abstract：INTRODUCTION:Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet aut...

journal_title：Autoimmunity

authors： Bossowski A,Stożek K,Rydzewska M,Niklińska W,Gąsowska M,Polnik D,Szalecki M,Mikłosz A,Chabowski A,Reszeć J

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical features of AIHA/ES patients with clonal Ig/TCR gene rearrangement. METHODS:Ig/TCR gene rearrangements were measured by BIOMED-2 PCR. 44 primary AIHA/ES patients were enrolled in the study. Clinical characteristics were analyzed and compared between patients with and without clona...

journal_title：Autoimmunity

authors： Zhu H,Zhao M,Cao Z,Yang J,Li Y,Xing L

更新日期：2020-11-01 00:00:00

abstract：:Pre-diabetes is a long-lasting condition that precedes type 2 diabetes (T2D). T2D has been shown to suppress the immune response. However, it remains unclear if immune activation occurs before the onset of T2D during the progression of the pre-diabetic state. This study sought to characterize the changes in general im...

journal_title：Autoimmunity

authors： Mzimela NC,Ngubane PS,Khathi A

更新日期：2019-02-01 00:00:00

abstract：:Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the...

journal_title：Autoimmunity

authors： Rego SL,Harvey S,Simpson SR,Hemphill WO,McIver ZA,Grayson JM,Perrino FW

更新日期：2018-11-01 00:00:00

abstract：:Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause t...

journal_title：Autoimmunity

authors： Mauney CH,Hollis T

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Autoimmune diseases, such as celiac disease (CD) and diabetes mellitus type 1, tend to co-occur within the same patient. The prevalence of CD in diabetic children is higher than in the general population, and is estimated to be 0.6-16.4%. The diagnosis of CD is based on histopathological examination and se...

journal_title：Autoimmunity

authors： Lewandowska K,Ciepiela O,Szypowska A,Wyhowski J,Głodkowska-Mrówka E,Popko K,Ostafin M,Pyrżak B,Demkow U

更新日期：2018-03-01 00:00:00

abstract：INTRODUCTION:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus. As murine models of LN are valuable tools to better understand its pathophysiology and to search for new effective treatments, we investigated the effects of the bioflavonoid quercetin on pristane-induced LN mice ...

journal_title：Autoimmunity

authors： Dos Santos M,Poletti PT,Favero G,Stacchiotti A,Bonomini F,Montanari CC,Bona SR,Marroni NP,Rezzani R,Veronese FV

更新日期：2018-03-01 00:00:00

abstract：:To investigate the expression patterns of activation-induced cytidine deaminase (AID) variants in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and examine their clinical implications, we isolated PBMCs from healthy controls (HC, n = 33) and patients with AS (n = 62), and meas...

journal_title：Autoimmunity

authors： Kim JY,Yoon HK,Song ST,Park SR,Shim SC

更新日期：2017-12-01 00:00:00

abstract：:Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. It is characterized by frequent re...

journal_title：Autoimmunity

authors： Kujur W,Gurram RK,Maurya SK,Nadeem S,Chodisetti SB,Khan N,Agrewala JN

更新日期：2017-08-01 00:00:00

abstract：:Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and n...

journal_title：Autoimmunity

authors： Khan MA,Alam K,Hassan SM,Rizvi MMA

更新日期：2017-06-01 00:00:00

abstract：:The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients,...

journal_title：Autoimmunity

authors： Dar SA,Haque S,Mandal RK,Singh T,Wahid M,Jawed A,Panda AK,Akhter N,Lohani M,Areeshi MY,Rai G,Datt S,Bhattacharya SN,Ramachandran VG,Das S

更新日期：2017-05-01 00:00:00

abstract：:Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs). Prognosis of AITDs varies in each patient. Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production of proinflammatory cytokines. UNC93B1 is a transcription factor ...

journal_title：Autoimmunity

authors： Inoue N,Katsumata Y,Watanabe M,Ishido N,Manabe Y,Watanabe A,Masutani R,Hidaka Y,Iwatani Y

更新日期：2017-05-01 00:00:00

abstract：:Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore,...

journal_title：Autoimmunity

authors： Sarter K,Kulagin M,Schett G,Harris NL,Zaiss MM

更新日期：2017-05-01 00:00:00

abstract：:Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first time serum DNase1-activity in a large consecutive cohort of treatment-naïve patients with autoimmune...

journal_title：Autoimmunity

authors： Gatselis NK,Vakrakou AG,Zachou K,Androutsakos T,Azariadis K,Hatzis G,Manoussakis MN,Dalekos GN

更新日期：2017-03-01 00:00:00

abstract：:Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on quality of life and can be life threatening. Rupture of vulnerable ath...

journal_title：Autoimmunity

authors： Kyaw T,Tipping P,Bobik A,Toh BH

更新日期：2017-02-01 00:00:00

abstract：:Dicer and Drosha are RNase III enzymes that are necessary for the biogenesis of most miRNAs. However, there are no reports on the association of Dicer and Drosha with the pathogenesis of autoimmune thyroid disease (AITD). We genotyped DICER rs3742330A/G and rs1057035T/C as well as DROSHA rs644236C/T and rs10719C/T pol...

journal_title：Autoimmunity

authors： Saeki M,Watanabe M,Inoue N,Tokiyoshi E,Takuse Y,Arakawa Y,Hidaka Y,Iwatani Y

更新日期：2016-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE patients and contr...

journal_title：Autoimmunity

authors： Paradowska-Gorycka A,Sowinska A,Stypinska B,Grobelna MK,Walczyk M,Olesinska M,Piotrowski P,Jagodziński PP

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:T follicular helper (Tfh) cells are known to regulate humoral immune response. In this study we examined the correlation of different subsets of peripheral blood Tfh cells in patients with diabetic nephropathy (DN). METHODS:A total of 23 DN patients and 15 healthy controls (HC) were investigated for various...

journal_title：Autoimmunity

authors： Zhang N,Tai J,Qu Z,Zhang Z,Zhao S,He J,Zhang S,Jiang Y

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to characterise the functionally relevant minor lymphocyte subpopulations in whole blood of multiple sclerosis (MS) patients and their potential utility as biomarkers for treatment follow up. MATERIAL AND METHODS:Peripheral blood from 40 healthy donors (HD) and 66 MS patients [...

journal_title：Autoimmunity

authors： Teniente-Serra A,Grau-López L,Mansilla MJ,Fernández-Sanmartín M,Ester Condins A,Ramo-Tello C,Martínez-Cáceres E

更新日期：2016-06-01 00:00:00

abstract：:The effects of intravenous immunoglobulin (IVIG) products were recently examined in patients with Alzheimer's disease (AD). Although encouraging results were obtained in pilot studies, later trials produced negative results. The rationale for these studies was that IVIG contains antibodies to amyloid-beta (Aβ). Howeve...

journal_title：Autoimmunity

authors： Loeffler DA,Klaver AC,Coffey MP

更新日期：2015-06-01 00:00:00

abstract：:Glucocorticoids (GCs) strongly impact on different T cell subsets inducing generally immunosuppressive effects, whereas much less is known about the effect of GC on natural killer (NK) cells. The aims of this study were to investigate the effects of GC on T cell functions, including T cell-mediated anti-tumor immune r...

journal_title：Autoimmunity

authors： Yakimchuk K,Chen L,Hasni MS,Okret S,Jondal M

更新日期：2015-03-01 00:00:00

abstract：:The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...

journal_title：Autoimmunity

authors： Otani Y,Ichii O,Otsuka-Kanazawa S,Chihara M,Nakamura T,Kon Y

更新日期：2015-01-01 00:00:00

abstract：:Blockade of the complement cascade at the C5a/C5a receptor (C5aR)-axis is believed to be an attractive treatment avenue in rheumatoid arthritis (RA). However, the effects of such interventions during the early phases of arthritis remain to be clarified. In this study we use the murine delayed-type hypersensitivity art...

journal_title：Autoimmunity

authors： Atkinson SM,Nansen A,Usher PA,Sondergaard BC,Mackay CR,Friedrichsen B,Chang CC,Tang R,Skov S,Haase C,Hornum L

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Autoimmune polyendocrine syndrome type 1 (APS 1) is caused by mutations in the AIRE gene that induce intrathymic T-cell tolerance breakdown, which results in tissue-specific autoimmune diseases. DESIGN:To evaluate the effect of a well-defined T-cell repertoire impairment on humoral self-reactive fingerprints...

journal_title：Autoimmunity

authors： Dubucquoi S,Proust-Lemoine E,Kemp EH,Ryndak A,Lefèvre-Dutoit V,Bellart M,Saugier-Véber P,Duban-Deweer S,Wémeau JL,Prin L,Lefranc D

更新日期：2015-01-01 00:00:00

abstract：:Chronic immune thrombocytopenia (ITP) is characterized by autoimmune-mediated platelet destruction and impairment of thrombopoiesis. Mesenchymal stem cells (MSCs) are proposed to exhibit immune modulatory functions in self-tolerance maintenance. In this study, we aimed to characterize phenotypically and functionally b...

journal_title：Autoimmunity

authors： Zhang D,Li H,Ma L,Zhang X,Xue F,Zhou Z,Chi Y,Liu X,Huang Y,Yang Y,Yang R

更新日期：2014-12-01 00:00:00

abstract：:Chronic autoimmune thyroiditis (cAIT) leads to hypothyroidism due to T cell-mediated cytotoxicity in most cases. By contrast, Graves' disease (GD) with thyrotropin receptor stimulatory autoantibodies cause hyperthyroidism. Cytokines play a crucial role in modulating immune response in both disorders. The aim of study ...

journal_title：Autoimmunity

authors： Mikos H,Mikos M,Rabska-Pietrzak B,Niedziela M

更新日期：2014-11-01 00:00:00

abstract：:The G to A transition at position +1057 single nucleotide polymorphism site in CD86 gene results in the alanine to threonine substitution, which further affects the antigen-presenting cells' signal transduction. Thus, the purpose of this study was to determine the association between CD86 +1057G/A polymorphism and the...

journal_title：Autoimmunity

authors： Wu P,Wang Z,Lu S,Zhao X

更新日期：2014-11-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) have a significantly increased risk of cardiovascular disease (CVD). Increased prevalence of atherosclerosis may explain part of this enhanced risk, but SLE related CVD can also result from other mechanisms. Vascular events may be the result of several pathophysiologic ...

journal_title：Autoimmunity

authors： Gustafsson JT,Svenungsson E

更新日期：2014-03-01 00:00:00

abstract：:Immune profiling of non-obese diabetic (NOD) is a widely employed tool to assess the mechanisms of inflammatory insulitis. Our analysis of the female NOD colony revealed similar distribution of lymphoid lineages to wild type mice, and at various ages of prediabetic and diabetic mice. The profiles of mesenteric and pan...

journal_title：Autoimmunity

authors： Kaminitz A,Mizrahi K,Askenasy N

更新日期：2014-03-01 00:00:00

abstract：AIM:To assess the relationship of the Interleukin-10 (IL-10) -1082G/A (rs1800896), -819C/T (rs1800871) and -592C/A (rs1800872) polymorphism with inflammatory bowel disease (IBD) by means of meta-analysis. METHODS:Published data addressing the association between polymorphism of the IL-10 with Crohn's disease (CD) and ...

journal_title：Autoimmunity

authors： Zou L,Wang L,Gong X,Zhao H,Jiang A,Zheng S

更新日期：2014-02-01 00:00:00

abstract：:In the 1950s, the discovery of autoantibodies produced by B cells seemed to provide a compelling mechanism underlying autoimmune diseases. The discovery of T regulatory cells and other T helper cell subsets shifted the field back towards a T cell central view. The success of rituxan, a chimeric mAb targeting CD20 on B...

journal_title：Autoimmunity

authors： Luu VP,Vazquez MI,Zlotnik A

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:To study efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients. METHODS:The case records of 40 patients with lupus nephritis followed up in a single center between 1992 and 2011 (median duration = 8.37 years) were retrieved to determine efficacy and toxicity of the treat...

journal_title：Autoimmunity

authors： Bozzolo EP,Ramirez GA,Bonavida G,Lanzani C,Scotti R,Dell'antonio G,Baldissera E,Canti V,Manfredi AA,Rovere-Querini P,Sabbadini MG

更新日期：2013-12-01 00:00:00

abstract：:The objective of this study was to research the functionality of anti-endothelial cell antibodies (AECA) in pulmonary arterial hypertension (PAH) by assessing the effects of IgG from AECA-positive PAH patients on the induction of adhesion molecules on human umbilical vein endothelial cells (HUVECs) and on the producti...

journal_title：Autoimmunity

authors： Arends SJ,Damoiseaux JG,Duijvestijn AM,Debrus-Palmans L,Boomars KA,Brunner-La Rocca HP,Cohen Tervaert JW,van Paassen P

更新日期：2013-11-01 00:00:00

abstract：:Autoantibodies directed against nuclear antigens often arise in autoimmune disease associated with the failure to clear apoptotic cells in a swift and timely manner. Nucleic acids present in apoptotic cells and in membranous microparticles derived thereof exert adjuvant activity in the immune response to apoptosis. Th...

journal_title：Autoimmunity

authors： Bekeredjian-Ding I

更新日期：2013-08-01 00:00:00

abstract：:Human C-reactive protein (CRP) and serum amyloid component P (SAP) are well-characterised ligands for dying and dead cells, while facets of their physiological function still need to be unravelled. We partially characterised CRP and SAP from different species with similar acute-phase systems. Human, rabbit and porcine...

journal_title：Autoimmunity

authors： Mattecka S,Bock C,Vogt B,Yapici G,Schrödl W,Janko C,Schindler R,Sheriff A

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in Euro...

journal_title：Autoimmunity

authors： Muro Y,Sugiura K,Akiyama M

更新日期：2013-06-01 00:00:00

abstract：:Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/...

journal_title：Autoimmunity

authors： Saito K,Mori S,Date F,Ono M

更新日期：2013-06-01 00:00:00

abstract：:In a previous study, we showed that the Ly6G(-)CD11b(+) blood monocytes residing in naïve mice are intrinsically immunosuppressive and that loss of this suppressive function may contribute to the development of autoimmunity in experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis....

journal_title：Autoimmunity

authors： Slaney CY,Toker A,Fraser JD,Harper JL,Bäckström BT

更新日期：2013-06-01 00:00:00

abstract：:The autoimmune thyroid disorders, or AITDs, comprise 2 related disorders, Graves' disease and Hashimoto thyroiditis. In AITD, immune system produces antibodies against autothyroid antigens. The etiology of AITDs involves a complex interaction between genetic predisposing factors and environmental triggering factors. V...

journal_title：Autoimmunity

authors： Alkhateeb A,Jarun Y,Tashtoush R

更新日期：2013-05-01 00:00:00

abstract：:Zinc transporter 8 (ZnT8), a product of the SLC30A8 gene, is a target-antigen in autoimmune diabetes. Associations between ZnT8 antibody (ZnT8A), phenotype and the genetic variant rs13266634 in the SLC30A8 gene have primarily been studied in patients with young-onset diabetes. We explored such associations in adult-on...

journal_title：Autoimmunity

authors： Sørgjerd EP,Skorpen F,Kvaløy K,Midthjell K,Grill V

更新日期：2013-02-01 00:00:00