Expression of rheumatoid factor idiotypes 17.109, 6B6.6 and 4C9 in the sera of Pima Indians.

abstract：:We report in this paper on obvious fibrotic lesions in the liver of mice undergoing specified graft-versus-host reaction (GVHR). B6 CD8+ splenocytes were transferred into (bm 12 x bm 1)F1 mice to induce GVHR. Recipient mice had been thymectomized and administrated with anti-CD8 monoclonal antibody (mAb) to deplete CD8...

journal_title：Autoimmunity

authors： Inada S,Suzuki K,Kimura T,Hayashi A,Narita T,Yui R,Asakura H,Fujiwara M

更新日期：1995-01-01 00:00:00

abstract：:Pre-diabetes is a long-lasting condition that precedes type 2 diabetes (T2D). T2D has been shown to suppress the immune response. However, it remains unclear if immune activation occurs before the onset of T2D during the progression of the pre-diabetic state. This study sought to characterize the changes in general im...

journal_title：Autoimmunity

authors： Mzimela NC,Ngubane PS,Khathi A

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Thalidomide is used in cutaneous lupus erythematosus (CLE) refractory to conventional therapies. Peripheral neuropathy (PN) is the most severe side effect, but the incidence of PN and its relation to thalidomide dose are still unclear. OBJECTIVE:To prospectively evaluate the efficacy as well as the occurren...

journal_title：Autoimmunity

authors： Briani C,Zara G,Rondinone R,Iaccarino L,Ruggero S,Toffanin E,Ermani M,Ghirardello A,Zampieri S,Sarzi-Puttini P,Doria A

更新日期：2005-11-01 00:00:00

abstract：:It has been suggested that pancreatic beta-cell destruction occurring during the process leading to insulin-dependent diabetes mellitus (IDDM) involves formation of nitric oxide (NO). We have presently studied the effect of aminoguanidine (AG), which has recently been reported to inhibit generation of NO induced by th...

journal_title：Autoimmunity

authors： Holstad M,Sandler S

更新日期：1993-01-01 00:00:00

abstract：:Six different hybridomas secreting anti-SCM mAb and one control mAb were placed into adult mice along with [14C] amino acids for biosynthetically labeling. After sacrifice, the 14C mAb ascites along with serum, heart, kidney, lung and skeletal muscle were recovered. Tissue associated specific radio-activity (SpAc) and...

journal_title：Autoimmunity

authors： Lange CF

更新日期：1994-01-01 00:00:00

abstract：:Recent findings provide evidence of the critical role of innate immunity NALP1/NLRP1 and NALP3/NLRP3/CIAS1 genes in inflammatory diseases, and also in the predisposition to autoimmune disorders. We evaluated the possible association of five single nucleotide polymorphisms (SNPs), two in NLRP1 gene and three in NLRP3 g...

journal_title：Autoimmunity

authors： Pontillo A,Brandao L,Guimaraes R,Segat L,Araujo J,Crovella S

更新日期：2010-12-01 00:00:00

abstract：:Autoantibodies against the beta-cell M(r) 64,000 protein (p64), recently identified as an isoform of glutamic acid decarboxylase (GAD), are prevalent in patients with insulin-dependent diabetes mellitus (IDDM). Dog islets were found to represent an abundant source of native p64 allowing the study of antigen-antibody i...

journal_title：Autoimmunity

authors： Bärmeier H,Ahlmén J,Landin-Olsson M,Rajotte RV,Sundkvist G,Warnock G,Lernmark A

更新日期：1992-01-01 00:00:00

abstract：:In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of circumstances, observations encounters, that all have favored the rise of a family of agent based simulations of the Immune System. Franco Celada was among the firs...

journal_title：Autoimmunity

authors： Celada F

更新日期：2011-06-01 00:00:00

abstract：:Epstein-Barr virus (EBV) is a human herpesvirus hiding in a latent form in memory B cells in the majority of the world population. Although, primary EBV infection is asymptomatic or causes a self-limiting disease, infectious mononucleosis, the virus is associated with a wide variety of neoplasms developing in immunosu...

journal_title：Autoimmunity

authors： Niller HH,Wolf H,Minarovits J

更新日期：2008-05-01 00:00:00

abstract：:Autoimmune-prone NZB x NZW F1 (B/W F1) mice produce a high titer of anti-DNA antibodies, In vivo and in vitro studies showed that in the early life of these mice, the immunoglobulin isotype of these antibodies almost exclusively belongs to IgM class, however, IgG anti-DNA antibodies begin to develop when the mice are ...

journal_title：Autoimmunity

authors： Okada T,Abe M,Takiura F,Hirose S,Shirai T

更新日期：1990-01-01 00:00:00

abstract：:Recent years have witnessed an explosive growth in available biological data pertaining to autoimmunity research. This includes a tremendous quantity of sequence data (biological structures, genetic and physical maps, pathways, etc.) generated by genome and proteome projects plus extensive clinical and epidemiological...

journal_title：Autoimmunity

authors： Petrovsky N,Brusic V

更新日期：2006-12-01 00:00:00

abstract：:Pemphigus is an autoimmune cutaneous disease characterized by circulating autoantibodies that cause blistering and erosions on skin and mucous membranes. Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. The prin...

journal_title：Autoimmunity

authors： Frusić-Zlotkin M,Raichenberg D,Wang X,David M,Michel B,Milner Y

更新日期：2006-11-01 00:00:00

abstract：:T lymphocytes present in thyroid infiltrates of 6 patients with Hashimoto's thyroiditis (HT) and of 4 patients with Graves' disease (GD) were analyzed at clonal level and their profiles of mitogen-induced lymphokine secretion were characterized. Production of interleukin-2 (IL-2), interleukin-4 (IL-4), interferon-gamm...

journal_title：Autoimmunity

authors： Del Prete GF,Tiri A,De Carli M,Mariotti S,Pinchera A,Chretien I,Romagnani S,Ricci M

更新日期：1989-01-01 00:00:00

abstract：:DNA is a nuclear molecule that has both an intracellular and extracellular role. Inside the cell, it is the essential molecule of heredity while outside the cell it can have immunological activity, both alone and in the context of immune complexes. Furthermore, extracellular DNA has information content that can be min...

journal_title：Autoimmunity

authors： Pisetsky DS,Fairhurst AM

更新日期：2007-06-01 00:00:00

abstract：:Experimental autoimmune myocarditis could be produced in mice by repeated injection of syngeneic heart extract together with Klebsiella pneumoniae O3 lipopolysaccharide (KO3 LPS) as a powerful adjuvant. Histological changes in the cardiac lesions were characterized by infiltration with mononuclear cells in the myocard...

journal_title：Autoimmunity

authors： Kato N,Fujii Y,Agata N,Kido N,Ohta M,Naito S,Yokochi T

更新日期：1993-01-01 00:00:00

abstract：:Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patien...

journal_title：Autoimmunity

authors： Sanders DB,Evoli A

更新日期：2010-08-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a myocardial disease characterized by progressive depression of myocardial contractile function and by ventricular dilatation. Abnormalities of the cellular and humoral immune system are present in patients with myocarditis and DCM. Various circulating cardiac autoantibodies have been d...

journal_title：Autoimmunity

authors： Felix SB,Staudt A,Friedrich GB

更新日期：2001-01-01 00:00:00

abstract：:Elevated constitutive expression of major histocompatibility (MHC) class II antigens occurs in the enterocytes of patients with IBD. It has been suggested that this aberrant expression of class II molecules may play a role in the pathogenesis of IBD. We examined two possible reasons for such a finding. 1) Heightened s...

journal_title：Autoimmunity

authors： Salomon P,Pizzimenti A,Panja A,Reisman A,Mayer L

更新日期：1991-01-01 00:00:00

abstract：:Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the...

journal_title：Autoimmunity

authors： Rego SL,Harvey S,Simpson SR,Hemphill WO,McIver ZA,Grayson JM,Perrino FW

更新日期：2018-11-01 00:00:00

abstract：:The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed mo...

journal_title：Autoimmunity

authors： Fujino Y,Li Q,Chung H,Hikita N,Nussenblatt RB,Gery I,Chan CC

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVES:There have been few reports on the association of rheumatoid arthritis (RA) with anti-neutrophil cytoplasmic antigen (ANCA)-associated systemic vasculitides. METHODS:Here we present four cases of RA overlapping with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg-Strauss syndrome (CS...

journal_title：Autoimmunity

authors： Szilasi M,Mátyus J,File I,Szücs G,Rákóczi E,Pfliegler G,Szabó Z,Végh E,Szekanecz Z

更新日期：2012-06-01 00:00:00

abstract：:Experimental autoimmune uveoretinitis (EAU) induced by immunization of albino Lewis rats with a retinal soluble antigen (S-antigen) has been studied extensively by many workers. An intraorchidic injection of S-antigen 4 days prior to immunization of the animal with the antigen emulsified in adjuvant was found to preve...

journal_title：Autoimmunity

authors： Peng B,Yoshitoshi T,Shichi H

更新日期：1992-01-01 00:00:00

abstract：:Diabetes mellitus is a disorder characterized by hyperglycemia in both the fasting and post-prandial states. The two most common forms of diabetes mellitus, type 1 and type 2 (previously called juvenile-onset and adult-onset, respectively), comprise the vast majority of cases. Type 1 diabetes (T1DM) has been shown to ...

journal_title：Autoimmunity

authors： Taplin CE,Barker JM

更新日期：2008-02-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) have a significantly increased risk of cardiovascular disease (CVD). Increased prevalence of atherosclerosis may explain part of this enhanced risk, but SLE related CVD can also result from other mechanisms. Vascular events may be the result of several pathophysiologic ...

journal_title：Autoimmunity

authors： Gustafsson JT,Svenungsson E

更新日期：2014-03-01 00:00:00

abstract：:GM2 ganglioside is a potential peripheral nerve antigen for neuropathy-associated autoantibodies. However little data are available on their pathogenic effects, if any. In this study we have screened both neuropathy-associated and control sera for anti-GM2 antibodies and subsequently used high titre sera for immunohis...

journal_title：Autoimmunity

authors： O'Hanlon GM,Veitch J,Gallardo E,Illa I,Chancellor AM,Willison HJ

更新日期：2000-09-01 00:00:00

abstract：:The impact of maternal systemic autoimmune diseases on pregnancy outcome is not unequivocally defined. We analysed the pregnancy outcome of 221 pregnancies from 181 autoimmune patients, consecutively followed in a single Italian reference centre from 2001 to 2009. All patients were prospectively followed with monthly ...

journal_title：Autoimmunity

authors： Canti V,Castiglioni MT,Rosa S,Franchini S,Sabbadini MG,Manfredi AA,Rovere-Querini P

更新日期：2012-03-01 00:00:00

abstract：:Recent studies have demonstrated that the nephritogenicity of antibodies to dsDNA and nucleosomes confers to binding of glomerular membrane-associated nucleosomes, and not to cross-reacting glomerular antigens. There is no known parameter that determines antibody pathogenicity aside from specificity for dsDNA/nucleoso...

journal_title：Autoimmunity

authors： Mjelle JE,Kalaaji M,Rekvig OP

更新日期：2009-02-01 00:00:00

abstract：:Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on quality of life and can be life threatening. Rupture of vulnerable ath...

journal_title：Autoimmunity

authors： Kyaw T,Tipping P,Bobik A,Toh BH

更新日期：2017-02-01 00:00:00

abstract：:To explore the natural course of beta cell function in recent onset diabetes, a subgroup (n=157) of all incident cases (n=879) 15-34 years old, 1992-1993 in Sweden, and with positivity for at least one autoantibody of islet cell antibodies (ICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase an...

journal_title：Autoimmunity

authors： Törn C,Landin-Olsson M,Lernmark A,Scherstén B,Ostman J,Arnqvist HJ,Björk E,Blohmé G,Bolinder J,Eriksson J,Littorin B,Nyström L,Sundkvist G

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to characterise the functionally relevant minor lymphocyte subpopulations in whole blood of multiple sclerosis (MS) patients and their potential utility as biomarkers for treatment follow up. MATERIAL AND METHODS:Peripheral blood from 40 healthy donors (HD) and 66 MS patients [...

journal_title：Autoimmunity

authors： Teniente-Serra A,Grau-López L,Mansilla MJ,Fernández-Sanmartín M,Ester Condins A,Ramo-Tello C,Martínez-Cáceres E

更新日期：2016-06-01 00:00:00