Abstract:
:The endothelium of the vessel wall as a barrier between blood and the subendothelial matrix proteins is essential for preventing thrombus formation and subsequent atherosclerosis development. Atherosclerosis is an inflammatory disease in which immune and autoimmune mechanisms are involved. Recently, it was demonstrated that endothelial cells in the vessel wall can be damaged not only by classic risk factors, such as hyperlipidemia, smoking and disturbed blood flow, but also (auto)immune reactions to autoantigens present in the cell surface, among which heat shock protein 60 (HSP60) was mostly studied. HSP60 normally located in mitochondria can be translocated into the cell member in response to stress stimuli. Meanwhile, autoantibodies against HSP60 are present in most subjects, especially patients with heart attack and stroke. These autoantibodies may bind to HSP60 expressed in endothelial cells resulting in the cell damage, subsequently initiating the formation of atherosclerotic lesions. Based on the recent progress in the research field, the present review will update the mechanisms of immune response to endothelial cells by which cell damage can initiate the development of atherosclerosis.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Foteinos G,Xu Qdoi
10.1080/08916930903002529subject
Has Abstractpub_date
2009-11-01 00:00:00pages
627-33issue
7eissn
0891-6934issn
1607-842Xpii
10.1080/08916930903002529journal_volume
42pub_type
杂志文章,评审相关文献
AUTOIMMUNITY文献大全abstract:INTRODUCTION:Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet aut...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2020.1815194
更新日期:2020-11-01 00:00:00
abstract::Agalactosyl IgG (Gal(0) is a glycoform lacking terminal galactose from the oligosaccharides situated on the Fc. The percentage of circulating IgG that is Gal(0) is increased in a a number of autoimmune diseases, and in certain chronic infections associated with autoantibody production. However it is not known whether ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939508995306
更新日期:1995-01-01 00:00:00
abstract::The effects of intravenous immunoglobulin (IVIG) products were recently examined in patients with Alzheimer's disease (AD). Although encouraging results were obtained in pilot studies, later trials produced negative results. The rationale for these studies was that IVIG contains antibodies to amyloid-beta (Aβ). Howeve...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2014.983265
更新日期:2015-06-01 00:00:00
abstract::Recent studies have demonstrated that the nephritogenicity of antibodies to dsDNA and nucleosomes confers to binding of glomerular membrane-associated nucleosomes, and not to cross-reacting glomerular antigens. There is no known parameter that determines antibody pathogenicity aside from specificity for dsDNA/nucleoso...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802375729
更新日期:2009-02-01 00:00:00
abstract::The present study uses the agent-based model IMMSIM to simulate immune responses to a viral infection, with a focus on the impact of preformed memory (homologous and heterologous) on the quality and the efficacy of the response. The in machina results confirm the observed thwarting of new, naïve responses exerted by c...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.523275
更新日期:2011-06-01 00:00:00
abstract::It has been suggested that pancreatic beta-cell destruction occurring during the process leading to insulin-dependent diabetes mellitus (IDDM) involves formation of nitric oxide (NO). We have presently studied the effect of aminoguanidine (AG), which has recently been reported to inhibit generation of NO induced by th...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939309115754
更新日期:1993-01-01 00:00:00
abstract::Integrin-adressin binding is a critical step in lymphocte attachment to target tissues. The mucosal recognition systems (alpha E beta 7, alpha 4 beta 7, MADcam-1) have been implicated in the autoimmune process in rheumatoid arthritis. We developed a model for in vivo study of radio-labelled lymphocyte circulation and ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608995363
更新日期:1996-01-01 00:00:00
abstract::Blockade of the complement cascade at the C5a/C5a receptor (C5aR)-axis is believed to be an attractive treatment avenue in rheumatoid arthritis (RA). However, the effects of such interventions during the early phases of arthritis remain to be clarified. In this study we use the murine delayed-type hypersensitivity art...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2015.1031888
更新日期:2015-01-01 00:00:00
abstract::Adult and one week old marmosets were injected intravenously within a one month period or intraperitoneally within a 6 week period respectively, with monoclonal IgM having an anti-myelin associated glycoprotein antibody activity. No clinical or electrophysiological abnormalities could be detected in experimental anima...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909043611
更新日期:1989-01-01 00:00:00
abstract::The impact of maternal systemic autoimmune diseases on pregnancy outcome is not unequivocally defined. We analysed the pregnancy outcome of 221 pregnancies from 181 autoimmune patients, consecutively followed in a single Italian reference centre from 2001 to 2009. All patients were prospectively followed with monthly ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2011.593600
更新日期:2012-03-01 00:00:00
abstract::Worldwide population studies have generally agreed that rheumatoid arthritis (RA) is associated with a group of HLA-DRB1 alleles which share a common amino acid sequence at residues 70-74. This represents the first study to investigate the association of HLA-DRB1 genes with susceptibility to RA amongst Malay, Chinese ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930290024179
更新日期:2002-07-01 00:00:00
abstract::In addition to a lupus-like syndrome and massive T cell proliferation, MRL-lpr/lpr(MRL/l) mice develop an arthritic process very similar serologically and histologically to human rheumatoid arthritis (RA). Recently, we have developed in DBA/1 mice an experimental model of autoimmune arthritis (EAA) which shares clinic...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909034357
更新日期:1989-01-01 00:00:00
abstract::It is generally accepted that thyroid-associated ophthalmopathy (TAO) is an autoimmune disease of the eye muscle (EM) and the surrounding orbital connective tissue in which circulating antibodies play an important role. Antibodies against EM membrane proteins of 63-67kDa mol. wt. seem to be the best markers of ophthal...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908995967
更新日期:1999-01-01 00:00:00
abstract::Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.757307
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:Autoantibodies to tumor-associated antigens including survivin have been detected in sera from patients with hepatocellular carcinoma (HCC). However, little is known about autoantibody responses to tumor-associated antigens in patients with chronic hepatitis, which strongly predisposes to development of HCC....
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500289958
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:There have been few reports on the association of rheumatoid arthritis (RA) with anti-neutrophil cytoplasmic antigen (ANCA)-associated systemic vasculitides. METHODS:Here we present four cases of RA overlapping with Wegener's granulomatosis (WG), microscopic polyangiitis (MPA) and Churg-Strauss syndrome (CS...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.677078
更新日期:2012-06-01 00:00:00
abstract::Marked fluctuations in the levels of a common DNA-antibody idiotype, PR4-Id have been found on IgM and IgA antibodies in particular and to a lesser extent on IgG in serial bleeds of 14 lupus patients. Few clear cut examples were found of the PR4-Id levels reflecting disease activity. However, the idiotype expression w...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939108997118
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:Autoimmune diseases, such as celiac disease (CD) and diabetes mellitus type 1, tend to co-occur within the same patient. The prevalence of CD in diabetic children is higher than in the general population, and is estimated to be 0.6-16.4%. The diagnosis of CD is based on histopathological examination and se...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2018.1427226
更新日期:2018-03-01 00:00:00
abstract::A comparative study of tyrosine phosphorylation was performed on peripheral blood lymphocytes from systemic lupus erythematosus (SLE) patients and from healthy donors. Freshly isolated SLE lymphocytes presented an elevated tyrosine phosphorylation level when compared to healthy donors lymphocytes (p = 0.005). Among al...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608994714
更新日期:1996-01-01 00:00:00
abstract::Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2018.1522305
更新日期:2018-11-01 00:00:00
abstract::Pemphigus is an autoimmune cutaneous disease characterized by circulating autoantibodies that cause blistering and erosions on skin and mucous membranes. Circulating autoantibodies bind to epidermal cell membrane and cause cell-cell detachment (acantholysis), leading to epidermal tissue damage and cell death. The prin...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930600971836
更新日期:2006-11-01 00:00:00
abstract::Chronic immune thrombocytopenia (ITP) is characterized by autoimmune-mediated platelet destruction and impairment of thrombopoiesis. Mesenchymal stem cells (MSCs) are proposed to exhibit immune modulatory functions in self-tolerance maintenance. In this study, we aimed to characterize phenotypically and functionally b...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2014.938320
更新日期:2014-12-01 00:00:00
abstract::The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencie...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930701510673
更新日期:2007-12-01 00:00:00
abstract::Numerous human Cytochrome P450 enzymes (CYPs) associated with 'phase I' drug metabolism have been identified. Among them, CYP2D6 is thought to be the major target autoantigen to anti-liver kidney microsome (LKM)-1 autoantibody, a characteristic feature of autoimmune hepatitis (AIH) type II. In this study, we were able...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930108994106
更新日期:2000-01-01 00:00:00
abstract::Interleukin-1beta (IL-1beta) has been implicated to play an important role in the autoimmune beta cell lesion of insulin-dependent diabetes mellitus (IDDM) because of its inhibition of insulin secretion, direct islet cytotoxicity and alteration of islet cell antigen expression. We have previously demonstrated that IL-...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908995378
更新日期:1999-01-01 00:00:00
abstract::Epstein-Barr virus (EBV) is a human herpesvirus hiding in a latent form in memory B cells in the majority of the world population. Although, primary EBV infection is asymptomatic or causes a self-limiting disease, infectious mononucleosis, the virus is associated with a wide variety of neoplasms developing in immunosu...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930802024772
更新日期:2008-05-01 00:00:00
abstract::Systemic Lupus Erythematosus is an autoimmune disease characterized by the formation of anti-nuclear autoantibodies, particularly anti-chromatin. Although the aetiology of the disease has not yet been fully elucidated, several mechanisms have been proposed to be involved. Due to an aberrant apoptosis or decreased remo...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2012.719953
更新日期:2012-12-01 00:00:00
abstract::The functional and phenotypic characteristics of lymphocytes separated from myasthenic thymoma (Th-L) were compared with those of lymphocytes separated from non-thymomatous thymus associated with thymoma (NTh-L) of the same patients and NTh-L of myasthenia gravis (MG) patients without thymoma. We examined whether Th-L...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939808996286
更新日期:1998-01-01 00:00:00
abstract::Myelin oligodendrocyte glycoprotein (MOG) is postulated to be a target autoantigen in multiple sclerosis (MS). Here we investigated the encephalitogenicity of an immunodominant epitope of MOG, peptide 35-55, in various strains of mice. An MS-like disease was induced in NOD/Lt mice (H-2g7) and C57BL/6 mice (H-2b) by a ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939809003872
更新日期:1998-01-01 00:00:00
abstract::The immunomodulatory effects of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) have been elucidated at a cellular level and implicated in the pathogenesis of several complex diseases. Defects within the regulatory T cell compartment are one of the characteristics of primary biliary cirrhosis (PBC...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701619730
更新日期:2008-02-01 00:00:00