Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes: results from the HUNT study, Norway.

Abstract:

:Zinc transporter 8 (ZnT8), a product of the SLC30A8 gene, is a target-antigen in autoimmune diabetes. Associations between ZnT8 antibody (ZnT8A), phenotype and the genetic variant rs13266634 in the SLC30A8 gene have primarily been studied in patients with young-onset diabetes. We explored such associations in adult-onset autoimmune diabetes identified from the all-population based Nord-Trøndelag health Study (HUNT) ZnT8A (assayed by a fusion probe of C-terminal Arg325 and Trp325), and antibodies against glutamic decarboxylase (GADA) and tyrosine phosphatase-like protein insulinoma antigen-2 (IA-2A) were analysed in 266 subjects classified as having adult-onset autoimmune diabetes ( ≥ 25 years of age at diagnosis). Of these, 161 subjects fulfilled the criteria of latent autoimmune diabetes in adults (LADA), whereas 105 subjects were termed "classical" type 1 diabetes. Ten out of 161 LADA (6.2%) and 23 out of 105 adult-onset "classical" type 1 diabetic patients (22%) were ZnT8A positive. Adult-onset diabetic subjects positive both for GADA and IA-2A (n = 17), had lower waist circumference (p = 0.024) and higher fasting glucose levels (p = 0.023) than those positive both for GADA and ZnT8A (n = 13). Genotyping results of rs13266634 (available in 178 adult-onset diabetic subjects), showed a tendency for association between ZnT8A positivity and the TT- and CC genotypes of SNP rs13266634 (p = 0.101) using the standard cut-off level of 0.06ai, and a significant association at a lower cut-off level of 0.01ai (p = 0.005). We conclude that ZnT8A positivity in a population of adult-onset autoimmune diabetes is a less strong marker of autoimmunity than IA-2A. Further, positivity could be influenced by polymorphism of the SLC30A8 gene.

journal_name

Autoimmunity

journal_title

Autoimmunity

authors

Sørgjerd EP,Skorpen F,Kvaløy K,Midthjell K,Grill V

doi

10.3109/08916934.2012.732132

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

74-9

issue

1

eissn

0891-6934

issn

1607-842X

journal_volume

46

pub_type

杂志文章
  • Induction of hyperacute brain inflammation and demyelination by activated encephalitogenic T cells and a monoclonal antibody specific for a myelin/oligodendrocyte glycoprotein.

    abstract::CNS demyelinating inflammatory disease can be a multifactorial process mediated by cellular and antibody-mediated immune processes. Myelin basic protein (MBP)-specific T cells and pathogenic 8-18C5 antibody, specific for a myelin/oligodendrocyte glycoprotein (MOG), a minor component of CNS white matter, can coexist in...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916938909014690

    authors: Schluesener HJ,Lider O,Sobel RA

    更新日期:1989-01-01 00:00:00

  • SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.

    abstract::Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs. Its emerging role as an effector of innate immunity is affirmed by mutations in the SAMHD1 gene that cause t...

    journal_title:Autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1080/08916934.2018.1454912

    authors: Mauney CH,Hollis T

    更新日期:2018-05-01 00:00:00

  • Glutathione-s-transferase M1 and T1 polymorphisms and associations with type 1 diabetes age-at-onset.

    abstract::Type 1 diabetes (T1D) is an autoimmune disease characterized by pancreatic beta cell destruction involving auto-reactive T-cells, pro-inflammatory cytokines, reactive oxygen species (ROS) and loss of insulin. Monozygotic twin studies show a 20-60% concordance with T1D indicating there may be an environmental component...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/08916930500407238

    authors: Bekris LM,Shephard C,Peterson M,Hoehna J,Van Yserloo B,Rutledge E,Farin F,Kavanagh TJ,Lernmark A

    更新日期:2005-12-01 00:00:00

  • Assessment of common idiotype PR4-Id in serial bleeds from lupus patients.

    abstract::Marked fluctuations in the levels of a common DNA-antibody idiotype, PR4-Id have been found on IgM and IgA antibodies in particular and to a lesser extent on IgG in serial bleeds of 14 lupus patients. Few clear cut examples were found of the PR4-Id levels reflecting disease activity. However, the idiotype expression w...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939108997118

    authors: Pilcher C,Williams W,Isenberg DA

    更新日期:1991-01-01 00:00:00

  • Detection of anti-branched chain 2-oxo acid dehydrogenase complex (BCOADC)-E2 antibody in primary biliary cirrhosis by ELISA using recombinant fusion protein.

    abstract::Anti-M2 of anti-mitochondrial antibody (AMA) is a serological marker of primary biliary cirrhosis (PBC). Anti-pyruvate dehydrogenase complex-E2 (anti-PDC-E2) is recognized as the most frequently occurring anti-M2, and a routine laboratory test for this antibody has already been established. However, it is also known t...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939908994755

    authors: Miyakawa H,Abe K,Kitazawa E,Kikuchi K,Fujikawa H,Matsushita M,Kawaguchi N,Kako M

    更新日期:1999-01-01 00:00:00

  • Definitions of and contributions to cardiovascular disease in systemic lupus erythematosus.

    abstract::Patients with systemic lupus erythematosus (SLE) have a significantly increased risk of cardiovascular disease (CVD). Increased prevalence of atherosclerosis may explain part of this enhanced risk, but SLE related CVD can also result from other mechanisms. Vascular events may be the result of several pathophysiologic ...

    journal_title:Autoimmunity

    pub_type: 杂志文章,评审

    doi:10.3109/08916934.2013.856005

    authors: Gustafsson JT,Svenungsson E

    更新日期:2014-03-01 00:00:00

  • Organ-specific autoimmunity in granulocyte macrophage-colony stimulating factor (GM-CSF) deficient mice.

    abstract::Granulocyte macrophage-colony stimulating factor (GM-CSF) is a pleiotrophic proinflammatory cytokine that augments adaptive immunity by linking it to innate immunity. Experimental autoimmune gastritis is an animal model of human autoimmune gastritis and pernicious anaemia. We have previously shown that GM-CSF is expre...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/08916930290005954

    authors: Alderuccio F,Biondo M,Toh BH

    更新日期:2002-02-01 00:00:00

  • Reduced in vitro production of interferon-gamma, interleukin-4 and interleukin-12 and increased production of interleukin-6, interleukin-10 and tumour necrosis factor-alpha in systemic lupus erythematosus. Weak correlations of cytokine production with dis

    abstract::Production of cytokines in unstimulated and mitogen-stimulated cultures were evaluated by ELISPOT in 34 SLE patients with low to moderate disease activity and 23 healthy controls. Significantly reduced production of IFN gamma, IL4 and IL12 and significantly increased production of IL6, IL10 and TNF alpha were found in...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939908994055

    authors: Jones BM,Liu T,Wong RW

    更新日期:1999-10-01 00:00:00

  • Carbonic anhydrase III: a new target for autoantibodies in autoimmune diseases.

    abstract::The objective of this study was to identify new autoantibodies that could be useful for the diagnosis of rheumatoid arthritis (RA) using immunoblotting on synovial membrane proteins which represent the best source of candidate RA autoantigens. A new target protein with a molecular weight of 26 kDa was found to be reco...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/08916930701417473

    authors: Robert-Pachot M,Desbos A,Moreira A,Becchi M,Tebib J,Bonnin M,Aitsiselmi T,Bienvenu J,Fabien N

    更新日期:2007-07-01 00:00:00

  • The structure of human MHC class II genes.

    abstract::The class II molecules of the human major histocompatibility complex bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response. A salient feature of the class II molecules is their polymorphism. It has been shown that some a...

    journal_title:Autoimmunity

    pub_type: 杂志文章,评审

    doi:10.3109/08916939108997111

    authors: Rask L,Jonsson AK,Svensson AC,Gustafsson K,Andersson L

    更新日期:1991-01-01 00:00:00

  • Changes in thyrotropin receptor antibody after subtotal thyroidectomy in Graves' disease: comparison with the degree of lymphocytic infiltration in the thyroid.

    abstract::To evaluate changes in TSH receptor antibody after surgery in Graves' disease and its relationship with the degree of lymphocytic infiltration, serial serum levels of TSH receptor antibody were measured before and after the subtotal thyroidectomy in 50 patients with Graves' disease. In 22 (44%) out of 50 patients, thy...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939008995732

    authors: Cho BY,Oh SK,Shong YK,Kim SE,Yoo HY,Lee HK,Koh CS,Min HK

    更新日期:1990-01-01 00:00:00

  • MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease.

    abstract::The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916934.2015.1031889

    authors: Otani Y,Ichii O,Otsuka-Kanazawa S,Chihara M,Nakamura T,Kon Y

    更新日期:2015-01-01 00:00:00

  • Differential susceptibility to experimental allergic encephalomyelitis (EAE) in genetically defined A+ and A- rabbits.

    abstract::Only one out of 57 A-/A- rabbits immunized with rat or guinea-pig myelin developed clinical signs suggestive of EAE. On the contrary, clinical signs of acute or chronic EAE were found in two thirds of the 102 A+/A+ and A+/A- rabbits immunized in the same way. About one third of the diseased animals had reversible acut...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939008993369

    authors: Villarroya H,Dalix AM,Paraut M,Oriol R

    更新日期:1990-01-01 00:00:00

  • Prolactin modulates the incidence of diabetes in male and female NOD mice.

    abstract::The nonobese diabetic (NOD) mouse develops diabetes spontaneously due to autoimmune destruction of the pancreatic islets with a higher incidence in the female than the male. Prolactin (PRL), a hormone whose role has been previously focused on reproduction and lactation has been demonstrated to influence immune respons...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939409007991

    authors: Hawkins TA,Gala RR,Dunbar JC

    更新日期:1994-01-01 00:00:00

  • Immunosuppressive therapies in myasthenia gravis.

    abstract::Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patien...

    journal_title:Autoimmunity

    pub_type: 杂志文章,评审

    doi:10.3109/08916930903518107

    authors: Sanders DB,Evoli A

    更新日期:2010-08-01 00:00:00

  • Stress-induced cell surface expression and antigenic alteration of the Ro/SSA autoantigen.

    abstract::Recent studies have shown that Ro/SSA autoantigen is heterogeneous. There are two isoform families; the 60 kD forms (Ro60) and the 52 kD forms (Ro52). Recently we have found that autoantibodies to the Ro/SSA proteins are conformation dependent. Anti-Ro60 antibodies are mainly directed to the native protein and convers...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939508995297

    authors: Igarashi T,Itoh Y,Fukunaga Y,Yamamoto M

    更新日期:1995-01-01 00:00:00

  • Exposure of chromatin and not high affinity for dsDNA determines the nephritogenic impact of anti-dsDNA antibodies in (NZBxNZW)F1 mice.

    abstract::Recent studies have demonstrated that the nephritogenicity of antibodies to dsDNA and nucleosomes confers to binding of glomerular membrane-associated nucleosomes, and not to cross-reacting glomerular antigens. There is no known parameter that determines antibody pathogenicity aside from specificity for dsDNA/nucleoso...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/08916930802375729

    authors: Mjelle JE,Kalaaji M,Rekvig OP

    更新日期:2009-02-01 00:00:00

  • Evidence for a retroviral trigger in Graves' disease.

    abstract::An apparently high frequency of Graves' disease encountered in New Orleans, Louisiana, prompted an investigation for a possible infectious agent that might be triggering the disease in genetically susceptible individuals. We studied 40 patients with Graves' disease, and compared them to the following groups of control...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939509001938

    authors: Jaspan JB,Luo H,Ahmed B,Tenenbaum S,Voss T,Sander DM,Bollinger K,Baquet T,Garry RF

    更新日期:1995-01-01 00:00:00

  • T cell interactions with extracellular matrix proteins in patients with thyroid-associated ophthalmopathy.

    abstract::Although thyroid-associated ophthalmopathy (TAO) is now generally accepted as an autoimmune inflammatory disorder of the extraocular muscles and the orbital connective tissue, its aetiopathogenesis remains poorly understood. Recent data indicate that impaired interactions between T cells and extracellular matrix (ECM)...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939808993834

    authors: Bednarczuk T,Kiljanski J,Mrowiec T,Slon M,Ing E,Stolarski C,Kennerdell JS,Gorski A,Nauman J,Wall JR

    更新日期:1998-01-01 00:00:00

  • Effect of administration of apoptotic blebs on disease development in lupus mice.

    abstract:INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the formation of autoantibodies against nuclear components. Disturbed apoptosis and reduced clearance of apoptotic material have been assigned a role in the pathogenesis of SLE. During apoptosis, apoptotic blebs are formed, in whi...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916934.2012.664668

    authors: Fransen JH,Berden JH,Koeter CM,Adema GJ,Van Der Vlag J,Hilbrands LB

    更新日期:2012-06-01 00:00:00

  • The origin of extracellular DNA during the clearance of dead and dying cells.

    abstract::DNA is a nuclear molecule that has both an intracellular and extracellular role. Inside the cell, it is the essential molecule of heredity while outside the cell it can have immunological activity, both alone and in the context of immune complexes. Furthermore, extracellular DNA has information content that can be min...

    journal_title:Autoimmunity

    pub_type: 杂志文章,评审

    doi:10.1080/08916930701358826

    authors: Pisetsky DS,Fairhurst AM

    更新日期:2007-06-01 00:00:00

  • Low prevalence of anti-small ubiquitin-like modifier activating enzyme antibodies in dermatomyositis patients.

    abstract:BACKGROUND:The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in Euro...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916934.2012.755958

    authors: Muro Y,Sugiura K,Akiyama M

    更新日期:2013-06-01 00:00:00

  • Characteristics and clinical correlates of a novel thyroid-stimulating autoantibody.

    abstract::We reported a patient who gave birth to 3 children with transient neonatal hypothyroidism. She had 3 different antibodies (Ab) to the thyrotropin receptor (TSHR) in her serum, viz., TSH binding-inhibiting (TBIAb), thyroid-stimulating (TSAb) and an additional stimulating Ab (SAb). The SAb differed from TSAb in that its...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939409008006

    authors: Zakarija M,De Forteza R,McKenzie JM,Ghandur-Mnaymneh L

    更新日期:1994-01-01 00:00:00

  • A subgroup of human VH3 germline genes that encode a high-avidity synovial rheumatoid factor.

    abstract::We have previously derived and identified a highly avid monoclonal IgM rheumatoid factor (mRF), C6, from unstimulated rheumatoid synovial cells (RSC). At the time, the closet VH germline gene, VH26, demonstrated only 88% homology with C6. To identify the germline counterpart of C6, genomic DNA from the same rheumatoid...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939508993350

    authors: Wong A,Tait R,Kenny T,Gorin F,Robbins D

    更新日期:1995-01-01 00:00:00

  • Cytotoxic T lymphocyte antigen 4 heterozygous codon 49 A/G dimorphism is associated to latent autoimmune diabetes in adults (LADA).

    abstract::Autoimmune diabetes is an organ specific and multifactorial disorder with a classical onset as insulin dependent diabetes mellitus (IDDM) and with another form of onset as latent autoimmune diabetes in adults (LADA), which has a slower onset and a later progress to insulin dependency as a result of the beta cells dest...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/08916930500158203

    authors: Caputo M,Cerrone GE,López AP,Villalba A,Krochik GA,Cédola FN,Targovnik HM,Frechtel GD

    更新日期:2005-06-01 00:00:00

  • Endocrine pancreas histology of congenic BB-rat strains with reduced diabetes incidence after genetic manipulation on chromosomes 4, 6 and X.

    abstract::Congenic BB.SHR rat strains were established by crossing of spontaneously diabetic BB/OK rats and diabetes-resistant SHR rats. Chromosomal regions on which the genes Iddm 4 (BB.6s), Iddm6 (BB.Xs) and Iddm 2 (BB.LL) are located were exchanged. As a result of genetic manipulation diabetes incidence was markedly reduced ...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/0891693031000094683

    authors: Lucke S,Klöting I,Pusch A,Heinrich HW,Hahn HJ

    更新日期:2003-05-01 00:00:00

  • Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein.

    abstract::Myelin oligodendrocyte glycoprotein (MOG) is postulated to be a target autoantigen in multiple sclerosis (MS). Here we investigated the encephalitogenicity of an immunodominant epitope of MOG, peptide 35-55, in various strains of mice. An MS-like disease was induced in NOD/Lt mice (H-2g7) and C57BL/6 mice (H-2b) by a ...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939809003872

    authors: Slavin A,Ewing C,Liu J,Ichikawa M,Slavin J,Bernard CC

    更新日期:1998-01-01 00:00:00

  • NKT cell cytokine imbalance in murine diabetes mellitus.

    abstract::A minor subset of murine MHC class I-restricted T cells which express both the alphabeta form of the T cell receptor and a NK lineage marker, termed NKT cells, is capable of secreting significant amounts of Interleukin-4 and Interferon-y upon activation. As such NKT cells may play a role in development of Th1 and Th2 ...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916939908998535

    authors: Frey AB,Rao TD

    更新日期:1999-01-01 00:00:00

  • Serological proteome analysis reveals new specific biases in the IgM and IgG autoantibody repertoires in autoimmune polyendocrine syndrome type 1.

    abstract:OBJECTIVE:Autoimmune polyendocrine syndrome type 1 (APS 1) is caused by mutations in the AIRE gene that induce intrathymic T-cell tolerance breakdown, which results in tissue-specific autoimmune diseases. DESIGN:To evaluate the effect of a well-defined T-cell repertoire impairment on humoral self-reactive fingerprints...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.3109/08916934.2015.1077230

    authors: Dubucquoi S,Proust-Lemoine E,Kemp EH,Ryndak A,Lefèvre-Dutoit V,Bellart M,Saugier-Véber P,Duban-Deweer S,Wémeau JL,Prin L,Lefranc D

    更新日期:2015-01-01 00:00:00

  • Celiac antibodies in children with type 1 diabetes - A diagnostic validation study.

    abstract:INTRODUCTION:Autoimmune diseases, such as celiac disease (CD) and diabetes mellitus type 1, tend to co-occur within the same patient. The prevalence of CD in diabetic children is higher than in the general population, and is estimated to be 0.6-16.4%. The diagnosis of CD is based on histopathological examination and se...

    journal_title:Autoimmunity

    pub_type: 杂志文章

    doi:10.1080/08916934.2018.1427226

    authors: Lewandowska K,Ciepiela O,Szypowska A,Wyhowski J,Głodkowska-Mrówka E,Popko K,Ostafin M,Pyrżak B,Demkow U

    更新日期:2018-03-01 00:00:00