Abstract:
:The present study uses the agent-based model IMMSIM to simulate immune responses to a viral infection, with a focus on the impact of preformed memory (homologous and heterologous) on the quality and the efficacy of the response. The in machina results confirm the observed thwarting of new, naïve responses exerted by cross-reacting memory, but they also reveal that the competitive inhibition is made possible by the different time frame used by the primary and the secondary response, a well-known fact, epitomized by the interval of about 75 time steps between their peaks. This novel finding justifies the depression of naïve responses and the long-term consequences it could bring about and the role of memory as a player in a survival of the fittest game.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Pearson YE,Cheng Y,Selin LK,Puzone R,Celada Fdoi
10.3109/08916934.2011.523275subject
Has Abstractpub_date
2011-06-01 00:00:00pages
315-27issue
4eissn
0891-6934issn
1607-842Xjournal_volume
44pub_type
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