Abstract:
:Using a novel cytofluorometric method of cellular antigen quantification, we examined peripheral blood mononuclear cells (PBMC) from patients suffering from rheumatoid arthritis (RA) for quantitative modification of class II human leucocyte antigen (HLA) molecules expressed on the surface. Class II HLA molecules were detected by indirect immunofluorescence with a monomorphic monoclonal antibody. No change was observed in the density of class II HLA molecules at the surface of monocytes of RA patients as compared to that of paired healthy subjects. We confirmed that the percentage of class II HLA-bearing T cells was slightly increased in RA patients versus controls, but the density of class II antigens per cell could not be determined accurately. An increase in the density of class II HLA molecules on RA B cells was shown, suggesting that a chronic activation stage of this population contributes to the disease.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Eliaou JF,Andary M,Favier F,Carayon P,Poncelet P,Sany J,Brochier J,Clot Jdoi
10.3109/08916938808997166subject
Has Abstractpub_date
1988-01-01 00:00:00pages
217-22issue
3eissn
0891-6934issn
1607-842Xjournal_volume
1pub_type
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