Abstract:
:We have used the reverse transcriptase polymerase chain reaction (RT-PCR) technique to assess the expression of cytokine genes in various T cell subsets of autoimmune-prone mice. Our study confirmed the previously described features in lpr mice that IFN-gamma, TNF-alpha, and TNF-beta were transcribed by various T cell subsets. We in this study demonstrated that double negative (DN) T cells, the major cell population in lpr mice, failed to express interleukin-3 (IL-3), IL-4, IL-5, and IL-6 genes that influence B cell growth and activation. In contrast, DN T cells expressed Eta-1 gene that is shown to augment polyclonal activation of B cells and immunoglobulin production. Thus, it is conceivable that T cell-derived B cell-stimulatory activities in MRL/lpr mice can be attributed to Eta-1, rather than IL-3, IL-4, IL-5 or IL-6. We also demonstrated that CD4+ T cells infiltrating into kidney tissues of MRL/lpr mice expressed various cytokine genes such as IL-1, IL-5, IL-6, IFN-gamma, TNF-alpha, TNF-beta and TGF-beta.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Mori K,Kobayashi S,Inobe M,Jia WY,Tamakoshi M,Miyazaki T,Uede Tdoi
10.3109/08916939409014658subject
Has Abstractpub_date
1994-01-01 00:00:00pages
49-57issue
1eissn
0891-6934issn
1607-842Xjournal_volume
17pub_type
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