Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein.

abstract：:At least two signals for proliferation and cytokine secretion by T-cells are required. The first signal is delivered through the interaction of the T-cell receptor with major histocompatibility complex (MHC) molecules expressed on the surface of antigen-presenting cells (APC). The second or costimulatory signal is del...

journal_title：Autoimmunity

authors： Salmaso C,Olive D,Pesce G,Bagnasco M

更新日期：2002-05-01 00:00:00

abstract：:Epidermolysis bullosa acquisita (EBA) is a rare and acquired autoimmune subepidermal bullous disease of skin and mucosa. EBA includes various distinct clinical manifestations resembling genetic dystrophic epidermolysis bullosa (DEB), Bullous pemphigus, Brunsting-Perry pemphigoid, or cicatricial pemphigoid. These patie...

journal_title：Autoimmunity

authors： Chen M,Kim GH,Prakash L,Woodley DT

更新日期：2012-02-01 00:00:00

abstract：:IL-6 is a paracrine and autocrine cytokine, which acts in the regulation of immunological and inflammatory processes. Its production can be observed in different cell types, as well as thyrocytes. The purpose of the study was to examine the serum IL-6 levels between the patients with Graves' disease (N = 47) and witho...

journal_title：Autoimmunity

authors： Molnár I,Balázs C

更新日期：1997-01-01 00:00:00

abstract：:The immunomodulatory effects of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) have been elucidated at a cellular level and implicated in the pathogenesis of several complex diseases. Defects within the regulatory T cell compartment are one of the characteristics of primary biliary cirrhosis (PBC...

journal_title：Autoimmunity

authors： Oertelt-Prigione S,Mao TK,Selmi C,Tsuneyama K,Ansari AA,Coppel RL,Invernizzi P,Podda M,Gershwin ME

更新日期：2008-02-01 00:00:00

abstract：:T lymphocytes present in thyroid infiltrates of 6 patients with Hashimoto's thyroiditis (HT) and of 4 patients with Graves' disease (GD) were analyzed at clonal level and their profiles of mitogen-induced lymphokine secretion were characterized. Production of interleukin-2 (IL-2), interleukin-4 (IL-4), interferon-gamm...

journal_title：Autoimmunity

authors： Del Prete GF,Tiri A,De Carli M,Mariotti S,Pinchera A,Chretien I,Romagnani S,Ricci M

更新日期：1989-01-01 00:00:00

abstract：:In a previous study, we showed that the Ly6G(-)CD11b(+) blood monocytes residing in naïve mice are intrinsically immunosuppressive and that loss of this suppressive function may contribute to the development of autoimmunity in experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis....

journal_title：Autoimmunity

authors： Slaney CY,Toker A,Fraser JD,Harper JL,Bäckström BT

更新日期：2013-06-01 00:00:00

abstract：:Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with strept...

journal_title：Autoimmunity

authors： Guilherme L,Kalil J,Cunningham M

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the formation of autoantibodies against nuclear components. Disturbed apoptosis and reduced clearance of apoptotic material have been assigned a role in the pathogenesis of SLE. During apoptosis, apoptotic blebs are formed, in whi...

journal_title：Autoimmunity

authors： Fransen JH,Berden JH,Koeter CM,Adema GJ,Van Der Vlag J,Hilbrands LB

更新日期：2012-06-01 00:00:00

abstract：:Peripheral blood B lymphocytes of multiple sclerosis (MS) patients and control persons were transformed with Epstein-Barr virus. Antibody production of transformed cells against isolated human myelin was investigated by enzyme-linked immunosorbent assay (ELISA). Cells producing reactive antibodies were cloned and prop...

journal_title：Autoimmunity

authors： Uhlig H,Dernick R

更新日期：1989-01-01 00:00:00

abstract：:In the 1950s, the discovery of autoantibodies produced by B cells seemed to provide a compelling mechanism underlying autoimmune diseases. The discovery of T regulatory cells and other T helper cell subsets shifted the field back towards a T cell central view. The success of rituxan, a chimeric mAb targeting CD20 on B...

journal_title：Autoimmunity

authors： Luu VP,Vazquez MI,Zlotnik A

更新日期：2014-02-01 00:00:00

abstract：:Elevated constitutive expression of major histocompatibility (MHC) class II antigens occurs in the enterocytes of patients with IBD. It has been suggested that this aberrant expression of class II molecules may play a role in the pathogenesis of IBD. We examined two possible reasons for such a finding. 1) Heightened s...

journal_title：Autoimmunity

authors： Salomon P,Pizzimenti A,Panja A,Reisman A,Mayer L

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:T follicular helper (Tfh) cells are known to regulate humoral immune response. In this study we examined the correlation of different subsets of peripheral blood Tfh cells in patients with diabetic nephropathy (DN). METHODS:A total of 23 DN patients and 15 healthy controls (HC) were investigated for various...

journal_title：Autoimmunity

authors： Zhang N,Tai J,Qu Z,Zhang Z,Zhao S,He J,Zhang S,Jiang Y

更新日期：2016-09-01 00:00:00

abstract：:A patient with chronic ITP relapsed after conventional therapy but following an infusion with low dose anti D (Rho) immunoglobulin, she entered a remission which has now lasted 10 months. This is difficult to explain on the basis of long term macrophage Fc receptor blockade and suggests an alternative mechanism of act...

journal_title：Autoimmunity

authors： Smith NA,Chakraverty RK,Obeid D,Boughton BJ

更新日期：1989-01-01 00:00:00

abstract：:To investigate the expression patterns of activation-induced cytidine deaminase (AID) variants in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and examine their clinical implications, we isolated PBMCs from healthy controls (HC, n = 33) and patients with AS (n = 62), and meas...

journal_title：Autoimmunity

authors： Kim JY,Yoon HK,Song ST,Park SR,Shim SC

更新日期：2017-12-01 00:00:00

abstract：:The nature of the immunosuppressive effect of antithyroid drugs has been a subject of controversy. It has been claimed that these agents exert a direct effect on the immune system, although we and others have suggested that the drugs affect the thyroid cells primarily with consequent reduced thyrocyte-immunocyte signa...

journal_title：Autoimmunity

authors： Aguayo J,Michaud P,Iitaka M,Degroot LJ,Row VV,Volpé R

更新日期：1989-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPLA) were discovered during the course of Mediterranean spotted fever (MSF) caused by Rickettsia conorii and characterized by endothelial cell (EC) damage resulting from this organism's tropism for EC. In two MSF patients, two types of aPLA were identified: antiphosphatidylethanolamine an...

journal_title：Autoimmunity

authors： Sotto A,Bérard M,Bessis D,Porneuf M,Jourdan J,Boffa MC

更新日期：1995-01-01 00:00:00

abstract：:A comparative study of tyrosine phosphorylation was performed on peripheral blood lymphocytes from systemic lupus erythematosus (SLE) patients and from healthy donors. Freshly isolated SLE lymphocytes presented an elevated tyrosine phosphorylation level when compared to healthy donors lymphocytes (p = 0.005). Among al...

journal_title：Autoimmunity

authors： Matache C,Stefanescu M,Onu A,Szegli G,Barel M,Tanaseanu S,Matei I,Bouillie S,Frade R

更新日期：1996-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a devastating autoimmune disease that affects more than 1 million people worldwide and severely compromises motor and sensory function through demyelination and axonal loss. This review covers current therapies, lessons learned from failed clinical trials, genetic susceptibility, key cell ty...

journal_title：Autoimmunity

authors： Slavin A,Kelly-Modis L,Labadia M,Ryan K,Brown ML

更新日期：2010-11-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is characterised by immune-mediated damage to the intra-hepatic biliary epithelial cells (BEC). Immuno-modulatory/suppressive therapy represents, therefore, alogical approach to treatment in this disease. Conventional immuno-suppressive and immuno-modulatory agents suffer from the bread...

journal_title：Autoimmunity

authors： Jones DE,Palmer JM,Robe A,Kirby JA

更新日期：2002-12-01 00:00:00

abstract：:Systemic Lupus Erythematosus is an autoimmune disease characterized by the formation of anti-nuclear autoantibodies, particularly anti-chromatin. Although the aetiology of the disease has not yet been fully elucidated, several mechanisms have been proposed to be involved. Due to an aberrant apoptosis or decreased remo...

journal_title：Autoimmunity

authors： Bouts YM,Wolthuis DF,Dirkx MF,Pieterse E,Simons EM,van Boekel AM,Dieker JW,van der Vlag J

更新日期：2012-12-01 00:00:00

abstract：:Macrophages from autoimmune diabetes prone BB rats were found to produce radical oxygen intermediates (ROI) at an enhanced rate when compared to diabetes resistant BB or normal Wistar rats. The release of ROI was determined by chemiluminescence using in parallel luminol and lucigenin as detector molecules. In diabetes...

journal_title：Autoimmunity

authors： Brenner HH,Burkart V,Rothe H,Kolb H

更新日期：1993-01-01 00:00:00

abstract：:In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of circumstances, observations encounters, that all have favored the rise of a family of agent based simulations of the Immune System. Franco Celada was among the firs...

journal_title：Autoimmunity

authors： Celada F

更新日期：2011-06-01 00:00:00

abstract：:Acquired myasthenia gravis (MG), a neurological autoimmune disease, is caused by autoantibodies against components of the neuromuscular junction that lead to disabling muscle fatigability. The thymus is clearly involved in the pathogenesis of early-onset MG with anti-acetylcholine receptor antibodies, and thymic hyper...

journal_title：Autoimmunity

authors： Le Panse R,Bismuth J,Cizeron-Clairac G,Weiss JM,Cufi P,Dartevelle P,De Rosbo NK,Berrih-Aknin S

更新日期：2010-08-01 00:00:00

abstract：:HLA-DP+ T cells in peripheral blood from 23 patients with systemic lupus erythematosus (SLE) were examined using two-colour flow cytometry analysis. A marked increase of HLA-DP+ T cells was observed in patients with SLE (20.5-98.7%; 59.8 +/- 20.8%) in comparison to normal subjects (1.3-20.6%; 11.1 +/- 7.2%), and the r...

journal_title：Autoimmunity

authors： Tokano Y,Hishikawa T,Hirose T,Sekigawa I,Hashimoto H,Okumura K,Hirose S

更新日期：1990-01-01 00:00:00

abstract：:Apoptotic cells are readily recognized and engulfed by phagocytes and usually do not induce inflammation or tissue damage. Furthermore, they can actively suppress a pro-inflammatory response in phagocytes: In the presence of apoptotic cells, activated monocytes/macrophages produce more of the anti-inflammatory and imm...

journal_title：Autoimmunity

authors： Girkontaite I,Urbonaviciute V,Maseda D,Neubert K,Herrmann M,Voll RE

更新日期：2007-06-01 00:00:00

abstract：:The presence of autoantibodies (aAbs) to thyroglobulin (TG) and thyroperoxidase (TPO) in most of the patients with autoimmune thyroid disease is now well documented. Studies of these aAbs suggested that some, termed TGPO aAbs, could interact with both TG and TPO. This hypothesis was investigated using IgG fraction fro...

journal_title：Autoimmunity

authors： Ruf J,Ferrand M,Durand-Gorde JM,Carayon P

更新日期：1992-01-01 00:00:00

abstract：:Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental anima...

journal_title：Autoimmunity

authors： Dancea S,Dellagi K,Renaud F,Mahouy G,Hauw JJ,Brouet JC

更新日期：1989-01-01 00:00:00

abstract：:The HEp2 cell cultures appeared highly sensitive in detecting the antinuclear antibodies (ANAb) in systemic sclerosis, principally anticentromere antibodies of the CREST syndrome. The immunoblotting used with either complex cellular extracts from HeLa and rabbit thymus or purified nuclear components (high mobility gro...

journal_title：Autoimmunity

authors： Briolay J,Gioud M,Monier JC,Rodde JL,Cohen J,Roux B,Kaliss B

更新日期：1989-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE patients and contr...

journal_title：Autoimmunity

authors： Paradowska-Gorycka A,Sowinska A,Stypinska B,Grobelna MK,Walczyk M,Olesinska M,Piotrowski P,Jagodziński PP

更新日期：2016-09-01 00:00:00

abstract：:To assess the specificity of autoantibodies (aAbs) directed against the ribosomal P-proteins (RPPaAbs) in patients with systemic lupus erythematosus (SLE) and to investigate aAbs directed to other ribosomal proteins, 100 SLE, 100 rheumatoid arthritis (RA), 25 thyroiditis and 20 blood-donors were analyzed in a comparat...

journal_title：Autoimmunity

authors： Desbos A,Gonzalo P,Monier JC,Tebib J,Reboud JP,Perrier H,Bienvenu J,Fabien N

更新日期：2002-11-01 00:00:00