Abstract:
:There is a need for methods to improve the diagnosis, patient staging and evaluation of therapeutic response in patients with autoimmune conditions to improve patient care. Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are two inflammatory diseases characterized by involvement of innate and adaptive immune components that change the metabolic state of their respective target tissues, thus providing an opportunity for molecular imaging probes to detect such changes. Optimally, such probes and the imaging methods employed would be non-invasive, robust and reproducible, give a quantitative result, report on the status of the affected tissue(s) and respond to the effects of a therapeutic molecule. Positron emission tomography (PET) and single photon emission computed tomography (SPECT) are nuclear imaging approaches that have the potential to satisfy such requirements. In this review, the work to date and the potential of PET and SPECT imaging probes in these two inflammatory conditions, IBD and RA, are discussed.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
McBride HJdoi
10.3109/08916931003674766subject
Has Abstractpub_date
2010-11-01 00:00:00pages
539-49issue
7eissn
0891-6934issn
1607-842Xjournal_volume
43pub_type
杂志文章,评审相关文献
AUTOIMMUNITY文献大全abstract::In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of circumstances, observations encounters, that all have favored the rise of a family of agent based simulations of the Immune System. Franco Celada was among the firs...
journal_title:Autoimmunity
pub_type:
doi:10.3109/08916934.2010.523239
更新日期:2011-06-01 00:00:00
abstract::An analysis of the cell-surface expression of activation markers on B- and T-cells was done to compare patients with myasthenia gravis (MG) and healthy non-myasthenic controls. Marker expression was determined by immunostaining of peripheral blood mononuclear cells (PBMC) isolated from MG patients and from controls. T...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908993860
更新日期:1999-01-01 00:00:00
abstract::Interleukin 1beta (IL-1) is cytotoxic to rat pancreatic beta-cells in vitro, and increased expression of IL-1 mRNA is found in the islets of Langerhans during development of diabetes in BB/Wor/Mol-BB2 (BB-DP) rats and NOD mice. It has been proposed that IL-1 induces a race between protective and deleterious proteins i...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930008995982
更新日期:2000-01-01 00:00:00
abstract::Thyroid lymphocyte RNA from a Hashimoto patient with high serum levels of autoantibodies to thyroid peroxidase (TPO) was used to construct a phage display antibody library in the phagemid vector pComb3. The library (100,000cfu) encoded IgG1 heavy chains together with kappa light chains. Selection of the phages display...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409010651
更新日期:1994-01-01 00:00:00
abstract::Embryonic tissue expresses a very low level of MHC molecules, and these few appear only late in ontogeny. Possibly related are deficiencies in the expression of TAP molecules and also the fetus' need to avoid maternal immunologic rejection. However, the fetus may overcome the lack of Ag-presenting molecules when threa...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939709008021
更新日期:1997-01-01 00:00:00
abstract::We analyzed morphologically autoimmune disease in MRL/MpJ mice bearing both the Yaa and lpr genes (MRL-lpr,Yaa mice), and compared it with that in MRL/MpJ-lpr/lpr (MRL-lpr) mice, in order to examine the effect of the Yaa gene on lpr-induced tissue-specific immunopathologies. MRL-lpr,Yaa male mice developed glomerulone...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309079229
更新日期:1993-01-01 00:00:00
abstract::TGF-beta1 is a pleiotropic cytokine, which prevents inappropriate autoimmune responses and balances the requirements of proper immune cell levels during pathologic states that trigger the immune response. We assessed the serum levels of TGF-beta1 and determined the relationship between TGF-beta1 and clinical parameter...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930902831977
更新日期:2009-05-01 00:00:00
abstract::Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701262986
更新日期:2007-05-01 00:00:00
abstract::Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2018.1522305
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Henoch-Schonlein purpura (HSP) is a systemic vasculitis characterized by IgA-containing deposits in the skin, joints, gastrointestinal mucosa and glomeruli. HSP is much rarer in adults than in children. Among a number of other pathogenic factors, Helicobacter pylori (Hp) has recently been implicated in the ga...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930232000114535
更新日期:2003-08-01 00:00:00
abstract::Blockade of the complement cascade at the C5a/C5a receptor (C5aR)-axis is believed to be an attractive treatment avenue in rheumatoid arthritis (RA). However, the effects of such interventions during the early phases of arthritis remain to be clarified. In this study we use the murine delayed-type hypersensitivity art...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2015.1031888
更新日期:2015-01-01 00:00:00
abstract::Antiphospholipid antibodies (aPLA) were discovered during the course of Mediterranean spotted fever (MSF) caused by Rickettsia conorii and characterized by endothelial cell (EC) damage resulting from this organism's tropism for EC. In two MSF patients, two types of aPLA were identified: antiphosphatidylethanolamine an...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508993359
更新日期:1995-01-01 00:00:00
abstract::The biological basis for autoimmunity and immunoincompetence in the BB rat has yet to be localized. In spite of normal thymic histology, thymocyte subsets and blastogenesis, thymus gland products (thymosins) have yet to be studied. In the present report, thymus gland function was studied by measuring thymosin alpha 1 ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938809001924
更新日期:1988-01-01 00:00:00
abstract::We have used the reverse transcriptase polymerase chain reaction (RT-PCR) technique to assess the expression of cytokine genes in various T cell subsets of autoimmune-prone mice. Our study confirmed the previously described features in lpr mice that IFN-gamma, TNF-alpha, and TNF-beta were transcribed by various T cell...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409014658
更新日期:1994-01-01 00:00:00
abstract::Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on quality of life and can be life threatening. Rupture of vulnerable ath...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916934.2017.1280669
更新日期:2017-02-01 00:00:00
abstract::Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first time serum DNase1-activity in a large consecutive cohort of treatment-naïve patients with autoimmune...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2017.1279610
更新日期:2017-03-01 00:00:00
abstract::T lymphocytes present in thyroid infiltrates of 6 patients with Hashimoto's thyroiditis (HT) and of 4 patients with Graves' disease (GD) were analyzed at clonal level and their profiles of mitogen-induced lymphokine secretion were characterized. Production of interleukin-2 (IL-2), interleukin-4 (IL-4), interferon-gamm...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909014703
更新日期:1989-01-01 00:00:00
abstract::Thyroid lymphocyte RNA from a Hashimoto patient exhibiting high titre serum IgG autoantibodies against thyroglobulin (Tg) has been used to construct a Fab library in phage lambda. Screening of this library with radioiodinated Tg has permitted the cloning of an anti-Tg antibody (MH52) with an affinity of 4.5 x 10(9) mo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209150320
更新日期:1992-01-01 00:00:00
abstract::Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patien...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916930903518107
更新日期:2010-08-01 00:00:00
abstract::DNA is a nuclear molecule that has both an intracellular and extracellular role. Inside the cell, it is the essential molecule of heredity while outside the cell it can have immunological activity, both alone and in the context of immune complexes. Furthermore, extracellular DNA has information content that can be min...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930701358826
更新日期:2007-06-01 00:00:00
abstract::The MRL/lpr model of SLE resembles human lupus in its various immunopathologic characteristics including the presence of high-level IgG and anti-DNA antibody production and multisystem organ involvement (nephritis, arthritis, and vasculitis). Our previous studies have shown that IL-1 overactivity in B cells plays a po...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939609001949
更新日期:1996-01-01 00:00:00
abstract::Diabetes mellitus is a disorder characterized by hyperglycemia in both the fasting and post-prandial states. The two most common forms of diabetes mellitus, type 1 and type 2 (previously called juvenile-onset and adult-onset, respectively), comprise the vast majority of cases. Type 1 diabetes (T1DM) has been shown to ...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930701619169
更新日期:2008-02-01 00:00:00
abstract::Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severity in two different inflammatory arthritis models. Furthermore,...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2016.1261837
更新日期:2017-05-01 00:00:00
abstract::Recent studies have shown that Ro/SSA autoantigen is heterogeneous. There are two isoform families; the 60 kD forms (Ro60) and the 52 kD forms (Ro52). Recently we have found that autoantibodies to the Ro/SSA proteins are conformation dependent. Anti-Ro60 antibodies are mainly directed to the native protein and convers...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508995297
更新日期:1995-01-01 00:00:00
abstract::This study was undertaken to determine whether the expression of 17.109, 6B6.6 and 4C9 rheumatoid factor (RF) idiotypes is predictive of the development of rheumatoid arthritis (RA) and whether the RF response is idiotypically restricted in an inbred population of Pima Indians who have a genetic predisposition for the...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409009526
更新日期:1994-01-01 00:00:00
abstract::Numerous groups have now validated high-throughput approaches to autoantibody profiling in a variety of systems. Recently, we have used autoantigen microarray technology to identify distinct autoantibody profiles in H-2 congenic MRL/lpr mice (Sekine et al., manuscript in preparation), and we are expanding this platfor...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930410001710686
更新日期:2004-06-01 00:00:00
abstract::A large number of malaria immune persons from Eastern India were found to possess antibodies to the ribosomal phosphoprotein P0 (PfP0) of the human malarial parasite Plasmodium falciparum. The characterization of PfP0 has been reported recently, and it has been shown that antibodies against PfP0 inhibit P. falciparum ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2002.11873702
更新日期:2001-01-01 00:00:00
abstract::Numerous studies have shown that autoantigens may be clustered in the blebs of apoptotic cells. However, it is not yet clear in what circumstances apoptotic cells could be immunogenic rather than tolerogenic when interacting with macrophages, dendritic cells, and B cells. In order to further study this question we com...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930410001666622
更新日期:2004-03-01 00:00:00
abstract::Various amounts of the bacterium, Brucella abortus (BA) were injected intravenously into autoimmune NZB/W F1 mice and non-autoimmune BDF1 mice and then the localization of BA in the thymus was traced using an immunohistochemical method at 30 min and 3 h after injection. The results showed that a greater amount of BA b...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939109004813
更新日期:1991-01-01 00:00:00
abstract::In order to know whether effector cells are capable of recognizing the epidermal targets in pemphigus vulgaris (PV) and bullous pemphigoid (BP), non-adherent cells (NAC) of peripheral blood from 27 primary PV, 19 BP patients and 12 healthy volunteers were used in cytotoxic tests. Autologous, allogenic and murine epide...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938908997095
更新日期:1989-01-01 00:00:00