Nitric oxide production is not involved in the effects of interleukin-1 beta on cAMP, thyroglobulin and interleukin-6 in TSH-stimulated human thyroid cells.


:Interleukin (IL)-1 inhibits the function of insulin-producing rat pancreatic beta-cells in vitro and in vivo, and it has been postulated that the IL-1 effect is mediated through the cytokine inducible nitric oxide (NO) synthase. IL-1 inhibits the function of cultured human thyroid cells too, and in this study human thyroid cell production of NO in response to the TSH-stimulated influence of IL-1 beta (10(5) U/l) and TNF-alpha (10(6) U/l), alone or in combination was measured. IL-1 beta, but not TNF-alpha, induced an increase in nitrite production, which was significantly reduced by the competitive inhibitor of nitric oxide synthase L-NG-monomethyl-arginine (L-NMMA) (0.1 mmol/L and 0.5 mmol/L). However, the nitrite production was unrelated to the IL-1 beta-induced inhibition of thyroglobulin (Tg) and cyclic AMP (cAMP) and the IL-1 beta-induced IL-6 production. Thus, it is unlikely that NO is a second mediator of the demonstrated effects of IL-1 beta and TNF-alpha on human thyroid cells in culture.






Rasmussen AK,Di Marco R,Diamant M,Feldt-Rasmussen U,Bendtzen K




Has Abstract


1994-01-01 00:00:00












  • The infectious etiology of vasculitis.

    abstract::Infectious agents have been implicated in the etiopathogenesis of various vasculitides via numerous and overlapping mechanisms including direct microbial invasion of endothelial cells, immune complex mediated vessel wall damage and stimulation of autoreactive B and/or T cells through molecular mimicry and superantigen...


    pub_type: 杂志文章,评审


    authors: Lidar M,Lipschitz N,Langevitz P,Shoenfeld Y

    更新日期:2009-08-01 00:00:00

  • Sera from lupus patients inhibit growth of P. falciparum in culture.

    abstract::A large number of malaria immune persons from Eastern India were found to possess antibodies to the ribosomal phosphoprotein P0 (PfP0) of the human malarial parasite Plasmodium falciparum. The characterization of PfP0 has been reported recently, and it has been shown that antibodies against PfP0 inhibit P. falciparum ...


    pub_type: 杂志文章


    authors: Singh S,Chatterjee S,Sohoni R,Badakere S,Sharma S

    更新日期:2001-01-01 00:00:00

  • Pregnancy outcomes in patients with systemic autoimmunity.

    abstract::The impact of maternal systemic autoimmune diseases on pregnancy outcome is not unequivocally defined. We analysed the pregnancy outcome of 221 pregnancies from 181 autoimmune patients, consecutively followed in a single Italian reference centre from 2001 to 2009. All patients were prospectively followed with monthly ...


    pub_type: 杂志文章


    authors: Canti V,Castiglioni MT,Rosa S,Franchini S,Sabbadini MG,Manfredi AA,Rovere-Querini P

    更新日期:2012-03-01 00:00:00

  • Complement regulatory proteins and autoimmunity.

    abstract::The complement system is known to be involved in autoimmunity at several levels. Activated complement contributes to the inflammatory tissue injury characteristic of many autoimmune disease settings. On the other hand, early components of the classical pathway, including C1q, C4 and C2, are thought to be important for...


    pub_type: 杂志文章,评审


    authors: Song WC

    更新日期:2006-08-01 00:00:00

  • Elevated levels of anti-Helicobacter pylori antibodies in Henoch-Schönlein purpura.

    abstract:OBJECTIVE:Henoch-Schonlein purpura (HSP) is a systemic vasculitis characterized by IgA-containing deposits in the skin, joints, gastrointestinal mucosa and glomeruli. HSP is much rarer in adults than in children. Among a number of other pathogenic factors, Helicobacter pylori (Hp) has recently been implicated in the ga...


    pub_type: 杂志文章


    authors: Novák J,Szekanecz Z,Sebesi J,Takáts A,Demeter P,Bene L,Sipka S,Csiki Z

    更新日期:2003-08-01 00:00:00

  • Antiphospholipid antibody production during Mediterranean spotted fever.

    abstract::Antiphospholipid antibodies (aPLA) were discovered during the course of Mediterranean spotted fever (MSF) caused by Rickettsia conorii and characterized by endothelial cell (EC) damage resulting from this organism's tropism for EC. In two MSF patients, two types of aPLA were identified: antiphosphatidylethanolamine an...


    pub_type: 杂志文章


    authors: Sotto A,Bérard M,Bessis D,Porneuf M,Jourdan J,Boffa MC

    更新日期:1995-01-01 00:00:00

  • Immunopathology of experimental autoimmune uveoretinitis in primates.

    abstract::The eyes and pineal glands from 10 monkeys immunized with S-antigen were studied using routine histopathological and immunohistochemical techniques. Seven out of 10 animals developed uveitis between 19 and 33 days after the initial immunization. Histopathology of the eyes harvested 70 days after immunization showed mo...


    pub_type: 杂志文章


    authors: Fujino Y,Li Q,Chung H,Hikita N,Nussenblatt RB,Gery I,Chan CC

    更新日期:1992-01-01 00:00:00

  • Anti-68 kDa antibodies in autoimmune sensorineural hearing loss: are these autoantibodies really a diagnostic tool?

    abstract:OBJECTIVES:Autoimmune sensorineural hearing loss (ASNHL) is a relatively rare disorder which can lead to total deafness. At present, no specific laboratory test with adequate sensitivity and specificity is available to confirm the clinical suspicion of ASNHL. The aim of this study was to identify if evaluation of anti-...


    pub_type: 杂志文章


    authors: Bonaguri C,Orsoni JG,Zavota L,Monica C,Russo A,Pellistri I,Rubino P,Giovannelli L,Manzotti F,Piazza F

    更新日期:2007-02-01 00:00:00

  • Intermittent feeding and fasting reduces diabetes incidence in BB rats.

    abstract::Food intake may be one of several factors which influence the risk of development of insulin dependent diabetes mellitus, but the influence of the pattern of food supply has not been studied previously. The aim of the present study was to investigate the effect of intermittent feeding and fasting upon diabetes in BB r...


    pub_type: 杂志文章


    authors: Pedersen CR,Hagemann I,Bock T,Buschard K

    更新日期:1999-01-01 00:00:00

  • HLA-DRB1 genes and susceptibility to rheumatoid arthritis in three ethnic groups from Malaysia.

    abstract::Worldwide population studies have generally agreed that rheumatoid arthritis (RA) is associated with a group of HLA-DRB1 alleles which share a common amino acid sequence at residues 70-74. This represents the first study to investigate the association of HLA-DRB1 genes with susceptibility to RA amongst Malay, Chinese ...


    pub_type: 杂志文章


    authors: Kong KF,Yeap SS,Chow SK,Phipps ME

    更新日期:2002-07-01 00:00:00

  • In vivo migration of tonsil lymphocytes in rheumatoid synovial tissue engrafted in SCID mice: involvement of LFA-1.

    abstract::Integrin-adressin binding is a critical step in lymphocte attachment to target tissues. The mucosal recognition systems (alpha E beta 7, alpha 4 beta 7, MADcam-1) have been implicated in the autoimmune process in rheumatoid arthritis. We developed a model for in vivo study of radio-labelled lymphocyte circulation and ...


    pub_type: 杂志文章


    authors: Jorgensen C,Couret I,Canovas F,Bologna C,Brochier J,Reme T,Sany J

    更新日期:1996-01-01 00:00:00

  • Sjögren's syndrome-like autoimmune sialadenitis in MRL-Faslpr mice is associated with expression of glucocorticoid-induced TNF receptor-related protein (GITR) ligand and 4-1BB ligand.

    abstract::Although costimulatory molecules have been shown to play crucial roles in the immune response, their involvement in the pathogenesis of Sjögren's syndrome is incompletely understood. In this study, we evaluated the relationship between the severity of spontaneous Sjögren's syndrome-like autoimmune sialadenitis in MRL/...


    pub_type: 杂志文章


    authors: Saito K,Mori S,Date F,Ono M

    更新日期:2013-06-01 00:00:00

  • Immunosuppressive therapies in myasthenia gravis.

    abstract::Immunosuppression is the mainstay of treatment for myasthenia gravis (MG). In this paper, we review the mechanisms of action and clinical application of corticosteroids and different classes of immunosuppressive drugs that are currently used in MG patients, and present the results of their use in more than 1000 patien...


    pub_type: 杂志文章,评审


    authors: Sanders DB,Evoli A

    更新日期:2010-08-01 00:00:00

  • NKT cell cytokine imbalance in murine diabetes mellitus.

    abstract::A minor subset of murine MHC class I-restricted T cells which express both the alphabeta form of the T cell receptor and a NK lineage marker, termed NKT cells, is capable of secreting significant amounts of Interleukin-4 and Interferon-y upon activation. As such NKT cells may play a role in development of Th1 and Th2 ...


    pub_type: 杂志文章


    authors: Frey AB,Rao TD

    更新日期:1999-01-01 00:00:00

  • Expression of major histocompatibility complex class II antigen in NOD mouse thyroid.

    abstract::Non obese diabetic (NOD) mice spontaneously develop thyroiditis in addition to diabetes. Mononuclear cells begin to infiltrate the thyroid of these animals in the first month of life. The expression of major histocompatibility complex (MHC) class II (Ia) antigens by cells in the thyroid from NOD mice of various ages w...


    pub_type: 杂志文章


    authors: Margolese H,O'Keefe C,Chung F,Ertug F,Wall JR,Bernard NF

    更新日期:1994-01-01 00:00:00

  • The prevalence of anti-acetylcholinesterase antibodies in autoimmune disease.

    abstract::A robust and precise enzyme linked immunosorbent assay (ELISA) with proven sensitivity and specificity has been employed to detect human antibodies (allogenic/autogenic) to human acetylcholinesterase (AChE). The sensitivity of the method has been established using mouse monoclonal antibodies (0.8 ng/ml) and uniquely, ...


    pub_type: 杂志文章


    authors: Geen J,Howells RC,Ludgate M,Hullin DA,Hogg SI

    更新日期:2004-12-01 00:00:00

  • Flow cytometric analysis of the LE cell phenomenon.

    abstract::A flow cytometry-based phagocytosis assay was developed and utilized to measure the LE cell phenomenon at the single cell level in vitro. Since the lupus erythematosus (LE) cell phenomenon is a special form of necro-phagocytosis in the presence of anti-dsDNA antibodies, dead substrate cells or chicken erythrocytes nuc...


    pub_type: 杂志文章


    authors: Böhm I

    更新日期:2004-02-01 00:00:00

  • Polyarthritis in MRL-lpr/lpr mice: mouse type II collagen is antigenic but not arthritogenic.

    abstract::In addition to a lupus-like syndrome and massive T cell proliferation, MRL-lpr/lpr(MRL/l) mice develop an arthritic process very similar serologically and histologically to human rheumatoid arthritis (RA). Recently, we have developed in DBA/1 mice an experimental model of autoimmune arthritis (EAA) which shares clinic...


    pub_type: 杂志文章


    authors: Boissier MC,Texier B,Carlioz A,Fournier C

    更新日期:1989-01-01 00:00:00

  • Allograft inflammatory factor-1 and its immune regulation.

    abstract::The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma (IFN-gamma) inducible Ca(2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins including ionized Ca(2+)-binding adaptor 1, microglia response factor-1, and daintain are identical with AIF-1. The expre...


    pub_type: 杂志文章,评审


    authors: Liu G,Ma H,Jiang L,Zhao Y

    更新日期:2007-03-01 00:00:00

  • Premature vascular damage in systemic lupus erythematosus.

    abstract::Systemic lupus erythematosus (SLE) is a disease associated with a striking increase in the risk of premature cardiovascular (CV) complications due to accelerated atherosclerosis. Traditional CV risk factors seem to be less important predictors of CV events than the presence of active SLE. Immune dysregulation characte...


    pub_type: 杂志文章,评审


    authors: Kaplan MJ

    更新日期:2009-11-01 00:00:00

  • Cloning and characterisation of TPO autoantibodies using combinatorial phage display libraries.

    abstract::Thyroid lymphocyte RNA from a Hashimoto patient with high serum levels of autoantibodies to thyroid peroxidase (TPO) was used to construct a phage display antibody library in the phagemid vector pComb3. The library (100,000cfu) encoded IgG1 heavy chains together with kappa light chains. Selection of the phages display...


    pub_type: 杂志文章


    authors: Hexham JM,Partridge LJ,Furmaniak J,Petersen VB,Colls JC,Pegg C,Rees Smith B,Burton DR

    更新日期:1994-01-01 00:00:00

  • MRL/MpJ-Fas(lpr) mice show abnormalities in ovarian function and morphology with the progression of autoimmune disease.

    abstract::The immune system is known to affect reproductive function, and maternal-fetal immune tolerance is essential for a successful pregnancy. To investigate the relationship between autoimmune disease and female reproductive function, we performed a comparative analysis of the ovarian phenotypes for C57BL/6 mice, autoimmun...


    pub_type: 杂志文章


    authors: Otani Y,Ichii O,Otsuka-Kanazawa S,Chihara M,Nakamura T,Kon Y

    更新日期:2015-01-01 00:00:00

  • Expression of B cell receptor-associated signaling molecules in human lupus.

    abstract::B cell receptor (BcR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated co-receptors. Mounting evidence indicates that abnormal BcR signaling, such as occurs in SHP-1 and Lyn-deficient mice, results in production of pathogenic autoantibodies and lupus-like glome...


    pub_type: 杂志文章


    authors: Huck S,Le Corre R,Youinou P,Zouali M

    更新日期:2001-05-01 00:00:00

  • Introduction: knowledge is survival-the mission of the immune system and its stochastic simulations.

    abstract::In this introduction the timeliness and interest of dedicating an issue of Autoimmunity to mostly "discrete" models is motivated by highlighting number of circumstances, observations encounters, that all have favored the rise of a family of agent based simulations of the Immune System. Franco Celada was among the firs...




    authors: Celada F

    更新日期:2011-06-01 00:00:00

  • Thymic remodeling associated with hyperplasia in myasthenia gravis.

    abstract::Acquired myasthenia gravis (MG), a neurological autoimmune disease, is caused by autoantibodies against components of the neuromuscular junction that lead to disabling muscle fatigability. The thymus is clearly involved in the pathogenesis of early-onset MG with anti-acetylcholine receptor antibodies, and thymic hyper...


    pub_type: 杂志文章,评审


    authors: Le Panse R,Bismuth J,Cizeron-Clairac G,Weiss JM,Cufi P,Dartevelle P,De Rosbo NK,Berrih-Aknin S

    更新日期:2010-08-01 00:00:00

  • Cytotoxic T lymphocyte antigen 4 heterozygous codon 49 A/G dimorphism is associated to latent autoimmune diabetes in adults (LADA).

    abstract::Autoimmune diabetes is an organ specific and multifactorial disorder with a classical onset as insulin dependent diabetes mellitus (IDDM) and with another form of onset as latent autoimmune diabetes in adults (LADA), which has a slower onset and a later progress to insulin dependency as a result of the beta cells dest...


    pub_type: 杂志文章


    authors: Caputo M,Cerrone GE,López AP,Villalba A,Krochik GA,Cédola FN,Targovnik HM,Frechtel GD

    更新日期:2005-06-01 00:00:00

  • Effect of administration of apoptotic blebs on disease development in lupus mice.

    abstract:INTRODUCTION:Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by the formation of autoantibodies against nuclear components. Disturbed apoptosis and reduced clearance of apoptotic material have been assigned a role in the pathogenesis of SLE. During apoptosis, apoptotic blebs are formed, in whi...


    pub_type: 杂志文章


    authors: Fransen JH,Berden JH,Koeter CM,Adema GJ,Van Der Vlag J,Hilbrands LB

    更新日期:2012-06-01 00:00:00

  • Caerulomycin A suppresses the differentiation of naïve T cells and alleviates the symptoms of experimental autoimmune encephalomyelitis.

    abstract::Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease. Experimental autoimmune encephalomyelitis (EAE) is an animal model of MS. It is characterized by frequent re...


    pub_type: 杂志文章


    authors: Kujur W,Gurram RK,Maurya SK,Nadeem S,Chodisetti SB,Khan N,Agrewala JN

    更新日期:2017-08-01 00:00:00

  • Low prevalence of anti-small ubiquitin-like modifier activating enzyme antibodies in dermatomyositis patients.

    abstract:BACKGROUND:The myositis-specific autoantibodies that characterize certain forms of inflammatory myopathy are useful in diagnosing dermatomyositis (DM) / polymyositis and predicting its prognosis. Autoantibodies to small ubiquitin-like modifier activating enzyme (SAE) have been identified as a DM-marker antibody in Euro...


    pub_type: 杂志文章


    authors: Muro Y,Sugiura K,Akiyama M

    更新日期:2013-06-01 00:00:00

  • Pathogenic mechanisms in systemic lupus erythematosus.

    abstract::Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the dysfunction of T cells, B cells, and dendritic cells and by the production of antinuclear autoantibodies. This editorial provides a synopsis of newly discovered genetic factors and signaling pathways in lupus pathogenesis that ar...


    pub_type: 社论


    authors: Perl A

    更新日期:2010-02-01 00:00:00