Abstract:
:Infectious agents have been implicated in the etiopathogenesis of various vasculitides via numerous and overlapping mechanisms including direct microbial invasion of endothelial cells, immune complex mediated vessel wall damage and stimulation of autoreactive B and/or T cells through molecular mimicry and superantigens. While the causative role of hepatitis B virus in polyarteritis nodosa and hepatitis C virus in mixed cryoglobulinemia is clearly established, evidence for the association of other infectious agents with vasculitis, including human immunodeficiency virus, parvovirus B19, cytomegalovirus, varicella zoster virus, Staphylococcus aureus, rickettsiaceae, Treponema pallidum and Borrelia burgdorferi, among numerous others, is accumulating. The spectrum of association of infectious agents; bacteria, viruses and parasites, with systemic vasculitides, will be reviewed herewith.
journal_name
Autoimmunityjournal_title
Autoimmunityauthors
Lidar M,Lipschitz N,Langevitz P,Shoenfeld Ydoi
10.1080/08916930802613210subject
Has Abstractpub_date
2009-08-01 00:00:00pages
432-8issue
5eissn
0891-6934issn
1607-842Xpii
10.1080/08916930802613210journal_volume
42pub_type
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