Abstract:
:TGF-beta1 is a pleiotropic cytokine, which prevents inappropriate autoimmune responses and balances the requirements of proper immune cell levels during pathologic states that trigger the immune response. We assessed the serum levels of TGF-beta1 and determined the relationship between TGF-beta1 and clinical parameters in patients with rheumatoid arthritis (RA) and Sjögren's syndrome (SS) secondary to RA (SS + RA). Comparison of the serum levels of TGF-beta1 in patients with RA, SS + RA and NHD differed significantly (51.7 +/- 12.4 ng/ml (RA); 33.0 +/- 3.1 ng/ml (SS + RA) and versus 31.6 +/- 2.0 ng/ml (NHD)). We further found correlations between TGF-beta1 levels and radiologically defined joint damage determined by the Steinbrocker scoring system, symptoms and signs of SS. We conclude that serum levels of TGF-beta1 may reflect ongoing autoimmune inflammation and correlate with joint damage in RA.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Mieliauskaite D,Venalis P,Dumalakiene I,Venalis A,Distler Jdoi
10.1080/08916930902831977subject
Has Abstractpub_date
2009-05-01 00:00:00pages
356-8issue
4eissn
0891-6934issn
1607-842Xpii
10.1080/08916930902831977journal_volume
42pub_type
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