Characteristics and clinical correlates of a novel thyroid-stimulating autoantibody.

abstract：:We analyzed morphologically autoimmune disease in MRL/MpJ mice bearing both the Yaa and lpr genes (MRL-lpr,Yaa mice), and compared it with that in MRL/MpJ-lpr/lpr (MRL-lpr) mice, in order to examine the effect of the Yaa gene on lpr-induced tissue-specific immunopathologies. MRL-lpr,Yaa male mice developed glomerulone...

journal_title：Autoimmunity

authors： Suzuka H,Yoshifusa H,Nakamura Y,Miyawaki S,Shibata Y

更新日期：1993-01-01 00:00:00

abstract：:Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/...

journal_title：Autoimmunity

authors： Saito K,Mori S,Date F,Ono M

更新日期：2013-06-01 00:00:00

abstract：:We have used the MRL/lpr murine model of spontaneous lupus to investigate three questions in infection immunity: (1) does mycobacterial infection have any effect on the mortality of the autoimmunity-prone lpr mice?; (2) does the infection modify the progression of kidney disease of lpr lupus?; and (3) does the lpr gen...

journal_title：Autoimmunity

authors： Castro AP,Esaguy N,Aguas AP

更新日期：1993-01-01 00:00:00

abstract：:The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma (IFN-gamma) inducible Ca(2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins including ionized Ca(2+)-binding adaptor 1, microglia response factor-1, and daintain are identical with AIF-1. The expre...

journal_title：Autoimmunity

authors： Liu G,Ma H,Jiang L,Zhao Y

更新日期：2007-03-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic beta cell destruction involving auto-reactive T-cells, pro-inflammatory cytokines, reactive oxygen species (ROS) and loss of insulin. Monozygotic twin studies show a 20-60% concordance with T1D indicating there may be an environmental component...

journal_title：Autoimmunity

authors： Bekris LM,Shephard C,Peterson M,Hoehna J,Van Yserloo B,Rutledge E,Farin F,Kavanagh TJ,Lernmark A

更新日期：2005-12-01 00:00:00

abstract：:GM2 ganglioside is a potential peripheral nerve antigen for neuropathy-associated autoantibodies. However little data are available on their pathogenic effects, if any. In this study we have screened both neuropathy-associated and control sera for anti-GM2 antibodies and subsequently used high titre sera for immunohis...

journal_title：Autoimmunity

authors： O'Hanlon GM,Veitch J,Gallardo E,Illa I,Chancellor AM,Willison HJ

更新日期：2000-09-01 00:00:00

abstract：:A patient with chronic ITP relapsed after conventional therapy but following an infusion with low dose anti D (Rho) immunoglobulin, she entered a remission which has now lasted 10 months. This is difficult to explain on the basis of long term macrophage Fc receptor blockade and suggests an alternative mechanism of act...

journal_title：Autoimmunity

authors： Smith NA,Chakraverty RK,Obeid D,Boughton BJ

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:T follicular helper (Tfh) cells are known to regulate humoral immune response. In this study we examined the correlation of different subsets of peripheral blood Tfh cells in patients with diabetic nephropathy (DN). METHODS:A total of 23 DN patients and 15 healthy controls (HC) were investigated for various...

journal_title：Autoimmunity

authors： Zhang N,Tai J,Qu Z,Zhang Z,Zhao S,He J,Zhang S,Jiang Y

更新日期：2016-09-01 00:00:00

abstract：:Congenic B10.BR/SgSnJ H-2kTlaa mice were infected with a diabetogenic strain of coxsackievirus CB4 to correlate abnormalities of sugar metabolism with virus replication in islets, 64,000-M(r) (64K) islet autoantigen expression, 64K antibody development, and pancreas histopathology in early and late infection. Plaque a...

journal_title：Autoimmunity

authors： Gerling I,Chatterjee NK

更新日期：1993-01-01 00:00:00

abstract：:Decades of research have provided strong evidence for a reciprocal relationship between the immune system and hormones of the hypothalamus-pituitary-thyroid (HPT) axis. Thyroid stimulating hormone (TSH), in particular, has been shown to have a variety of immune-regulating cytokine-like activities that can influence th...

journal_title：Autoimmunity

authors： Klein JR

更新日期：2003-09-01 00:00:00

abstract：:HLA-DP+ T cells in peripheral blood from 23 patients with systemic lupus erythematosus (SLE) were examined using two-colour flow cytometry analysis. A marked increase of HLA-DP+ T cells was observed in patients with SLE (20.5-98.7%; 59.8 +/- 20.8%) in comparison to normal subjects (1.3-20.6%; 11.1 +/- 7.2%), and the r...

journal_title：Autoimmunity

authors： Tokano Y,Hishikawa T,Hirose T,Sekigawa I,Hashimoto H,Okumura K,Hirose S

更新日期：1990-01-01 00:00:00

abstract：:Recent studies have shown that Ro/SSA autoantigen is heterogeneous. There are two isoform families; the 60 kD forms (Ro60) and the 52 kD forms (Ro52). Recently we have found that autoantibodies to the Ro/SSA proteins are conformation dependent. Anti-Ro60 antibodies are mainly directed to the native protein and convers...

journal_title：Autoimmunity

authors： Igarashi T,Itoh Y,Fukunaga Y,Yamamoto M

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet aut...

journal_title：Autoimmunity

authors： Bossowski A,Stożek K,Rydzewska M,Niklińska W,Gąsowska M,Polnik D,Szalecki M,Mikłosz A,Chabowski A,Reszeć J

更新日期：2020-11-01 00:00:00

abstract：:There is a need for methods to improve the diagnosis, patient staging and evaluation of therapeutic response in patients with autoimmune conditions to improve patient care. Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are two inflammatory diseases characterized by involvement of innate and adaptive i...

journal_title：Autoimmunity

authors： McBride HJ

更新日期：2010-11-01 00:00:00

abstract：:Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in...

journal_title：Autoimmunity

authors： Jones BM,Liu T,Wong RW

更新日期：1999-10-01 00:00:00

abstract：:The biological basis for autoimmunity and immunoincompetence in the BB rat has yet to be localized. In spite of normal thymic histology, thymocyte subsets and blastogenesis, thymus gland products (thymosins) have yet to be studied. In the present report, thymus gland function was studied by measuring thymosin alpha 1 ...

journal_title：Autoimmunity

authors： Winter WE,Robbins V,Elder M,Barrett D,Martin N,Maclaren NK

更新日期：1988-01-01 00:00:00

abstract：:Interleukin (IL)-1 inhibits the function of insulin-producing rat pancreatic beta-cells in vitro and in vivo, and it has been postulated that the IL-1 effect is mediated through the cytokine inducible nitric oxide (NO) synthase. IL-1 inhibits the function of cultured human thyroid cells too, and in this study human th...

journal_title：Autoimmunity

authors： Rasmussen AK,Di Marco R,Diamant M,Feldt-Rasmussen U,Bendtzen K

更新日期：1994-01-01 00:00:00

abstract：:The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some a...

journal_title：Autoimmunity

authors： Rask L,Jonsson AK,Svensson AC,Gustafsson K,Andersson L

更新日期：1991-01-01 00:00:00

abstract：:The present study investigated the expressed number of CR1 on erythrocytes (E) in relationship of the CR1 density genotype from 46 patients with systemic lupus erythematosus (SLE) and 47 healthy volunteers. The CR1 genotype was determined by a method based on polymerase chain reaction (PCR) amplification of the genomi...

journal_title：Autoimmunity

authors： Kiss E,Csipö I,Cohen JH,Reveil B,Kávai M,Szegedi G

更新日期：1996-01-01 00:00:00

abstract：:Previous studies directed towards identifying epitopes on type II collagen (CII) important in collagen induced arthritis (CIA) in mice have focused primarily on responses mounted in susceptible H-2q strains. However, the nature of T and B cell responses against CII in susceptible H-2r strains remains ill-defined. In a...

journal_title：Autoimmunity

authors： Nabozny GH,Griffiths MM,Harper DS,Luthra HS,David CS

更新日期：1995-01-01 00:00:00

abstract：:Non obese diabetic (NOD) mice spontaneously develop thyroiditis in addition to diabetes. Mononuclear cells begin to infiltrate the thyroid of these animals in the first month of life. The expression of major histocompatibility complex (MHC) class II (Ia) antigens by cells in the thyroid from NOD mice of various ages w...

journal_title：Autoimmunity

authors： Margolese H,O'Keefe C,Chung F,Ertug F,Wall JR,Bernard NF

更新日期：1994-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a devastating autoimmune disease that affects more than 1 million people worldwide and severely compromises motor and sensory function through demyelination and axonal loss. This review covers current therapies, lessons learned from failed clinical trials, genetic susceptibility, key cell ty...

journal_title：Autoimmunity

authors： Slavin A,Kelly-Modis L,Labadia M,Ryan K,Brown ML

更新日期：2010-11-01 00:00:00

abstract：:Congenital heart block is a serious condition with significant mortality due in most cases to the transplacental transfer of autoantibodies from an otherwise asymptomatic mother. Although SSA/Ro and SSB/La autoantibodies have been implicated, attention has focused recently on autoantibodies to envelope proteins of end...

journal_title：Autoimmunity

authors： de Parseval N,Forrest G,Venables PJ,Heidmann T

更新日期：1999-01-01 00:00:00

abstract：INTRODUCTION:Autoimmune diseases, such as celiac disease (CD) and diabetes mellitus type 1, tend to co-occur within the same patient. The prevalence of CD in diabetic children is higher than in the general population, and is estimated to be 0.6-16.4%. The diagnosis of CD is based on histopathological examination and se...

journal_title：Autoimmunity

authors： Lewandowska K,Ciepiela O,Szypowska A,Wyhowski J,Głodkowska-Mrówka E,Popko K,Ostafin M,Pyrżak B,Demkow U

更新日期：2018-03-01 00:00:00

abstract：:This study was undertaken to determine whether the expression of 17.109, 6B6.6 and 4C9 rheumatoid factor (RF) idiotypes is predictive of the development of rheumatoid arthritis (RA) and whether the RF response is idiotypically restricted in an inbred population of Pima Indians who have a genetic predisposition for the...

journal_title：Autoimmunity

authors： Davidson A,Keiser HD,del Puente A,Bennett PH,Schrohenloher R,Koopman WJ

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:Autoimmune polyendocrine syndrome type 1 (APS 1) is caused by mutations in the AIRE gene that induce intrathymic T-cell tolerance breakdown, which results in tissue-specific autoimmune diseases. DESIGN:To evaluate the effect of a well-defined T-cell repertoire impairment on humoral self-reactive fingerprints...

journal_title：Autoimmunity

authors： Dubucquoi S,Proust-Lemoine E,Kemp EH,Ryndak A,Lefèvre-Dutoit V,Bellart M,Saugier-Véber P,Duban-Deweer S,Wémeau JL,Prin L,Lefranc D

更新日期：2015-01-01 00:00:00

abstract：:Autoimmune diabetes is an organ specific and multifactorial disorder with a classical onset as insulin dependent diabetes mellitus (IDDM) and with another form of onset as latent autoimmune diabetes in adults (LADA), which has a slower onset and a later progress to insulin dependency as a result of the beta cells dest...

journal_title：Autoimmunity

authors： Caputo M,Cerrone GE,López AP,Villalba A,Krochik GA,Cédola FN,Targovnik HM,Frechtel GD

更新日期：2005-06-01 00:00:00

abstract：:Anti-M2 of anti-mitochondrial antibody (AMA) is a serological marker of primary biliary cirrhosis (PBC). Anti-pyruvate dehydrogenase complex-E2 (anti-PDC-E2) is recognized as the most frequently occurring anti-M2, and a routine laboratory test for this antibody has already been established. However, it is also known t...

journal_title：Autoimmunity

authors： Miyakawa H,Abe K,Kitazawa E,Kikuchi K,Fujikawa H,Matsushita M,Kawaguchi N,Kako M

更新日期：1999-01-01 00:00:00

abstract：:In a previous work we characterized a major epitope of thyroid peroxidase (TPO), which was recognised by 66% of 157 patients with autoimmune thyroid disease (AITD) and 9 out of 50 patients with non-thyroidal autoimmune disease (NTAID) 6 of whom had antibodies to the gastric parietal cell antigen (PCA). In the present ...

journal_title：Autoimmunity

authors： Elisei R,Mariotti S,Swillens S,Vassart G,Ludgate M

更新日期：1990-01-01 00:00:00

abstract：:To evaluate changes in TSH receptor antibody after surgery in Graves' disease and its relationship with the degree of lymphocytic infiltration, serial serum levels of TSH receptor antibody were measured before and after the subtotal thyroidectomy in 50 patients with Graves' disease. In 22 (44%) out of 50 patients, thy...

journal_title：Autoimmunity

authors： Cho BY,Oh SK,Shong YK,Kim SE,Yoo HY,Lee HK,Koh CS,Min HK

更新日期：1990-01-01 00:00:00