Nitration of H2B histone elicits an immune response in experimental animals.

abstract：:We have previously derived and identified a highly avid monoclonal IgM rheumatoid factor (mRF), C6, from unstimulated rheumatoid synovial cells (RSC). At the time, the closet VH germline gene, VH26, demonstrated only 88% homology with C6. To identify the germline counterpart of C6, genomic DNA from the same rheumatoid...

journal_title：Autoimmunity

authors： Wong A,Tait R,Kenny T,Gorin F,Robbins D

更新日期：1995-01-01 00:00:00

abstract：:Various amounts of the bacterium, Brucella abortus (BA) were injected intravenously into autoimmune NZB/W F1 mice and non-autoimmune BDF1 mice and then the localization of BA in the thymus was traced using an immunohistochemical method at 30 min and 3 h after injection. The results showed that a greater amount of BA b...

journal_title：Autoimmunity

authors： Ohmori J,Miyakawa K,Matsuno K,Kotani M

更新日期：1991-01-01 00:00:00

abstract：:The immunomodulatory effects of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) have been elucidated at a cellular level and implicated in the pathogenesis of several complex diseases. Defects within the regulatory T cell compartment are one of the characteristics of primary biliary cirrhosis (PBC...

journal_title：Autoimmunity

authors： Oertelt-Prigione S,Mao TK,Selmi C,Tsuneyama K,Ansari AA,Coppel RL,Invernizzi P,Podda M,Gershwin ME

更新日期：2008-02-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM), celiac disease (CD) and autoimmune thyroid disease (ATD) are autoimmune conditions relatively common in paediatric age and frequently occur in association in the same subject. This event is not by chance and requires an explanation. Here, we studied the distribution of HLA-DQ αβ hetero...

journal_title：Autoimmunity

authors： Larizza D,Calcaterra V,Klersy C,Badulli C,Caramagna C,Ricci A,Brambilla P,Salvaneschi L,Martinetti M

更新日期：2012-09-01 00:00:00

abstract：:Dicer and Drosha are RNase III enzymes that are necessary for the biogenesis of most miRNAs. However, there are no reports on the association of Dicer and Drosha with the pathogenesis of autoimmune thyroid disease (AITD). We genotyped DICER rs3742330A/G and rs1057035T/C as well as DROSHA rs644236C/T and rs10719C/T pol...

journal_title：Autoimmunity

authors： Saeki M,Watanabe M,Inoue N,Tokiyoshi E,Takuse Y,Arakawa Y,Hidaka Y,Iwatani Y

更新日期：2016-12-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) have a significantly increased risk of cardiovascular disease (CVD). Increased prevalence of atherosclerosis may explain part of this enhanced risk, but SLE related CVD can also result from other mechanisms. Vascular events may be the result of several pathophysiologic ...

journal_title：Autoimmunity

authors： Gustafsson JT,Svenungsson E

更新日期：2014-03-01 00:00:00

abstract：:Proteinase 3 (PR3)-specific antineutrophil cytoplasmic autoantibodies (PR3-ANCA) recognize conformational epitopes on PR3. This study evaluates PR3-ANCA target epitopes utilizing a novel recombinant PR3 (rPR3) produced to accommodate manipulations of the N-terminal domain. The rPR3 molecule contains an N-terminus six ...

journal_title：Autoimmunity

authors： Farrag L,Pendergraft WF 3rd,Yang JJ,Jennette JC,Falk RJ,Preston GA

更新日期：2007-11-01 00:00:00

abstract：:The present study investigated the expressed number of CR1 on erythrocytes (E) in relationship of the CR1 density genotype from 46 patients with systemic lupus erythematosus (SLE) and 47 healthy volunteers. The CR1 genotype was determined by a method based on polymerase chain reaction (PCR) amplification of the genomi...

journal_title：Autoimmunity

authors： Kiss E,Csipö I,Cohen JH,Reveil B,Kávai M,Szegedi G

更新日期：1996-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the dysfunction of T cells, B cells, and dendritic cells and by the production of antinuclear autoantibodies. This editorial provides a synopsis of newly discovered genetic factors and signaling pathways in lupus pathogenesis that ar...

journal_title：Autoimmunity

authors： Perl A

更新日期：2010-02-01 00:00:00

abstract：:Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore,...

journal_title：Autoimmunity

authors： Sarter K,Kulagin M,Schett G,Harris NL,Zaiss MM

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in Euro...

journal_title：Autoimmunity

authors： Muro Y,Sugiura K,Akiyama M

更新日期：2013-06-01 00:00:00

abstract：:Interleukin 1beta (IL-1) is cytotoxic to rat pancreatic beta-cells in vitro, and increased expression of IL-1 mRNA is found in the islets of Langerhans during development of diabetes in BB/Wor/Mol-BB2 (BB-DP) rats and NOD mice. It has been proposed that IL-1 induces a race between protective and deleterious proteins i...

journal_title：Autoimmunity

authors： Christensen UB,Larsen PM,Fey SJ,Andersen HU,Nawrocki A,Sparre T,Mandrup-Poulsen T,Nerup J

更新日期：2000-01-01 00:00:00

abstract：:Recent years have witnessed an explosive growth in available biological data pertaining to autoimmunity research. This includes a tremendous quantity of sequence data (biological structures, genetic and physical maps, pathways, etc.) generated by genome and proteome projects plus extensive clinical and epidemiological...

journal_title：Autoimmunity

authors： Petrovsky N,Brusic V

更新日期：2006-12-01 00:00:00

abstract：:Peripheral blood B lymphocytes of multiple sclerosis (MS) patients and control persons were transformed with Epstein-Barr virus. Antibody production of transformed cells against isolated human myelin was investigated by enzyme-linked immunosorbent assay (ELISA). Cells producing reactive antibodies were cloned and prop...

journal_title：Autoimmunity

authors： Uhlig H,Dernick R

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Henoch-Schonlein purpura (HSP) is a systemic vasculitis characterized by IgA-containing deposits in the skin, joints, gastrointestinal mucosa and glomeruli. HSP is much rarer in adults than in children. Among a number of other pathogenic factors, Helicobacter pylori (Hp) has recently been implicated in the ga...

journal_title：Autoimmunity

authors： Novák J,Szekanecz Z,Sebesi J,Takáts A,Demeter P,Bene L,Sipka S,Csiki Z

更新日期：2003-08-01 00:00:00

abstract：:It has been shown that cationic anti-DNA antibodies have nephritogenic potential in murine models of lupus nephritis. More recently, we have reported that there is a close relationship between the presence of circulating cationic anti-DNA antibodies and the development of lupus nephritis in humans, and that the cation...

journal_title：Autoimmunity

authors： Suzuki N,Otuka I,Harada T,Mizushima Y,Sakane T

更新日期：1994-01-01 00:00:00

abstract：:Autoantigen-reactive T lymphocytes have been implicated in the pathogenesis organ-specific autoimmune disease. Thyroglobulin (Tg) is one of the primary autoantigens associated with autoimmune lymphocytic thyroiditis (LT). These experiments investigated the pathogenicity of a lymphocyte line derived from spontaneously-...

journal_title：Autoimmunity

authors： Allen EM,Thupari JN

更新日期：1996-01-01 00:00:00

abstract：:A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...

journal_title：Autoimmunity

authors： Marmont AM,Gualandi F,Occhini D,Morandi F,Ferretti E,Pezzolo A,Strada P,Ravetti JL,Pistoia V,Falanga A,Bacigalupo A

更新日期：2006-09-01 00:00:00

abstract：:The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencie...

journal_title：Autoimmunity

authors： Truedsson L,Bengtsson AA,Sturfelt G

更新日期：2007-12-01 00:00:00

abstract：:The biological basis for autoimmunity and immunoincompetence in the BB rat has yet to be localized. In spite of normal thymic histology, thymocyte subsets and blastogenesis, thymus gland products (thymosins) have yet to be studied. In the present report, thymus gland function was studied by measuring thymosin alpha 1 ...

journal_title：Autoimmunity

authors： Winter WE,Robbins V,Elder M,Barrett D,Martin N,Maclaren NK

更新日期：1988-01-01 00:00:00

abstract：:Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71%), in particular anti-parietal cells (26.6%), antithyroglobulin (24.4%) and antithyroi...

journal_title：Autoimmunity

authors： Lorini R,Orecchia G,Martinetti M,Dugoujon JM,Cuccia M

更新日期：1992-01-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (HSCT) offers the unique opportunity to replace a diseased hematopoietic or immune system by healthy donor cells. Proof of principle comes from experimental animal data, from the experience with severe aplastic anemia, from observations of patients with concomitant au...

journal_title：Autoimmunity

authors： Gratwohl A

更新日期：2008-12-01 00:00:00

abstract：:HLA-DP+ T cells in peripheral blood from 23 patients with systemic lupus erythematosus (SLE) were examined using two-colour flow cytometry analysis. A marked increase of HLA-DP+ T cells was observed in patients with SLE (20.5-98.7%; 59.8 +/- 20.8%) in comparison to normal subjects (1.3-20.6%; 11.1 +/- 7.2%), and the r...

journal_title：Autoimmunity

authors： Tokano Y,Hishikawa T,Hirose T,Sekigawa I,Hashimoto H,Okumura K,Hirose S

更新日期：1990-01-01 00:00:00

abstract：:This review focuses on recent advances and new hypothesis in the understanding of the T and dendritic cells contribution to the pathogenesis of idiopathic inflammatory myopathies (IIMs), especially polymyositis (PM) and dermatomyositis (DM). The new data show that non-specific amplification of muscle inflammation by T...

journal_title：Autoimmunity

authors： Chevrel G,Page G,Miossec P

更新日期：2006-05-01 00:00:00

abstract：:Numerous studies have shown that autoantigens may be clustered in the blebs of apoptotic cells. However, it is not yet clear in what circumstances apoptotic cells could be immunogenic rather than tolerogenic when interacting with macrophages, dendritic cells, and B cells. In order to further study this question we com...

journal_title：Autoimmunity

authors： Shoshan Y,Mevorach D

更新日期：2004-03-01 00:00:00

abstract：:Subcutaneous insulin treatment of young diabetes prone BB rats has been shown previously to suppress the development of autoimmune diabetes. In this study the hypothesis was tested that exogenous insulin may deviate the autoimmune process by acting on the Th1/Th2 cytokine balance in the pancreas. BB rats were implante...

journal_title：Autoimmunity

authors： Kolb H,Wörz-Pagenstert U,Kleemann R,Rothe H,Rowsell P,Rastegar S,Scott FW

更新日期：1997-01-01 00:00:00

abstract：:We analyzed morphologically autoimmune disease in MRL/MpJ mice bearing both the Yaa and lpr genes (MRL-lpr,Yaa mice), and compared it with that in MRL/MpJ-lpr/lpr (MRL-lpr) mice, in order to examine the effect of the Yaa gene on lpr-induced tissue-specific immunopathologies. MRL-lpr,Yaa male mice developed glomerulone...

journal_title：Autoimmunity

authors： Suzuka H,Yoshifusa H,Nakamura Y,Miyawaki S,Shibata Y

更新日期：1993-01-01 00:00:00

abstract：:Linomide (quinoline-3-carboxamide), a well tolerated, orally administered compound was recently shown to be effective in the prevention and treatment of several autoimmune diseases in experimental animal models. We have investigated its effect on specific humoral immune responses directed to T-cell-dependent soluble o...

journal_title：Autoimmunity

authors： Morecki S,Nabet C,Falk P,Fridkis-Hareli M,Pecht I,Mond JJ,Slavin S

更新日期：1997-01-01 00:00:00

abstract：:The presence of autoimmune rheumatic diseases in several members of the same family, the concurrence of autoimmune rheumatic with non-rheumatic diseases in relatives of patients, the presence of autoantibodies in sera from healthy relatives of autoimmune-disease patients, the development of two or more autoimmune rheu...

journal_title：Autoimmunity

authors： Rodríguez-Reyna TS,Alarcón-Segovia D

更新日期：2005-05-01 00:00:00

abstract：:Five separate monoclonal antibodies (MoAbs) to human thyroid peroxidase (hTPO) were raised by immunising Balb/c mice with hTPO purified from detergent solubilised thyroid microsomes by high performance liquid chromatography (HPLC). The epitope specificities of these MoAbs were determined by assessing their ability to ...

journal_title：Autoimmunity

authors： Ewins DL,Barnett PS,Tomlinson RW,McGregor AM,Banga JP

更新日期：1992-01-01 00:00:00