Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes: results from the HUNT study, Norway.

abstract：:Chronic immune thrombocytopenia (ITP) is characterized by autoimmune-mediated platelet destruction and impairment of thrombopoiesis. Mesenchymal stem cells (MSCs) are proposed to exhibit immune modulatory functions in self-tolerance maintenance. In this study, we aimed to characterize phenotypically and functionally b...

journal_title：Autoimmunity

authors： Zhang D,Li H,Ma L,Zhang X,Xue F,Zhou Z,Chi Y,Liu X,Huang Y,Yang Y,Yang R

更新日期：2014-12-01 00:00:00

abstract：:In order to know whether effector cells are capable of recognizing the epidermal targets in pemphigus vulgaris (PV) and bullous pemphigoid (BP), non-adherent cells (NAC) of peripheral blood from 27 primary PV, 19 BP patients and 12 healthy volunteers were used in cytotoxic tests. Autologous, allogenic and murine epide...

journal_title：Autoimmunity

authors： Grando SA,Glukhenky BT,Drannik GN,Kostromin AP,Boiko YYa,Senyuk OF

更新日期：1989-01-01 00:00:00

abstract：:The presence of autoimmune rheumatic diseases in several members of the same family, the concurrence of autoimmune rheumatic with non-rheumatic diseases in relatives of patients, the presence of autoantibodies in sera from healthy relatives of autoimmune-disease patients, the development of two or more autoimmune rheu...

journal_title：Autoimmunity

authors： Rodríguez-Reyna TS,Alarcón-Segovia D

更新日期：2005-05-01 00:00:00

abstract：:At least two signals for proliferation and cytokine secretion by T-cells are required. The first signal is delivered through the interaction of the T-cell receptor with major histocompatibility complex (MHC) molecules expressed on the surface of antigen-presenting cells (APC). The second or costimulatory signal is del...

journal_title：Autoimmunity

authors： Salmaso C,Olive D,Pesce G,Bagnasco M

更新日期：2002-05-01 00:00:00

abstract：:Agalactosyl IgG (Gal(0) is a glycoform lacking terminal galactose from the oligosaccharides situated on the Fc. The percentage of circulating IgG that is Gal(0) is increased in a a number of autoimmune diseases, and in certain chronic infections associated with autoantibody production. However it is not known whether ...

journal_title：Autoimmunity

authors： Pilkington C,Yeung E,Isenberg D,Lefvert AK,Rook GA

更新日期：1995-01-01 00:00:00

abstract：:The autoimmune thyroid disorders, or AITDs, comprise 2 related disorders, Graves' disease and Hashimoto thyroiditis. In AITD, immune system produces antibodies against autothyroid antigens. The etiology of AITDs involves a complex interaction between genetic predisposing factors and environmental triggering factors. V...

journal_title：Autoimmunity

authors： Alkhateeb A,Jarun Y,Tashtoush R

更新日期：2013-05-01 00:00:00

abstract：:To evaluate changes in TSH receptor antibody after surgery in Graves' disease and its relationship with the degree of lymphocytic infiltration, serial serum levels of TSH receptor antibody were measured before and after the subtotal thyroidectomy in 50 patients with Graves' disease. In 22 (44%) out of 50 patients, thy...

journal_title：Autoimmunity

authors： Cho BY,Oh SK,Shong YK,Kim SE,Yoo HY,Lee HK,Koh CS,Min HK

更新日期：1990-01-01 00:00:00

abstract：:The concordance rate of Graves' disease in pairs of identical twins of 30 to 60% points to the influence of environmental factors, and infections have often been incriminated in the pathogenesis. More than 15 years ago we demonstrated an increased frequency of antibodies to Yersinia enterocolitica (Y. ent.) serotype 3...

journal_title：Autoimmunity

authors： Bech K

更新日期：1990-01-01 00:00:00

abstract：:Chronic autoimmune thyroiditis (cAIT) leads to hypothyroidism due to T cell-mediated cytotoxicity in most cases. By contrast, Graves' disease (GD) with thyrotropin receptor stimulatory autoantibodies cause hyperthyroidism. Cytokines play a crucial role in modulating immune response in both disorders. The aim of study ...

journal_title：Autoimmunity

authors： Mikos H,Mikos M,Rabska-Pietrzak B,Niedziela M

更新日期：2014-11-01 00:00:00

abstract：MOTIVATION:The human immune system evolved a multi-layered control mechanism to eliminate self-reactive cells. Of these so-called tolerance induction mechanisms, lymphocytes T education in the thymus gland represents the very first one. This complicated process is not fully understood and quantitative models able to he...

journal_title：Autoimmunity

authors： Castiglione F,Santoni D,Rapin N

更新日期：2011-06-01 00:00:00

abstract：:The cytokine profile and occurrence of apoptosis during experimental melanin-protein induced uveitis (EMIU) were investigated and compared with that of experimental autoimmune uveoretinitis (EAU). EMIU or EAU was induced in Lewis rats. Eyes were collected at different time points after immunization. Cytokine mRNA expr...

journal_title：Autoimmunity

authors： Li Q,Sun B,Matteson DM,O'Brien TP,Chan CC

更新日期：1999-01-01 00:00:00

abstract：:A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...

journal_title：Autoimmunity

authors： Marmont AM,Gualandi F,Occhini D,Morandi F,Ferretti E,Pezzolo A,Strada P,Ravetti JL,Pistoia V,Falanga A,Bacigalupo A

更新日期：2006-09-01 00:00:00

abstract：:The objective of this study was to research the functionality of anti-endothelial cell antibodies (AECA) in pulmonary arterial hypertension (PAH) by assessing the effects of IgG from AECA-positive PAH patients on the induction of adhesion molecules on human umbilical vein endothelial cells (HUVECs) and on the producti...

journal_title：Autoimmunity

authors： Arends SJ,Damoiseaux JG,Duijvestijn AM,Debrus-Palmans L,Boomars KA,Brunner-La Rocca HP,Cohen Tervaert JW,van Paassen P

更新日期：2013-11-01 00:00:00

abstract：:We have used the reverse transcriptase polymerase chain reaction (RT-PCR) technique to assess the expression of cytokine genes in various T cell subsets of autoimmune-prone mice. Our study confirmed the previously described features in lpr mice that IFN-gamma, TNF-alpha, and TNF-beta were transcribed by various T cell...

journal_title：Autoimmunity

authors： Mori K,Kobayashi S,Inobe M,Jia WY,Tamakoshi M,Miyazaki T,Uede T

更新日期：1994-01-01 00:00:00

abstract：:Experimental autoimmune uveoretinitis (EAU) induced by immunization of albino Lewis rats with a retinal soluble antigen (S-antigen) has been studied extensively by many workers. An intraorchidic injection of S-antigen 4 days prior to immunization of the animal with the antigen emulsified in adjuvant was found to preve...

journal_title：Autoimmunity

authors： Peng B,Yoshitoshi T,Shichi H

更新日期：1992-01-01 00:00:00

abstract：:Anti-phospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of autoantibody (AAb) to phospholipid (PL)-binding proteins, such as beta2-glycoprotein I (beta2GPI), and clinical manifestations including thrombosis and/or recurrent pregnancy loss. beta2GPI-reactive T cells are clearly implicat...

journal_title：Autoimmunity

authors： Tolomeo T,Rico De Souza A,Roter E,Dieudé M,Amireault P,Subang R,Levine JS,Rauch J

更新日期：2009-05-01 00:00:00

abstract：:The functional and phenotypic characteristics of lymphocytes separated from myasthenic thymoma (Th-L) were compared with those of lymphocytes separated from non-thymomatous thymus associated with thymoma (NTh-L) of the same patients and NTh-L of myasthenia gravis (MG) patients without thymoma. We examined whether Th-L...

journal_title：Autoimmunity

authors： Takahashi K,Saito S,Monden Y

更新日期：1998-01-01 00:00:00

abstract：:Carbonic anhydrase II (CAII) is expressed on alveolar epithelium and participates to CO2 elimination, fluid secretion and post-capillary pH regulation. CAII is overexpressed in animal models of lung fibrosis in sites of epithelial injury. Autoantibodies directed against CAII (anti-CAII) have been described in sera fro...

journal_title：Autoimmunity

authors： Alessandri C,Bombardieri M,Scrivo R,Viganego F,Conti F,de Luca N,Riccieri V,Valesini G

更新日期：2003-03-01 00:00:00

abstract：:The objective of this study was to identify new autoantibodies that could be useful for the diagnosis of rheumatoid arthritis (RA) using immunoblotting on synovial membrane proteins which represent the best source of candidate RA autoantigens. A new target protein with a molecular weight of 26 kDa was found to be reco...

journal_title：Autoimmunity

authors： Robert-Pachot M,Desbos A,Moreira A,Becchi M,Tebib J,Bonnin M,Aitsiselmi T,Bienvenu J,Fabien N

更新日期：2007-07-01 00:00:00

abstract：:Glucocorticoids (GCs) strongly impact on different T cell subsets inducing generally immunosuppressive effects, whereas much less is known about the effect of GC on natural killer (NK) cells. The aims of this study were to investigate the effects of GC on T cell functions, including T cell-mediated anti-tumor immune r...

journal_title：Autoimmunity

authors： Yakimchuk K,Chen L,Hasni MS,Okret S,Jondal M

更新日期：2015-03-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is preceded by the presence of antibodies against islet proteins including a protein tyrosine phosphatase (PTP) designated IA-2. Recently, we cloned a novel PTP named IAR which shares 43% sequence identity with IA-2 and is recognised by antibodies from a majority of patients ...

journal_title：Autoimmunity

authors： Schmidli RS,Colman PG,Cui L,Yu WP,Kewming K,Jankulovski C,Harrison LC,Pallen CJ,DeAizpurua HJ

更新日期：1998-01-01 00:00:00

abstract：:A minor subset of murine MHC class I-restricted T cells which express both the alphabeta form of the T cell receptor and a NK lineage marker, termed NKT cells, is capable of secreting significant amounts of Interleukin-4 and Interferon-y upon activation. As such NKT cells may play a role in development of Th1 and Th2 ...

journal_title：Autoimmunity

authors： Frey AB,Rao TD

更新日期：1999-01-01 00:00:00

abstract：:The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencie...

journal_title：Autoimmunity

authors： Truedsson L,Bengtsson AA,Sturfelt G

更新日期：2007-12-01 00:00:00

abstract：:We have previously derived and identified a highly avid monoclonal IgM rheumatoid factor (mRF), C6, from unstimulated rheumatoid synovial cells (RSC). At the time, the closet VH germline gene, VH26, demonstrated only 88% homology with C6. To identify the germline counterpart of C6, genomic DNA from the same rheumatoid...

journal_title：Autoimmunity

authors： Wong A,Tait R,Kenny T,Gorin F,Robbins D

更新日期：1995-01-01 00:00:00

abstract：:The biological basis for autoimmunity and immunoincompetence in the BB rat has yet to be localized. In spite of normal thymic histology, thymocyte subsets and blastogenesis, thymus gland products (thymosins) have yet to be studied. In the present report, thymus gland function was studied by measuring thymosin alpha 1 ...

journal_title：Autoimmunity

authors： Winter WE,Robbins V,Elder M,Barrett D,Martin N,Maclaren NK

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in Euro...

journal_title：Autoimmunity

authors： Muro Y,Sugiura K,Akiyama M

更新日期：2013-06-01 00:00:00

abstract：:Interleukin (IL)-1 inhibits the function of insulin-producing rat pancreatic beta-cells in vitro and in vivo, and it has been postulated that the IL-1 effect is mediated through the cytokine inducible nitric oxide (NO) synthase. IL-1 inhibits the function of cultured human thyroid cells too, and in this study human th...

journal_title：Autoimmunity

authors： Rasmussen AK,Di Marco R,Diamant M,Feldt-Rasmussen U,Bendtzen K

更新日期：1994-01-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a disease characterized by excessive proinflammatory cytokine production and damage to multiple organ systems. To investigate the potential association between cytokine gene polymorphisms and SLE, we performed a case-control study based on Polish population. SLE patients and contr...

journal_title：Autoimmunity

authors： Paradowska-Gorycka A,Sowinska A,Stypinska B,Grobelna MK,Walczyk M,Olesinska M,Piotrowski P,Jagodziński PP

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Serum C-X-C motif chemokine 10 (CXCL10) levels have been shown to be elevated in autoimmune thyroid diseases (AITD). This study sought to determine whether newly diagnosed AITD patients with neuromuscular findings had higher levels of CXCL10 than those without neuromuscular manifestations. DESIGN:A total of ...

journal_title：Autoimmunity

authors： Cakir M,Levendoglu F,Kiyici A,Coskun Y

更新日期：2011-09-01 00:00:00

abstract：:The thymic medulla is a complex microenvironment which plays a crucial role in central tolerance induction. Using a quantitative histological analysis of non-obese diabetic (NOD) mice, we show that the medulla undergoes several structural modifications during the course of the disease in NOD mice. Indeed, the majority...

journal_title：Autoimmunity

authors： Atlan-Gepner C,Naspetti M,Valéro R,Barad M,Lepault F,Vialettes B,Naquet P

更新日期：1999-01-01 00:00:00