their...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10110579
更新日期:2018-10-23 00:00:00
abstract::The non-structural protein NSs of the Phenuiviridae family members appears to have a role in the host immunity escape. The stability of Toscana virus (TOSV) NSs protein was tested by a cycloheximide (CHX) chase approach on cells transfected with NSs deleted versions fused to a reporter gene. The presence of intrinsica...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12101153
更新日期:2020-10-12 00:00:00
abstract::Andes orthohantavirus (ANDV) is an important human pathogen causing hantavirus cardiopulmonary syndrome (HCPS) with a fatality rate of 30% in Chile. Around 60% of all cases have a severe clinical course, while the others have a mild clinical course. The main goal of this study was to understand if the genetic variatio...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11080680
更新日期:2019-07-25 00:00:00
abstract::Due to the emergence of non-endemic mosquito vectors and the recent outbreaks of mosquito-borne diseases, mosquito-borne pathogens are considered an increasing risk to public and animal health in Europe. To obtain a status quo regarding mosquito-borne viruses and their vectors in Germany, 97,648 mosquitoes collected f...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10070389
更新日期:2018-07-23 00:00:00
abstract::Temperate bacteriophages possess a molecular switch, which regulates the lytic and lysogenic growth. The genomes of the temperate telomere phages N15, PY54 and ɸKO2 harbor a primary immunity region (immB) comprising genes for the prophage repressor, the lytic repressor and a putative antiterminator. The roles of these...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v7062746
更新日期:2015-06-02 00:00:00
abstract::Ringspot symptoms in European mountain ash (Sorbus aucuparia L.), fig mosaic, rose rosette, raspberry leaf blotch, pigeonpea sterility mosaic (Cajanus cajan) and High Plains disease of maize and wheat were found to be associated with viruses that share several characteristics. They all have single-stranded multipartit...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v4091515
更新日期:2012-09-01 00:00:00
abstract::Viral infection of different cell types induces a unique spectrum of host defence genes, including interferon-stimulated genes (ISGs) and genes encoding other proteins with antiviral potential. Although hundreds of ISGs have been described, the vast majority have not been functionally characterised. Cellular proteins ...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9120376
更新日期:2017-12-07 00:00:00
abstract::Human coronaviruses cause both upper and lower respiratory tract infections in humans. In 2012, a sixth human coronavirus (hCoV) was isolated from a patient presenting with severe respiratory illness. The 60-year-old man died as a result of renal and respiratory failure after admission to a hospital in Jeddah, Saudi A...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v10020093
更新日期:2018-02-24 00:00:00
abstract::Environmental genomics can describe all forms of organisms--cellular and viral--present in a community. The analysis of such eco-systems biology data relies heavily on reference databases, e.g., taxonomy or gene function databases. Reference databases of symbiosis sensu lato, although essential for the analysis of org...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8030066
更新日期:2016-03-01 00:00:00
abstract::Rabies is a viral infection that targets the nervous system, specifically neurons. The clinical manifestations of the disease are dramatic and their outcome fatal; paradoxically, conventional histopathological descriptions reveal only subtle changes in the affected nervous tissue. Some researchers have considered that...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10030112
更新日期:2018-03-06 00:00:00
abstract::Rabies is a highly fatal zoonotic disease which is primarily caused by rabies virus (RABV) although other members of the genus Lyssavirus can cause rabies as well. As yet, 14 serologically and genetically diverse lyssaviruses have been identified, mostly in bats. To assess the quality of rabies vaccines and immunoglob...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v8090254
更新日期:2016-09-16 00:00:00
abstract::Equine influenza, caused by the H3N8 subtype, is a highly contagious respiratory disease affecting equid populations worldwide and has led to serious epidemics and transboundary pandemics. This study describes the phylogenetic characterization and replication kinetics of recently-isolated H3N8 virus from a nasal swab ...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v10010031
更新日期:2018-01-11 00:00:00
abstract::Feline immunodeficiency virus (FIV) is a naturally occurring T-cell tropic lentiviral disease of felids with many similarities to HIV/AIDS in humans. Similar to primate lentiviral-host interactions, feline APOBEC3 (A3) has been shown to inhibit FIV infection in a host-specific manner and feline A3 degradation is media...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11090831
更新日期:2019-09-07 00:00:00
abstract::In response to viral infection, host cells activate various antiviral responses to inhibit virus replication. While feline herpesvirus 1 (FHV-1) manipulates the host early innate immune response in many different ways, the host could activate the antiviral response to counteract it through some unknown mechanisms. Mic...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12010002
更新日期:2019-12-18 00:00:00
abstract::The extension of virology beyond its traditional medical, veterinary, or agricultural applications, now called environmental virology, has shown that viruses are both the most numerous and diverse biological entities on Earth. In particular, virus isolations from unicellular eukaryotic hosts (heterotrophic and photosy...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v12101130
更新日期:2020-10-06 00:00:00
abstract::Thermobifida fusca is of biotechnological interest due to its ability to produce an array of plant cell wall hydrolytic enzymes. Nonetheless, only one T. fusca bacteriophage with genome information has been reported to date. This study was aimed at discovering more relevant bacteriophages to expand the existing knowle...
journal_title:Viruses
pub_type: 杂志文章
doi:10.3390/v11111042
更新日期:2019-11-08 00:00:00
abstract::The Flaviviridae family comprises a number of human pathogens, which, although sharing structural and functional features, cause diseases with very different outcomes. This can be explained by the plurality of functions exerted by the few proteins coded by viral genomes, with some of these functions shared among membe...
journal_title:Viruses
pub_type: 杂志文章,评审
doi:10.3390/v9030042
更新日期:2017-03-13 00:00:00