Impaired indoleamine 2,3-dioxygenase production contributes to the development of autoimmunity in primary biliary cirrhosis.


:The immunomodulatory effects of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) have been elucidated at a cellular level and implicated in the pathogenesis of several complex diseases. Defects within the regulatory T cell compartment are one of the characteristics of primary biliary cirrhosis (PBC), an autoimmune chronic cholestatic liver disease, a phenotype that has also been shown in disease-mimicking animal models of this disease. We hypothesized that IDO dysregulation could lead to altered frequency and/or function of T cells at the level of antigen processing/presentation and we thus investigated IDO in peripheral monocytes and bile duct cells from patients with PBC. Both expression and activation manifested an impaired IFN-gamma response in peripheral monocytes while a peculiar IDO expression profile in bile duct cells characterized early stage PBC. Further, we observed an increased frequency of a gain-of-function SNP within the TGF-beta promoter region, a molecule known to suppress IDO transcription. In conclusion, we submit that an impaired IDO induction characterizes PBC and might represent a contributing factor in disease pathogenesis in association with several specific defects in the target tissue.






Oertelt-Prigione S,Mao TK,Selmi C,Tsuneyama K,Ansari AA,Coppel RL,Invernizzi P,Podda M,Gershwin ME




Has Abstract


2008-02-01 00:00:00














  • Intermittent feeding and fasting reduces diabetes incidence in BB rats.

    abstract::Food intake may be one of several factors which influence the risk of development of insulin dependent diabetes mellitus, but the influence of the pattern of food supply has not been studied previously. The aim of the present study was to investigate the effect of intermittent feeding and fasting upon diabetes in BB r...


    pub_type: 杂志文章


    authors: Pedersen CR,Hagemann I,Bock T,Buschard K

    更新日期:1999-01-01 00:00:00

  • Changes in thyrotropin receptor antibody after subtotal thyroidectomy in Graves' disease: comparison with the degree of lymphocytic infiltration in the thyroid.

    abstract::To evaluate changes in TSH receptor antibody after surgery in Graves' disease and its relationship with the degree of lymphocytic infiltration, serial serum levels of TSH receptor antibody were measured before and after the subtotal thyroidectomy in 50 patients with Graves' disease. In 22 (44%) out of 50 patients, thy...


    pub_type: 杂志文章


    authors: Cho BY,Oh SK,Shong YK,Kim SE,Yoo HY,Lee HK,Koh CS,Min HK

    更新日期:1990-01-01 00:00:00

  • Expression of activation-induced cytidine deaminase splicing variants in patients with ankylosing spondylitis.

    abstract::To investigate the expression patterns of activation-induced cytidine deaminase (AID) variants in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and examine their clinical implications, we isolated PBMCs from healthy controls (HC, n = 33) and patients with AS (n = 62), and meas...


    pub_type: 杂志文章


    authors: Kim JY,Yoon HK,Song ST,Park SR,Shim SC

    更新日期:2017-12-01 00:00:00

  • Polymorphisms in NLRP1 gene and susceptibility to autoimmune thyroid disease.

    abstract::The autoimmune thyroid disorders, or AITDs, comprise 2 related disorders, Graves' disease and Hashimoto thyroiditis. In AITD, immune system produces antibodies against autothyroid antigens. The etiology of AITDs involves a complex interaction between genetic predisposing factors and environmental triggering factors. V...


    pub_type: 杂志文章


    authors: Alkhateeb A,Jarun Y,Tashtoush R

    更新日期:2013-05-01 00:00:00

  • Oral tolerisation to pyruvate dehydrogenase complex as a potential therapy for primary biliary cirrhosis.

    abstract::Primary biliary cirrhosis (PBC) is characterised by immune-mediated damage to the intra-hepatic biliary epithelial cells (BEC). Immuno-modulatory/suppressive therapy represents, therefore, alogical approach to treatment in this disease. Conventional immuno-suppressive and immuno-modulatory agents suffer from the bread...


    pub_type: 杂志文章


    authors: Jones DE,Palmer JM,Robe A,Kirby JA

    更新日期:2002-12-01 00:00:00

  • The structure of human MHC class II genes.

    abstract::The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some a...


    pub_type: 杂志文章,评审


    authors: Rask L,Jonsson AK,Svensson AC,Gustafsson K,Andersson L

    更新日期:1991-01-01 00:00:00

  • T cell interactions with extracellular matrix proteins in patients with thyroid-associated ophthalmopathy.

    abstract::Although thyroid-associated ophthalmopathy (TAO) is now generally accepted as an autoimmune inflammatory disorder of the extraocular muscles and the orbital connective tissue, its aetiopathogenesis remains poorly understood. Recent data indicate that impaired interactions between T cells and extracellular matrix (ECM)...


    pub_type: 杂志文章


    authors: Bednarczuk T,Kiljanski J,Mrowiec T,Slon M,Ing E,Stolarski C,Kennerdell JS,Gorski A,Nauman J,Wall JR

    更新日期:1998-01-01 00:00:00

  • Functional and isokinetic assessment of muscle strength in patients with idiopathic inflammatory myopathies.

    abstract:OBJECTIVE:To assess muscle strength in patients with idiopathic inflammatory myopathies (IIM) using neuromuscular scales and isokinetic testing. METHODS:Muscle function was evaluated in 27 IIM patients being followed at the Rheumatology Unit of the University of Pisa using: (i) a modified version of the grading system...


    pub_type: 杂志文章


    authors: Neri R,Mosca M,Stampacchia G,Vesprini E,Tavoni A,d'Ascanio A,Bombardieri S

    更新日期:2006-05-01 00:00:00

  • Distinct surface phenotypes of B cells responsible for spontaneous production of IgM and IgG anti-DNA antibodies in autoimmune-prone NZB x NZW F1 mice.

    abstract::Autoimmune-prone NZB x NZW F1 (B/W F1) mice produce a high titer of anti-DNA antibodies, In vivo and in vitro studies showed that in the early life of these mice, the immunoglobulin isotype of these antibodies almost exclusively belongs to IgM class, however, IgG anti-DNA antibodies begin to develop when the mice are ...


    pub_type: 杂志文章


    authors: Okada T,Abe M,Takiura F,Hirose S,Shirai T

    更新日期:1990-01-01 00:00:00

  • Concentric fibrosis and cellular infiltration around bile ducts induced by graft-versus-host reaction in mice: a role of CD8+ cells.

    abstract::We report in this paper on obvious fibrotic lesions in the liver of mice undergoing specified graft-versus-host reaction (GVHR). B6 CD8+ splenocytes were transferred into (bm 12 x bm 1)F1 mice to induce GVHR. Recipient mice had been thymectomized and administrated with anti-CD8 monoclonal antibody (mAb) to deplete CD8...


    pub_type: 杂志文章


    authors: Inada S,Suzuki K,Kimura T,Hayashi A,Narita T,Yui R,Asakura H,Fujiwara M

    更新日期:1995-01-01 00:00:00

  • The changes in immune cell concentration during the progression of pre-diabetes to type 2 diabetes in a high-fat high-carbohydrate diet-induced pre-diabetic rat model.

    abstract::Pre-diabetes is a long-lasting condition that precedes type 2 diabetes (T2D). T2D has been shown to suppress the immune response. However, it remains unclear if immune activation occurs before the onset of T2D during the progression of the pre-diabetic state. This study sought to characterize the changes in general im...


    pub_type: 杂志文章


    authors: Mzimela NC,Ngubane PS,Khathi A

    更新日期:2019-02-01 00:00:00

  • Apoptotic cells selectively suppress the Th1 cytokine interferon gamma in stimulated human peripheral blood mononuclear cells and shift the Th1/Th2 balance towards Th2.

    abstract::Apoptotic cells are readily recognized and engulfed by phagocytes and usually do not induce inflammation or tissue damage. Furthermore, they can actively suppress a pro-inflammatory response in phagocytes: In the presence of apoptotic cells, activated monocytes/macrophages produce more of the anti-inflammatory and imm...


    pub_type: 杂志文章


    authors: Girkontaite I,Urbonaviciute V,Maseda D,Neubert K,Herrmann M,Voll RE

    更新日期:2007-06-01 00:00:00

  • Sera from lupus patients inhibit growth of P. falciparum in culture.

    abstract::A large number of malaria immune persons from Eastern India were found to possess antibodies to the ribosomal phosphoprotein P0 (PfP0) of the human malarial parasite Plasmodium falciparum. The characterization of PfP0 has been reported recently, and it has been shown that antibodies against PfP0 inhibit P. falciparum ...


    pub_type: 杂志文章


    authors: Singh S,Chatterjee S,Sohoni R,Badakere S,Sharma S

    更新日期:2001-01-01 00:00:00

  • NKT cell cytokine imbalance in murine diabetes mellitus.

    abstract::A minor subset of murine MHC class I-restricted T cells which express both the alphabeta form of the T cell receptor and a NK lineage marker, termed NKT cells, is capable of secreting significant amounts of Interleukin-4 and Interferon-y upon activation. As such NKT cells may play a role in development of Th1 and Th2 ...


    pub_type: 杂志文章


    authors: Frey AB,Rao TD

    更新日期:1999-01-01 00:00:00

  • Nature of 64 kDa eye muscle and thyroid membrane proteins and their significance in thyroid-associated ophthalmopathy--an hypothesis.

    abstract::Although a variety of eye muscle antigens are recognized by autoantibodies in the serum from patients with thyroid associated ophthalmopathy (TAO) 64 kDa membrane proteins, which are also expressed in the thyroid, are most closely linked to the development of ophthalmopathy in patients with autoimmune thyroid disease....


    pub_type: 杂志文章,评审


    authors: Boucher A,Bernard N,Zhang ZG,Rodien P,Salvi M,Wall JR

    更新日期:1993-01-01 00:00:00

  • Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct.

    abstract::Islet-infiltrating lymphocytes of individual male and female non-obese diabetic (NOD) mice were examined with the purpose of determining the differences that lead to a predominance of diabetes in female versus males NOD mice. When normalized for the amount of islet lymphocytes recovered, the infiltrating lymphocytes o...


    pub_type: 杂志文章


    authors: Young EF,Hess PR,Arnold LW,Tisch R,Frelinger JA

    更新日期:2009-01-01 00:00:00

  • Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease.

    abstract::Molecular mimicry is a hallmark of the pathogenesis of rheumatic fever where the streptococcal group A carbohydrate epitope, N-acetyl glucosamine, and the a-helical coiled-coil streptococcal M protein structurally mimic cardiac myosin in the human disease, rheumatic carditis, and in animal models immunized with strept...


    pub_type: 杂志文章,评审


    authors: Guilherme L,Kalil J,Cunningham M

    更新日期:2006-02-01 00:00:00

  • Uric acid and HMGB1 are involved in the induction of autoantibodies elicited in mice infected with mouse hepatitis virus A59.

    abstract::We have shown that mice infected with mouse hepatitis virus A59 develop autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH). Because it has been proposed that the immune system is stimulated by alarm signals called damage-associated molecular patterns or alarmins, we investigated the partic...


    pub_type: 杂志文章


    authors: Duhalde-Vega M,Retegui LA

    更新日期:2011-12-01 00:00:00

  • CD86 +1057G/A polymorphism and risk of chronic immune thrombocytopenia.

    abstract::The G to A transition at position +1057 single nucleotide polymorphism site in CD86 gene results in the alanine to threonine substitution, which further affects the antigen-presenting cells' signal transduction. Thus, the purpose of this study was to determine the association between CD86 +1057G/A polymorphism and the...


    pub_type: 杂志文章


    authors: Wu P,Wang Z,Lu S,Zhao X

    更新日期:2014-11-01 00:00:00

  • T lymphocyte activation in myasthenic thymoma.

    abstract::The functional and phenotypic characteristics of lymphocytes separated from myasthenic thymoma (Th-L) were compared with those of lymphocytes separated from non-thymomatous thymus associated with thymoma (NTh-L) of the same patients and NTh-L of myasthenia gravis (MG) patients without thymoma. We examined whether Th-L...


    pub_type: 杂志文章


    authors: Takahashi K,Saito S,Monden Y

    更新日期:1998-01-01 00:00:00

  • Follow-up of avidity and titer of anti-myeloperoxidase antibodies in sera from patients with primary ANCA-associated vasculitis.

    abstract::Antineutrophil cytoplasmic antibodies (ANCA) are important serologic markers for ANCA-associated vasculitis (AAV). Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA....


    pub_type: 杂志文章


    authors: Lin W,Chen M,Zhao MH

    更新日期:2009-03-01 00:00:00

  • Polymorphisms and expression of toll-like receptors in autoimmune thyroid diseases.

    abstract::Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs). Prognosis of AITDs varies in each patient. Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production of proinflammatory cytokines. UNC93B1 is a transcription factor ...


    pub_type: 杂志文章


    authors: Inoue N,Katsumata Y,Watanabe M,Ishido N,Manabe Y,Watanabe A,Masutani R,Hidaka Y,Iwatani Y

    更新日期:2017-05-01 00:00:00

  • MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease.

    abstract::The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...


    pub_type: 杂志文章


    authors: Otani Y,Ichii O,Otsuka-Kanazawa S,Chihara M,Nakamura T,Kon Y

    更新日期:2015-01-01 00:00:00

  • Induction of hyperacute brain inflammation and demyelination by activated encephalitogenic T cells and a monoclonal antibody specific for a myelin/oligodendrocyte glycoprotein.

    abstract::CNS demyelinating inflammatory disease can be a multifactorial process mediated by cellular and antibody-mediated immune processes. Myelin basic protein (MBP)-specific T cells and pathogenic 8-18C5 antibody, specific for a myelin/oligodendrocyte glycoprotein (MOG), a minor component of CNS white matter, can coexist in...


    pub_type: 杂志文章


    authors: Schluesener HJ,Lider O,Sobel RA

    更新日期:1989-01-01 00:00:00

  • Allogeneic hematopoietic stem cell transplantation for severe autoimmune diseases.

    abstract::Allogeneic hematopoietic stem cell transplantation (HSCT) offers the unique opportunity to replace a diseased hematopoietic or immune system by healthy donor cells. Proof of principle comes from experimental animal data, from the experience with severe aplastic anemia, from observations of patients with concomitant au...


    pub_type: 杂志文章


    authors: Gratwohl A

    更新日期:2008-12-01 00:00:00

  • Effect of administration of apoptotic blebs on disease development in lupus mice.

    abstract:INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the formation of autoantibodies against nuclear components. Disturbed apoptosis and reduced clearance of apoptotic material have been assigned a role in the pathogenesis of SLE. During apoptosis, apoptotic blebs are formed, in whi...


    pub_type: 杂志文章


    authors: Fransen JH,Berden JH,Koeter CM,Adema GJ,Van Der Vlag J,Hilbrands LB

    更新日期:2012-06-01 00:00:00

  • Cell-surface expression of lymphocyte activation markers in myasthenia gravis.

    abstract::An analysis of the cell-surface expression of activation markers on B- and T-cells was done to compare patients with myasthenia gravis (MG) and healthy non-myasthenic controls. Marker expression was determined by immunostaining of peripheral blood mononuclear cells (PBMC) isolated from MG patients and from controls. T...


    pub_type: 杂志文章


    authors: Ragheb S,Bealmear B,Lisak R

    更新日期:1999-01-01 00:00:00

  • Protective effects of quercetin treatment in a pristane-induced mouse model of lupus nephritis.

    abstract:INTRODUCTION:Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus. As murine models of LN are valuable tools to better understand its pathophysiology and to search for new effective treatments, we investigated the effects of the bioflavonoid quercetin on pristane-induced LN mice ...


    pub_type: 杂志文章


    authors: Dos Santos M,Poletti PT,Favero G,Stacchiotti A,Bonomini F,Montanari CC,Bona SR,Marroni NP,Rezzani R,Veronese FV

    更新日期:2018-03-01 00:00:00

  • Aβ anti-idiotypic antibodies are present in intravenous immunoglobulin and are produced in mice following its administration.

    abstract::The effects of intravenous immunoglobulin (IVIG) products were recently examined in patients with Alzheimer's disease (AD). Although encouraging results were obtained in pilot studies, later trials produced negative results. The rationale for these studies was that IVIG contains antibodies to amyloid-beta (Aβ). Howeve...


    pub_type: 杂志文章


    authors: Loeffler DA,Klaver AC,Coffey MP

    更新日期:2015-06-01 00:00:00

  • Fetal exposure to interferon-gamma leads to induction of antigen-presenting molecules and leukocyte recruitment.

    abstract::Embryonic tissue expresses a very low level of MHC molecules, and these few appear only late in ontogeny. Possibly related are deficiencies in the expression of TAP molecules and also the fetus' need to avoid maternal immunologic rejection. However, the fetus may overcome the lack of Ag-presenting molecules when threa...


    pub_type: 杂志文章


    authors: Lee MS,Sarvetnick N

    更新日期:1997-01-01 00:00:00