Abstract:
:The Foxo subfamily of forkhead (Fox) transcription factors are mammalian homologues of the Caenorhabditis elegans DAF-16 longevity gene, and play key roles in cellular and organism survival, death, proliferation and metabolism. A growing body of evidence indicates that Foxo proteins furthermore play critical roles in immune cell homeostasis, modulating inflammation in some disease states such as inflammatory arthritis and systemic lupus erythematosus (SLE), via fundamental roles in T cells, B cells, neurophils and other myeloid lineages. This review summarizes current knowledge of the Foxo family members in general and in immunity, including their potential use as therapeutic targets.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Peng SLdoi
10.1080/08916930701464913subject
Has Abstractpub_date
2007-09-01 00:00:00pages
462-9issue
6eissn
0891-6934issn
1607-842Xpii
781630767journal_volume
40pub_type
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