Abstract:
:Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore, we show that excretory-secretory (ES) products from Hp directly suppress osteoclast differentiation in vitro. Taken together, these results demonstrate that helminth infections can dampen autoimmune diseases and highlight a previously unrecognized and important role for ES products, by directly impacting on bone destruction.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Sarter K,Kulagin M,Schett G,Harris NL,Zaiss MMdoi
10.1080/08916934.2016.1261837subject
Has Abstractpub_date
2017-05-01 00:00:00pages
151-157issue
3eissn
0891-6934issn
1607-842Xjournal_volume
50pub_type
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