Abstract:
:Marked fluctuations in the levels of a common DNA-antibody idiotype, PR4-Id have been found on IgM and IgA antibodies in particular and to a lesser extent on IgG in serial bleeds of 14 lupus patients. Few clear cut examples were found of the PR4-Id levels reflecting disease activity. However, the idiotype expression was not simply related to total immunoglobulin levels and the controlling mechanisms of idiotype expression on different isotypes remain a matter of conjecture.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Pilcher C,Williams W,Isenberg DAdoi
10.3109/08916939108997118subject
Has Abstractpub_date
1991-01-01 00:00:00pages
7-12issue
1eissn
0891-6934issn
1607-842Xjournal_volume
9pub_type
杂志文章相关文献
AUTOIMMUNITY文献大全abstract::This review focuses on recent advances and new hypothesis in the understanding of the T and dendritic cells contribution to the pathogenesis of idiopathic inflammatory myopathies (IIMs), especially polymyositis (PM) and dermatomyositis (DM). The new data show that non-specific amplification of muscle inflammation by T...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930600622173
更新日期:2006-05-01 00:00:00
abstract::The present study investigated the expressed number of CR1 on erythrocytes (E) in relationship of the CR1 density genotype from 46 patients with systemic lupus erythematosus (SLE) and 47 healthy volunteers. The CR1 genotype was determined by a method based on polymerase chain reaction (PCR) amplification of the genomi...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608994726
更新日期:1996-01-01 00:00:00
abstract::Subcutaneous insulin treatment of young diabetes prone BB rats has been shown previously to suppress the development of autoimmune diabetes. In this study the hypothesis was tested that exogenous insulin may deviate the autoimmune process by acting on the Th1/Th2 cytokine balance in the pancreas. BB rats were implante...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939709009544
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To study efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients. METHODS:The case records of 40 patients with lupus nephritis followed up in a single center between 1992 and 2011 (median duration = 8.37 years) were retrieved to determine efficacy and toxicity of the treat...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2013.817560
更新日期:2013-12-01 00:00:00
abstract::Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause t...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916934.2018.1454912
更新日期:2018-05-01 00:00:00
abstract::At least two signals for proliferation and cytokine secretion by T-cells are required. The first signal is delivered through the interaction of the T-cell receptor with major histocompatibility complex (MHC) molecules expressed on the surface of antigen-presenting cells (APC). The second or costimulatory signal is del...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930290013441
更新日期:2002-05-01 00:00:00
abstract::Thyroid lymphocyte RNA from a Hashimoto patient exhibiting high titre serum IgG autoantibodies against thyroglobulin (Tg) has been used to construct a Fab library in phage lambda. Screening of this library with radioiodinated Tg has permitted the cloning of an anti-Tg antibody (MH52) with an affinity of 4.5 x 10(9) mo...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209150320
更新日期:1992-01-01 00:00:00
abstract::An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious agent that might be triggering the disease in genetically susceptible individuals. We studied 40 patients with Graves' disease, and compared them to the following groups of control...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939509001938
更新日期:1995-01-01 00:00:00
abstract::We reported a patient who gave birth to 3 children with transient neonatal hypothyroidism. She had 3 different antibodies (Ab) to the thyrotropin receptor (TSHR) in her serum, viz., TSH binding-inhibiting (TBIAb), thyroid-stimulating (TSAb) and an additional stimulating Ab (SAb). The SAb differed from TSAb in that its...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939409008006
更新日期:1994-01-01 00:00:00
abstract::The cytokine profile and occurrence of apoptosis during experimental melanin-protein induced uveitis (EMIU) were investigated and compared with that of experimental autoimmune uveoretinitis (EAU). EMIU or EAU was induced in Lewis rats. Eyes were collected at different time points after immunization. Cytokine mRNA expr...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908993851
更新日期:1999-01-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) is a disease associated with a striking increase in the risk of premature cardiovascular (CV) complications due to accelerated atherosclerosis. Traditional CV risk factors seem to be less important predictors of CV events than the presence of active SLE. Immune dysregulation characte...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.1080/08916930903002479
更新日期:2009-11-01 00:00:00
abstract::Recent studies have demonstrated that the nephritogenicity of antibodies to dsDNA and nucleosomes confers to binding of glomerular membrane-associated nucleosomes, and not to cross-reacting glomerular antigens. There is no known parameter that determines antibody pathogenicity aside from specificity for dsDNA/nucleoso...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930802375729
更新日期:2009-02-01 00:00:00
abstract::Autoantibodies against the beta-cell M(r) 64,000 protein (p64), recently identified as an isoform of glutamic acid decarboxylase (GAD), are prevalent in patients with insulin-dependent diabetes mellitus (IDDM). Dog islets were found to represent an abundant source of native p64 allowing the study of antigen-antibody i...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939209004823
更新日期:1992-01-01 00:00:00
abstract::The immunomodulatory effects of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) have been elucidated at a cellular level and implicated in the pathogenesis of several complex diseases. Defects within the regulatory T cell compartment are one of the characteristics of primary biliary cirrhosis (PBC...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930701619730
更新日期:2008-02-01 00:00:00
abstract::Embryonic tissue expresses a very low level of MHC molecules, and these few appear only late in ontogeny. Possibly related are deficiencies in the expression of TAP molecules and also the fetus' need to avoid maternal immunologic rejection. However, the fetus may overcome the lack of Ag-presenting molecules when threa...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939709008021
更新日期:1997-01-01 00:00:00
abstract::In addition to a lupus-like syndrome and massive T cell proliferation, MRL-lpr/lpr(MRL/l) mice develop an arthritic process very similar serologically and histologically to human rheumatoid arthritis (RA). Recently, we have developed in DBA/1 mice an experimental model of autoimmune arthritis (EAA) which shares clinic...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938909034357
更新日期:1989-01-01 00:00:00
abstract::Food intake may be one of several factors which influence the risk of development of insulin dependent diabetes mellitus, but the influence of the pattern of food supply has not been studied previously. The aim of the present study was to investigate the effect of intermittent feeding and fasting upon diabetes in BB r...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939908993805
更新日期:1999-01-01 00:00:00
abstract::CD4+ T cells play a crucial role in the development of lupus in MRL-lpr/lpr mice: incomplete deletion/silencing of self-reactive CD4+ T cells leads to T cell activation, which causes both polyclonal B cell activation and T cell infiltration of multiple organs. Furthermore, anti-CD4 antibody therapy ameliorates disease...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939608995346
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet aut...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2020.1815194
更新日期:2020-11-01 00:00:00
abstract::Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and n...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916934.2017.1347643
更新日期:2017-06-01 00:00:00
abstract::Patients with systemic lupus erythematosus (SLE) have a significantly increased risk of cardiovascular disease (CVD). Increased prevalence of atherosclerosis may explain part of this enhanced risk, but SLE related CVD can also result from other mechanisms. Vascular events may be the result of several pathophysiologic ...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916934.2013.856005
更新日期:2014-03-01 00:00:00
abstract::A flow cytometry-based phagocytosis assay was developed and utilized to measure the LE cell phenomenon at the single cell level in vitro. Since the lupus erythematosus (LE) cell phenomenon is a special form of necro-phagocytosis in the presence of anti-dsDNA antibodies, dead substrate cells or chicken erythrocytes nuc...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930310001630325
更新日期:2004-02-01 00:00:00
abstract::Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916934.2012.757307
更新日期:2013-06-01 00:00:00
abstract::Using a novel cytofluorometric method of cellular antigen quantification, we examined peripheral blood mononuclear cells (PBMC) from patients suffering from rheumatoid arthritis (RA) for quantitative modification of class II human leucocyte antigen (HLA) molecules expressed on the surface. Class II HLA molecules were ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916938808997166
更新日期:1988-01-01 00:00:00
abstract::Autoimmune-prone NZB x NZW F1 (B/W F1) mice produce a high titer of anti-DNA antibodies, In vivo and in vitro studies showed that in the early life of these mice, the immunoglobulin isotype of these antibodies almost exclusively belongs to IgM class, however, IgG anti-DNA antibodies begin to develop when the mice are ...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939008993383
更新日期:1990-01-01 00:00:00
abstract::Elevated constitutive expression of major histocompatibility (MHC) class II antigens occurs in the enterocytes of patients with IBD. It has been suggested that this aberrant expression of class II molecules may play a role in the pathogenesis of IBD. We examined two possible reasons for such a finding. 1) Heightened s...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916939109006750
更新日期:1991-01-01 00:00:00
abstract::There is a need for methods to improve the diagnosis, patient staging and evaluation of therapeutic response in patients with autoimmune conditions to improve patient care. Inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) are two inflammatory diseases characterized by involvement of innate and adaptive i...
journal_title:Autoimmunity
pub_type: 杂志文章,评审
doi:10.3109/08916931003674766
更新日期:2010-11-01 00:00:00
abstract::The aim of this study was to examine the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correlation with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=2...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.3109/08916930109014693
更新日期:2001-01-01 00:00:00
abstract::The presence of autoimmune rheumatic diseases in several members of the same family, the concurrence of autoimmune rheumatic with non-rheumatic diseases in relatives of patients, the presence of autoantibodies in sera from healthy relatives of autoimmune-disease patients, the development of two or more autoimmune rheu...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500050145
更新日期:2005-05-01 00:00:00
abstract::Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic beta cell destruction involving auto-reactive T-cells, pro-inflammatory cytokines, reactive oxygen species (ROS) and loss of insulin. Monozygotic twin studies show a 20-60% concordance with T1D indicating there may be an environmental component...
journal_title:Autoimmunity
pub_type: 杂志文章
doi:10.1080/08916930500407238
更新日期:2005-12-01 00:00:00