Role of CCR5 Delta32 bp deletion in RA and SLE.

abstract：:Recent findings provide evidence of the critical role of innate immunity NALP1/NLRP1 and NALP3/NLRP3/CIAS1 genes in inflammatory diseases, and also in the predisposition to autoimmune disorders. We evaluated the possible association of five single nucleotide polymorphisms (SNPs), two in NLRP1 gene and three in NLRP3 g...

journal_title：Autoimmunity

authors： Pontillo A,Brandao L,Guimaraes R,Segat L,Araujo J,Crovella S

更新日期：2010-12-01 00:00:00

abstract：:The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencie...

journal_title：Autoimmunity

authors： Truedsson L,Bengtsson AA,Sturfelt G

更新日期：2007-12-01 00:00:00

abstract：:Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause t...

journal_title：Autoimmunity

authors： Mauney CH,Hollis T

更新日期：2018-05-01 00:00:00

abstract：:Congenital heart block is a serious condition with significant mortality due in most cases to the transplacental transfer of autoantibodies from an otherwise asymptomatic mother. Although SSA/Ro and SSB/La autoantibodies have been implicated, attention has focused recently on autoantibodies to envelope proteins of end...

journal_title：Autoimmunity

authors： de Parseval N,Forrest G,Venables PJ,Heidmann T

更新日期：1999-01-01 00:00:00

abstract：:In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of circumstances, observations encounters, that all have favored the rise of a family of agent based simulations of the Immune System. Franco Celada was among the firs...

journal_title：Autoimmunity

authors： Celada F

更新日期：2011-06-01 00:00:00

abstract：:Glycosaminoglycan (GAG) accumulation in the retrobulbar space of patients with thyroid-associated ophthalmopathy (TAO) has been documented in a number of immunohistochemical studies. In order to gain further insight into possible immunopathogenic mechanisms, the influence of humoral immunity on retrobulbar fibroblasts...

journal_title：Autoimmunity

authors： Kahaly G,Stover C,Otto E,Beyer J,Schuler M

更新日期：1992-01-01 00:00:00

abstract：:Chronic immune thrombocytopenia (ITP) is characterized by autoimmune-mediated platelet destruction and impairment of thrombopoiesis. Mesenchymal stem cells (MSCs) are proposed to exhibit immune modulatory functions in self-tolerance maintenance. In this study, we aimed to characterize phenotypically and functionally b...

journal_title：Autoimmunity

authors： Zhang D,Li H,Ma L,Zhang X,Xue F,Zhou Z,Chi Y,Liu X,Huang Y,Yang Y,Yang R

更新日期：2014-12-01 00:00:00

abstract：:Primary biliary cirrhosis (PBC) is characterised by immune-mediated damage to the intra-hepatic biliary epithelial cells (BEC). Immuno-modulatory/suppressive therapy represents, therefore, alogical approach to treatment in this disease. Conventional immuno-suppressive and immuno-modulatory agents suffer from the bread...

journal_title：Autoimmunity

authors： Jones DE,Palmer JM,Robe A,Kirby JA

更新日期：2002-12-01 00:00:00

abstract：:We have previously derived and identified a highly avid monoclonal IgM rheumatoid factor (mRF), C6, from unstimulated rheumatoid synovial cells (RSC). At the time, the closet VH germline gene, VH26, demonstrated only 88% homology with C6. To identify the germline counterpart of C6, genomic DNA from the same rheumatoid...

journal_title：Autoimmunity

authors： Wong A,Tait R,Kenny T,Gorin F,Robbins D

更新日期：1995-01-01 00:00:00

abstract：:Chronic autoimmune thyroiditis (cAIT) leads to hypothyroidism due to T cell-mediated cytotoxicity in most cases. By contrast, Graves' disease (GD) with thyrotropin receptor stimulatory autoantibodies cause hyperthyroidism. Cytokines play a crucial role in modulating immune response in both disorders. The aim of study ...

journal_title：Autoimmunity

authors： Mikos H,Mikos M,Rabska-Pietrzak B,Niedziela M

更新日期：2014-11-01 00:00:00

abstract：:Proteinase 3 (PR3)-specific antineutrophil cytoplasmic autoantibodies (PR3-ANCA) recognize conformational epitopes on PR3. This study evaluates PR3-ANCA target epitopes utilizing a novel recombinant PR3 (rPR3) produced to accommodate manipulations of the N-terminal domain. The rPR3 molecule contains an N-terminus six ...

journal_title：Autoimmunity

authors： Farrag L,Pendergraft WF 3rd,Yang JJ,Jennette JC,Falk RJ,Preston GA

更新日期：2007-11-01 00:00:00

abstract：:The aim of this study was to examine the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correlation with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=2...

journal_title：Autoimmunity

authors： Wang ZH,Liao YH,Fu M

更新日期：2001-01-01 00:00:00

abstract：:Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...

journal_title：Autoimmunity

authors： Keith MP,Moratz C,Egan R,Zacharia A,Greidinger EL,Hoffman RW,Tsokos GC

更新日期：2007-05-01 00:00:00

abstract：:Subcutaneous insulin treatment of young diabetes prone BB rats has been shown previously to suppress the development of autoimmune diabetes. In this study the hypothesis was tested that exogenous insulin may deviate the autoimmune process by acting on the Th1/Th2 cytokine balance in the pancreas. BB rats were implante...

journal_title：Autoimmunity

authors： Kolb H,Wörz-Pagenstert U,Kleemann R,Rothe H,Rowsell P,Rastegar S,Scott FW

更新日期：1997-01-01 00:00:00

abstract：:A comparative study of tyrosine phosphorylation was performed on peripheral blood lymphocytes from systemic lupus erythematosus (SLE) patients and from healthy donors. Freshly isolated SLE lymphocytes presented an elevated tyrosine phosphorylation level when compared to healthy donors lymphocytes (p = 0.005). Among al...

journal_title：Autoimmunity

authors： Matache C,Stefanescu M,Onu A,Szegli G,Barel M,Tanaseanu S,Matei I,Bouillie S,Frade R

更新日期：1996-01-01 00:00:00

abstract：:Environmental agents have been implicated in the pathogenesis of insulin dependent diabetes (IDD). These studies were designed to learn if dietary protein influences the development of IDD in the BB rat. Specifically, analysis involved the effects of substituting a modified, semi-synthetic diet (AIN-76) containing soy...

journal_title：Autoimmunity

authors： Atkinson MA,Winter WE,Skordis N,Beppu H,Riley WM,Maclaren NK

更新日期：1988-01-01 00:00:00

abstract：:We reported a patient who gave birth to 3 children with transient neonatal hypothyroidism. She had 3 different antibodies (Ab) to the thyrotropin receptor (TSHR) in her serum, viz., TSH binding-inhibiting (TBIAb), thyroid-stimulating (TSAb) and an additional stimulating Ab (SAb). The SAb differed from TSAb in that its...

journal_title：Autoimmunity

authors： Zakarija M,De Forteza R,McKenzie JM,Ghandur-Mnaymneh L

更新日期：1994-01-01 00:00:00

abstract：:It is generally accepted that thyroid-associated ophthalmopathy (TAO) is an autoimmune disease of the eye muscle (EM) and the surrounding orbital connective tissue in which circulating antibodies play an important role. Antibodies against EM membrane proteins of 63-67kDa mol. wt. seem to be the best markers of ophthal...

journal_title：Autoimmunity

authors： Gunji K,Kubota S,Stolarski C,Wengrowicz S,Kennerdell JS,Wall JR

更新日期：1999-01-01 00:00:00

abstract：MOTIVATION:The human immune system evolved a multi-layered control mechanism to eliminate self-reactive cells. Of these so-called tolerance induction mechanisms, lymphocytes T education in the thymus gland represents the very first one. This complicated process is not fully understood and quantitative models able to he...

journal_title：Autoimmunity

authors： Castiglione F,Santoni D,Rapin N

更新日期：2011-06-01 00:00:00

abstract：:Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and n...

journal_title：Autoimmunity

authors： Khan MA,Alam K,Hassan SM,Rizvi MMA

更新日期：2017-06-01 00:00:00

abstract：:Augmented and prolonged expression of CD40 ligand (CD40L) was recently reported in lymphoid cells from human lupus patients, suggesting that CD40/CD40L pathway was involved in the pathogenesis of systemic autoimmune diseases. This study was thus designed to study the expression of CD40 and CD40L among cell populations...

journal_title：Autoimmunity

authors： Liu MF,Chao SC,Wang CR,Lei HY

更新日期：2001-01-01 00:00:00

abstract：:Although a variety of eye muscle antigens are recognized by autoantibodies in the serum from patients with thyroid associated ophthalmopathy (TAO) 64 kDa membrane proteins, which are also expressed in the thyroid, are most closely linked to the development of ophthalmopathy in patients with autoimmune thyroid disease....

journal_title：Autoimmunity

authors： Boucher A,Bernard N,Zhang ZG,Rodien P,Salvi M,Wall JR

更新日期：1993-01-01 00:00:00

abstract：:Interleukin 1beta (IL-1) is cytotoxic to rat pancreatic beta-cells in vitro, and increased expression of IL-1 mRNA is found in the islets of Langerhans during development of diabetes in BB/Wor/Mol-BB2 (BB-DP) rats and NOD mice. It has been proposed that IL-1 induces a race between protective and deleterious proteins i...

journal_title：Autoimmunity

authors： Christensen UB,Larsen PM,Fey SJ,Andersen HU,Nawrocki A,Sparre T,Mandrup-Poulsen T,Nerup J

更新日期：2000-01-01 00:00:00

abstract：:Acquired myasthenia gravis (MG), a neurological autoimmune disease, is caused by autoantibodies against components of the neuromuscular junction that lead to disabling muscle fatigability. The thymus is clearly involved in the pathogenesis of early-onset MG with anti-acetylcholine receptor antibodies, and thymic hyper...

journal_title：Autoimmunity

authors： Le Panse R,Bismuth J,Cizeron-Clairac G,Weiss JM,Cufi P,Dartevelle P,De Rosbo NK,Berrih-Aknin S

更新日期：2010-08-01 00:00:00

abstract：:Food intake may be one of several factors which influence the risk of development of insulin dependent diabetes mellitus, but the influence of the pattern of food supply has not been studied previously. The aim of the present study was to investigate the effect of intermittent feeding and fasting upon diabetes in BB r...

journal_title：Autoimmunity

authors： Pedersen CR,Hagemann I,Bock T,Buschard K

更新日期：1999-01-01 00:00:00

abstract：:Programmed cell death 1 (PD-1) was isolated in 1992 by subtractive-hybridization technique, as a molecule whose expression is enhanced by apoptotic stimuli. Since then we have been analyzing the function of PD-1 in the regulation of immune responses. Generation of PD-1 deficient mice, pathophysiological analyses of au...

journal_title：Autoimmunity

authors： Okazaki T,Wang J

更新日期：2005-08-01 00:00:00

abstract：:Antineutrophil cytoplasmic antibodies (ANCA) are a sensitive and specific marker for ANCA-associated systemic vasculitis. Using indirect immunofluorescence on ethanol-fixed neutrophils, two major fluoroscopic patterns can be recognised: a diffuse cytoplasmic staining (C-ANCA), and a perinuclear/nuclear staining (P-ANC...

journal_title：Autoimmunity

authors： Radice A,Sinico RA

更新日期：2005-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE patients and contr...

journal_title：Autoimmunity

authors： Paradowska-Gorycka A,Sowinska A,Stypinska B,Grobelna MK,Walczyk M,Olesinska M,Piotrowski P,Jagodziński PP

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to characterise the functionally relevant minor lymphocyte subpopulations in whole blood of multiple sclerosis (MS) patients and their potential utility as biomarkers for treatment follow up. MATERIAL AND METHODS:Peripheral blood from 40 healthy donors (HD) and 66 MS patients [...

journal_title：Autoimmunity

authors： Teniente-Serra A,Grau-López L,Mansilla MJ,Fernández-Sanmartín M,Ester Condins A,Ramo-Tello C,Martínez-Cáceres E

更新日期：2016-06-01 00:00:00

abstract：:The goal of contemporary research in pemphigus vulgaris and pemphigus foliaceus is to achieve and maintain clinical remission without corticosteroids. Recent advances of knowledge on pemphigus autoimmunity scrutinize old dogmas, resolve controversies, and open novel perspectives for treatment. Elucidation of intimate ...

journal_title：Autoimmunity

authors： Grando SA

更新日期：2012-02-01 00:00:00