Abstract:
:This paper describes the idiotypic specificities of eight murine monoclonal antibodies directed to three independent epitopes on retinal S-antigen. The antigenic sites recognised by these monoclonal antibodies have previously been localised to a small region near the C-terminal of bovine S-antigen. Xenogeneic, site-related anti-idiotypes prepared against each of the monoclonal antibodies recognised common idiotypes only amongst those monoclonal antibodies which reacted with the same epitope on S-antigen. Two of the three idiotypes were detected in the sera of BALB/c mice but not in two strains of rat immunised with xenogeneic S-antigen and none could be detected in the sera of patients with anti-photoreceptor autoantibodies. Our results demonstrate that the idiotypes of murine monoclonal antibodies to retinal S-antigen exhibit restricted epitope specificity but are species-restricted and imply that the S-antigen lacks a dominant antigenic epitope.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Suleyman S,Kasp E,Ellis B,Banga JP,Dumonde DCdoi
10.3109/08916939109006744subject
Has Abstractpub_date
1991-01-01 00:00:00pages
91-7issue
2eissn
0891-6934issn
1607-842Xjournal_volume
9pub_type
杂志文章相关文献
AUTOIMMUNITY文献大全abstract:OBJECTIVE:To assess muscle strength in patients with idiopathic inflammatory myopathies (IIM) using neuromuscular scales and isokinetic testing. METHODS:Muscle function was evaluated in 27 IIM patients being followed at the Rheumatology Unit of the University of Pisa using: (i) a modified version of the grading system...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600623817
更新日期:2006-05-01 00:00:00
abstract::Embryonic tissue expresses a very low level of MHC molecules, and these few appear only late in ontogeny. Possibly related are deficiencies in the expression of TAP molecules and also the fetus' need to avoid maternal immunologic rejection. However, the fetus may overcome the lack of Ag-presenting molecules when threa...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939709008021
更新日期:1997-01-01 00:00:00
abstract:AIM:To assess the relationship of the Interleukin-10 (IL-10) -1082G/A (rs1800896), -819C/T (rs1800871) and -592C/A (rs1800872) polymorphism with inflammatory bowel disease (IBD) by means of meta-analysis. METHODS:Published data addressing the association between polymorphism of the IL-10 with Crohn's disease (CD) and ...
journal_title:Autoimmunity
pub_type: 杂志文章,meta分析
doi:10.3109/08916934.2013.843672
更新日期:2014-02-01 00:00:00
abstract::Hybridoma cell lines producing natural autoantibodies (NAA), generated from A.SW mice with progressive experimental autoimmune encephalomyelitis (P-EAE), have been shown to cause demyelination and renal pathology when injected into naive mice. To investigate the relative contribution of these antibodies to disease pat...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930801890280
更新日期:2008-08-01 00:00:00
abstract:INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the formation of autoantibodies against nuclear components. Disturbed apoptosis and reduced clearance of apoptotic material have been assigned a role in the pathogenesis of SLE. During apoptosis, apoptotic blebs are formed, in whi...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.664668
更新日期:2012-06-01 00:00:00
abstract::It has been shown in animal toxicity models that administration of Cyclosporine, CsA, to a pregnant mouse greatly increases the risk that the offspring will develop autoimmunity. Immunization starting at birth has been shown to prevent autoimmunity in other animal models of autoimmunity and early immunization is assoc...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939809003860
更新日期:1998-01-01 00:00:00
abstract::Evidence is growing that autoimmune reactivity results from a combination of endogenous (e.g. MHC type) and environmental factors. Our experimental study focuses on the induction of autoimmune reactivity by microbial factors. Splenic formation and serum levels of anti-erythrocyte antibodies and circulating immune comp...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309004838
更新日期:1993-01-01 00:00:00
abstract::Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on quality of life and can be life threatening. Rupture of vulnerable ath...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916934.2017.1280669
更新日期:2017-02-01 00:00:00
abstract::Recent studies have shown that Ro/SSA autoantigen is heterogeneous. There are two isoform families; the 60 kD forms (Ro60) and the 52 kD forms (Ro52). Recently we have found that autoantibodies to the Ro/SSA proteins are conformation dependent. Anti-Ro60 antibodies are mainly directed to the native protein and convers...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508995297
更新日期:1995-01-01 00:00:00
abstract::The presence of autoimmune rheumatic diseases in several members of the same family, the concurrence of autoimmune rheumatic with non-rheumatic diseases in relatives of patients, the presence of autoantibodies in sera from healthy relatives of autoimmune-disease patients, the development of two or more autoimmune rheu...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500050145
更新日期:2005-05-01 00:00:00
abstract::Human Toll-like receptors (TLRs) are crucial for the recognition of invading pathogens and for the activation of both innate and adaptive immunity. Upon stimulation, TLRs recruit various protein kinases via several adaptor molecules, such as MyD88, leading to the activation of NFkB. The identification of TLR signaling...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930410001704944
更新日期:2004-05-01 00:00:00
abstract::Myocarditis, often initiated by viral infection, may progress to autoimmune inflammatory heart disease, dilated cardiomyopathy and heart failure. Although cardiac myosin is a dominant autoantigen in animal models of myocarditis and is released from the heart during viral myocarditis, the characterization, role and sig...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802031579
更新日期:2008-09-01 00:00:00
abstract::Anti-phospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of autoantibody (AAb) to phospholipid (PL)-binding proteins, such as beta2-glycoprotein I (beta2GPI), and clinical manifestations including thrombosis and/or recurrent pregnancy loss. beta2GPI-reactive T cells are clearly implicat...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902828254
更新日期:2009-05-01 00:00:00
abstract::Congenic B10.BR/SgSnJ H-2kTlaa mice were infected with a diabetogenic strain of coxsackievirus CB4 to correlate abnormalities of sugar metabolism with virus replication in islets, 64,000-M(r) (64K) islet autoantigen expression, 64K antibody development, and pancreas histopathology in early and late infection. Plaque a...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309077366
更新日期:1993-01-01 00:00:00
abstract::To assess the specificity of autoantibodies (aAbs) directed against the ribosomal P-proteins (RPPaAbs) in patients with systemic lupus erythematosus (SLE) and to investigate aAbs directed to other ribosomal proteins, 100 SLE, 100 rheumatoid arthritis (RA), 25 thyroiditis and 20 blood-donors were analyzed in a comparat...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/0891693021000045714
更新日期:2002-11-01 00:00:00
abstract::We reported a patient who gave birth to 3 children with transient neonatal hypothyroidism. She had 3 different antibodies (Ab) to the thyrotropin receptor (TSHR) in her serum, viz., TSH binding-inhibiting (TBIAb), thyroid-stimulating (TSAb) and an additional stimulating Ab (SAb). The SAb differed from TSAb in that its...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409008006
更新日期:1994-01-01 00:00:00
abstract::DNA is a nuclear molecule that has both an intracellular and extracellular role. Inside the cell, it is the essential molecule of heredity while outside the cell it can have immunological activity, both alone and in the context of immune complexes. Furthermore, extracellular DNA has information content that can be min...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930701358826
更新日期:2007-06-01 00:00:00
abstract::Congenic BB.SHR rat strains were established by crossing of spontaneously diabetic BB/OK rats and diabetes-resistant SHR rats. Chromosomal regions on which the genes Iddm 4 (BB.6s), Iddm6 (BB.Xs) and Iddm 2 (BB.LL) are located were exchanged. As a result of genetic manipulation diabetes incidence was markedly reduced ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/0891693031000094683
更新日期:2003-05-01 00:00:00
abstract::Acquired myasthenia gravis (MG), a neurological autoimmune disease, is caused by autoantibodies against components of the neuromuscular junction that lead to disabling muscle fatigability. The thymus is clearly involved in the pathogenesis of early-onset MG with anti-acetylcholine receptor antibodies, and thymic hyper...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916930903563491
更新日期:2010-08-01 00:00:00
abstract::Using a novel cytofluorometric method of cellular antigen quantification, we examined peripheral blood mononuclear cells (PBMC) from patients suffering from rheumatoid arthritis (RA) for quantitative modification of class II human leucocyte antigen (HLA) molecules expressed on the surface. Class II HLA molecules were ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938808997166
更新日期:1988-01-01 00:00:00
abstract::Polymorphisms in the upstream regulatory region of the HLA class II DQA1 gene are currently defined by 10 different alleles. Two of them carrying a Y-box mutation are associated with susceptibility to oligoarticular juvenile idiopathic arthritis (OA-JIA). We investigated allele-dependent differences in HLA-DQA1 gene e...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902832652
更新日期:2009-05-01 00:00:00
abstract::The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed mo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209112339
更新日期:1992-01-01 00:00:00
abstract::On different tissue sections, binding of gliadin to reticular matrix components was observed which was Ca2+-dependent, inhibited by Cu2+ and Zn2+ ions, by putrescine, and by preincubation with antibodies against tissue transglutaminase (tTG) suggesting that binding of gliadin is mediated by tTG. tTG was able to bind t...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939808995366
更新日期:1998-01-01 00:00:00
abstract::Autoimmune diabetes is an organ specific and multifactorial disorder with a classical onset as insulin dependent diabetes mellitus (IDDM) and with another form of onset as latent autoimmune diabetes in adults (LADA), which has a slower onset and a later progress to insulin dependency as a result of the beta cells dest...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500158203
更新日期:2005-06-01 00:00:00
abstract::The objective of this study was to identify new autoantibodies that could be useful for the diagnosis of rheumatoid arthritis (RA) using immunoblotting on synovial membrane proteins which represent the best source of candidate RA autoantigens. A new target protein with a molecular weight of 26 kDa was found to be reco...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701417473
更新日期:2007-07-01 00:00:00
abstract::Type 1 diabetes mellitus (T1DM) is the result of the autoimmune response against pancreatic insulin producing beta cells. This autoimmune response begins months or even years before the first presentation of signs and symptoms of hyperglycemia and at the time of clinical diagnosis near 30% of beta-cell mass still rema...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802200208
更新日期:2008-12-01 00:00:00
abstract::Pemphigus is an autoimmune cutaneous disease characterized by circulating autoantibodies that cause blistering and erosions on skin and mucous membranes. Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. The prin...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600971836
更新日期:2006-11-01 00:00:00
abstract::Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patien...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916930903518107
更新日期:2010-08-01 00:00:00
abstract::The present study uses the agent-based model IMMSIM to simulate immune responses to a viral infection, with a focus on the impact of preformed memory (homologous and heterologous) on the quality and the efficacy of the response. The in machina results confirm the observed thwarting of new, naïve responses exerted by c...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.523275
更新日期:2011-06-01 00:00:00
abstract::The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2015.1031889
更新日期:2015-01-01 00:00:00