Evidence for a retroviral trigger in Graves' disease.

abstract：:Blockade of the complement cascade at the C5a/C5a receptor (C5aR)-axis is believed to be an attractive treatment avenue in rheumatoid arthritis (RA). However, the effects of such interventions during the early phases of arthritis remain to be clarified. In this study we use the murine delayed-type hypersensitivity art...

journal_title：Autoimmunity

authors： Atkinson SM,Nansen A,Usher PA,Sondergaard BC,Mackay CR,Friedrichsen B,Chang CC,Tang R,Skov S,Haase C,Hornum L

更新日期：2015-01-01 00:00:00

abstract：:Recent studies have shown that Ro/SSA autoantigen is heterogeneous. There are two isoform families; the 60 kD forms (Ro60) and the 52 kD forms (Ro52). Recently we have found that autoantibodies to the Ro/SSA proteins are conformation dependent. Anti-Ro60 antibodies are mainly directed to the native protein and convers...

journal_title：Autoimmunity

authors： Igarashi T,Itoh Y,Fukunaga Y,Yamamoto M

更新日期：1995-01-01 00:00:00

abstract：:Previous studies directed towards identifying epitopes on type II collagen (CII) important in collagen induced arthritis (CIA) in mice have focused primarily on responses mounted in susceptible H-2q strains. However, the nature of T and B cell responses against CII in susceptible H-2r strains remains ill-defined. In a...

journal_title：Autoimmunity

authors： Nabozny GH,Griffiths MM,Harper DS,Luthra HS,David CS

更新日期：1995-01-01 00:00:00

abstract：:The HEp2 cell cultures appeared highly sensitive in detecting the antinuclear antibodies (ANAb) in systemic sclerosis, principally anticentromere antibodies of the CREST syndrome. The immunoblotting used with either complex cellular extracts from HeLa and rabbit thymus or purified nuclear components (high mobility gro...

journal_title：Autoimmunity

authors： Briolay J,Gioud M,Monier JC,Rodde JL,Cohen J,Roux B,Kaliss B

更新日期：1989-01-01 00:00:00

abstract：:The T cell repertoire expressed by Tsk2 mice, a novel experimental model of systemic sclerosis, was examined to determine whether cells infiltrating the areas of involved skin exhibit a T cell receptor (TCR) bias. Reverse transcription-polymerase chain reactions (RT-PCR) were conducted using RNA extracted from lymph n...

journal_title：Autoimmunity

authors： Wooley PH,Sud S,Langendorfer A,Calkins C,Christner PJ,Peters J,Jimenez SA

更新日期：1998-01-01 00:00:00

abstract：:Myelin oligodendrocyte glycoprotein (MOG) is postulated to be a target autoantigen in multiple sclerosis (MS). Here we investigated the encephalitogenicity of an immunodominant epitope of MOG, peptide 35-55, in various strains of mice. An MS-like disease was induced in NOD/Lt mice (H-2g7) and C57BL/6 mice (H-2b) by a ...

journal_title：Autoimmunity

authors： Slavin A,Ewing C,Liu J,Ichikawa M,Slavin J,Bernard CC

更新日期：1998-01-01 00:00:00

abstract：MOTIVATION:The human immune system evolved a multi-layered control mechanism to eliminate self-reactive cells. Of these so-called tolerance induction mechanisms, lymphocytes T education in the thymus gland represents the very first one. This complicated process is not fully understood and quantitative models able to he...

journal_title：Autoimmunity

authors： Castiglione F,Santoni D,Rapin N

更新日期：2011-06-01 00:00:00

abstract：:Apoptotic cells are readily recognized and engulfed by phagocytes and usually do not induce inflammation or tissue damage. Furthermore, they can actively suppress a pro-inflammatory response in phagocytes: In the presence of apoptotic cells, activated monocytes/macrophages produce more of the anti-inflammatory and imm...

journal_title：Autoimmunity

authors： Girkontaite I,Urbonaviciute V,Maseda D,Neubert K,Herrmann M,Voll RE

更新日期：2007-06-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE patients and contr...

journal_title：Autoimmunity

authors： Paradowska-Gorycka A,Sowinska A,Stypinska B,Grobelna MK,Walczyk M,Olesinska M,Piotrowski P,Jagodziński PP

更新日期：2016-09-01 00:00:00

abstract：:Multiple sclerosis (MS) is a devastating autoimmune disease that affects more than 1 million people worldwide and severely compromises motor and sensory function through demyelination and axonal loss. This review covers current therapies, lessons learned from failed clinical trials, genetic susceptibility, key cell ty...

journal_title：Autoimmunity

authors： Slavin A,Kelly-Modis L,Labadia M,Ryan K,Brown ML

更新日期：2010-11-01 00:00:00

abstract：:Numerous studies have shown that autoantigens may be clustered in the blebs of apoptotic cells. However, it is not yet clear in what circumstances apoptotic cells could be immunogenic rather than tolerogenic when interacting with macrophages, dendritic cells, and B cells. In order to further study this question we com...

journal_title：Autoimmunity

authors： Shoshan Y,Mevorach D

更新日期：2004-03-01 00:00:00

abstract：:CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Delta32 for the development of RA has been suggested, future study is required to est...

journal_title：Autoimmunity

authors： Martens HA,Kallenberg CG,Bijl M

更新日期：2009-05-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is a myocardial disease characterized by progressive depression of myocardial contractile function and by ventricular dilatation. Abnormalities of the cellular and humoral immune system are present in patients with myocarditis and DCM. Various circulating cardiac autoantibodies have been d...

journal_title：Autoimmunity

authors： Felix SB,Staudt A,Friedrich GB

更新日期：2001-01-01 00:00:00

abstract：:The Foxo subfamily of forkhead (Fox) transcription factors are mammalian homologues of the Caenorhabditis elegans DAF-16 longevity gene, and play key roles in cellular and organism survival, death, proliferation and metabolism. A growing body of evidence indicates that Foxo proteins furthermore play critical roles in ...

journal_title：Autoimmunity

authors： Peng SL

更新日期：2007-09-01 00:00:00

abstract：:Tissue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial an...

journal_title：Autoimmunity

authors： Sjöber K,Eriksson S,Tenngart B,Roth EB,Leffler H,Stenberg P

更新日期：2002-08-01 00:00:00

abstract：:Congenital heart block (CHB), a life-threatening manifestation of neonatal lupus, offers aunique opportunity to study the effect or arm of immunity and define the pathogenicity of an autoantibody in mediating tissue injury. This review focuses on our recent in vitro model which supports a cascade from antibody insult ...

journal_title：Autoimmunity

authors： Buyon JP,Clancy RM

更新日期：2003-02-01 00:00:00

abstract：:Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on quality of life and can be life threatening. Rupture of vulnerable ath...

journal_title：Autoimmunity

authors： Kyaw T,Tipping P,Bobik A,Toh BH

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in Euro...

journal_title：Autoimmunity

authors： Muro Y,Sugiura K,Akiyama M

更新日期：2013-06-01 00:00:00

abstract：:The nature of the immunosuppressive effect of antithyroid drugs has been a subject of controversy. It has been claimed that these agents exert a direct effect on the immune system, although we and others have suggested that the drugs affect the thyroid cells primarily with consequent reduced thyrocyte-immunocyte signa...

journal_title：Autoimmunity

authors： Aguayo J,Michaud P,Iitaka M,Degroot LJ,Row VV,Volpé R

更新日期：1989-01-01 00:00:00

abstract：:A large number of malaria immune persons from Eastern India were found to possess antibodies to the ribosomal phosphoprotein P0 (PfP0) of the human malarial parasite Plasmodium falciparum. The characterization of PfP0 has been reported recently, and it has been shown that antibodies against PfP0 inhibit P. falciparum ...

journal_title：Autoimmunity

authors： Singh S,Chatterjee S,Sohoni R,Badakere S,Sharma S

更新日期：2001-01-01 00:00:00

abstract：:Deoxyribonuclease1 (DNase1) is involved in chromatin degradation of apoptotic cells. Its deficiency results in accumulation of self-DNA, which in turn may induce inflammation and autoimmunity. We assessed for the first time serum DNase1-activity in a large consecutive cohort of treatment-naïve patients with autoimmune...

journal_title：Autoimmunity

authors： Gatselis NK,Vakrakou AG,Zachou K,Androutsakos T,Azariadis K,Hatzis G,Manoussakis MN,Dalekos GN

更新日期：2017-03-01 00:00:00

abstract：:Natural Abs and autoantibodies bind antigens displayed by ischemia-conditioned tissues, followed by complement activation and enhanced tissue injury during reperfusion. Anti-ribonucleoprotein (RNP) Ab is associated with lung disease in patients with autoimmune disease but it is not known whether these abs contribute t...

journal_title：Autoimmunity

authors： Keith MP,Moratz C,Egan R,Zacharia A,Greidinger EL,Hoffman RW,Tsokos GC

更新日期：2007-05-01 00:00:00

abstract：:Histone H2B is an autoantigen that appears in circulation due to altered apoptosis/or insufficient clearance and is likely to be involved in the induction and progression of autoimmune diseases since modified-H2B is immunogenic. Our studies demonstrate that tyrosines of H2B histone spontaneously converts to free and n...

journal_title：Autoimmunity

authors： Khan MA,Alam K,Hassan SM,Rizvi MMA

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:To study efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients. METHODS:The case records of 40 patients with lupus nephritis followed up in a single center between 1992 and 2011 (median duration = 8.37 years) were retrieved to determine efficacy and toxicity of the treat...

journal_title：Autoimmunity

authors： Bozzolo EP,Ramirez GA,Bonavida G,Lanzani C,Scotti R,Dell'antonio G,Baldissera E,Canti V,Manfredi AA,Rovere-Querini P,Sabbadini MG

更新日期：2013-12-01 00:00:00

abstract：:Pemphigus vulgaris is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3, a 130 kDa epidermal protein. To further characterize the epitope(s) of pemphigus vulgaris antigen we established two human-human hybridoma by fusion of the peripheral blood monon...

journal_title：Autoimmunity

authors： Bhol KC,Ahmed AR

更新日期：2002-03-01 00:00:00

abstract：:It has been suggested that pancreatic beta-cell destruction occurring during the process leading to insulin-dependent diabetes mellitus (IDDM) involves formation of nitric oxide (NO). We have presently studied the effect of aminoguanidine (AG), which has recently been reported to inhibit generation of NO induced by th...

journal_title：Autoimmunity

authors： Holstad M,Sandler S

更新日期：1993-01-01 00:00:00

abstract：:Congenital heart block is a serious condition with significant mortality due in most cases to the transplacental transfer of autoantibodies from an otherwise asymptomatic mother. Although SSA/Ro and SSB/La autoantibodies have been implicated, attention has focused recently on autoantibodies to envelope proteins of end...

journal_title：Autoimmunity

authors： de Parseval N,Forrest G,Venables PJ,Heidmann T

更新日期：1999-01-01 00:00:00

abstract：:Interleukin 1beta (IL-1) is cytotoxic to rat pancreatic beta-cells in vitro, and increased expression of IL-1 mRNA is found in the islets of Langerhans during development of diabetes in BB/Wor/Mol-BB2 (BB-DP) rats and NOD mice. It has been proposed that IL-1 induces a race between protective and deleterious proteins i...

journal_title：Autoimmunity

authors： Christensen UB,Larsen PM,Fey SJ,Andersen HU,Nawrocki A,Sparre T,Mandrup-Poulsen T,Nerup J

更新日期：2000-01-01 00:00:00

abstract：:Antiphospholipid antibodies (aPLA) were discovered during the course of Mediterranean spotted fever (MSF) caused by Rickettsia conorii and characterized by endothelial cell (EC) damage resulting from this organism's tropism for EC. In two MSF patients, two types of aPLA were identified: antiphosphatidylethanolamine an...

journal_title：Autoimmunity

authors： Sotto A,Bérard M,Bessis D,Porneuf M,Jourdan J,Boffa MC

更新日期：1995-01-01 00:00:00

abstract：:Zinc transporter 8 (ZnT8), a product of the SLC30A8 gene, is a target-antigen in autoimmune diabetes. Associations between ZnT8 antibody (ZnT8A), phenotype and the genetic variant rs13266634 in the SLC30A8 gene have primarily been studied in patients with young-onset diabetes. We explored such associations in adult-on...

journal_title：Autoimmunity

authors： Sørgjerd EP,Skorpen F,Kvaløy K,Midthjell K,Grill V

更新日期：2013-02-01 00:00:00