Nitric oxide production is not involved in the effects of interleukin-1 beta on cAMP, thyroglobulin and interleukin-6 in TSH-stimulated human thyroid cells.

abstract：:B cell receptor (BcR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated co-receptors. Mounting evidence indicates that abnormal BcR signaling, such as occurs in SHP-1 and Lyn-deficient mice, results in production of pathogenic autoantibodies and lupus-like glome...

journal_title：Autoimmunity

authors： Huck S,Le Corre R,Youinou P,Zouali M

更新日期：2001-05-01 00:00:00

abstract：:Autoantibodies directed against nuclear antigens often arise in autoimmune disease associated with the failure to clear apoptotic cells in a swift and timely manner. Nucleic acids present in apoptotic cells and in membranous microparticles derived thereof exert adjuvant activity in the immune response to apoptosis. Th...

journal_title：Autoimmunity

authors： Bekeredjian-Ding I

更新日期：2013-08-01 00:00:00

abstract：:The aim of this study was to examine the frequency of occurrence of autoantibodies against beta1-adrenoceptors in patients with hepatitis virus myocarditis (HVM) and its possible correlation with clinical characteristics. A total of 103 patients with viral myocarditis were divided into a positive group (HVM group, n=2...

journal_title：Autoimmunity

authors： Wang ZH,Liao YH,Fu M

更新日期：2001-01-01 00:00:00

abstract：:The effects of intravenous immunoglobulin (IVIG) products were recently examined in patients with Alzheimer's disease (AD). Although encouraging results were obtained in pilot studies, later trials produced negative results. The rationale for these studies was that IVIG contains antibodies to amyloid-beta (Aβ). Howeve...

journal_title：Autoimmunity

authors： Loeffler DA,Klaver AC,Coffey MP

更新日期：2015-06-01 00:00:00

abstract：:CCR5 and its ligands play important roles in rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A deletion of 32 bp in its gene leads to the production of a non-functional receptor. Although a protective effect of CCR5 Delta32 for the development of RA has been suggested, future study is required to est...

journal_title：Autoimmunity

authors： Martens HA,Kallenberg CG,Bijl M

更新日期：2009-05-01 00:00:00

abstract：:The thymic medulla is a complex microenvironment which plays a crucial role in central tolerance induction. Using a quantitative histological analysis of non-obese diabetic (NOD) mice, we show that the medulla undergoes several structural modifications during the course of the disease in NOD mice. Indeed, the majority...

journal_title：Autoimmunity

authors： Atlan-Gepner C,Naspetti M,Valéro R,Barad M,Lepault F,Vialettes B,Naquet P

更新日期：1999-01-01 00:00:00

abstract：:The nature of the immunosuppressive effect of antithyroid drugs has been a subject of controversy. It has been claimed that these agents exert a direct effect on the immune system, although we and others have suggested that the drugs affect the thyroid cells primarily with consequent reduced thyrocyte-immunocyte signa...

journal_title：Autoimmunity

authors： Aguayo J,Michaud P,Iitaka M,Degroot LJ,Row VV,Volpé R

更新日期：1989-01-01 00:00:00

abstract：:We analysed the presence of anti-cyclic citrullinated peptide (anti-CCP) and anti-keratin (AKA) antibodies of the IgG class in sera of patients with defined juvenile idiopathic arthritis (JIA) of various subgroups with more than one year duration of the disease. Enzyme-linked immunosorbent assay (Immunoscan RA, Eurodi...

journal_title：Autoimmunity

authors： Hromadnikova I,Stechova K,Pavla V,Hridelova D,Houbova B,Voslarova S,Nekvasilova H,Vavrinec J

更新日期：2002-09-01 00:00:00

abstract：:A patient with severe Evans syndrome received an allo-BMT from his HLA-identical sister on November, 2000. Full marrow and blood donor chimerism were achieved only after 5 donor lymphocyte infusions (DLI), and coincided with complete clinical remission and disappearence of auto-antibodies. Five years later, hemolytic ...

journal_title：Autoimmunity

authors： Marmont AM,Gualandi F,Occhini D,Morandi F,Ferretti E,Pezzolo A,Strada P,Ravetti JL,Pistoia V,Falanga A,Bacigalupo A

更新日期：2006-09-01 00:00:00

abstract：:Numerous studies have shown that autoantigens may be clustered in the blebs of apoptotic cells. However, it is not yet clear in what circumstances apoptotic cells could be immunogenic rather than tolerogenic when interacting with macrophages, dendritic cells, and B cells. In order to further study this question we com...

journal_title：Autoimmunity

authors： Shoshan Y,Mevorach D

更新日期：2004-03-01 00:00:00

abstract：:Atherosclerosis is initiated by cholesterol entry into arteries that triggers chronic immune-inflammatory lesions in the vessels. Early lesions are clinically insignificant but advanced complex lesions and vulnerable rupture prone lesions impact on quality of life and can be life threatening. Rupture of vulnerable ath...

journal_title：Autoimmunity

authors： Kyaw T,Tipping P,Bobik A,Toh BH

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical features of AIHA/ES patients with clonal Ig/TCR gene rearrangement. METHODS:Ig/TCR gene rearrangements were measured by BIOMED-2 PCR. 44 primary AIHA/ES patients were enrolled in the study. Clinical characteristics were analyzed and compared between patients with and without clona...

journal_title：Autoimmunity

authors： Zhu H,Zhao M,Cao Z,Yang J,Li Y,Xing L

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVES:Autoantibodies to tumor-associated antigens including survivin have been detected in sera from patients with hepatocellular carcinoma (HCC). However, little is known about autoantibody responses to tumor-associated antigens in patients with chronic hepatitis, which strongly predisposes to development of HCC....

journal_title：Autoimmunity

authors： Yagihashi A,Asanuma K,Kobayashi D,Tsuji N,Torigoe T,Sato N,Watanabe N

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to characterise the functionally relevant minor lymphocyte subpopulations in whole blood of multiple sclerosis (MS) patients and their potential utility as biomarkers for treatment follow up. MATERIAL AND METHODS:Peripheral blood from 40 healthy donors (HD) and 66 MS patients [...

journal_title：Autoimmunity

authors： Teniente-Serra A,Grau-López L,Mansilla MJ,Fernández-Sanmartín M,Ester Condins A,Ramo-Tello C,Martínez-Cáceres E

更新日期：2016-06-01 00:00:00

abstract：:It is generally accepted that thyroid-associated ophthalmopathy (TAO) is an autoimmune disease of the eye muscle (EM) and the surrounding orbital connective tissue in which circulating antibodies play an important role. Antibodies against EM membrane proteins of 63-67kDa mol. wt. seem to be the best markers of ophthal...

journal_title：Autoimmunity

authors： Gunji K,Kubota S,Stolarski C,Wengrowicz S,Kennerdell JS,Wall JR

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:T follicular helper (Tfh) cells are known to regulate humoral immune response. In this study we examined the correlation of different subsets of peripheral blood Tfh cells in patients with diabetic nephropathy (DN). METHODS:A total of 23 DN patients and 15 healthy controls (HC) were investigated for various...

journal_title：Autoimmunity

authors： Zhang N,Tai J,Qu Z,Zhang Z,Zhao S,He J,Zhang S,Jiang Y

更新日期：2016-09-01 00:00:00

abstract：:Pre-diabetes is a long-lasting condition that precedes type 2 diabetes (T2D). T2D has been shown to suppress the immune response. However, it remains unclear if immune activation occurs before the onset of T2D during the progression of the pre-diabetic state. This study sought to characterize the changes in general im...

journal_title：Autoimmunity

authors： Mzimela NC,Ngubane PS,Khathi A

更新日期：2019-02-01 00:00:00

abstract：:Pemphigus vulgaris is a potentially fatal autoimmune mucocutaneous disease associated with production of IgG autoantibodies to desmoglein 3, a 130 kDa epidermal protein. To further characterize the epitope(s) of pemphigus vulgaris antigen we established two human-human hybridoma by fusion of the peripheral blood monon...

journal_title：Autoimmunity

authors： Bhol KC,Ahmed AR

更新日期：2002-03-01 00:00:00

abstract：:To evaluate changes in TSH receptor antibody after surgery in Graves' disease and its relationship with the degree of lymphocytic infiltration, serial serum levels of TSH receptor antibody were measured before and after the subtotal thyroidectomy in 50 patients with Graves' disease. In 22 (44%) out of 50 patients, thy...

journal_title：Autoimmunity

authors： Cho BY,Oh SK,Shong YK,Kim SE,Yoo HY,Lee HK,Koh CS,Min HK

更新日期：1990-01-01 00:00:00

abstract：:T and B lymphocytes are central regulators and effectors of immune responses and are believed to have a key role in many autoimmune diseases. Targeting the activation or effector function of lymphocytes is a potentially effective approach to treat autoimmunity. Typically, T-cell activation occurs after engagement of t...

journal_title：Autoimmunity

authors： Felix NJ,Suri A,Salter-Cid L,Nadler SG,Gujrathi S,Corbo M,Aranda R

更新日期：2010-11-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) have a significantly increased risk of cardiovascular disease (CVD). Increased prevalence of atherosclerosis may explain part of this enhanced risk, but SLE related CVD can also result from other mechanisms. Vascular events may be the result of several pathophysiologic ...

journal_title：Autoimmunity

authors： Gustafsson JT,Svenungsson E

更新日期：2014-03-01 00:00:00

abstract：:Augmented and prolonged expression of CD40 ligand (CD40L) was recently reported in lymphoid cells from human lupus patients, suggesting that CD40/CD40L pathway was involved in the pathogenesis of systemic autoimmune diseases. This study was thus designed to study the expression of CD40 and CD40L among cell populations...

journal_title：Autoimmunity

authors： Liu MF,Chao SC,Wang CR,Lei HY

更新日期：2001-01-01 00:00:00

abstract：:In a previous study, we showed that the Ly6G(-)CD11b(+) blood monocytes residing in naïve mice are intrinsically immunosuppressive and that loss of this suppressive function may contribute to the development of autoimmunity in experimental autoimmune encephalomyelitis (EAE), a murine model of human multiple sclerosis....

journal_title：Autoimmunity

authors： Slaney CY,Toker A,Fraser JD,Harper JL,Bäckström BT

更新日期：2013-06-01 00:00:00

abstract：:The T cell repertoire expressed by Tsk2 mice, a novel experimental model of systemic sclerosis, was examined to determine whether cells infiltrating the areas of involved skin exhibit a T cell receptor (TCR) bias. Reverse transcription-polymerase chain reactions (RT-PCR) were conducted using RNA extracted from lymph n...

journal_title：Autoimmunity

authors： Wooley PH,Sud S,Langendorfer A,Calkins C,Christner PJ,Peters J,Jimenez SA

更新日期：1998-01-01 00:00:00

abstract：:A robust and precise enzyme linked immunosorbent assay (ELISA) with proven sensitivity and specificity has been employed to detect human antibodies (allogenic/autogenic) to human acetylcholinesterase (AChE). The sensitivity of the method has been established using mouse monoclonal antibodies (0.8 ng/ml) and uniquely, ...

journal_title：Autoimmunity

authors： Geen J,Howells RC,Ludgate M,Hullin DA,Hogg SI

更新日期：2004-12-01 00:00:00

abstract：:The autoimmune thyroid disorders, or AITDs, comprise 2 related disorders, Graves' disease and Hashimoto thyroiditis. In AITD, immune system produces antibodies against autothyroid antigens. The etiology of AITDs involves a complex interaction between genetic predisposing factors and environmental triggering factors. V...

journal_title：Autoimmunity

authors： Alkhateeb A,Jarun Y,Tashtoush R

更新日期：2013-05-01 00:00:00

abstract：:Blockade of the complement cascade at the C5a/C5a receptor (C5aR)-axis is believed to be an attractive treatment avenue in rheumatoid arthritis (RA). However, the effects of such interventions during the early phases of arthritis remain to be clarified. In this study we use the murine delayed-type hypersensitivity art...

journal_title：Autoimmunity

authors： Atkinson SM,Nansen A,Usher PA,Sondergaard BC,Mackay CR,Friedrichsen B,Chang CC,Tang R,Skov S,Haase C,Hornum L

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet aut...

journal_title：Autoimmunity

authors： Bossowski A,Stożek K,Rydzewska M,Niklińska W,Gąsowska M,Polnik D,Szalecki M,Mikłosz A,Chabowski A,Reszeć J

更新日期：2020-11-01 00:00:00

abstract：:To investigate the expression patterns of activation-induced cytidine deaminase (AID) variants in peripheral blood mononuclear cells (PBMCs) of patients with ankylosing spondylitis (AS) and examine their clinical implications, we isolated PBMCs from healthy controls (HC, n = 33) and patients with AS (n = 62), and meas...

journal_title：Autoimmunity

authors： Kim JY,Yoon HK,Song ST,Park SR,Shim SC

更新日期：2017-12-01 00:00:00

abstract：:The expression of major histocompatibility complex class II molecules (Ia antigen) has been analyzed by immunoperoxidase staining in thyroids of normal C3H mice, of iodine-deficient mice with a hyperplastic goiter and of mice during goiter involution induced by administration of either a high iodide dose (HID, 10 micr...

journal_title：Autoimmunity

authors： Toussaint-Demylle D,Many MC,Theisen H,Kraal G,Denef JF

更新日期：1990-01-01 00:00:00