T cells demonstrate a Th1-biased response to native beta2-glycoprotein I in a murine model of anti-phospholipid antibody induction.

abstract：:The HEp2 cell cultures appeared highly sensitive in detecting the antinuclear antibodies (ANAb) in systemic sclerosis, principally anticentromere antibodies of the CREST syndrome. The immunoblotting used with either complex cellular extracts from HeLa and rabbit thymus or purified nuclear components (high mobility gro...

journal_title：Autoimmunity

authors： Briolay J,Gioud M,Monier JC,Rodde JL,Cohen J,Roux B,Kaliss B

更新日期：1989-01-01 00:00:00

abstract：:TGF-beta1 is a pleiotropic cytokine, which prevents inappropriate autoimmune responses and balances the requirements of proper immune cell levels during pathologic states that trigger the immune response. We assessed the serum levels of TGF-beta1 and determined the relationship between TGF-beta1 and clinical parameter...

journal_title：Autoimmunity

authors： Mieliauskaite D,Venalis P,Dumalakiene I,Venalis A,Distler J

更新日期：2009-05-01 00:00:00

abstract：:Linomide (quinoline-3-carboxamide), a well tolerated, orally administered compound was recently shown to be effective in the prevention and treatment of several autoimmune diseases in experimental animal models. We have investigated its effect on specific humoral immune responses directed to T-cell-dependent soluble o...

journal_title：Autoimmunity

authors： Morecki S,Nabet C,Falk P,Fridkis-Hareli M,Pecht I,Mond JJ,Slavin S

更新日期：1997-01-01 00:00:00

abstract：:The present study uses the agent-based model IMMSIM to simulate immune responses to a viral infection, with a focus on the impact of preformed memory (homologous and heterologous) on the quality and the efficacy of the response. The in machina results confirm the observed thwarting of new, naïve responses exerted by c...

journal_title：Autoimmunity

authors： Pearson YE,Cheng Y,Selin LK,Puzone R,Celada F

更新日期：2011-06-01 00:00:00

abstract：:Eighty-six patients affected by vitiligo were investigated for Gm, and Km polymorphisms, HLA markers and the presence of organ and non organ-specific autoantibodies. Vitiligo patients had an increased frequency of autoantibodies (71%), in particular anti-parietal cells (26.6%), antithyroglobulin (24.4%) and antithyroi...

journal_title：Autoimmunity

authors： Lorini R,Orecchia G,Martinetti M,Dugoujon JM,Cuccia M

更新日期：1992-01-01 00:00:00

abstract：:To explore the natural course of beta cell function in recent onset diabetes, a subgroup (n=157) of all incident cases (n=879) 15-34 years old, 1992-1993 in Sweden, and with positivity for at least one autoantibody of islet cell antibodies (ICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase an...

journal_title：Autoimmunity

authors： Törn C,Landin-Olsson M,Lernmark A,Scherstén B,Ostman J,Arnqvist HJ,Björk E,Blohmé G,Bolinder J,Eriksson J,Littorin B,Nyström L,Sundkvist G

更新日期：2001-01-01 00:00:00

abstract：:The association of interleukin-6 (IL-6)-174G > C (rs1800795) single nucleotide polymorphism (SNP) with the risk of acquiring rheumatoid arthritis (RA) is a relevant issue because of conflicting and consensus lacking reports published in literature. We investigated IL-6-174G > C promoter polymorphism in 34 RA patients,...

journal_title：Autoimmunity

authors： Dar SA,Haque S,Mandal RK,Singh T,Wahid M,Jawed A,Panda AK,Akhter N,Lohani M,Areeshi MY,Rai G,Datt S,Bhattacharya SN,Ramachandran VG,Das S

更新日期：2017-05-01 00:00:00

abstract：:CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Delta32 for the development of RA has been suggested, future study is required to est...

journal_title：Autoimmunity

authors： Martens HA,Kallenberg CG,Bijl M

更新日期：2009-05-01 00:00:00

abstract：:Although thyroid-associated ophthalmopathy (TAO) is now generally accepted as an autoimmune inflammatory disorder of the extraocular muscles and the orbital connective tissue, its aetiopathogenesis remains poorly understood. Recent data indicate that impaired interactions between T cells and extracellular matrix (ECM)...

journal_title：Autoimmunity

authors： Bednarczuk T,Kiljanski J,Mrowiec T,Slon M,Ing E,Stolarski C,Kennerdell JS,Gorski A,Nauman J,Wall JR

更新日期：1998-01-01 00:00:00

abstract：:We have shown that mice infected with mouse hepatitis virus A59 develop autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH). Because it has been proposed that the immune system is stimulated by alarm signals called damage-associated molecular patterns or alarmins, we investigated the partic...

journal_title：Autoimmunity

authors： Duhalde-Vega M,Retegui LA

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVE:Serum C-X-C motif chemokine 10 (CXCL10) levels have been shown to be elevated in autoimmune thyroid diseases (AITD). This study sought to determine whether newly diagnosed AITD patients with neuromuscular findings had higher levels of CXCL10 than those without neuromuscular manifestations. DESIGN:A total of ...

journal_title：Autoimmunity

authors： Cakir M,Levendoglu F,Kiyici A,Coskun Y

更新日期：2011-09-01 00:00:00

abstract：:We have previously reported that lymphoid cells from systemic lupus erythematosus (SLE) mice with established disease migrate aberrantly. This study evaluates the abnormal lymphocyte migration patterns found in MRL-lpr/lpr (MRL/l) mice in relation to age, disease manifestations and the expression of lymphocyte homing ...

journal_title：Autoimmunity

authors： Schrieber L,Manolios N,Cohen MG,Paull SA,Guiffre AK,Hopper KE

更新日期：1989-01-01 00:00:00

abstract：:Interleukin (IL)-15 and CD30 may be associated with the ongoing intestinal immunologic activation in celiac disease (CD). We studied duodenal biopsies and blood samples of patients with active CD (Cel) and controls in order to determine the regulatory role proposed for CD30(+) T cells in this Th1-driven disease and th...

journal_title：Autoimmunity

authors： Periolo N,Guillén L,Bernardo D,Niveloni SI,Hwang HJ,Garrote JA,Bai JC,Arranz E,Cherñavsky AC

更新日期：2010-06-01 00:00:00

abstract：:Insulin-dependent diabetes mellitus (IDDM) is preceded by the presence of antibodies against islet proteins including a protein tyrosine phosphatase (PTP) designated IA-2. Recently, we cloned a novel PTP named IAR which shares 43% sequence identity with IA-2 and is recognised by antibodies from a majority of patients ...

journal_title：Autoimmunity

authors： Schmidli RS,Colman PG,Cui L,Yu WP,Kewming K,Jankulovski C,Harrison LC,Pallen CJ,DeAizpurua HJ

更新日期：1998-01-01 00:00:00

abstract：:The Foxo subfamily of forkhead (Fox) transcription factors are mammalian homologues of the Caenorhabditis elegans DAF-16 longevity gene, and play key roles in cellular and organism survival, death, proliferation and metabolism. A growing body of evidence indicates that Foxo proteins furthermore play critical roles in ...

journal_title：Autoimmunity

authors： Peng SL

更新日期：2007-09-01 00:00:00

abstract：:The impact of maternal systemic autoimmune diseases on pregnancy outcome is not unequivocally defined. We analysed the pregnancy outcome of 221 pregnancies from 181 autoimmune patients, consecutively followed in a single Italian reference centre from 2001 to 2009. All patients were prospectively followed with monthly ...

journal_title：Autoimmunity

authors： Canti V,Castiglioni MT,Rosa S,Franchini S,Sabbadini MG,Manfredi AA,Rovere-Querini P

更新日期：2012-03-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the dysfunction of T cells, B cells, and dendritic cells and by the production of antinuclear autoantibodies. This editorial provides a synopsis of newly discovered genetic factors and signaling pathways in lupus pathogenesis that ar...

journal_title：Autoimmunity

authors： Perl A

更新日期：2010-02-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a disease associated with a striking increase in the risk of premature cardiovascular (CV) complications due to accelerated atherosclerosis. Traditional CV risk factors seem to be less important predictors of CV events than the presence of active SLE. Immune dysregulation characte...

journal_title：Autoimmunity

authors： Kaplan MJ

更新日期：2009-11-01 00:00:00

abstract：:Thyroid lymphocyte RNA from a Hashimoto patient with high serum levels of autoantibodies to thyroid peroxidase (TPO) was used to construct a phage display antibody library in the phagemid vector pComb3. The library (100,000cfu) encoded IgG1 heavy chains together with kappa light chains. Selection of the phages display...

journal_title：Autoimmunity

authors： Hexham JM,Partridge LJ,Furmaniak J,Petersen VB,Colls JC,Pegg C,Rees Smith B,Burton DR

更新日期：1994-01-01 00:00:00

abstract：:This review focuses on recent advances and new hypothesis in the understanding of the T and dendritic cells contribution to the pathogenesis of idiopathic inflammatory myopathies (IIMs), especially polymyositis (PM) and dermatomyositis (DM). The new data show that non-specific amplification of muscle inflammation by T...

journal_title：Autoimmunity

authors： Chevrel G,Page G,Miossec P

更新日期：2006-05-01 00:00:00

abstract：:Dicer and Drosha are RNase III enzymes that are necessary for the biogenesis of most miRNAs. However, there are no reports on the association of Dicer and Drosha with the pathogenesis of autoimmune thyroid disease (AITD). We genotyped DICER rs3742330A/G and rs1057035T/C as well as DROSHA rs644236C/T and rs10719C/T pol...

journal_title：Autoimmunity

authors： Saeki M,Watanabe M,Inoue N,Tokiyoshi E,Takuse Y,Arakawa Y,Hidaka Y,Iwatani Y

更新日期：2016-12-01 00:00:00

abstract：:Congenic BB.SHR rat strains were established by crossing of spontaneously diabetic BB/OK rats and diabetes-resistant SHR rats. Chromosomal regions on which the genes Iddm 4 (BB.6s), Iddm6 (BB.Xs) and Iddm 2 (BB.LL) are located were exchanged. As a result of genetic manipulation diabetes incidence was markedly reduced ...

journal_title：Autoimmunity

authors： Lucke S,Klöting I,Pusch A,Heinrich HW,Hahn HJ

更新日期：2003-05-01 00:00:00

abstract：:Marked fluctuations in the levels of a common DNA-antibody idiotype, PR4-Id have been found on IgM and IgA antibodies in particular and to a lesser extent on IgG in serial bleeds of 14 lupus patients. Few clear cut examples were found of the PR4-Id levels reflecting disease activity. However, the idiotype expression w...

journal_title：Autoimmunity

authors： Pilcher C,Williams W,Isenberg DA

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:Henoch-Schonlein purpura (HSP) is a systemic vasculitis characterized by IgA-containing deposits in the skin, joints, gastrointestinal mucosa and glomeruli. HSP is much rarer in adults than in children. Among a number of other pathogenic factors, Helicobacter pylori (Hp) has recently been implicated in the ga...

journal_title：Autoimmunity

authors： Novák J,Szekanecz Z,Sebesi J,Takáts A,Demeter P,Bene L,Sipka S,Csiki Z

更新日期：2003-08-01 00:00:00

abstract：:The aim of our study was to investigate and characterize regulatory T cells (Treg) in peripheral blood of patients with connective tissue diseases (Systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, poly- and dermatomyositis) as compared with blood from healthy controls. Treg cells were quantified a...

journal_title：Autoimmunity

authors： Banica L,Besliu A,Pistol G,Stavaru C,Ionescu R,Forsea AM,Tanaseanu C,Dumitrache S,Otelea D,Tamsulea I,Tanaseanu S,Chitonu C,Paraschiv S,Balteanu M,Stefanescu M,Matache C

更新日期：2009-01-01 00:00:00

abstract：:We report in this paper on obvious fibrotic lesions in the liver of mice undergoing specified graft-versus-host reaction (GVHR). B6 CD8+ splenocytes were transferred into (bm 12 x bm 1)F1 mice to induce GVHR. Recipient mice had been thymectomized and administrated with anti-CD8 monoclonal antibody (mAb) to deplete CD8...

journal_title：Autoimmunity

authors： Inada S,Suzuki K,Kimura T,Hayashi A,Narita T,Yui R,Asakura H,Fujiwara M

更新日期：1995-01-01 00:00:00

abstract：:This study was undertaken to determine whether the expression of 17.109, 6B6.6 and 4C9 rheumatoid factor (RF) idiotypes is predictive of the development of rheumatoid arthritis (RA) and whether the RF response is idiotypically restricted in an inbred population of Pima Indians who have a genetic predisposition for the...

journal_title：Autoimmunity

authors： Davidson A,Keiser HD,del Puente A,Bennett PH,Schrohenloher R,Koopman WJ

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVES:Autoimmune sensorineural hearing loss (ASNHL) is a relatively rare disorder which can lead to total deafness. At present, no specific laboratory test with adequate sensitivity and specificity is available to confirm the clinical suspicion of ASNHL. The aim of this study was to identify if evaluation of anti-...

journal_title：Autoimmunity

authors： Bonaguri C,Orsoni JG,Zavota L,Monica C,Russo A,Pellistri I,Rubino P,Giovannelli L,Manzotti F,Piazza F

更新日期：2007-02-01 00:00:00

abstract：:In a previous work we characterized a major epitope of thyroid peroxidase (TPO), which was recognised by 66% of 157 patients with autoimmune thyroid disease (AITD) and 9 out of 50 patients with non-thyroidal autoimmune disease (NTAID) 6 of whom had antibodies to the gastric parietal cell antigen (PCA). In the present ...

journal_title：Autoimmunity

authors： Elisei R,Mariotti S,Swillens S,Vassart G,Ludgate M

更新日期：1990-01-01 00:00:00

abstract：:Systemic Lupus Erythematosus is an autoimmune disease characterized by the formation of anti-nuclear autoantibodies, particularly anti-chromatin. Although the aetiology of the disease has not yet been fully elucidated, several mechanisms have been proposed to be involved. Due to an aberrant apoptosis or decreased remo...

journal_title：Autoimmunity

authors： Bouts YM,Wolthuis DF,Dirkx MF,Pieterse E,Simons EM,van Boekel AM,Dieker JW,van der Vlag J

更新日期：2012-12-01 00:00:00