Apoptosis and NET formation in the pathogenesis of SLE.

abstract：:The nature of the immunosuppressive effect of antithyroid drugs has been a subject of controversy. It has been claimed that these agents exert a direct effect on the immune system, although we and others have suggested that the drugs affect the thyroid cells primarily with consequent reduced thyrocyte-immunocyte signa...

journal_title：Autoimmunity

authors： Aguayo J,Michaud P,Iitaka M,Degroot LJ,Row VV,Volpé R

更新日期：1989-01-01 00:00:00

abstract：:Food intake may be one of several factors which influence the risk of development of insulin dependent diabetes mellitus, but the influence of the pattern of food supply has not been studied previously. The aim of the present study was to investigate the effect of intermittent feeding and fasting upon diabetes in BB r...

journal_title：Autoimmunity

authors： Pedersen CR,Hagemann I,Bock T,Buschard K

更新日期：1999-01-01 00:00:00

abstract：:The objective of this study was to identify new autoantibodies that could be useful for the diagnosis of rheumatoid arthritis (RA) using immunoblotting on synovial membrane proteins which represent the best source of candidate RA autoantigens. A new target protein with a molecular weight of 26 kDa was found to be reco...

journal_title：Autoimmunity

authors： Robert-Pachot M,Desbos A,Moreira A,Becchi M,Tebib J,Bonnin M,Aitsiselmi T,Bienvenu J,Fabien N

更新日期：2007-07-01 00:00:00

abstract：:At least two signals for proliferation and cytokine secretion by T-cells are required. The first signal is delivered through the interaction of the T-cell receptor with major histocompatibility complex (MHC) molecules expressed on the surface of antigen-presenting cells (APC). The second or costimulatory signal is del...

journal_title：Autoimmunity

authors： Salmaso C,Olive D,Pesce G,Bagnasco M

更新日期：2002-05-01 00:00:00

abstract：:In the present study, the spontaneous elevation of the transcription of heat shock protein (hsp 70) gene in kidney lymphoid cells of lupus-prone mice (MRL-lpr/lpr) is shown by Northern blot and nuclear run on transcription assay. By quantification analysis of hsp 70 gene transcription, more than ten times of the enhan...

journal_title：Autoimmunity

authors： Deguchi Y

更新日期：1991-01-01 00:00:00

abstract：:Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in...

journal_title：Autoimmunity

authors： Jones BM,Liu T,Wong RW

更新日期：1999-10-01 00:00:00

abstract：:To evaluate changes in TSH receptor antibody after surgery in Graves' disease and its relationship with the degree of lymphocytic infiltration, serial serum levels of TSH receptor antibody were measured before and after the subtotal thyroidectomy in 50 patients with Graves' disease. In 22 (44%) out of 50 patients, thy...

journal_title：Autoimmunity

authors： Cho BY,Oh SK,Shong YK,Kim SE,Yoo HY,Lee HK,Koh CS,Min HK

更新日期：1990-01-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is preceded by the presence of antibodies against islet proteins including a protein tyrosine phosphatase (PTP) designated IA-2. Recently, we cloned a novel PTP named IAR which shares 43% sequence identity with IA-2 and is recognised by antibodies from a majority of patients ...

journal_title：Autoimmunity

authors： Schmidli RS,Colman PG,Cui L,Yu WP,Kewming K,Jankulovski C,Harrison LC,Pallen CJ,DeAizpurua HJ

更新日期：1998-01-01 00:00:00

abstract：:Recent findings provide evidence of the critical role of innate immunity NALP1/NLRP1 and NALP3/NLRP3/CIAS1 genes in inflammatory diseases, and also in the predisposition to autoimmune disorders. We evaluated the possible association of five single nucleotide polymorphisms (SNPs), two in NLRP1 gene and three in NLRP3 g...

journal_title：Autoimmunity

authors： Pontillo A,Brandao L,Guimaraes R,Segat L,Araujo J,Crovella S

更新日期：2010-12-01 00:00:00

abstract：:The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed mo...

journal_title：Autoimmunity

authors： Fujino Y,Li Q,Chung H,Hikita N,Nussenblatt RB,Gery I,Chan CC

更新日期：1992-01-01 00:00:00

abstract：:We have used the reverse transcriptase polymerase chain reaction (RT-PCR) technique to assess the expression of cytokine genes in various T cell subsets of autoimmune-prone mice. Our study confirmed the previously described features in lpr mice that IFN-gamma, TNF-alpha, and TNF-beta were transcribed by various T cell...

journal_title：Autoimmunity

authors： Mori K,Kobayashi S,Inobe M,Jia WY,Tamakoshi M,Miyazaki T,Uede T

更新日期：1994-01-01 00:00:00

abstract：:In a previous work we characterized a major epitope of thyroid peroxidase (TPO), which was recognised by 66% of 157 patients with autoimmune thyroid disease (AITD) and 9 out of 50 patients with non-thyroidal autoimmune disease (NTAID) 6 of whom had antibodies to the gastric parietal cell antigen (PCA). In the present ...

journal_title：Autoimmunity

authors： Elisei R,Mariotti S,Swillens S,Vassart G,Ludgate M

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:There have been few reports on the association of rheumatoid arthritis (RA) with anti-neutrophil cytoplasmic antigen (ANCA)-associated systemic vasculitides. METHODS:Here we present four cases of RA overlapping with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg-Strauss syndrome (CS...

journal_title：Autoimmunity

authors： Szilasi M,Mátyus J,File I,Szücs G,Rákóczi E,Pfliegler G,Szabó Z,Végh E,Szekanecz Z

更新日期：2012-06-01 00:00:00

abstract：:The presence of autoantibodies (aAbs) to thyroglobulin (TG) and thyroperoxidase (TPO) in most of the patients with autoimmune thyroid disease is now well documented. Studies of these aAbs suggested that some, termed TGPO aAbs, could interact with both TG and TPO. This hypothesis was investigated using IgG fraction fro...

journal_title：Autoimmunity

authors： Ruf J,Ferrand M,Durand-Gorde JM,Carayon P

更新日期：1992-01-01 00:00:00

abstract：:Human C-reactive protein (CRP) and serum amyloid component P (SAP) are well-characterised ligands for dying and dead cells, while facets of their physiological function still need to be unravelled. We partially characterised CRP and SAP from different species with similar acute-phase systems. Human, rabbit and porcine...

journal_title：Autoimmunity

authors： Mattecka S,Bock C,Vogt B,Yapici G,Schrödl W,Janko C,Schindler R,Sheriff A

更新日期：2013-08-01 00:00:00

abstract：:Glycosaminoglycan (GAG) accumulation in the retrobulbar space of patients with thyroid-associated ophthalmopathy (TAO) has been documented in a number of immunohistochemical studies. In order to gain further insight into possible immunopathogenic mechanisms, the influence of humoral immunity on retrobulbar fibroblasts...

journal_title：Autoimmunity

authors： Kahaly G,Stover C,Otto E,Beyer J,Schuler M

更新日期：1992-01-01 00:00:00

abstract：:CD4+ T cells play a crucial role in the development of lupus in MRL-lpr/lpr mice: incomplete deletion/silencing of self-reactive CD4+ T cells leads to T cell activation, which causes both polyclonal B cell activation and T cell infiltration of multiple organs. Furthermore, anti-CD4 antibody therapy ameliorates disease...

journal_title：Autoimmunity

authors： Duan JM,Fagard R,Madaio MP

更新日期：1996-01-01 00:00:00

abstract：:The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...

journal_title：Autoimmunity

authors： Otani Y,Ichii O,Otsuka-Kanazawa S,Chihara M,Nakamura T,Kon Y

更新日期：2015-01-01 00:00:00

abstract：:The aim of our study was to investigate and characterize regulatory T cells (Treg) in peripheral blood of patients with connective tissue diseases (Systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, poly- and dermatomyositis) as compared with blood from healthy controls. Treg cells were quantified a...

journal_title：Autoimmunity

authors： Banica L,Besliu A,Pistol G,Stavaru C,Ionescu R,Forsea AM,Tanaseanu C,Dumitrache S,Otelea D,Tamsulea I,Tanaseanu S,Chitonu C,Paraschiv S,Balteanu M,Stefanescu M,Matache C

更新日期：2009-01-01 00:00:00

abstract：:The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients,...

journal_title：Autoimmunity

authors： Dar SA,Haque S,Mandal RK,Singh T,Wahid M,Jawed A,Panda AK,Akhter N,Lohani M,Areeshi MY,Rai G,Datt S,Bhattacharya SN,Ramachandran VG,Das S

更新日期：2017-05-01 00:00:00

abstract：:Diabetes mellitus is a disorder characterized by hyperglycemia in both the fasting and post-prandial states. The two most common forms of diabetes mellitus, type 1 and type 2 (previously called juvenile-onset and adult-onset, respectively), comprise the vast majority of cases. Type 1 diabetes (T1DM) has been shown to ...

journal_title：Autoimmunity

authors： Taplin CE,Barker JM

更新日期：2008-02-01 00:00:00

abstract：:The aim of this study was to examine the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correlation with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=2...

journal_title：Autoimmunity

authors： Wang ZH,Liao YH,Fu M

更新日期：2001-01-01 00:00:00

abstract：:A flow cytometry-based phagocytosis assay was developed and utilized to measure the LE cell phenomenon at the single cell level in vitro. Since the lupus erythematosus (LE) cell phenomenon is a special form of necro-phagocytosis in the presence of anti-dsDNA antibodies, dead substrate cells or chicken erythrocytes nuc...

journal_title：Autoimmunity

authors： Böhm I

更新日期：2004-02-01 00:00:00

abstract：:Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71%), in particular anti-parietal cells (26.6%), antithyroglobulin (24.4%) and antithyroi...

journal_title：Autoimmunity

authors： Lorini R,Orecchia G,Martinetti M,Dugoujon JM,Cuccia M

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Autoimmune polyendocrine syndrome type 1 (APS 1) is caused by mutations in the AIRE gene that induce intrathymic T-cell tolerance breakdown, which results in tissue-specific autoimmune diseases. DESIGN:To evaluate the effect of a well-defined T-cell repertoire impairment on humoral self-reactive fingerprints...

journal_title：Autoimmunity

authors： Dubucquoi S,Proust-Lemoine E,Kemp EH,Ryndak A,Lefèvre-Dutoit V,Bellart M,Saugier-Véber P,Duban-Deweer S,Wémeau JL,Prin L,Lefranc D

更新日期：2015-01-01 00:00:00

abstract：:We analyzed morphologically autoimmune disease in MRL/MpJ mice bearing both the Yaa and lpr genes (MRL-lpr,Yaa mice), and compared it with that in MRL/MpJ-lpr/lpr (MRL-lpr) mice, in order to examine the effect of the Yaa gene on lpr-induced tissue-specific immunopathologies. MRL-lpr,Yaa male mice developed glomerulone...

journal_title：Autoimmunity

authors： Suzuka H,Yoshifusa H,Nakamura Y,Miyawaki S,Shibata Y

更新日期：1993-01-01 00:00:00

abstract：:The cytokine profile and occurrence of apoptosis during experimental melanin-protein induced uveitis (EMIU) were investigated and compared with that of experimental autoimmune uveoretinitis (EAU). EMIU or EAU was induced in Lewis rats. Eyes were collected at different time points after immunization. Cytokine mRNA expr...

journal_title：Autoimmunity

authors： Li Q,Sun B,Matteson DM,O'Brien TP,Chan CC

更新日期：1999-01-01 00:00:00

abstract：:Anti-M2 of anti-mitochondrial antibody (AMA) is a serological marker of primary biliary cirrhosis (PBC). Anti-pyruvate dehydrogenase complex-E2 (anti-PDC-E2) is recognized as the most frequently occurring anti-M2, and a routine laboratory test for this antibody has already been established. However, it is also known t...

journal_title：Autoimmunity

authors： Miyakawa H,Abe K,Kitazawa E,Kikuchi K,Fujikawa H,Matsushita M,Kawaguchi N,Kako M

更新日期：1999-01-01 00:00:00

abstract：:Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patien...

journal_title：Autoimmunity

authors： Sanders DB,Evoli A

更新日期：2010-08-01 00:00:00

abstract：:Embryonic tissue expresses a very low level of MHC molecules, and these few appear only late in ontogeny. Possibly related are deficiencies in the expression of TAP molecules and also the fetus' need to avoid maternal immunologic rejection. However, the fetus may overcome the lack of Ag-presenting molecules when threa...

journal_title：Autoimmunity

authors： Lee MS,Sarvetnick N

更新日期：1997-01-01 00:00:00