Abstract:
:Experimental autoimmune uveoretinitis (EAU) induced by immunization of albino Lewis rats with a retinal soluble antigen (S-antigen) has been studied extensively by many workers. An intraorchidic injection of S-antigen 4 days prior to immunization of the animal with the antigen emulsified in adjuvant was found to prevent the onset of the disease. Orchiectomy in 24 hr after the intraorchidic injection did not abolish the effect of treatment. The systemic suppression induced by the orchidic treatment persisted at least for 3 weeks after treatment. In rats that received orchidic treatment, delayed-type hypersensitivity was markedly inhibited but anti-S-antigen antibody levels in the serum were as high as those in immunized rats without orchidic pretreatment. These results indicate that antigen challenge to the testis is a novel method to systemic activation of the immunosuppressive mechanism.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Peng B,Yoshitoshi T,Shichi Hdoi
10.3109/08916939209083134subject
Has Abstractpub_date
1992-01-01 00:00:00pages
149-53issue
2eissn
0891-6934issn
1607-842Xjournal_volume
14pub_type
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