Abstract:
:The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed moderate to marked uveoretinitis, subretinal fibrosis, retinal necrosis and gliosis. The pineal glands demonstrated chronic pinealitis. The infiltrating cells were both CD3 and CD19/CD22 lymphocytes with a ratio of 1.4 in the eye and 2.2 in the pineal gland. The ratio of CD4 to CD8 lymphocytes was 1.5:1. MHC Class II antigens and adhesion molecule (ICAM-1) were observed on resident cells. The influx of B lymphocytes and the formation of subretinal fibrosis differentiate the disease in the monkey from that in the rat and mouse. These findings are similar to Vogt-Koyanagi-Harada syndrome and subretinal fibrosis with uveitis syndrome in human.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Fujino Y,Li Q,Chung H,Hikita N,Nussenblatt RB,Gery I,Chan CCdoi
10.3109/08916939209112339subject
Has Abstractpub_date
1992-01-01 00:00:00pages
303-9issue
4eissn
0891-6934issn
1607-842Xjournal_volume
13pub_type
杂志文章相关文献
AUTOIMMUNITY文献大全abstract::Systemic Lupus Erythematosus is an autoimmune disease characterized by the formation of anti-nuclear autoantibodies, particularly anti-chromatin. Although the aetiology of the disease has not yet been fully elucidated, several mechanisms have been proposed to be involved. Due to an aberrant apoptosis or decreased remo...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2012.719953
更新日期:2012-12-01 00:00:00
abstract::Six different hybridomas secreting anti-SCM mAb and one control mAb were placed into adult mice along with [14C] amino acids for biosynthetically labeling. After sacrifice, the 14C mAb ascites along with serum, heart, kidney, lung and skeletal muscle were recovered. Tissue associated specific radio-activity (SpAc) and...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939408995693
更新日期:1994-01-01 00:00:00
abstract::Immune profiling of non-obese diabetic (NOD) is a widely employed tool to assess the mechanisms of inflammatory insulitis. Our analysis of the female NOD colony revealed similar distribution of lymphoid lineages to wild type mice, and at various ages of prediabetic and diabetic mice. The profiles of mesenteric and pan...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2013.866103
更新日期:2014-03-01 00:00:00
abstract::Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first time serum DNase1-activity in a large consecutive cohort of treatment-naïve patients with autoimmune...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2017.1279610
更新日期:2017-03-01 00:00:00
abstract::Type 1 diabetes mellitus (T1DM) is the result of the autoimmune response against pancreatic insulin producing beta cells. This autoimmune response begins months or even years before the first presentation of signs and symptoms of hyperglycemia and at the time of clinical diagnosis near 30% of beta-cell mass still rema...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802200208
更新日期:2008-12-01 00:00:00
abstract::Autoimmune-prone NZB x NZW F1 (B/W F1) mice produce a high titer of anti-DNA antibodies, In vivo and in vitro studies showed that in the early life of these mice, the immunoglobulin isotype of these antibodies almost exclusively belongs to IgM class, however, IgG anti-DNA antibodies begin to develop when the mice are ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008993383
更新日期:1990-01-01 00:00:00
abstract::An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious agent that might be triggering the disease in genetically susceptible individuals. We studied 40 patients with Graves' disease, and compared them to the following groups of control...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939509001938
更新日期:1995-01-01 00:00:00
abstract::Pre-diabetes is a long-lasting condition that precedes type 2 diabetes (T2D). T2D has been shown to suppress the immune response. However, it remains unclear if immune activation occurs before the onset of T2D during the progression of the pre-diabetic state. This study sought to characterize the changes in general im...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2019.1575820
更新日期:2019-02-01 00:00:00
abstract:AIM:To assess the relationship of the Interleukin-10 (IL-10) -1082G/A (rs1800896), -819C/T (rs1800871) and -592C/A (rs1800872) polymorphism with inflammatory bowel disease (IBD) by means of meta-analysis. METHODS:Published data addressing the association between polymorphism of the IL-10 with Crohn's disease (CD) and ...
journal_title:Autoimmunity
pub_type: 杂志文章,meta分析
doi:10.3109/08916934.2013.843672
更新日期:2014-02-01 00:00:00
abstract::Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2018.1522305
更新日期:2018-11-01 00:00:00
abstract::DNA is a nuclear molecule that has both an intracellular and extracellular role. Inside the cell, it is the essential molecule of heredity while outside the cell it can have immunological activity, both alone and in the context of immune complexes. Furthermore, extracellular DNA has information content that can be min...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930701358826
更新日期:2007-06-01 00:00:00
abstract::Environmental agents have been implicated in the pathogenesis of insulin dependent diabetes (IDD). These studies were designed to learn if dietary protein influences the development of IDD in the BB rat. Specifically, analysis involved the effects of substituting a modified, semi-synthetic diet (AIN-76) containing soy...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938809019939
更新日期:1988-01-01 00:00:00
abstract::Interleukin-1beta (IL-1beta) has been implicated to play an important role in the autoimmune beta cell lesion of insulin-dependent diabetes mellitus (IDDM) because of its inhibition of insulin secretion, direct islet cytotoxicity and alteration of islet cell antigen expression. We have previously demonstrated that IL-...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908995378
更新日期:1999-01-01 00:00:00
abstract::It has been shown that cationic anti-DNA antibodies have nephritogenic potential in murine models of lupus nephritis. More recently, we have reported that there is a close relationship between the presence of circulating cationic anti-DNA antibodies and the development of lupus nephritis in humans, and that the cation...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409009538
更新日期:1994-01-01 00:00:00
abstract::Using a novel cytofluorometric method of cellular antigen quantification, we examined peripheral blood mononuclear cells (PBMC) from patients suffering from rheumatoid arthritis (RA) for quantitative modification of class II human leucocyte antigen (HLA) molecules expressed on the surface. Class II HLA molecules were ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938808997166
更新日期:1988-01-01 00:00:00
abstract::There is a need for methods to improve the diagnosis, patient staging and evaluation of therapeutic response in patients with autoimmune conditions to improve patient care. Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are two inflammatory diseases characterized by involvement of innate and adaptive i...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916931003674766
更新日期:2010-11-01 00:00:00
abstract::At least two signals for proliferation and cytokine secretion by T-cells are required. The first signal is delivered through the interaction of the T-cell receptor with major histocompatibility complex (MHC) molecules expressed on the surface of antigen-presenting cells (APC). The second or costimulatory signal is del...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930290013441
更新日期:2002-05-01 00:00:00
abstract::Augmented and prolonged expression of CD40 ligand (CD40L) was recently reported in lymphoid cells from human lupus patients, suggesting that CD40/CD40L pathway was involved in the pathogenesis of systemic autoimmune diseases. This study was thus designed to study the expression of CD40 and CD40L among cell populations...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930109001958
更新日期:2001-01-01 00:00:00
abstract::Only one out of 57 A-/A- rabbits immunized with rat or guinea-pig myelin developed clinical signs suggestive of EAE. On the contrary, clinical signs of acute or chronic EAE were found in two thirds of the 102 A+/A+ and A+/A- rabbits immunized in the same way. About one third of the diseased animals had reversible acut...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008993369
更新日期:1990-01-01 00:00:00
abstract::Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs). Prognosis of AITDs varies in each patient. Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production of proinflammatory cytokines. UNC93B1 is a transcription factor ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2016.1261835
更新日期:2017-05-01 00:00:00
abstract::A minor subset of murine MHC class I-restricted T cells which express both the alphabeta form of the T cell receptor and a NK lineage marker, termed NKT cells, is capable of secreting significant amounts of Interleukin-4 and Interferon-y upon activation. As such NKT cells may play a role in development of Th1 and Th2 ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908998535
更新日期:1999-01-01 00:00:00
abstract::NZB (H-2d) mice are well known for the production of IgM autoantibodies to ssDNA. However, an F1 cross between NZB and either NZW or SWR mice is required to produce IgG nephritogenic antibodies to dsDNA and glomerulonephritis. The contribution of parental class II loci in the hybrid mice is clearly important to the de...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939108997132
更新日期:1991-01-01 00:00:00
abstract::Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial an...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/73-0891693021000005402
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVES:Autoimmune sensorineural hearing loss (ASNHL) is a relatively rare disorder which can lead to total deafness. At present, no specific laboratory test with adequate sensitivity and specificity is available to confirm the clinical suspicion of ASNHL. The aim of this study was to identify if evaluation of anti-...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930601119377
更新日期:2007-02-01 00:00:00
abstract::To investigate the expression patterns of activation-induced cytidine deaminase (AID) variants in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and examine their clinical implications, we isolated PBMCs from healthy controls (HC, n = 33) and patients with AS (n = 62), and meas...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2017.1385777
更新日期:2017-12-01 00:00:00
abstract::GM2 ganglioside is a potential peripheral nerve antigen for neuropathy-associated autoantibodies. However little data are available on their pathogenic effects, if any. In this study we have screened both neuropathy-associated and control sera for anti-GM2 antibodies and subsequently used high titre sera for immunohis...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930008994083
更新日期:2000-09-01 00:00:00
abstract::Experimental autoimmune uveoretinitis (EAU) induced by immunization of albino Lewis rats with a retinal soluble antigen (S-antigen) has been studied extensively by many workers. An intraorchidic injection of S-antigen 4 days prior to immunization of the animal with the antigen emulsified in adjuvant was found to preve...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209083134
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:Autoantibodies to tumor-associated antigens including survivin have been detected in sera from patients with hepatocellular carcinoma (HCC). However, little is known about autoantibody responses to tumor-associated antigens in patients with chronic hepatitis, which strongly predisposes to development of HCC....
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500289958
更新日期:2005-09-01 00:00:00
abstract::Antineutrophil cytoplasmic antibodies (ANCA) are a sensitive and specific marker for ANCA-associated systemic vasculitis. Using indirect immunofluorescence on ethanol-fixed neutrophils, two major fluoroscopic patterns can be recognised: a diffuse cytoplasmic staining (C-ANCA), and a perinuclear/nuclear staining (P-ANC...
journal_title:Autoimmunity
pub_type: 历史文章,杂志文章,评审
doi:10.1080/08916930400022673
更新日期:2005-02-01 00:00:00
abstract::Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71%), in particular anti-parietal cells (26.6%), antithyroglobulin (24.4%) and antithyroi...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209035163
更新日期:1992-01-01 00:00:00